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| Meta analysis of compound trabeculectomy and traditional trabeculectomy in the treatment of primary angle-closure glaucoma |
| JIANG Pengfei1,2 LI Xiang1,2 PENG Qinghua1,2,3 |
1.College of Traditional Chinese Medicine, Hu′nan University of Chinese Medicine, Hu′nan Province, Changsha 410208, China;
2.Hu′nan Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Eye, Ear, Nose and Throat Diseases, Hu′nan Province, Changsha 410208, China;
3.Department of Ophthalmology, the First Affiliated Hospital of Hu′nan University of Chinese Medicine, Hu′nan Province, Changsha 410007, China |
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Abstract Objective To evaluate the efficacy of compound trabeculectomy and traditional trabeculectomy in the treatment of primary angle-closure glaucoma by Meta analysis. Methods According to the method of Cochrane systematic review, the databases of Cochrane library, PubMed, Embase, CBM, CNKI, VIP, Wanfang were retrieved by computer. The retrieval time limit was from January 2013 to January 2017. The randomized controlled trials of compound trabeculectomy (experimental group) and traditional trabeculectomy (control group) in the treamtent of primary angle-closure glaucoma in recent years were included in this study. RevMan 5.0 software was used to take data extraction and Meta analysis. Results A total of 7 RCTs were included, all of which were Chinese. Follow-up was mentioned, ranging from six months to one year. The control effects of intraocular pressure after operation for two months and one year in the experimental group were all better than those of control group, the differences were statistically significant [MD = -2.79, 95%CI (-3.42, -2.16), P ＜ 0.000 01; MD = -3.85, 95%CI (-4.85, -2.85), P ＜ 0.000 01]. There was no significant difference in the filtration bleb after operation between the two groups [RR = 1.10, 95%CI (0.78, 1.55), P = 0.58]. The incidence of complications in the experimental group was lower than that of control group, the difference was statistically significant [RR = 0.45, 95%CI (0.24, 0.84), P = 0.01]. Conclusion The long-term control of intraocular pressure after compound trabeculectomy is superior to the traditional trabeculectomy and the incidence of complications is lower than the traditional trabeculectomy.
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