宫颈癌组织中缺氧诱导因子-1α、葡萄糖转运蛋白1的表达及临床意义

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Abstract Objective To explore the expression and clinical significance of hypoxia-inducible factor-1α (HIF-1α) and glucose transporter-1 (Glut-1) in cervical carcinoma tissues. Methods From January 2015 to December 2017, the Third School of Clinical Medicine, Xinjiang Medical University, paraffin sections of cervical resection samples were randomly selected. The HIF-1α and Glut-1 expression of 87 cases of cervical carcinoma tissues (cervical carcinoma group), 75 cases of cervical intraepithelial neoplasia tissues (cervical intraepithelial neoplasia group) and 69 cases of cervical epithetium tissues (cervical epithetium group) was detected by immunohistochemical method, the relationship between the expression and the clinicopathological data was analyzed. Spearman test was used to analyze the correlation between the two proteins in cervical cancer tissues. Results The positive rate of HIF-1α in cervical carcinoma group (79.01%, 69/87) was significantly higher than that in cervical intraepithelial neoplasia group (13.33%, 10/75) and cervical epithetium group (5.80%, 4/69) (P < 0.01); the positive rate of Glut-1 in cervical carcinoma group (66.67%, 58/87) was significantly higher than that in cervical intraepithelial neoplasia group (24.00%, 18/75) (P < 0.01) and cervical epithetium group (20.29%, 14/69) (P < 0.01); the expression of HIF-1α was positively related with Glut-1 (r = 0.644, P < 0.05), and their expression was related with myometrial infiltration depth, lymph node metastasis and FIGO date (P < 0.05), but they were not related with age, cancer size, histological grades and tumor pathological types (P > 0.05). Conclusion The expression of HIF-1 and Glut-1 increased significantly in cervical carcinoma tissues, which is the potential biomarker of cervical cancer diagnosis and disease progression indication.

Key words： Cervical carcinoma Hypoxia-inducible factor-1α Glucose transporter-1 Diagnosis Disease progression

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	ZHANG Jie1 JIN Hua1 Gulimire·Buranjiang1 LI Xiaowen1 YAO Liyan2

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ZHANG Jie1 JIN Hua1 Gulimire·Buranjiang1 LI Xiaowen1 YAO Liyan2. The expression and clinical significance of hypoxia-inducible factor-1α and glucose transporter-1 in cervical carcinoma tissues[J]. 中国医药导报, 2019, 16(9): 86-89.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I9/86

[1] 刘萍.中国大陆13年宫颈癌临床流行病学大数据评价[J].中国实用妇科与产科杂志，2018，34（1）：41-45.
[2] Lyng H，Malinen E. Hypoxia in cervical cancer：from biology to imaging [J]. Clin Transl Imaging，2017，5（4）：373-388.
[3] Kristensen GB，Holm R，Malinen E，et al. Hypoxia-induced gene expression in chemoradio-resistant cervical cancer revealed by dynamic contrast-enhanced MRI [J]. Cancer Res，2012，72（20）：5285-5295.
[4] Zelenka J，Koncosova M，Ruml T. Targeting of stress response pathways in the prevention and treatment of cancer. Biotechnology advances [J]. Biotechnol Adv，2018，36（3）：583-602.
[5] Takasaki C，Kobayashi M，Ishibashi H，et al. Expression of hypoxia-inducible factor-1alpha affects tumor proliferation and antiapoptosis in surgically resected lung cancer [J]. Mol Clin Oncol，2016，5（2）：295-300.
[6] Rodríguez ME，Catrinacio C，Ropolo A，et al. A novel HIF-1α/VMP1-autophagic pathway induces resistance to photodynamic therapy in colon cancer cells [J]. Photochem Photobiol Sci，2017，16（11）：1631-1642.
[7] Courtnay R，Ngo DC，Malik N，et al. Cancer metabolism and the Warburg effect：the role of HIF-1 and PI3K [J]. Mol Biol Rep，2015，42（4）：841-851.
[8] Sun Y，Xing X，Liu Q，et al. Hypoxia-induced autophagy reduces radiosensitivity by the HIF-1 alpha/miR-210/Bcl-2 pathway in colon cancer cells [J]. Int J Oncol，2015， 46（2）：750-756.
[9] 孙慧霞，孙会，李国正.HIF-1α和Glut-1蛋白在中老年宫颈癌组织中的表达及其意义[J].中国妇产科临床杂志，2018，19（1）：16-19.
[10] Adekola K，Rosen ST，Shanmugam M. Glucose transporters in cancer metabolism [J]. Curr Opin Oncol，2012，24（6）：650-654.
[11] Zhao M，Zhang Z. Glucose transporter regulation in cancer：a profile and the loops [J]. Crit Rev Eukaryot Gene Expr，2016，26（3）：223-238.
[12] Ding X，Liu J，Liu T，et al. MiR-148b inhibits glycolysis in gastric cancer through targeting SLC2A1 [J]. Cancer Med，2017，6（6）：1301-1310.
[13] Tan Z，Yang C，Zhang X，et al. Expression of glucose transporter 1 and prognosis in non-small cell lung cancer：a pooled analysis of 1665 patients [J]. Oncotarget，2017，8（37）：60954-60961.
[14] Gonzalez-Menendez P，Hevia D，Mayo JC，et al. The dark side of glucose transporters in prostate cancer：are they a new feature to characterize carcinomas [J]. Int J Cancer，2018，142（12）：2414-2424.
[15] 陈赣洪.TLR4基因在宫颈癌组织中的表达及其与HIF-1α的相关性[J].实用癌症杂志，2013，28（6）：608-610.
[16] 应申鹏，曹学全，刘艳梅，等.缺氧诱导因子-1α与缺氧诱导因子-2α蛋白和mRNA在宫颈癌中的表达及其临床意义[J].中国临床药理学杂志，2017，33（19）：1893-1896.
[17] 王芳，尹立勇，娄娟，等.HIF-1α及其靶基因在宫颈癌中的表达[J].河北医科大学学报，2017，38（7）：764-769.
[18] Huang CY，Kuo WT，Huang YC，et al. Resistance to hypoxiainducednecroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells [J]. Cell Death Dis，2013，4（5）：e622.
[19] Wu XL，Wang LK，Yang DD，et al. Effects of Glut1 gene silencing on proliferation，differentiation，and apoptosis of colorectal cancercells by targeting the TGF-β/PI3K-AKT-mTOR signaling pathway [J]. J Cell Biochem，2018， 119（2）：2356-2367.
[20] Broecker-Preuss M，Becher-Boveleth N，Bockisch A，et al. Regulation of glucose uptake in lymphoma cell lines by c-MYC-and PI3K-dependent signaling pathways and impact of glycolytic pathways on cell viability [J]. J Transl Med，2017，15（1）：158-159.