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| Changes of serum indicators levels in patients with urinary obstructive sepsis and its significance |
| SHEN Longjiang ZUO Meiling CHEN Tao HUANG He PENG Hongliang QIAN Xiaohui |
| Department of Urology Surgery, the Fourth Hospital of Changsha, Hu′nan Province, Changsha 410000, China |
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Abstract Objective To investigate the changes of white blood count (WBC), lactic acid (Lac), platelet count (PLT) and arterial oxygen pressure (PaO2) in patients with urinary obstructive sepsis and its significance. Methods From January 2017 to June 2018, 68 patients with urinary obstructive sepsis (observation group) in the Fourth Hospital of Changsha were selected as the observation group, and 70 cases of urinary tract infection were selected as control group, the levels of WBC, Lac, PLT and PaO2 were detected, the prognosis was evaluated by chronic health evaluation Ⅱ (APACH Ⅱ). Results The WBC, Lac in the observation group at 6 h in the onset of disease were significantly higher than those in the control group (P < 0.05), while PLT and PaO2 were significantly lower than those of the control group (P < 0.05); the WBC, Lac in the observation group at 24 h in the onset of disease were significantly higher than those in 6 h and 12 h (P < 0.05); the PLT, PaO2 in the observation group at 12 h in the onset of disease were significantly lower than that in 6 h and 24 h (P < 0.05). There were positive correlations between WBC and acute physiological and APACH Ⅱ in the onset of 6 h (r = 0.422, P < 0.05), and PLT, PaO2 were negatively correlated with APACH II (r = -0.341, -0.336, P < 0.05). Conclusion The levels of WBC, Lac in patients with urinary obstructive sepsis are elevated, while the levels of PLT and PaO2 are decreased, and the levels of WBC, PLT and PaO2 are related to the severity of the patients.
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[1] 肖跃海，单玉喜，石家齐，等.动态监测降钙素原在尿脓毒血症诊治中的研究[J].中华实验外科杂志，2016，33（10）：2410-2414.
[2] 何君伟，曹家栋，王树声，等.嗜酸性粒细胞在尿源性脓毒血症中的临床意义[J].实用医学杂志，2017，33（9）：1445-1448.
[3] 王涛，陈海平，张瑜，等.可溶性髓样细胞触发受体1在尿源性脓毒血症患者中的临床意义[J].中国现代医学杂志，2016，26（16）：57-62.
[4] 那彦群，叶章群，孙光.2014版中国泌尿外科疾病诊断治疗指南[M].北京：人民卫生出版社，2014.
[5] 李建忠，宁松毅，刘广，等.降钙素原和内毒素联合检测对经皮肾镜碎石术尿源性脓毒血症的早期诊断价值[J].医学研究生学报，2016，29（9）：941-944.
[6] 行永利，张亚玲，杨楠.经皮肾镜取石或输尿管镜碎石术后尿源性脓毒血症13例报告[J].中国微创外科杂志，2017，17（9）：859-860.
[7] 余家俊，郭永连，李国灏，等.肾输尿管腔内微创术后尿源性脓毒血症患者临床治疗效果及诱发感染的相关因素分析[J].中华医院感染学杂志，2016，26（9）：2102-2104.
[8] 陈化磊，卓小岸，肖劲逐，等.尿源性感染导致脓毒血症患者血清sTREM-1的检测评价[J].中华医院感染学杂志，2017，27（16）：3669-3672.
[9] Mohseny AB，Velze VV，Steggerda SJ，et al. Late-onset sepsis due to urinary tract infection in very preterm neonates is not uncommon [J]. Eur J Pediatr，2018，177（1）：1-6.
[10] 陈玉红，赵钗，赵倩，等.中心静脉血氧饱和度联合静动脉二氧化碳分压差指导脓毒症患者容量管理[J].中国全科医学，2016，19（11）：1276-1281.
[11] 王善志，朱永俊，叶凤，等.慢性肾脏病3～5期患者的血清超敏cTnI水平及其与肾脏相关指标的关系[J].中国医药导报，2018，473（15）：75-77.
[12] 王东旭，朱宏斌，张靖，等.肝硬化脓毒血症的危险因素分析[J].疑难病杂志，2017，16（9）：907-910.
[13] Katayama S，Koyama K，Goto Y，et al. Body weight definitions for evaluating a urinary diagnosis of acute kidney injury in patients with sepsis [J]. BMC Nephrol，2018，19（1）：101.
[14] 吴明，杨秀林，周永刚，等.无创呼吸机治疗对尿毒症并急性左心衰患者的临床疗效分析[J].第三军医大学学报，2016，38（21）：2353-2356.
[15] Lysak N，Ebadi A，Bandyopadhyay S，et al. Unsupervised Machine Learning Analysis of Urinary Transcriptome Reveals Distinct Genotypic Clustering in Surgical Sepsis [J]. J Am Coll Surg，2017，225（4）：S66-S67.
[16] 曹乾嫱，付幼林，杨明，等.尿毒症对大鼠主动脉平滑肌TRPC1通道表达的影响[J].广东医学，2016，37（12）：1792-1794.
[17] Maras JS，Das S，Hussain MS，et al. Urinary Metabolomic Analysis or Early Prediction of Sepsis in Acute-on–Chronic Liver Failure Patients [J]. J Hepatol，2016，64（2）：S314.
[18] 陈国晓，张祥生，李政含，等.双镜联合诊治尿道源性血精血尿的临床体会[J].中国微创外科杂志，2017，17（12）：1101-1103.
[19] 高照，官凌菊，赵君军，等.气相色谱质谱联用法对运动员尿液中内源性类固醇水平特征的研究[J].药物分析杂志，2016，18（4）：645-654.
[20] 杨立新，马凤巧，胡跃世，等.多指标检测对于复杂性上尿路感染导致尿脓毒血症的价值分析[J].中华医院感染学杂志，2017，27（2）：284-287.
[21] 孙志刚，赵志红，马燕，等.血清NT-proBNP、尿液NGAL对脓毒血症患儿继发急性肾损伤的早期预测价值[J].山东医药，2017，57（28）：54-56. |
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