重度颅脑损伤患者NGAL及uCH-L1水平与预后的关系

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Abstract Objective To explore the expression of neutrophil gelatinase associated lipocalin (NGAL) and ubiquitin C-terminal hydrolase-L1 (uCH-L1) in patients with severe craniocerebral injury and its application in prognosis prediction. Methods Fifty-six patients with severe craniocerebral injury in the Second Affiliated Hospital of Xinjiang Medical University from June 2015 to January 2017 were enrolled as study objects. According to the levels of NGAL and uCH-L1 within 24 hours, the patients were respectively divided into high NGAL group (NGAL＞4.40 ng/mL, 38 cases), low NGAL group (NGAL≤4.40 ng/mL, 18 cases) and high uCH-L1 group (uCH-L1＞0.38 ng/L, 35 cases), low uCH-L1 group (uCH-L1≤0.38 ng/L, 21 cases). According to whether they were survived, 56 patients were divided into death group and survival group. The differences of related indicators in each group were compared, and the relationship of the expression levels of NGAL and uCH-L1 in each group and its prognosis was detected. Results Compared with the low NGAL group and the low uCH-L1 group, the patients in high NGAL group and high uCH-L1 group had longer admission time, lower systolic blood pressure (SBP) and diastolic blood pressure (DBP), lower Glasgow coma scale (GCS) score on admission, higher acute physiology and chronic health evaluation (APACHEⅡ) score and higher mortality rate, the differences were statistically significant (P ＜ 0.05 or P < 0.01). Compared with survival group, the NGAL and uCH-L1 in death group increased significantly, the differences were highly statistically significant (Ｐ＜ 0.01). The expression of NGAL was positively correlated with APACHEⅡ (r = 0.799，P ＜ 0.05), and uCH-L1 was positively correlated with APACHEⅡ score and NGAL (r = 0.659, P ＜ 0.05; ｒ＝ 0.726，Ｐ＜ 0.05). Conclusion The changes of NGAL and uCH-L1 in patients with severe craniocerebral injury were closely related to the prognosis of patients, and the increase of NGAL and uCH-L1 indicates poor prognosis.

Key words： Severe craniocerebral injury Neutrophil gelatinase associated lipocalin Ubiquitin C-terminal hydrolase-L1

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	WANG Jia ZHANG Hongyu SUN Xiaojing

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WANG Jia ZHANG Hongyu SUN Xiaojing. Study of relationship between prognosis and expression of NGAL, uCH-L1 in patients with severe craniocerebral injury[J]. 中国医药导报, 2018, 15(29): 116-119.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I29/116

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