纤维支气管镜肺泡灌洗治疗新生儿重症肺炎的临床效果

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Abstract Objective To investigate the clinical effect of bronchoalveolar lavage (BAL) in the treatment of neonatal severe pneumonia. Methods From November 2015 to January 2017, in Jiaxing Maternal and Child Health Hospital, 80 children with severe pneumonia neonates were selected, according to whether or not BAL treatment, they were divided into observation group (40 cases) and control group (40 cases). Both groups were given basic treatment measures such as anti-inflammation, oxygen inhalation, and immunity enhancement, the observation group was treated with BAL at the same time. The clinical symptom remission time, serum interleukin-2 (IL-2), interleukin-6 (IL-6), and interleukin-10 (IL-10), arterial oxygen partial pressure (PaO2), arterial carbon dioxide partial pressure (PaCO2), blood lactate levels before and after treatment and clinical efficacy were compared between the two groups. Results The disappearance of cyanosis, dyspnea remission time, heart rate recovery time, disappearance of pulmonary rales and hospital stay in ICU in the observation group were significantly shorter than in the control group, the differences were statistically significant (P < 0.05). Before treatment, the levels of serum IL-2, IL-6 and IL-10 were compared, the differences were not statistically significant (P > 0.05); after treatment, the levels of serum IL-6 and IL-10 in the observation group were lower than the control group, the level of IL-2 was higher than the control group, the differences were statistically significant (P < 0.05). Before treatment, the levels of PaO2, PaCO2, and blood lactic acid in the two groups were compared, the differences were not statistically significant (P > 0.05); after treatment, the levels of PaCO2, lactic acid in the observation group were lower than the control group, and the level of PaO2 was higher than the control group, the differences were statistically significant (P < 0.05). After 7 days of treatment, the clinical efficacy of the observation group was better than the control group, the difference was statistically significant (P < 0.05). Conclusion BAL combined with basic treatment has a more significant therapeutic effect on neonatal severe pneumonia.

Key words： Bronchoscopy Bronchoalveolar lavage Neonates Severe pneumonia

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	DING Wujun1 YAO Xiaoyan2 YANG Rongwei1

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DING Wujun1 YAO Xiaoyan2 YANG Rongwei1. Clinical effect of alveolar lavage with fiberoptic bronchoscope for severe neonatal pneumonia[J]. 中国医药导报, 2019, 16(9): 94-97.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I9/94

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