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| Analysis of the changes of erythrocyte morphology and vascular endothelial function in human peripheral blood cells after rushing into plateau |
| WANG Zejun1 LIU Yunsheng2▲ TAN Min3 XUE Rui4 |
1.Medical Teaching and Research Office of Cold Region, Department of Plateau Military Medicine, Army Medical University, Chongqing 400038, China;
2.Medical Research Office of PLA Rocket Force, Scientific Research Institute, Army Medical University, Chongqing 400038, China;
3.Dialysis Room, Department of Nephrology, Southwest Hospital of Army Medical University, Chongqing 400038, China;
4.Cadet Brigade, Army Medical University, Chongqing 400038, China |
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Abstract Objective To analyze the changes of erythrocyte morphology and vascular endothelial function in human peripheral blood after rushing into plateau, so as to provide references for prevention and treatment of acute mountain sickness (AMS). Methods From August 2015 to October 2017, a total of 195 healthy male objects going to rush into plateau in Chongqing were selected and 10 mL of peripheral blood was extracted before rushing into plateau (altitude 500 m) and after rushing into plateau (altitude 3500 m) to detect their erythrocyte morphology and vascular endothelial function. According to the occurrence of AMS, they were divided into occurrence group and non-occurrence group. The erythrocyte morphology and vascular endothelial function of the two groups were compared. Results After rushing into plateau, the number of normal red blood cells and serum nitric oxide (NO) of the objects decreased, the serum endothelin-1 (ET-1), vascular endothelial growth factor (VEGF) and von Willebrand factor (vWF) increased, the differences were statistically significant (P < 0.05). A total of 48 objects developed AMS, the incidence of which was 24.62%. After rushing into plateau, the number of normal forms of red blood cells in the two groups decreased, and the serum ET-1 increased, the above changes of occurrence group were more obvious than non-occurrence group, the differences were statistically significant (P < 0.05). As for occurrence group, the NO was lower than that before rushing into plateau, and VEGF, calcium mucin and vWF were higher than those before rushing into plateau, the differences were statistically significant (P < 0.05). Conclusion The peripheral blood erythrocytes tend to change deformities and the vascular endothelial function is impaired. The progress of these physiological changes may be an important cause of the occurrence of AMS.
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