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2018 Vol. 15, No. 29
Published: 2018-10-15
 
 
4 Research of the influence of Doxorubicin loaded melanin particles on drug resistance of anaplastic thyroid cancer cells
ZHANG Yuchun1,2 ZHANG Qing1 YANG Yu1 ZHAO Yijing1 WANG Kun1 MA Xianghua2
Objective To research the influence of Doxorubicin loaded melanin nanoparticles (DOX-MNPs) on drug resistance of anaplastic thyroid cancer (ATC) cells. Methods Dopamine-melanin nanoparticles (MNPs) were synthesized as previously reported and Doxorubicin (DOX) was loaded onto MNPs. The loading efficiency and capacity of MNPs at different mass ratios of DOX to MNPs were determined by UV-Vis spectroscopy and the characterization of nanoparticles was acquired by transmission electron microscopy (TEM) and Brookhaven Zeta PALS analyzer. HTh74 and HTh74R cells were incubated with various concentrations of free DOX and DOX-MNPs (0, 10, 20, 40, 80, 160 mg/L). Cell viability was determined by MTT, and intracellular DOX fluorescent signal was determined by flow cytometry studies. Results The MNPs was successfully synthesized and the loading efficiency of DOX-MNPs decreased with the increasing mass ratio of DOX to MNPs. The loading efficacy peaked at 93.45% when the mass ratio was 0.167:1. At this mass ratio, the obtained DOX-MNPs had similar morphology to MNPs, and zeta potential and size distribution of DOX-MNPs were 13.79 mV and (241.1±4.8) nm. In HTh74R cells, when the concentration of DOX-MNPs was higher than 20 mg/L, the cell viability was significantly lower than that of the equivalent drug concentration (P < 0.05), and the uptake rate of DOX-MNPs was significantly higher than that of free DOX (P < 0.05). The degree of uptake was similar to that of HTh74 cells. Conclusion The cellular uptake capacity and therapeutic effect of the DOX-MNPs are significantly higher than those of free DOX at the same drug concentration in drug-resistant HTh74R cells.
2018 Vol. 15 (29): 4-8 [Abstract] ( 231 ) HTML (1 KB)  PDF (804 KB)  ( 61 )
9 Serum level of SALL4 in gastric cancer patients and its effect on migration of gastric cancer cells
LIU Lei1 LI Yan2 GUO Yuanbiao1
Objective To investigate the difference of serum SALL4 levels between gastric cancer patients and healthy people, and to explore the role of SALL4 in the progression of gastric cancer. Methods A total of 47 patients with gastric cancer who were treated in the Third People′s Hospital of Chengdu from March 2016 to April 2018 and 29 healthy volunteers who participated in the physical examination were selected. The serum levels of SALL4 were detected by ELISA. The expression of SALL4 in mRNA level and protein level in various gastric cancer cell lines and gastric mucosa cells were analyzed by Real-time PCR and Western blot respectively. The effects of SALL4 on the cell migration and invasion ability were analyzed by siRNA interference. The expression levels of related molecules of epithelial-mesenchymal transition (EMT) were detected by Western blot. Results The serum SALL4 levels in patients with gastric cancer were significantly higher than those in healthy volunteers, and the difference was highly statistically significant (P < 0.0001). The expression of SALL4 mRNA and protein in various gastric cancer cell lines was higher than that in gastric mucosal cell lines. The migration and invasion ability of gastric cancer cells were significantly decreased after interfering SALL4 expression, and the differences were statistically significant (P < 0.05). Decreased expression of SALL4 leaded to the up-regulation of E-cadherin expression and the down-regulation of snail, β-catenin and Wnt3a. Conclusion SALL4 is related to the progression of gastric cancer. It may promote cell migration and invasion by inducing the EMT process in gastric cancer cells.
2018 Vol. 15 (29): 9-12,16 [Abstract] ( 270 ) HTML (1 KB)  PDF (771 KB)  ( 58 )
13 Comparison of different operative approaches of establishing renovascular hypertension rat models
SUN Jiajia1,2 TU Yue2 LIU Yang2,3
Objective To compare the advantages and disadvantages of back approach and abdominal approach of establishing renovascular hypertension rat models. Methods According to random number table method, 50 female SD rats were divided into control group (n = 10), abdominal approach group (n = 20) and back approach group (n = 20). Abdominal approach group was made an incision for about 2.5 cm along the abdominal medialline, back approach group was made two longitudinal incisions for about 1.5 cm along the bilateral paravertebral line where kidney located, both groups underwent ligation of posterior branches of bilateral renal arteries, with free diet after suture. The blood pressure, operation time, whether the wound was chewed, postoperative infection rate and mortality of the two groups were compared. Results After 3 months of operation, the blood pressure of abdominal approach group and back approach group was signifcantly higher than that of control group (P ＜ 0.05). Compared with abdominal approach group, the operation time of back approach group was shorter, the postoperative infection rate was lower, while the number of cases being chewed was larger, the differences were statistically significant (P ＜ 0.05). After 3 months of operation, there was no significant difference on the mortality between abdominal approach group and back approach group (P ＞ 0.05). Conclusion The two approaches of establishing renovascular hypertension rat models have their own characteristics, and the postoperative nursing care is very important. It is necessary to choose the approach according to the actual conditions.
2018 Vol. 15 (29): 13-16 [Abstract] ( 239 ) HTML (1 KB)  PDF (731 KB)  ( 94 )
17 The effect of siRNA interference with Rac1 expression on proliferation and migration of human lens epithelial cells
SUN Guoqing TANG Jianming▲
Objective To study the effect of Rac1 on the proliferation and migration of human lens epithelial cells SRA01/04, and to explore the role of Rac1 in the development and progression of posterior capsular opacities and capsular contraction syndrome. Methods SRA01/04 cells were divided into mock group and siRac1 group. Rac1-related siRNA was constructed and transiently transfected in siRac1 group cells. Western blot was used to detect the changes of Rac1 protein expression, CCK was used to detect the changes of cell growth cycle, flow cytometry was used to detect the cell cycle and apoptosis, Transwell was used to detect the effect of Rac1 on cell migration ability. Results The absorbance values of the two groups at 72 hours were higher than those at 24 hours (P ＜ 0.05), the absorbance values of siRac1 group at 48, 72 hours were lower than those of mock group (P ＜ 0.05). Compared with mock group, the relative expression of mRNA and protein in siRac1 group decreased significantly, the percentage of G1 phase cells increased significantly, while the percentage of S phase cells decreased significantly, the number of cells passing through the membrane reduced significantly, the differences were statistically significant (P ＜ 0.05). F-actin staining showed that the forming ability of pseudopodium in siRac1 group was significantly weaker than that of mock group. Conclusion Rac1 may affect the occurrence and development of posterior capsular opacities and capsular contraction syndrome through adjusting the proliferation and migration of lens epithelial cells.
2018 Vol. 15 (29): 17-20 [Abstract] ( 271 ) HTML (1 KB)  PDF (766 KB)  ( 181 )
21 Status of application of outcome measures in the clinical studies of knee osteoarthritis
FU Tao1* YU Changhe2* ZHANG Yang2 WENG Zhiwen2 SUN Yanyan LI Si′na3 LIU Changxin2 WANG Xiyou2
Knee osteoarthritis (KOA) tends to occur in the middle and old age, which has a great impact on the social life of the patients. At present, there is no unified standard for the clinical efficacy evaluation system for KOA, the main clinical evaluation of KOA is all kinds of subjective evaluation scales. The study analyzed and compared the advantages and disadvantages of 9 kinds of scale such as visual analog scale (VAS), Western Ontario and McMaster Universities osteoarthritis index (WOMAC index), knee injury and osteoarthritis outcome score (KOOS), Oxford Knee Scale (OKS) score, hospital for special surgery knee score (HSS), American Knee Society knee score (AKS), Lysholm knee score, Lequesne index and International Knee Documentation Committee Knee Score (IKDC) etc., and to gave recommendations for the selection and application of scale according to the different conditions, which laid the foundation for the selection of outcome evaluation indicators in clinical research of KOA in the future.
2018 Vol. 15 (29): 21-24,28 [Abstract] ( 344 ) HTML (1 KB)  PDF (684 KB)  ( 296 )
25 Clinical research progress of kidney-nourishing therapy for colorectal cancer
WU Chaojun LIU Ningning LI Qi
Colorectal cancer is one of the most common malignant tumors in China, and its pathogenesis is asthenia of healthy qi and sthenia of pathogenic factors. As the birth of genius, plenty of kidney essence leads to normal physiology activity, but chronic illness will decrease kidney essence and the deficiency of kidney Yang or kidney Yin causes various kinds of symptoms. Researches have found that lacking of kidney essence is a key link for the progression to colorectal cancer, having impacts on the on-set, prognosis and outcomes of colorectal cancer. Thereby kidney-nourishing therapy is significant in the treatment of colorectal cancer. This article explores the theoretical origin of the treatment of colorectal cancer using warming kidney, nourishing kidney and concludes the therapeutic effect such as alleviating gastrointestinal reaction, peripheral neurotoxicity, and strengthening the immune system in clinical trials, to provide evidence for the therapy based on kidney in treating tumor.
2018 Vol. 15 (29): 25-28 [Abstract] ( 217 ) HTML (1 KB)  PDF (657 KB)  ( 283 )
29 Research progress of the mechanism of drug resistance and detection methods of Mycobacterium tuberculosis
SONG Jing CHE Nanying
This article reviews the mechanism and detection methods of drug resistance in Mycobacterium tuberculosis（MTB）. The mechanism of drug resistance is divided into intrinsic resistance mechanism of cell wall permeability reduction and efflux pump action and acquired resistance mechanism of target gene mutation. With the development of molecular biology techniques, mutations in target genes are considered to be the main mechanism of drug resistance for MTB. The main detection methods for drug resistance are phenotypic susceptibility testing and molecular susceptibility testing. The phenotypic assay method is used as the golden standard, but the detection period is long, while gene mutation detection can be completed within a few hours, so there is a better application prospect in the diagnosis of tuberculosis. In this paper, the mechanism and detection methods of drug resistance in MTB are reviewed in order to provide some reference for the development of rapid molecular diagnostic tools and anti-tuberculosis drugs.
2018 Vol. 15 (29): 29-34 [Abstract] ( 310 ) HTML (1 KB)  PDF (750 KB)  ( 137 )
35 Research progress on breeding and cultivation techniques of Polygonatum sibiricum
BING Shuai ZHENG Xiaowen LIU Zheng TAN Huiying CHEN Wenhua GUO Ning SUN Xiaolei XU Lingchuan
Polygonati Rhizoma  is a common tonic chinese medicine in the market. In order to meet the needs of the market, artificial cultivation of Polygonatum sibiricum has become a hot spot in recent years. After systematically consulting and sorting out relevant data, the paper summarizes the propagation and cultivation techniques of Polygonatum sibiricum. It is found that the reproductive technology of Polygonatum sibiricum mainly consists of three forms of seed reproduction, tuber propagation and tissue culture. The main planting pattern is under forest interplanting. Its main diseases and pests are leaf spot, black spot, grub and black cutworm. Its best harvest time is from the autumn of that year to the early spring of second years. Steaming and cooking are the most common processing methods of Polygonatum sibiricum. Finally, the existing problems in propagation and cultivation of Polygonatum sibiricum are briefly described in this paper.
2018 Vol. 15 (29): 35-38 [Abstract] ( 275 ) HTML (1 KB)  PDF (719 KB)  ( 155 )
39 Research progress of the function of diacylglycerol kinase ζ
LI Wei1 CUI Shengnan1 ZHOU Zhihui2 DONG Changhu2
Diacylglycerol kinase (DGKZ), a type Ⅳ diacylglycerol kinase family (DGKs) isoenzyme, plays an important role in the cell′s life process. DGKZ gene, expressed in the brain, bone, heart and immune system of eukaryotes, is closely related to the occurrence and development of tumors. This article will summarize the current research progress of the gene from these four parts.
2018 Vol. 15 (29): 39-41 [Abstract] ( 342 ) HTML (1 KB)  PDF (653 KB)  ( 186 )
42 Research progress of traditional Chinese medicine in the treatment of early diabetic nephropathy
HAN Mingzhu1 LI Xiaohua2
Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes, and is one of the main causes of end-stage renal disease and death in diabetic patients. There are no specific therapeutics for DN, so the intervention of early DN is particularly important for patients. Traditional Chinese medicine has its unique advantages in treating early DN. This article reviews the research progress of traditional Chinese medicine in treating early DN in the past five years (2014-2018 year) from the etiology and pathogenesis, syndrome differentiation and traditional Chinese medicine treatment.
2018 Vol. 15 (29): 42-45 [Abstract] ( 363 ) HTML (1 KB)  PDF (658 KB)  ( 189 )
46 Progress in ultrasonography of carpal tunnel syndrome
ZHOU Qiaoyin1 SHEN Yifeng1 LI Shiliang2
Carpal tunnel syndrome (CTS) is a common peripheral nerve compression syndrome. The accuracy of wrist ultrasound has been confirmed, and the accuracy of the diagnosis of CTS is improved through the measurement of the transverse carpal ligament, the flattening rate, the median cross-sectional area of the median nerve, and the blood flow status of the median nerve. Ultrasound examination is more convenient and quicker than other examinations. It is not only possible to use ultrasound to observe changes in carotid anatomy before surgery, so that doctors can pre-judgment and post-operative review, and ultrasound real-time guidance also makes CTS safer and faster. This article discusses the related research progress from the aspects of ultrasound in the diagnosis and treatment of CTS.
2018 Vol. 15 (29): 46-49 [Abstract] ( 254 ) HTML (1 KB)  PDF (658 KB)  ( 78 )
50 Study on cognition of gynecological examination among adult female
SUN Gang ZHANG Yuyao▲
Objective To investigate cognition of gynecological examination among adult female. Methods From March 15th, 2017 to April 5th, 2017, 360 adult women were surveyed in Guangzhou with self-designed questionnaires randomly. The general situation of the respondent, gynecological examination knowledge, self-assessment of status and behavior of respondents were included in the questionnaires. The gynecological examination knowledge, self-assessment of health status, and behavior of respondents were observed. Results The correct rates of gynecological examination knowledge under different age groups, education levels, and childbearing status were statistically significant (P < 0.05). The effects of self-assessment of status between different gynecological examination knowledge understanding degree and gynecological physical examination cycles were highly statistically significant (P < 0.01). Most women seek medical treatment when suffering from gynecological diseases (82.5%), and the process of medical treatment focuses more on curative effect (61.0%) and privacy protection (21.2%). Conclusion Promote education through the cooperation of community, hospital through various channels. Improve women′s enthusiasm and initiative to acquire knowledge of gynecological examination by change traditional concepts. Improve the medical treatment and treatment technology of medical personnel and the level of doctor-patient communication. The routine of gynecological examination is guaranteed by governmental coercive force and public welfare function.
2018 Vol. 15 (29): 50-53 [Abstract] ( 255 ) HTML (1 KB)  PDF (403 KB)  ( 108 )
54 Investigation and analysis of the cognitive status of antimicrobial drugs among normal college students in Jilin Province
CUI Baoju
Objective To investigation and analysis of the cognitive status of antimicrobial drugs of students of three normal universities in Jilin Province, and study the importance and urgency of popularizing antibacterial drug knowledge and other healthy education in university. Methods The questionnaire was prepared by combining random stratification and cluster sampling. The survey target is the freshmen and junior students of three normal in Jilin Province, Northeast Normal University, Jilin Normal University and Changchun Normal University. The survey index inculding the awareness rate of antibacterial drugs, the abuse rate, the phenomenon of self-medication and whether they are eager to learn about antibacterial drugs. A total of 3000 questionnaires were issued and 2783 were recovered, with an effective rate of 92.77%. Results The results showed that junior students had 42.31% of basic knowledge in antibacterials, which was higher than freshmen (40.77%), with statistically significant difference (P < 0.05). Compared with freshmen (16.55%), the use of antimicrobial agents were haphazard and there were serious self-medication phenomena in junior students (32.05%), with statistically significant difference (P < 0.01). They were not optimistic about the cognitive status of antimicrobial drug abuse, and students are eager to acquire knowledge of antimicrobial drugs through specialized courses. Conclusion The subjects′ cognition of antibacterial drugs is not good and the reform of university health education course is imminent.
2018 Vol. 15 (29): 54-57 [Abstract] ( 263 ) HTML (1 KB)  PDF (445 KB)  ( 58 )
58 Effects and adverse reactions of Aluminum-Magnesium and Aspirin Tablets (Ⅱ) on stable ischemic heart disease
LI Lu CHEN Lin ZHOU Peng
Objective To evaluate the effect of Aluminum-Magnesium and Aspirin Tablets (Ⅱ) on the platelet aggregation function and gastrointestinal reaction for stable ischemic heart disease. Methods A total of 587 patients with stable ischemic heart disease requiring Aspirin and Clopidogrel dual antiplatelet aggregation treated in the Department of Cardiology, the First Affiliated Hospital of Chengdu Medical College from January 2015 to May 2016 were selected. They were divided into A, B, C group. 195 cases of group A were treated with Clopidogrel, 196 cases of group B were treated with Aspirin and Clopidogrel, and 196 cases of group C were treated with Aluminum-Magnesium and Aspirin Tablets (Ⅱ). The platelet aggregation rate, efficacy before and after 30 days′ treatment, incidence of adverse reactions were compared among the three groups. Results The platelet aggregation rate after 30 days′ treatment of the three groups were lower than that before treatment (P ＜ 0.05). After treatment, the platelet aggregation rate among the three groups were statistically different (P ＜ 0.05). After treatment, the platelet aggregation rate in group A was higher than that in group B and C (P ＜ 0.01); while the platelet aggregation rate had no difference between group B or C (P > 0.05). The treatment effect of all groups of anginas had no statistically significant difference (P ＞ 0.05). There was no significant difference in the incidence of cardiovascular adverse events among the three groups (P> 0.05). The incidence of gastrointestinal adverse reactions was lower in group C than that in groups A and B (P ＜ 0.05). Conclusion Aluminum-Magnesium and Aspirin Tablets (Ⅱ) has good clinical efficacy in patients with stable ischemic heart disease, and have fewer gastrointestinal adverse reactions.
2018 Vol. 15 (29): 58-61 [Abstract] ( 287 ) HTML (1 KB)  PDF (356 KB)  ( 136 )
62 Clinical effect of different dose of Atorvastatin on elderly patients with unstable carotid plaques complicated ischemic stroke in perioperative period
ZHENG Xiuguang ZHANG Zuowen▲
Objective To investigate the effects of different dose of Atorvastatin on elderly patients with unstable carotid plaques complicated ischemic stroke in perioperative period, and the effects on stress and carotid plaque stability. Methods Seventy-six elderly patients with fractures admitted to Jiangjin District Central Hospital in Chongqing City from January 2015 to April 2017 were selected and they were divided into observation group and control group according to the random number table method, with 38 cases in each group. The control group was given Atorvastatin 10 mg/d oral and the observation group was given Atorvastatin 20 mg/d oral. The treating course was 6 months. The clinical efficacy, stress response index and carotid plaque stability were observed in the two groups. Results After treatment, the total clinical effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After 4 weeks of treatment, the levels of malondialdehyde and low density lipoprotein in the observation group was significantly lower than those of the control group, the difference was statistically significant (P ＜ 0.05). After 6 months of treatment, scores of the scale of the National Institutes of Health of the United States (NIHSS), arterial plaque area and carotid artery intima thickness (Crouse) scores were significantly lower in the observation group than those in the control group, the difference was statistically significant (P ＜ 0.05). There was no significant difference in the adverse reaction between the two groups (P ＞ 0.05). Conclusion Large dose of Atorvastatin in the treatment of elderly fracture patients with unstable carotid artery atherosclerotic plaques complicated ischemic stroke in perioperative period has a satisfatory curative effect, which can effectively reduce the injury of oxidative stress, reduce the area of plaque, and it is safe and reliable.
2018 Vol. 15 (29): 62-65 [Abstract] ( 228 ) HTML (1 KB)  PDF (360 KB)  ( 41 )
66 Influence of free position delivery combined with natural shoulder delivery method on pregnancy outcome and puerpera postpartum recovery
Milibangguli·wubuli MA Ying DING Guifeng
Objective To explore the influence of free position delivery combined with natural shoulder delivery method on pregnancy outcome and puerpera postpartum recovery. Methods From July 2015 to July 2017, 68 cases of puerpera admitted in Urumqi Maternity and Child Healthcare Hospital were divided into control group and observation group by random table method, with 34 cases in each group. The control group was delivered by traditional position delivery combined with traditional shoulder delivery method, while the observation group was treated with free position delivery combined with natural shoulder delivery method. After the childbirth, the pregnancy outcomes, labor duration, postpartum recovery and reproductive tract injuries after childbirth were statistically analyzed. Results Compared with the control group, the cesarean section rate, neonatal asphyxia, clavicular fracture and the incidence of shoulder dystocia, 2 h postpartum blood loss and labor pain in the observation group were significantly lower, the control sense of delivery was significantly higher; the first, second, third and total stage of delivery time in observation group were significantly lower, the lactation volume was higher, the uterine height, lochia discharge and anxiety were lower, the maternal postpartum urinary retention and perineal laceration Ⅲ degree was significantly lower in observation group; the differences were statistically significant (P < 0.05). Conclusion Free position delivery combined with natural shoulder delivery method can effectively improve the pregnancy outcome, facilitate postpartum recovery, shorten the delivery process and reduce the degree of genital tract injury, which is worthy of clinical application.
2018 Vol. 15 (29): 66-69,78 [Abstract] ( 254 ) HTML (1 KB)  PDF (569 KB)  ( 106 )
70 Comparison of the growth and nutritional status for the very preterm infants before and after 5 years
XU Wenying1 DING Sufang1 ZHANG Li1 WANG Yumei1 LI Min1 HAN Liangrong2 YUE Hongni1
Objective To contrast the different general condition, perinatal factor, growing development, nutritional support and growth outcome status among very preterm infants (VPI) before and after 5 years. Methods The data of the VPI who treated in the Neonatal Medical Center of Huai′an Maternity and Child Healthcare Hospital from January 1 to December 31, 2010 and January 1 to December 31, 2015. A total of 82 cases in 2010 and 134 cases in 2015 were divided into two groups according to the year of birth according to the inclusion criteria of hospitalization and discharge within 24 h after birth. Results The differences in the general condition and perinatal factor such as gestational age, birth weight, discharge gestational age, discharge body weight, incidence of very low birth weight infant, days of hospitalization, incidence of placental abruption in mothers; differences in the growing development and nutritional support such as minimum weight, restore birth weight time, growth rate, total enteral feeding time, time of gastrointestinal nutrition reach at 418 kJ/(kg·d), total gastrointestinal feeding time, initial amino acid usage time, initial amino acid usage dosage, accumulated amino acid usage time, initial intralipid usage time, initial intralipid usage dosage, accumulated intralipid usage time; differences in the growth outcome: incidence of total Extrauterine growth retardation (EUGR), incidence of mild EUGR were existed between the two groups the differences were statistically significant (P < 0.05). Conclusion The growth and nutritional status of VPI are on a upward trend. Pay attention to the VPI with lower birth weight, lower gestational age and severe complications, the more treatment and support in strategy paid, the better growth and hospital outcome gained.
2018 Vol. 15 (29): 70-73 [Abstract] ( 278 ) HTML (1 KB)  PDF (550 KB)  ( 165 )
74 Effect of long acting glucocorticoid combined with gonadotropin-releasing agonist laparoscopic irrigation in the treatment of endometriosis
MENG Xianning LI Hongxia HUO Zhiping WU Ya′nan WANG Hongli HAO Yuanyuan
Objective To explore the application effect of long acting glucocorticoid combined with gonadotropin releasing agonist laparoscopic irrigation in endometriosis (EMS). Methods From January 2014 to December 2016, 69 patients with EMS treated by laparoscopic surgery in Central Hospital of China National Petroleum Company were selected as the study objects. Patients were divided into two groups according to washing methods. Thirty-four cases in the control group, and laparoscopic electrocoagulation and cauterization were used to wash pelvic cavity repeatedly with 1000 mL of 0.9% physiological saline during operation. Thirty-five cases in the experimental group were treated with the same method as the control group. Intraoperative irrigation was done with 0.9 % saline 500 mL + 20 mg Dexamethasone and 0.9% saline + Triptorelin 3.75 mg, first with saline Dexamethasone lavage fluid, and then with Triptorelin diluent lavage. The changes of dysmenorrhea, pelvic pain, sexual intercourse pain and inflammatory factor levels in the two groups before and after operation for 3, 6 and 12 months were observed. All patients were followed up for 1 year after operation, and the pregnancy, recurrence and adverse reactions were observed. Results One day and three day after operation, the serum levels of C reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor (TNF-α) in the two groups were lower than those before operation(P < 0.05). One day after operation, the levels of CRP, IL-6, and TNF-α in the experimental group were lower than those of the control group (P < 0.05); the visual analogue score (VAS) scores at 3 and 12 months post operatively in both groups were lower than those before operation; and the 3, 6 and 12 months postoperatively were lower than those before the same group (P < 0.05), 6 and 12 month postoperative the VAS scores of the study group were lower than those of the control group(P < 0.05). The rate of spontaneous pregnancy in the experimental group was 65.71%, higher than that in the control group (38.24%, P < 0.05), and the recurrence rate in the study group was 2.86%, lower than that in the control group (29.41%, P < 0.05). During the one year of follow-up period, there was no significant difference in the total incidence of adverse reactions between the two groups (P > 0.05). Conclusion Glucocorticoid combined with gonadotropin-releasing hormone agonist laparoscopic surgical cavity rinse in the treatment of EMS can reduce the levels of inflammatory factors and the degree of postoperative pain, improve the one year natural pregnancy rate, and it is worthy of clinical promotion.
2018 Vol. 15 (29): 74-78 [Abstract] ( 232 ) HTML (1 KB)  PDF (528 KB)  ( 195 )
79 Clinical efficacy of Cabergoline in the treatment of female hyperprolactinemia
SU Yaqin ZHANG Ningning LIANG Xiaoqing ZHANG Shaojing WEI Yongzhi
Objective To explore the application value of Cabergoline in the treatment of abnormal menstruation and galactorrhea in women with hyperprolactinemia. Methods Patients with hyperprolactinemia treated from June 2014 to June 2017 in the First Hospital of Shijiazhuang City  were selected. They were divided into two groups according to the random number table. The observation group (n = 45) was treated with Cabergoline, while the control group (n = 45) was treated with Bromocriptine. Before and after treatment, the changes of the serum prolactin value, the clinical symptom effect, the incidence of drug adverse reaction and the drug resistance of the two groups were recorded. Results The serum prolactin values of observation group at 2 and 3 months after treatment were lower than those of control group (P < 0.05). The effective rate of abnormal menstruation in observation group was higher than that of control group (P < 0.05). There was no statistically significant difference in treatment efficiency between the two groups for galactorrhea, visual impairment, headache and other symptoms (P > 0.05). The incidence of adverse reaction such as nausea, vomiting, hypotension, and mental symptoms in observation group were lower than those in control group (P < 0.05). There was no statistically significant difference in drug resistance rate between two groups (P > 0.05). Conclusion Compared with the Bromocriptine, Cabergoline has better effect on reducing prolactin value, improvement of abnormal menstruation and lower incidence of drug adverse reactions in women with hyperprolactinemia.
2018 Vol. 15 (29): 79-81,87 [Abstract] ( 213 ) HTML (1 KB)  PDF (931 KB)  ( 104 )
82 Meta analysis on rs760805 polymorphism in RUNX3 gene and risk of gastric cancer
ZHU Xiaoyun1* MA Ruchao2* YU Honggang1
Objective To systematically evaluate the association between rs760805 polymorphism in Runt-related transcription factor 3 (RUNX3) gene and risk of gastric cancer. Methods PubMed, EMbase, The Cochrane Library (Issue 3, 2018), CMB, CNKI, VIP and Wanfang databases were searched, retrieval time form creating database to March 2018, the data of case-control studies on the correlation between polymorphisms of RUNX3 gene and risk of gastric cancer were retrieved, the language was limited to Chinese and English. Two evaluators independently screened literature, extracted data and evaluated the bias risk of included studies, and used Newcastle-Ottawa scale (NOS) to evaluate research quality. All genotype models of RUNX3 (rs760805) were compared, including A and T, AA and TT, AA and TA+TT, TA and TT, AA+TA and TT, and their distribution in case group and control group was comprehensively analyzed. Q-test and I2 value were used to analyze the heterogeneity among the studies, egger′s regression was used to verify the evaluation of publication bias, and Stata 12.0 software was used for Meta-analysis. The correlation of RUNX3 (rs760805) gene polymorphism with the risk of gastric cancer was calculated by using the odds ratio (OR) and 95% confidence interval (95%CI). Results A total of 5 case-control studies were included (gastric cancer cases: 1363, healthy controls: 1346). The results of Meta-analysis showed that (rs760805) polymorphism in RUNX3 gene was associated with risk of gastric cancer [A vs. T: OR = 1.27, 95%CI (1.01, 1.59), P = 0.039; AA+TA vs. TT: OR = 1.30, 95%CI (0.96, 1.77), P = 0.091; AA vs. TT+TA: OR = 1.18, 95%CI (0.99, 1.41), P = 0.073; AA vs. TT: OR = 1.51, 95%CI (0.97, 2.33), P = 0.065; TA vs. TT: OR = 0.73, 95%CI (0.32, 1.63), P = 0.437]. Conclusion There is a correlation between the genetic polymorphism of RUNX3 (rs760805) and the risk of gastric cancer, and allele A may be a potential risk factor for gastric cancer.
2018 Vol. 15 (29): 82-87 [Abstract] ( 368 ) HTML (1 KB)  PDF (1302 KB)  ( 119 )
88 Factor analysis related to dynamic ileus after laparoscopic radical resection for colorectal cancar
YAN Zhengrong LEI Ling YANG Hua LI Quanlin
Objective To investigate the risk factors related to dynamic ileus after laparoscopic radical resection for colorectal cancer. Methods A retrospective study of 181 patients with colorectal cancer who received laparoscopic radical resection at Nanchong Central Hospital from January 2015 to December 2016 was conducted. Univariate and multivariate Logistic analysis of the risk factors related to dynamic ileus after laparoscopic radical resection for colorectal cancer were performed. Results There were 11 patients were complicated with dynamic ileus postoperatively. The results revealed that gender, operation time, location of tumor, intra-abdominal infections were correlated risk factors with postoperative dynamic ileus. While the rate of postoperative ileus patients with colorectal cancer who received laparoscopic radical resection could be reduced by comprehensive nursing intervention. Conclusion Male patients who received radical resection of colorectal cancer, especially received right hemicolectomy should enhance their vigilance. It is effective to shorten the operation time, prevent the intra-abdominal infections and conduct comprehensive nursing to reduced the postoperative dynamic ileus.
2018 Vol. 15 (29): 88-91 [Abstract] ( 219 ) HTML (1 KB)  PDF (604 KB)  ( 227 )
92 Application effect of external application of Chinese herbs on sore and acupoints in combination with acupuncture in the treatment of cancer pain in patients with lung cancer
GAO Jianqing1 LEI Yanrong1 CHEN Hongbei2
Objective To observe the application effect of external application of Chinese herbs on sore and acupoints in combination with acupuncture in the treatment of cancer pain in patients with lung cancer. Methods From January 2016 to January 2018, 114 cases of patients with lung cancer pain treated in the Affiliated Hospital of Chengdu University of TCM were randomly divided into two groups by random number table method. The control group (57 cases) was treated with external application of Chinese herbs on acupoints and sore, and the observation group (57 cases) was treated with acupoints acupuncture on the basis of the control group. The therapeutic effect of the two groups was observed, the quality of life improvement before and after treatment was detected by comprehensive quality of life questionnaire (CQOL-74), serum tumor necrosis factor-α (TNF-α) and leukocytes-6 (IL-6) were detected by enzyme-linked immunosorbent assay (ELISA). The status of hospital anxiety and depression scale (HADS) before and after treatment was detected. Results The total effective rate of the observation group (92.98%) was higher than that of the control group (78.95%), the difference was statistically significant (P ＜ 0.05). After treatment, the material living state, body function, social function, psychological function and overall quality of life of the two groups were significantly higher than those before treatment, and the effect of the observation group was better than that of the control group, the differences were statistically significant (P ＜ 0.05). After treatment, the levels of serum TNF-α, IL-6 and HADS scores of the two groups were significantly lower than those before treatment, and the observation group was better than the control group, the differences were statistically significant (P ＜ 0.05). Conclusion External application of Chinese herbs on sore and acupoints in combination with acupuncture can significantly alleviate the pain of lung cancer patients, reduce the contents of serum inflammatory factors and improve the quality of life of patients.
2018 Vol. 15 (29): 92-95 [Abstract] ( 268 ) HTML (1 KB)  PDF (571 KB)  ( 83 )
96 Comparison study of early radiotherapy combined with EP and EC therapy for limited-stage small cell lung cancer
MA Wenqing1 ZHANG Xuguang2 ZHAO Haiquan1 XU Yongmao1
Objective To explore the clinical effect and security on early radiotherapy combined with EP or EC therapy for limited-stage small cell lung cancer (LSCLC) and the influence on levels of the serum Ki-67 and VEGF. Methods A total of 70 cases with LSCLC in Department of Radiotherapy, the 97th Hospital of People′s Liberation Army from January 2013 to December 2014 were selected, and they were divided into EP group and EC group by the random number table method, with 35 cases in each group. The EP group was treated with VP-16 and DDP, while EC group was treated with and VP-16 and CBP. A treating course was 21 days, and both groups were treated for 6 courses. Concurrent radiotherapy was initiated after 2 courses of continuous chemotherapy. The clinical effect and adverse reactions were evaluated; the survival time was followed up. The levels of serum Ki-67 and VEGF before and after treatment were tested via ELISA. Results In EP group, the effective rate was 71.43%, and the disease control rate was 85.71%, while in EC group, they were 68.57%, 80.00% respectively, and there was no significant difference (P ＞ 0.05). In EP group, the overall survival time (OS) was 21.6 months, the 1-year survival rate was 74.29%, while in EC group, the OS was 22.1 months, the 1-year survival rate was 77.14%, and there was no significant difference (P ＞ 0.05). The adverse reactions rate of bone marrow suppression (neutrophile granulocyte, platelet decrease) was lower in EP group, while rate of gastrointestinal reaction, radiation pneumonitis, oesophagitis, abnormal liver function between the two groups had no significant difference (P ＞ 0.05). Compared with the levels of Ki-67, VEGF before treatment, the levels of Ki-67, VEGF decreased remarkably in the two groups after treatment, while more obvious in EC group(P ＜ 0.05). Conclusion There is no significant difference with the short-term effect in LSCLC between EP or EC therapy combined with early radiotherapy treatment, but EP therapy has fewer adverse reactions, with more obvious effect on suppressing the levels of serum Ki-67 and VEGF.
2018 Vol. 15 (29): 96-99 [Abstract] ( 255 ) HTML (1 KB)  PDF (573 KB)  ( 103 )
100 Influence of sequential DC-CIK cell therapy on survival rate and immune function after local advanced non-small cell lung cancer surgery
AI Yueqin1 JIANG Longwei2▲ ZHAO Hua2 GAO Yanrong2 JIA Shaochang2
Objective To investigate the influence of Dendritic cell (DC) and Cytokine-induced killer (CIK) cell therapy on the survival rate and immune function of local non-small cell lung cancer. Methods From January 2014 to January 2017, in Bayi Hospital Affiliated Nanjing University of Chinese Medicine, 40 NSCLC patients were selected, they were divided into treatment group (22 cases) and control group (18 cases) by random sampling table method. The control group was treated with adjuvant chemotherapy alone, and the treatment group was treated with DC, CIK combined with chemotherapy. The postoperative survival rate, serum tumor markers, immune function, and adverse reactions of patients in two groups were compared. Results The median survival time of the treatment group was compared with the control group, the difference was not statistically significant (P > 0.05), but the disease-free survival time of the treatment group was higher than the control group, the difference was statistically significant (P < 0.05). After treatment, serum tumor markers CEA and CYFRA21-1 in two groups were compared, the difference was not statistically significant (P > 0.05). After treatment, the ratio of helper T cells and CD4+/CD8+ T cells in the treatment group were significantly higher than the control group, the differences were statistically significant (P < 0.05), and the rDNA transcription activity of T lymphocytes in the treated group was significantly higher than the control group, the difference was statistically significant (P < 0.05). There was no significant difference in chemotherapy-related adverse effects between the two groups, in the treatment group, 3 patients with DC and CIK treatment had related fever reactions. Conclusion Sequential use of DC-CIK cells in patients with locally advanced non-small cell lung cancer can lead to clinical benefit of disease-free survival and enhanced immune function. It is a safe and effective treatment and worthy of clinical promotion and application.
2018 Vol. 15 (29): 100-103,107 [Abstract] ( 240 ) HTML (1 KB)  PDF (622 KB)  ( 163 )
104 Mainly immune phenotype of gastrointestinal stromal tumor and its correlation with risk grading and prognosis
GUO Yingxue1 JIA Jianbin1 NIE Shuangfa2 LI Lei2 WANG Tao2 FEI Jiandong2▲
Objective To analyze gastrointestinal stromal tumors (GIST) immunophenotype and its relationship with risk classification and prognosis. Methods From April 2015 to April 2017, in the First Affiliated Hospital of Hebei North University, 65 GIST patients were selected. The tissue paraffin section were dealed with SABC method, the expression of CD34, CD117, SMA, DOG1, Ki-67, S-100 and Desmin were analyzed, patients were given follow-up. Results The positive rates of CD117, DOG1, S-100 and Desmin were 96.9%, 100.0%, 6.2% and 4.6%, respectively; the positive rates of CD34, SMA and Ki-67 were 89.2%, 29.2% and 29.2% respectively; the positive expression of CD34 was not correlated with mitotic phase, risk grade and tumor size (P > 0.05); the positive expression of SMA was not correlated with mitotic phase, risk phase and tumor size (P > 0.05); Ki-67 expression was positively correlated with mitotic number, risk grade and tumor size (r = 0.715, 0.418, 0.397, P < 0.05); Ki-67 positive recurrence rate was 36.4%, mortality rate was 27.3%, and Ki-67 negative recurrence rate was 6.9%, the mortality rate was 3.4%, and the differences between the two groups were statistically significant (P < 0.05). Conclusion When diagnosing GIST, it can be combined with CD34, CD117 and DOG1, which have better complementarity. Detecting the levels of SMA, S-100 and Desmin protein can improve the accuracy of clinical diagnosis. Combined with Ki-67 factors, the prognosis of patients with GIST can be evaluated effectively.
2018 Vol. 15 (29): 104-107 [Abstract] ( 275 ) HTML (1 KB)  PDF (608 KB)  ( 56 )
108 Retrospective analysis of the CsA concentration monitoring strategies of 104 children with aplastic anemia
CHENG Xiaoling1 MA Jie2 CHEN Zhenping2 SHI Qiang1 TIAN Chao1 WU Runhui2 WANG Xiaoling1
Objective To analyze the factors influencing the blood concentration of cyclosporine A (CsA) in treatment of children with aplastic anemia (AA), and provide reference for the therapeutic drug monitoring of CsA and individualized medication. Methods Clinical data of 104 children with non-severe AA treated in Beijing Children′s Hospital, Capital Medical University from January 2014 to December 2017 were enrolled in this study, including gender, age, weight, clinical diagnosis, CsA blood concentration, usage and dosage, combined medication, and adverse drug reaction, et al. The results were analyzed statically. Results Among the first time of therapeutic drug monitoring children, only 18% (19 cases) were within the therapeutic window. Constituent ratios of children with dose titration once, twice, three times, four times, equal or more than five times were 21% (22 cases), 20% (21 cases), 13% (14 cases), 9% (8 cases), 19% (20 cases) respectively. The median times of therapeutic drug monitoring was 3 times (1-13 times). There were 9 cases treated combined with Berberine and 1 case was treated with Voriconazole, and the blood concentration reached the therapeutic window after the combination of drugs of 104 cases. Children with adverse reattioms were coun ted among the 104 cases, and there were 9.6% (10 cases) simply appearing hairy adverse reaction, 4.8% (5 cases) simply appearing gingiva hyperplasia, 11.6% (12 cases) appearing the two, 1.9% (2 cases) with blood pressure increasing, 1.9% (2 cases) with abnormal liver enzymes. Conclusion The pharmacokinetic parameters of CsA vary greatly among individuals, and the concentration of CsA blood drug is affected by many factors. Especially for children, timely monitoring the concentration of CsA blood drug of children with AA can guide their individualized medication rationally. It is imperative to find ways to optimize and improve the concentration of CsA.
2018 Vol. 15 (29): 108-111 [Abstract] ( 291 ) HTML (1 KB)  PDF (544 KB)  ( 101 )
112 Analysis of the changes of erythrocyte morphology and vascular endothelial function in human peripheral blood cells after rushing into plateau
WANG Zejun1 LIU Yunsheng2▲ TAN Min3 XUE Rui4
Objective To analyze the changes of erythrocyte morphology and vascular endothelial function in human peripheral blood after rushing into plateau, so as to provide references for prevention and treatment of acute mountain sickness (AMS). Methods From August 2015 to October 2017, a total of 195 healthy male objects going to rush into plateau in Chongqing were selected and 10 mL of peripheral blood was extracted before rushing into plateau (altitude 500 m) and after rushing into plateau (altitude 3500 m) to detect their erythrocyte morphology and vascular endothelial function. According to the occurrence of AMS, they were divided into occurrence group and non-occurrence group. The erythrocyte morphology and vascular endothelial function of the two groups were compared. Results After rushing into plateau, the number of normal red blood cells and serum nitric oxide (NO) of the objects decreased, the serum endothelin-1 (ET-1), vascular endothelial growth factor (VEGF) and von Willebrand factor (vWF) increased, the differences were statistically significant (P < 0.05). A total of 48 objects developed AMS, the incidence of which was 24.62%. After rushing into plateau, the number of normal forms of red blood cells in the two groups decreased, and the serum ET-1 increased, the above changes of occurrence group were more obvious than non-occurrence group, the differences were statistically significant (P < 0.05). As for occurrence group, the NO was lower than that before rushing into plateau, and VEGF, calcium mucin and vWF were higher than those before rushing into plateau, the differences were statistically significant (P < 0.05). Conclusion The peripheral blood erythrocytes tend to change deformities and the vascular endothelial function is impaired. The progress of these physiological changes may be an important cause of the occurrence of AMS.
2018 Vol. 15 (29): 112-115 [Abstract] ( 236 ) HTML (1 KB)  PDF (579 KB)  ( 161 )
116 Study of relationship between prognosis and expression of NGAL, uCH-L1 in patients with severe craniocerebral injury
WANG Jia ZHANG Hongyu SUN Xiaojing
Objective To explore the expression of neutrophil gelatinase associated lipocalin (NGAL) and ubiquitin C-terminal hydrolase-L1 (uCH-L1) in patients with severe craniocerebral injury and its application in prognosis prediction. Methods Fifty-six patients with severe craniocerebral injury in the Second Affiliated Hospital of Xinjiang Medical University from June 2015 to January 2017 were enrolled as study objects. According to the levels of NGAL and uCH-L1 within 24 hours, the patients were respectively divided into high NGAL group (NGAL＞4.40 ng/mL, 38 cases), low NGAL group (NGAL≤4.40 ng/mL, 18 cases) and high uCH-L1 group (uCH-L1＞0.38 ng/L, 35 cases), low uCH-L1 group (uCH-L1≤0.38 ng/L, 21 cases). According to whether they were survived, 56 patients were divided into death group and survival group. The differences of related indicators in each group were compared, and the relationship of the expression levels of NGAL and uCH-L1 in each group and its prognosis was detected. Results Compared with the low NGAL group and the low uCH-L1 group, the patients in high NGAL group and high uCH-L1 group had longer admission time, lower systolic blood pressure (SBP) and diastolic blood pressure (DBP), lower Glasgow coma scale (GCS) score on admission, higher acute physiology and chronic health evaluation (APACHEⅡ) score and higher mortality rate, the differences were statistically significant (P ＜ 0.05 or P < 0.01). Compared with survival group, the NGAL and uCH-L1 in death group increased significantly, the differences were highly statistically significant (Ｐ ＜ 0.01). The expression of NGAL was positively correlated with APACHEⅡ (r = 0.799，P ＜ 0.05), and uCH-L1 was positively correlated with APACHEⅡ score and NGAL (r = 0.659, P ＜ 0.05; ｒ ＝ 0.726，Ｐ ＜ 0.05). Conclusion The changes of NGAL and uCH-L1 in patients with severe craniocerebral injury were closely related to the prognosis of patients, and the increase of NGAL and uCH-L1 indicates poor prognosis.
2018 Vol. 15 (29): 116-119 [Abstract] ( 186 ) HTML (1 KB)  PDF (735 KB)  ( 120 )
120 Comparison of clinical efficacy between single and three-hole thoracoscope applied in radical lung cancer surgery
JIN Zhiyong GUO Zhanlin▲ KANG Shirong
Objective To analyze the clinical efficacy, related incident index and visual analogue scale (VAS) scores of single and three-hole thoracoscope applied in radical lung cancer surgery. Methods The clinical data of 100 patients with lung cancer treated in the the Affiliated Hospital of Inner Mongolia Medical University from January 2016 and January 2018 were selected. According to different surgeries performed, they were divided into observation group and control group, with 50 cases in each group. Patients in the control group received radical lung cancer surgery with three-hole thoracoscope, while those in the observation group received radical lung cancer surgery with single-hole thoracoscope. The situation of surgery, pain, detected serum indicators were compared between the two groups. Results Compared with the control group, the blood loss and drainage volume were less, and the length of incision was shorter, the indwelling of drainage tube and hospitalized time were shorter in the observation group (P ＜ 0.01). The VAS scores at the 1st, 3rd and 5th day after operation in the observation group were lower than those in the control group (P ＜ 0.01). The postoperative content of C-reactive protein (CRP) and proealcitonin (PCT) in the observation group were less than those in the control group (P ＜ 0.05). The postoperative levels of IgA, IgG, IgM, CD3+, CD4+, CD4+/CD8+ in the observation group were higher than those in the control group (P ＜ 0.01). The incidence of complications in the observation group was lower than that in the control group (P ＜ 0.05). Conclusion Compared with radical lung cancer surgery with three-hole thoracoscope, single-hole thoracoscopic surgery has advantages of smaller invasion, less blood loss, more rapid recovery and fewer complications, it can completely clean lymph nodes, and causes less impact on the patients′ stress and immune status after surgery. It is effective surgical method. 
2018 Vol. 15 (29): 120-123,128 [Abstract] ( 312 ) HTML (1 KB)  PDF (601 KB)  ( 146 )
124 The appication of narrow-band imaging magnifying endoscopy combined with serum pepsinogen and gastrin in the diagnosis of gastric cancer
SU Zhenhua WANG Liang WEI Sichen WEI Xinliang KONG Yu WANG Weiwei SHI Xiaomeng GUO Ruixue
Objective To discuss the effect of narrow-band imaging magnifying endoscopy (NBI-ME) combined with serum pepsinogen (PG) and gastrin (G-17) in diagnosis of gastric cancer. Methods A total of 172 patients treated in Department of Gastroenterology, Cangzhou Central Hospital from August 2015 to August 2017 were selected. Firstly, PG and G-17 were tested in the patients. Then, the NBI-ME plus pathology examination were further used to examine the patients with abnormal PG and G-17 results. According to the pathology results, all the patients were divided into non-atrophic gastritis group (control group, 50 cases), atrophic gastritis group (55 cases), and gastric carcer group (67 cases). The sensitivity, specific degree, positive predictive value, negative predictive value and accuracy of serum PGⅠ, PGR and G-17 among the three groups, and their effectiveness to the diagnosis of gastric cancer were evaluated. Results Compared with the control group, the levels of PGⅠ and PGR (PGⅠ/Ⅱ) were lower, and the level of G-17 was higher in the atrophic gastritis group and gastric cancer group (P ＜ 0.05). Compared with the atrophic gastritis group, the levels of G-17 was higher and PGⅠ, PGR were lower in the gastric cancer group (P ＜ 0.05). The pathology assay was used as the gold standard, the sensitivity of the PGⅠ with 70 μg/L as the diagnostic value in the diagnosis of gastric cancer was 71.87%, the specificity was 89.18%, and the accuracy was 56.39%. The sensitivity of the PGR with 7.0 as the diagnostic value diagnosis of gastric cancer was 41.93%, the specificity was 82.97%, and the accuracy was 75.58%. The sensitivity of G-17 with 15 pmol/L as the diagnostic value in the diagnosis of gastric cancer was 60.61%, the specificity was 71.22% and the accuracy was 69.19%. The sensitivity of G-17 combined with PGR in the diagnosis of gastric cancer was 51.35%, the specificity of 92.59% and the accuracy of 83.72%. The sensitivity of G-17 combined with PGⅠ in the diagnosis of gastric cancer was 43.37%, the specificity of 83.58% and the accuracy of 75.58%. Conclusion The combination of PG and G-17, followed with further examination of NBI-ME in the diagnosis of gastric cancer could improve the diagnostic rate in the early period, and it is worthy of clinical application.
2018 Vol. 15 (29): 124-128 [Abstract] ( 216 ) HTML (1 KB)  PDF (598 KB)  ( 116 )
129 Analysis of off-label use of Caffeine Citrate Injection in Neonatology Department of our hospital
WU Minzhi WANG Ying SI Tubing
Objective To investigate and analyze the off-label use of Caffeine Citrate Injection among inpatients in Neonatology Department of the Third Affiliated Hospital of Guangzhou Medical University (“our hospital” for short), to provide reference for rational use of medicine in clinic. Methods The medical records of hospitalized children who received Caffeine Citrate Injection in Neonatology Department of our hospital from January to December 2017 were randomly selected to analyze the off-label use of Caffeine Citrate Injection. Results A total of 253 medical records of hospitalized children were taken, it was found that the off-label use of Caffeine Citrate Injection was common, the main manifestations were over indication, over-applicable population, inconsistence of usage, dosage and medication course of treatment with the instructions. Conclusion It is necessary to pay close attention to the situation of the off-label use in clinical medication, carry out intervention and feedback timely, and gradually standardize the behavior of the off-label use in clinical medication, so as to promote rational drug use.
2018 Vol. 15 (29): 129-132 [Abstract] ( 253 ) HTML (1 KB)  PDF (348 KB)  ( 136 )
133 Application effect of special training for early activity based on Roy adaptation mode in ICU patients with mechanical ventilation
HOU Fang1 LIU Hailing1 HUANG Ying1 ZHANG Li2▲
Objective To observe the application effect of special training for early activity based on Roy adaptation mode in Intensive Care Unit (ICU) patients with mechanical ventilation and its influences on ICU-acquired weakness (ICU-AW) and quality of life. Methods From January to December 2017, in Department of Critical Care Medicine, NO.1 Hospital Affiliated to Xinjiang Medical University, 84 ICU patients with mechanical ventilation who received therapy were selected, according to random number table method, they were divided into control group and observation group, with 42 cases in each group. The control group was given conventional mode of special training for early activity, while the observation group was given special training for early activity based on Roy adaptation mode, Medical Research Council (MRC) score and brief scale of WHO quality of life (WHO QOL-BREF) were employed to assess muscle strength and life of quality respectively. Then, days of use of ventilator, ICU treatment, the hospitalization, incidences of ICU-AW, MRC score and life of quality in the two groups were compared. Results The days of using ventilator, ICU treatment and hospitalization in the observation group were less than the control group, the differences were statistically significant (P < 0.05). When moving out of the ICU ward, compared with the control group, the observation group had lower incidence of ICU-AW and higher MRC scores, the differences were statistically significant (P < 0.05). As to life of quality, scores of physiology, psychology, society, circumstance and total scores that reflected life of quality in the observation group were higher than the control group when moving out of ICU ward, the differences were statistically significant (P < 0.05). Conclusion Special training for early activity based on Roy adaptation mode has well application effect on ICU patients with mechanical ventilation. It can shorten time of mechanical ventilation, ICU treatment, reduce incidence of ICU-AW and improve quality of life.
2018 Vol. 15 (29): 133-136 [Abstract] ( 773 ) HTML (1 KB)  PDF (596 KB)  ( 79 )
137 Application of micro class combined with experiential learning in teaching peripheral venous indwelling needles for nursing interns in Department of Cardiology
HU Jingwen LIU Meili GUO Yan
Objective To explore the application effect of micro classroom combined with experiential learning in the clinical teaching of peripheral venous indwelling needle for nursing students in Department of Cardiology. Methods In Department of Cardiology, the First Affiliated Hospital of Xi′an Jiaotong University, according to the time of clinical practice of nursing students, 37 nursing students from July to August 2017 were selected as the control group, and 40 nursing students from September to October 2017 were selected as the observation group. The control group was given the clinical practice according to the traditional needle operation mode, and the observation group was given the micro class combined with experiential learning, the evaluation of learning effect, theorety and operation examination results of nursing students in two groups were observed. Results The scores of theory and operation examination in the observation group were higher than the control group, the differences were statistically significant (P < 0.05). The evaluation results of nursing students in the observation group were better than the control group, the differences were statistically significant (P < 0.05 or P < 0.01). Conclusion The combination of micro classroom and experiential learning can stimulate the initiative of the nursing students and improve the learning effect of the peripheral venous indwelling needle operation, and the students′ acceptance and recognition of the learning method are high.
2018 Vol. 15 (29): 137-140,148 [Abstract] ( 277 ) HTML (1 KB)  PDF (614 KB)  ( 203 )
141 Study on effect of continuity care on family management of asthma in children
LIANG Juan1 BAI Bo2 HU Xuehui3 ZHANG Meixia3 WANG Ping1
Objective To study the effects of continuity care on the family management of asthma in children. Methods From May to December 2016, in Paediatrics Outpatient, Xijing Hospital, Air Force Medical University, 60 children with moderate persistent asthma were selected, they were divided into observation group and control group by random number table method, with 30 cases in each group. The control group was given general nursing interventions, the observation group was given continuing health education nursing services outside the hospital. Six months after the intervention, the changes of peak expiratory flow predicted values (PEF%), forced expiratory volume in one second to forced vital capacity ratio (FEV1%), pediatric asthma quality of life questionnaire (PAQLQ) score, the times of acute exacerbations of asthma and revisit and the scores of asthma symptom in asthmatic children were observed. Results Six months after the intervention, PEF% and FEV1% in two groups were significantly higher than those before the intervention, the differences were statistically significant (P < 0.05). The PEF%, FEV1%, and PAQLQ scores in the observation group were significantly higher than the control group, the differences were statistically significant (P < 0.05). The times of asthma attacks and revisits, asthma symptom scores in the observation group were significantly lower than the control group, the differences were statistically significant (P < 0.05). Conclusion Continuity care has significant effect on children asthma management, it can effectively reduce the frequency of acute seizures and improve the quality of life in children with asthma, it is worthy of clinical application.
2018 Vol. 15 (29): 141-144 [Abstract] ( 270 ) HTML (1 KB)  PDF (594 KB)  ( 60 )
145 Evaluation value of nurses′ observation scale combined with Braden scale in pressure ulcer risk of inpatients in Department of Psychiatry and Psychology
CAI Lidan LUO Xinyou LIN Jiahao YANG Yun ZHOU Dan
Objective To investigate the value of nurses′ observation scale for inpatient evaluation (NOSIE) combined with Braden scale in pressure ulcer risk of inpatients in Department of Psychiatry and Psychology. Methods From January to May 2018, in Department of Psychiatry and Psychology, Nanfang Hospital of Southern Medical University, 90 newly admitted patients were selected, according to the NOSIE score, they were divided into mild condition group (48 cases) and severe condition group (42 cases). The risk of pressure ulcer in two groups were evaluated and compared with Braden pressure ulcer risk assessment scale. After taking the corresponding nursing measures,  the actual situation of pressure ulcer in two groups were compared. Results The risk rate of pressure ulcer in severe condition group was higher than mild condition group, the difference was statistically significant (P < 0.05). After nursing intervention, the incidence rate of pressure ulcer in two groups was significantly lower than the risk rate, the difference was statistically significant (P < 0.05), but there was no statistically significant difference in the incidence of pressure ulcer between two groups (P > 0.05). Conclusion Combined application of NOSIE and Braden scale can effectively assess the risk of pressure ulcer in inpatients of Department of Psychiatry and Psychology. It is benefit to take appropriate nursing measures for the patients with the disease.
2018 Vol. 15 (29): 145-148 [Abstract] ( 223 ) HTML (1 KB)  PDF (545 KB)  ( 107 )
149 Effect of case teaching method on diabetes knowledge and exercise prescription ability of community nurses
CHEN Jie1 ZHAO Chunyan2▲ ZHU Yuanyuan1 WANG Yanxian1 HAO Xiaomei1
Objective To explore the effect of case teaching method on improving the management of diabetes in community nurses. Methods From November 2017 to January 2018, 80 community nurses from community health centers in Shanghai and participated in the training practice were selected. They were trained with the case teaching method, and surveyed the community nurses before and after the training with diabetes knowledge questionnaire and the diabetes sports management plan questionnaire. Results The scores of basic knowledge of diabetes mellitus, sports adaptation and contraindications, exercise frequency, exercise time, exercise intensity, exercise mode, and total scores after training were higher than before training, the differences were statistically significant (P < 0.05); the scores of diabetes mellitus specialist nurses diabetic knowledge, attitude, behavior after training were higher than  before training, the differences were statistically significant (P < 0.05). Conclusion Through the application of case teaching method in the specialty training, in the specialty theory knowledge, the communication skill, the exercise plan establishment ability of the community diabetes specialist nurses are obvious enhancement, it has laid the solid foundation for the community nurse in the diabetes movement management work.
2018 Vol. 15 (29): 149-151,156 [Abstract] ( 195 ) HTML (1 KB)  PDF (1041 KB)  ( 95 )
152 Research on traditional Chinese medicine health of Yunnan Province community elderly care service platform based on O2O
SUN Yanling ZHANG Wei GENG Hui
Based on the particularities of community traditional Chinese medicine (TCM) health elderly care service, to explore the O2O platform model of Yunnan Province community TCM health care service, which combines the communication of TCM health care culture with the promotion of TCM health literacy and TCM health assessment with TCM health services. However, the implementation of O2O platform is restricted by a series of factors, such as low informations level of grass-roots community health service institutions, urgent need to establish multi-party cooperation mechanism, and insufficient TCM health literacy of elderly people in the community. At the present stage, the key to promot the development of the O2O platform is to strengthen the concept and skills of TCM health care for the elderly in the community. At the same time, the government should play the role of guidance and supervision, promote the integration of the TCM health care service industry in the community, and improve the TCM health service capacity in the community.
2018 Vol. 15 (29): 152-156 [Abstract] ( 213 ) HTML (1 KB)  PDF (675 KB)  ( 198 )
157 Analysis of the differences between instructions for domestic and foreign Ceftriaxone Sodium for Injection from the perspective of medication safety
WANG Fang LI Yonghui GUO Ruifeng LIU Xinxin
Objective To explore the problems and deficiencies of Ceftriaxone Sodium for Injection′s domestic drug instructions in medication safety and to provide reference for clinical safety of medication and medicine production enterprise to revise and perfect instruction. Methods Shandong Lukang Pharmaceutical Co., Ltd. and Hoffmann-La Roche Inc. were separately selected as the representatives of domestic and foreign manufacturers. The safety related items in the specifications of the latest edition of the two manufacturers (both revised in 2015) were compared and analyzed to look for differences, and the potential safety risks were discussed, the countermeasures were proposed. Results There were differences between the two instructions in usage and dosage, adverse drug reactions, indications, warning signs, contraindications, announcements, and intormation for the patients. Domestic instruction was simpler than foreign instruction, the guidance for safe medication especially for children was not specific enough, even key items of safe medication, such as contraindication, were missing informations. Conclusion This study suggests that domestic instructions are lack of informations on drug safety and there are risks and hidden dangers; it is suggested that drug manufacturers should take initiative and timely revise and improve the safety information in the instructions.
2018 Vol. 15 (29): 157-160 [Abstract] ( 247 ) HTML (1 KB)  PDF (736 KB)  ( 117 )
161 A bibliometric analysis related research literature of sleep quality among older adults in China based on SATI software
KONG Chan1 GAO Xudong2 LIU Qingqing1 CHEN Junchun1 HUANG Juan2
Objective To analyze the situation and development trend of sleep quality among older adults in China, so as to provide reference for future research. Methods Literatures related to sleep quality among older adults in the four major domestic databases of China (CNKI, SinoMed, Wanfang, VIP) from January 2008 to December 2017 were chosen, bibliometric analysis software was used to analyze the related informations. Results The volume of papers published kept a steady growth, papers were mainly from the costal developed provinces. High-yielding institutions were mainly in hospital, the three key words of sleep quality, sleep disorder and older adults were the central nodes in the social network of the common node. Conclusion The sleep quality of older adults has aroused the concern of clinicians, but the overall quality of the papers is not high, better improvement methods are to be explored.
2018 Vol. 15 (29): 161-164,172 [Abstract] ( 244 ) HTML (1 KB)  PDF (1186 KB)  ( 58 )
165 Study of the effect of early participation and aged service learning on improving knowledge and attitude of medical students
GUO Qing QIN Wei▲
Objective To investigate the effects of early participation and aged service learning on improving the knowledge and attitudes of medical students. Methods In September 2017, 90 graduates of the second year of undergraduate degree were recruited for a comprehensive university clinical medicine major, they were divided into experimental group and control group, with 45 graduates in each group. The experimental group was paired with the elderly in the community, and an 8-week elderly service study was conducted. The control group did not give any intervention. Before and after the intervention, the Kogan′s attitudes towards old people (KAOP) and facts on aging quiz (FAQ1) were used to evaluate the intervention effect of the two groups. Results There were no statistically significant in KAOP total scores and each dimension scores before the intervention between the two groups (P ＞ 0.05), after the intervention, the KAOP total scores and each dimension scores of experimental group were higher than those of control group, the differences were statistically significant (P ＜ 0.05). There was no statistically significant in FAQ1 score before the intervention between the two groups (P ＞ 0.05), after the intervention, the FAQ1 score of experimental group was higher than that of control group, the difference was statistically significant (P ＜ 0.05). Conclusion Early participation and aged service learning is beneficial to improving medical students' attitude towards the elderly, at the same time helping medical students to master more knowledge of aging.
2018 Vol. 15 (29): 165-168 [Abstract] ( 752 ) HTML (1 KB)  PDF (735 KB)  ( 138 )
169 Ifluence of  Mongolian mind-body interactive psychotherapy on cognitive function of depression
MENG Genhua1 Nagongbilige1 Sarnai Arlud1 LI Haojun2
Objective To evaluate the effect of Mongolian mind-body interactive psychotherapy on cognitive function of depression. Methods From June 2015 to June 2016, in Inner Mongolia International Mongolian Hospital, 30 depression patients given Mongolian mind-body interactive treatment for 21 d were selected. SAS and SDS were given before and after treatment to evaluate clinical symptoms, and observe the improvement of depression; repetitive complete neuropsychological state test (RBANS) and Stroop color words test were used to evaluated cognition function, change of cognition function were analyzed. Results The scores of SAS, SDS before and after treatment were compared, the difference was statistically significant (P < 0.01). In Stroop test, single color test time before and after treatment was compared, the difference was statistically significant (P < 0.01), but color interference, single word test time, color interference test time, word meaning interference test time before and after treatment were compared, the differences were not statistically significant (P > 0.05). The RBANS test showed three indexes such as immediate memory, speech function and delayed memory  before and after treatment was compared, the differences were statistically significant (P < 0.01), and the attention before and after treatment was compared, the difference was statistically significant (P < 0.05), but visual range before and after treatment was compared, the difference was not statistically significant (P < 0.05). Conclusion A 21 d of Mongolian mind-body interactive psychotherapy can improved the part of cognitive function, and reduce the depression symptoms.
2018 Vol. 15 (29): 169-172 [Abstract] ( 1052 ) HTML (1 KB)  PDF (738 KB)  ( 57 )
173 Application reasearch of medical performance allocation model based on settlement by disease score
ZHENG Yongjun
Objective To provide realistic basis for the establishment of a scientific and reasonable system performance allocation scheme, adapt to pose a question in the performance distribution, through the Surgery Department of Sanxiang Hospital of Zhongshan City as the object of the study. Methods A retrospective analysis was conducted on the results of the performance distribution of the six surgical departments, including Joint Surgery, Spine Surgery, General Surgery, Urology, Gynecology, and Otolaryngology, from January 2015 to December 2016. The current performance allocation scheme was as model 1, and model 2 was established based on the performance distribution scheme set up by health insurance; Current performance results were as dependent variables, income, health insurance score, average hospital stay, model 2 results as independent variables, t test was used for the analysis of metering data, Pearson correlation analysis was adopted for multifactor analysis. Results Income and disease score had significant influence on model 1 (r = 0.655, 0.656, P < 0.05). Conclusion The performance distribution model based on the disease score combined with medical errors and other quality indicators can effectively reflect the technical value of medical personnel on the basis of guaranteeing medical quality. It is characterized by simple operation, less amount of work and short time, which can achieve scientific operation performance evaluation result with lower cost and had great application value.
2018 Vol. 15 (29): 173-176 [Abstract] ( 770 ) HTML (1 KB)  PDF (761 KB)  ( 124 )
177 Application of thyroid automatic retractor in thyroid surgery
CUI Jianchun1* LIU Xuewei2* JIANG Jiuzhi3 SONG Renfeng4 YU Changshuai5 GAO Yang1 MA Shuai1 LI Li1▲
Small incision thyroid surgery has become the mainstream of thyroid surgery in China′s first-class hospital at Grade 3 because of its obvious advantages such as safety, minimal invasiveness, cosmetic use, and low medical costs. In this study, the use of thyroid automatic retractor, combined with arched retractor to complete the retraction of the upper and lower flaps of the small incision thyroidectomy and the exposure of the surgical field, so that the surgical procedure of cutting and exposing is more simple, convenient, fast, minimally invasive, and safe. It has achieved good clinical results through clinical application in a number of county-level primary hospitals in China, and is expected to be promoted and used in a wider range of primary hospitals.
2018 Vol. 15 (29): 177-180 [Abstract] ( 302 ) HTML (1 KB)  PDF (784 KB)  ( 73 )
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