不同剂量阿托伐他汀在合并颈动脉不稳定斑块的高龄骨折患者围术期缺血性脑卒中中的治疗效果

Abstract
Figure/Table
References (23)
Related Citation (15)

Download: PDF (360 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the effects of different dose of Atorvastatin on elderly patients with unstable carotid plaques complicated ischemic stroke in perioperative period, and the effects on stress and carotid plaque stability. Methods Seventy-six elderly patients with fractures admitted to Jiangjin District Central Hospital in Chongqing City from January 2015 to April 2017 were selected and they were divided into observation group and control group according to the random number table method, with 38 cases in each group. The control group was given Atorvastatin 10 mg/d oral and the observation group was given Atorvastatin 20 mg/d oral. The treating course was 6 months. The clinical efficacy, stress response index and carotid plaque stability were observed in the two groups. Results After treatment, the total clinical effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After 4 weeks of treatment, the levels of malondialdehyde and low density lipoprotein in the observation group was significantly lower than those of the control group, the difference was statistically significant (P ＜ 0.05). After 6 months of treatment, scores of the scale of the National Institutes of Health of the United States (NIHSS), arterial plaque area and carotid artery intima thickness (Crouse) scores were significantly lower in the observation group than those in the control group, the difference was statistically significant (P ＜ 0.05). There was no significant difference in the adverse reaction between the two groups (P ＞ 0.05). Conclusion Large dose of Atorvastatin in the treatment of elderly fracture patients with unstable carotid artery atherosclerotic plaques complicated ischemic stroke in perioperative period has a satisfatory curative effect, which can effectively reduce the injury of oxidative stress, reduce the area of plaque, and it is safe and reliable.

Key words： Atorvastatin Advanced fracture Carotid plaque Ischemic stroke Oxidative stress

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHENG Xiuguang ZHANG Zuowen▲

Cite this article:

ZHENG Xiuguang ZHANG Zuowen▲. Clinical effect of different dose of Atorvastatin on elderly patients with unstable carotid plaques complicated ischemic stroke in perioperative period[J]. 中国医药导报, 2018, 15(29): 62-65.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I29/62

[1] 孟钰童，龙安华，谭晶，等.老年髋部骨折术后急性脑卒中发生的危险因素分析与预后分析[J].中华创伤骨科杂志，2015，17（9）：740-744.
[2] 何苏，黄莺莺，隆世宇.阿托伐他汀联合拜阿司匹林对缺血性脑血管病患者颈部动脉斑块及血清OxLDL、hs-CRP的影响[J].海南医学，2016，27（1）：30-31.
[3] Mizuma A，Iijima K，Kohara S，et al. Effect of atorvastatin co-treatment on inhibition of platelet activation by clopidogrel in patients with ischemic stroke [J]. Int J Stroke，2015，10（8）：E90-E91.
[4] 何必华，胡东辉.阿托伐他汀对急性缺血性卒中患者血清hs-CRP水平及预后的影响[J].中国实用神经疾病杂志，2016，19（10）：63-64.
[5] 中华医学会神经病学分会，中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志，2015，48（4）：246-257.
[6] 中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南2010[J].中国全科医学，2011，14（35）：4013-4017.
[7] Yang J，Pan Y，Li X，et al. Atorvastatin attenuates cognitive deficits through Akt1/caspase-3 signaling pathway in ischemic stroke [J]. Brain Res，2015，1629：231-239.
[8] 孟文超，高美景，王立羽.阿托伐他汀治疗老年缺血性卒中合并高脂血症患者的疗效与安全性[J].中国循证心血管医学杂志，2017，9（6）：700-702.
[9] Yu Y，Zhu C，Liu C，et al. Effect of Prior Atorvastatin Treatment on the Frequency of Hospital Acquired Pneumonia and Evolution of Biomarkers in Patients with Acute Ischemic Stroke：A Multicenter Prospective Study [J]. Biomed Res Int，2017，2017：5642704.
[10] Berwanger O，de Barros E Silva PG，Barbosa RR，et al. Atorvastatin for high-risk statin-na?觙ve patients undergoing noncardiac surgery：The Lowering the Risk of Operative Complications Using Atorvastatin Loading Dose（LOAD）randomized trial [J]. Am Heart J，2017，184：88-96.
[11] 罗栋为，唐小荣，吴振东.强化降脂治疗用于颅内动脉狭窄的临床疗效及安全性观察[J].黑龙江医药，2016， 29（4）：653-654.
[12] Rodríguez-Perea AL，Gutierrez-Vargas J，Cardona-Gómez GP，et al. Atorvastatin Modulates Regulatory T Cells and Attenuates Cerebral Damage in a Model of Transient Middle Cerebral Artery Occlusion in Rats [J]. J Neuroimmune Pharmacol，2017，12（1）：152-162.
[13] 周华，朱浩，赵中，等.不同剂量阿托伐他汀对颈动脉斑块患者氧化应激指标的影响[J].海南医学，2017，28（16）：2593-2595.
[14] 黄必武，郭韵诗，王子源.阿托伐他汀钙对急性脑梗死患者颈动脉硬化斑块及超敏C反应蛋白、血脂水平影响[J].中国当代医药，2016，23（36）：45-47.
[15] 庞伟，周琛，麦超，等.阿托伐他汀钙联合氯吡格雷预防TIA发作后脑梗死的作用及对血脂水平、凝血功能的影响[J].中国医药科学，2018，8（3）：70-72，88.
[16] Yue YH，Bai XD，Zhang HJ，et al. Gene Polymorphisms Affect the Effectiveness of Atorvastatin in Treating Ischemic Stroke Patients [J]. Cell Physiol Biochem，2016， 39（2）：630-638.
[17] Zhang J，Mu X，Breker DA，et al. Atorvastatin treatment is associated with increased BDNF level and improved functional recovery after atherothrombotic stroke [J]. Int J Neurosci，2017，127（1）：92-97.
[18] 戴阳阳.大剂量阿托伐他汀强化治疗急性缺血性脑卒中临床疗效观察[J].淮海医药，2016，34（3）：327-329.
[19] 梁骥，刘生刚.不同剂量阿托伐他汀治疗早期急性缺血性脑卒中的临床疗效比较[J].基层医学论坛，2016，20（4）：440-442.
[20] 王洪伟.他汀类药物联合阿司匹林治疗急性缺血性脑卒中的疗效分析[J].中国医药科学，2016，6（19）：87-89.
[21] Simani L，Naderi N，Khodagholi F，et al. Association of Long-Term Atorvastatin with Escalated Stroke-Induced Neuroinflammation in Rats [J]. J Mol Neurosci，2017，61（1）：32-41.
[22] 周红霞，兴元，范利娟，等.阿托伐他汀在急性缺血性脑卒中患者中的临床研究[J].中国临床药理学杂志，2016， 32（1）：72-74.
[23] Palacio E，Viadero-Cervera R，Revilla M，et al. Utility of treatment with atorvastatin 40 mg plus ezetimibe 10 mg versus atorvastatin 80 mg in reducing the levels of LDL cholesterol in patients with ischaemic stroke or transient ischaemic attack [J]. Rev Neurol，2016，62（5）：203-210.