RUNX3（rs760805）基因多态性与胃癌发病风险的Meta分析

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Abstract Objective To systematically evaluate the association between rs760805 polymorphism in Runt-related transcription factor 3 (RUNX3) gene and risk of gastric cancer. Methods PubMed, EMbase, The Cochrane Library (Issue 3, 2018), CMB, CNKI, VIP and Wanfang databases were searched, retrieval time form creating database to March 2018, the data of case-control studies on the correlation between polymorphisms of RUNX3 gene and risk of gastric cancer were retrieved, the language was limited to Chinese and English. Two evaluators independently screened literature, extracted data and evaluated the bias risk of included studies, and used Newcastle-Ottawa scale (NOS) to evaluate research quality. All genotype models of RUNX3 (rs760805) were compared, including A and T, AA and TT, AA and TA+TT, TA and TT, AA+TA and TT, and their distribution in case group and control group was comprehensively analyzed. Q-test and I2 value were used to analyze the heterogeneity among the studies, egger′s regression was used to verify the evaluation of publication bias, and Stata 12.0 software was used for Meta-analysis. The correlation of RUNX3 (rs760805) gene polymorphism with the risk of gastric cancer was calculated by using the odds ratio (OR) and 95% confidence interval (95%CI). Results A total of 5 case-control studies were included (gastric cancer cases: 1363, healthy controls: 1346). The results of Meta-analysis showed that (rs760805) polymorphism in RUNX3 gene was associated with risk of gastric cancer [A vs. T: OR = 1.27, 95%CI (1.01, 1.59), P = 0.039; AA+TA vs. TT: OR = 1.30, 95%CI (0.96, 1.77), P = 0.091; AA vs. TT+TA: OR = 1.18, 95%CI (0.99, 1.41), P = 0.073; AA vs. TT: OR = 1.51, 95%CI (0.97, 2.33), P = 0.065; TA vs. TT: OR = 0.73, 95%CI (0.32, 1.63), P = 0.437]. Conclusion There is a correlation between the genetic polymorphism of RUNX3 (rs760805) and the risk of gastric cancer, and allele A may be a potential risk factor for gastric cancer.

Key words： Gastric cancer Runt-related transcription factor 3 Gene polymorphism Onset risk Systematic evaluation Meta-analysis

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	ZHU Xiaoyun1* MA Ruchao2* YU Honggang1

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ZHU Xiaoyun1* MA Ruchao2* YU Honggang1. Meta analysis on rs760805 polymorphism in RUNX3 gene and risk of gastric cancer[J]. 中国医药导报, 2018, 15(29): 82-87.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I29/82

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