窄带成像放大内镜联合胃蛋白酶原、胃泌素在胃癌诊断中的应用

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Abstract Objective To discuss the effect of narrow-band imaging magnifying endoscopy (NBI-ME) combined with serum pepsinogen (PG) and gastrin (G-17) in diagnosis of gastric cancer. Methods A total of 172 patients treated in Department of Gastroenterology, Cangzhou Central Hospital from August 2015 to August 2017 were selected. Firstly, PG and G-17 were tested in the patients. Then, the NBI-ME plus pathology examination were further used to examine the patients with abnormal PG and G-17 results. According to the pathology results, all the patients were divided into non-atrophic gastritis group (control group, 50 cases), atrophic gastritis group (55 cases), and gastric carcer group (67 cases). The sensitivity, specific degree, positive predictive value, negative predictive value and accuracy of serum PGⅠ, PGR and G-17 among the three groups, and their effectiveness to the diagnosis of gastric cancer were evaluated. Results Compared with the control group, the levels of PGⅠ and PGR (PGⅠ/Ⅱ) were lower, and the level of G-17 was higher in the atrophic gastritis group and gastric cancer group (P ＜ 0.05). Compared with the atrophic gastritis group, the levels of G-17 was higher and PGⅠ, PGR were lower in the gastric cancer group (P ＜ 0.05). The pathology assay was used as the gold standard, the sensitivity of the PGⅠ with 70 μg/L as the diagnostic value in the diagnosis of gastric cancer was 71.87%, the specificity was 89.18%, and the accuracy was 56.39%. The sensitivity of the PGR with 7.0 as the diagnostic value diagnosis of gastric cancer was 41.93%, the specificity was 82.97%, and the accuracy was 75.58%. The sensitivity of G-17 with 15 pmol/L as the diagnostic value in the diagnosis of gastric cancer was 60.61%, the specificity was 71.22% and the accuracy was 69.19%. The sensitivity of G-17 combined with PGR in the diagnosis of gastric cancer was 51.35%, the specificity of 92.59% and the accuracy of 83.72%. The sensitivity of G-17 combined with PGⅠ in the diagnosis of gastric cancer was 43.37%, the specificity of 83.58% and the accuracy of 75.58%. Conclusion The combination of PG and G-17, followed with further examination of NBI-ME in the diagnosis of gastric cancer could improve the diagnostic rate in the early period, and it is worthy of clinical application.

Key words： Gastric cancer Pepsinogen Gastrin-17 Narrow-band imaging magnifying endoscopy

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	SU Zhenhua WANG Liang WEI Sichen WEI Xinliang KONG Yu WANG Weiwei SHI Xiaomeng GUO Ruixue

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SU Zhenhua WANG Liang WEI Sichen WEI Xinliang KONG Yu WANG Weiwei SHI Xiaomeng GUO Ruixue. The appication of narrow-band imaging magnifying endoscopy combined with serum pepsinogen and gastrin in the diagnosis of gastric cancer[J]. 中国医药导报, 2018, 15(29): 124-128.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I29/124

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