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| Comparison study of early radiotherapy combined with EP and EC therapy for limited-stage small cell lung cancer |
| MA Wenqing1 ZHANG Xuguang2 ZHAO Haiquan1 XU Yongmao1 |
1.Department of Radiotherapy, the 97th Hospital of People′s Liberation Army, Jiangsu Province, Xuzhou 221001, China;
2.Department of Radiotherapy, Xuzhou Cancer Hospital, Jiangsu Province, Xuzhou 221001, China |
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Abstract Objective To explore the clinical effect and security on early radiotherapy combined with EP or EC therapy for limited-stage small cell lung cancer (LSCLC) and the influence on levels of the serum Ki-67 and VEGF. Methods A total of 70 cases with LSCLC in Department of Radiotherapy, the 97th Hospital of People′s Liberation Army from January 2013 to December 2014 were selected, and they were divided into EP group and EC group by the random number table method, with 35 cases in each group. The EP group was treated with VP-16 and DDP, while EC group was treated with and VP-16 and CBP. A treating course was 21 days, and both groups were treated for 6 courses. Concurrent radiotherapy was initiated after 2 courses of continuous chemotherapy. The clinical effect and adverse reactions were evaluated; the survival time was followed up. The levels of serum Ki-67 and VEGF before and after treatment were tested via ELISA. Results In EP group, the effective rate was 71.43%, and the disease control rate was 85.71%, while in EC group, they were 68.57%, 80.00% respectively, and there was no significant difference (P ＞ 0.05). In EP group, the overall survival time (OS) was 21.6 months, the 1-year survival rate was 74.29%, while in EC group, the OS was 22.1 months, the 1-year survival rate was 77.14%, and there was no significant difference (P ＞ 0.05). The adverse reactions rate of bone marrow suppression (neutrophile granulocyte, platelet decrease) was lower in EP group, while rate of gastrointestinal reaction, radiation pneumonitis, oesophagitis, abnormal liver function between the two groups had no significant difference (P ＞ 0.05). Compared with the levels of Ki-67, VEGF before treatment, the levels of Ki-67, VEGF decreased remarkably in the two groups after treatment, while more obvious in EC group(P ＜ 0.05). Conclusion There is no significant difference with the short-term effect in LSCLC between EP or EC therapy combined with early radiotherapy treatment, but EP therapy has fewer adverse reactions, with more obvious effect on suppressing the levels of serum Ki-67 and VEGF.
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