不同手术入路构建肾血管性高血压大鼠模型的比较

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Abstract Objective To compare the advantages and disadvantages of back approach and abdominal approach of establishing renovascular hypertension rat models. Methods According to random number table method, 50 female SD rats were divided into control group (n = 10), abdominal approach group (n = 20) and back approach group (n = 20). Abdominal approach group was made an incision for about 2.5 cm along the abdominal medialline, back approach group was made two longitudinal incisions for about 1.5 cm along the bilateral paravertebral line where kidney located, both groups underwent ligation of posterior branches of bilateral renal arteries, with free diet after suture. The blood pressure, operation time, whether the wound was chewed, postoperative infection rate and mortality of the two groups were compared. Results After 3 months of operation, the blood pressure of abdominal approach group and back approach group was signifcantly higher than that of control group (P ＜ 0.05). Compared with abdominal approach group, the operation time of back approach group was shorter, the postoperative infection rate was lower, while the number of cases being chewed was larger, the differences were statistically significant (P ＜ 0.05). After 3 months of operation, there was no significant difference on the mortality between abdominal approach group and back approach group (P ＞ 0.05). Conclusion The two approaches of establishing renovascular hypertension rat models have their own characteristics, and the postoperative nursing care is very important. It is necessary to choose the approach according to the actual conditions.

Key words： Renovascular hypertension Renal artery Rat model

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	SUN Jiajia1
	2 TU Yue2 LIU Yang2
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SUN Jiajia1,2 TU Yue2 LIU Yang2,3. Comparison of different operative approaches of establishing renovascular hypertension rat models[J]. 中国医药导报, 2018, 15(29): 13-16.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I29/13

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