中国医药导报
      Home                                                                                    中文
中国医药导报
 
Forthcoming Articles
Current Issue
Archive
Advanced Search
Read Articles
Download Articles
Email Alert
 
Quick Search  
  Adv Search
2017 Vol. 14, No. 23
Published: 2017-08-15
 
 
4 Expression of MMRN2 in breast cancer and its influence on prognosis
LI Huaping SUN Shengrong▲ CHEN Chuang WANG Yuan
Objective To investigate the expression of MMRN2 in breast cancer and its influence on prognosis, discuss the mechanism of MMRN2 in breast cancer. Methods Western blot and qRT-PCR were used to detect the expression of MMRN2 in 50 pairs of human breast invasive ductal carcinoma specimens and adjacent tissues, which had excision by surgery in Renmin Hospital of Wuhan University from January 2013 to April 2017. The relationship between the expression of MMRN2 and the pathologic features and prognosis of patients were analyzed. Results The expression of MMRN2 in breast cancer was down-regulated (P < 0.01), and the expression of MMRN2 was not correlated with the pathological characteristics of patients (P > 0.05). Up-regulated MMRN2 could prolong the overall survival (P = 0.036) and no recurrence survival time (P = 0.019) of patients with breast cancer. Conclusion MMRN2 is a tumor suppressor gene for breast cancer, and can serve as a potential target for molecular treatment of breast cancer, improve patients′ survival.
2017 Vol. 14 (23): 4-7 [Abstract] ( 224 ) HTML (1 KB)  PDF (769 KB)  ( 55 )
8 Dynamic comparative study on the therapeutic effect of astragalus polysaccharide and Simvastatin in rats with hyperlipidemia
YUAN Qianfa TANG Simeng CHEN Siyu YANG Zemin
Objective To compare the therapeutic effects of astragalus polysaccharide and Simvastatin in rats with hyperlipidemia. Methods The model of rats with hyperlipidemia was induced by high fat diet. The SD rats were randomly divided into normal group, disease model group, Simvastatin group and astragalus polysaccharide group by completely random method. The normal group was fed with basal feed, the other three groups were fed with high fat diet, among which, the astragalus polysaccharide group was given astragalus polysaccharide 700 mg/kg by gavage, Simvastatin group was given Simvastatin 6.7 mg/kg by gavage, normal group and disease model group were given normal saline by gavage. The amount of water intake, food intake, energy intake, excretion and body weight of the rats were recorded. The serum samples were collected every 4 weeks. The changes of the contents of blood glucose, triacylglycerol (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected. Results After high fat diet for 8 weeks, the amount of energy intake, body weight and the levels of serum lipid, transaminase in disease model group were all significantly higher than those of normal group (P ＜ 0.05), while the amount of food intake, water intake, excretion were significantly lower than those of normal group (P ＜ 0.05). After drug intervention for 4 weeks, the contents of TC, TG and LDL-C in Simvastatin group were significantly lower than those of disease model group (P ＜ 0.05), while there were no statistically significant differences of the contents of TC, TG and LDL-C between astragalus polysaccharide group and disease model group (P ＞ 0.05). After drug intervention for 8 weeks, the amount of water intake, excretion, body weight and the levels of blood lipid in astragalus polysaccharide group and Simvastatin group were significantly improved compared with those of disease model group (P ＜ 0.05). In addition, the levels of blood glucose and transaminase in astragalus polysaccharide group were also significantly improved compared with those of disease model group (P ＜ 0.05), while the indexes above in the Simvastatin group were not significantly improved. Conclusion The effects of lipid-lowering of astragalus polysaccharide is slow, but it can achieve the same effects of lipid-lowering as Simvastatin through prolonging drug administration, and the improvement for blood glucose and transaminase is better than Simvastatin.
2017 Vol. 14 (23): 8-12 [Abstract] ( 168 ) HTML (1 KB)  PDF (1282 KB)  ( 44 )
13 Meta-analysis of therapeutic efficacy of Xingnaojing Injection combined with Naloxone Injection in the treatment of acute cerebral hemorrhage patients with coma
ZHANG Fen1 ZHENG Yan2 ZHUANG Fengjuan3
Objective To evaluate therapeutic efficacy of Xingnaojing Injection combined with Naloxone Injection in the treatment of acute cerebral hemorrhage patients with coma. Methods Ran domized controlled trials of the therapeutic efficacy of Xingnaojing Injection combined with Naloxone Injection in the treatment of acute cerebral hemorrhage patients with coma, PubMed, Cochrane Library, Embase, PEDro, NTIS, CNKI, Wanfang Data, VIP were collected (from the establilshment to May 2017). Key words including "Xingnaojing", "Naloxone", "Cerebral Hemorrhage", "Coma", "Syncope", "Consciousness". Meta-analysis was performed by RevMan 5.3 software. Results A total of 10 RCTs were screened, which 916 patients were included. Meta analysis showed that the combined drugs can improve total effective rate of treatment [OR = 3.37, 95%CI(2.04, 5.56)]，significantly reduced cerebral hematoma area [OR = －3.75, 95%CI(－6.61, －1.34)], patients GCS score was higher than the conventional treatment score [OR=2.87, 95%CI(2.27, 3.48)], the improvement degree of NHISS score was better than that of control group [OR=－6.05, 95%CI(－7.88, －4.22)]. Conclusion Combination therapy is effective in the treatment of acute cerebral hemorrhage accompanied with coma, and have a batter synergistic effect and clinical application value.
2017 Vol. 14 (23): 13-17 [Abstract] ( 196 ) HTML (1 KB)  PDF (1251 KB)  ( 54 )
18 Analgesic effect of electroacupuncture with different parameters combinationson SNL and endorphin expression of hypothalamus in rats
ZHOU Jie1 CHEN Zhenyu2 GONG Jie3 ZHUANG Shengjian4 SHAO Xiaomei5 FANG Jianqiao5▲
Objective To evaluate the analgesic effect of neuropathic painmodel rat of electroacupuncture with different parameter combinations, select the best parameter combination of electroacupuncture treatment forneuropathic pain. Methods 30 SD male rats were randomly divided into normal group (N group), model group (M group), 2 Hz group，120 Hz  group, and 2/120 Hz group, with 6 rats in each group. Neuropathic pain model was established by spinal nerve ligation (SNL). EA groups were given electroacupuncture on ipsilateral of Zusanli (ST36) and Kunlun (BL60). The Paw withdraw thresholds of each rat were measured as an assessment of nociception before and 24 hours after operation and at the 1st, 3rd, 5th, 7th, 9th, 10th day after the treatment. The ENK and β-END concentration of hypothalamus were measured by RIA. Results PWTs of 2 Hz groups was higher than M group in every time point (P < 0.05 or P < 0.01); at the 3rd, 5th, 7th after EA, the PWTs of 2 Hz group were higher than 120 Hz group and 2/120 Hz group (P < 0.05 or P < 0.01); at the 1st, 7th, 9th, 10th after EA, the PWTs of 120 Hz group and 2/100 Hz group were higher than M group (P < 0.05 or P < 0.01). The β-END concentration of hypothalamus of EA groups was higher than M group and N group (P < 0.01). The ENK concentration of hypothalamus of 2/120 Hz EA group was higher than M group, N group, 2 Hz EA group and 120 Hz EA group (P < 0.05 or P < 0.01). Conclusion Different parameter combinations electroacupuncture have analgesic action for neuropathic pain modal rat, but the analgesia effect is different. Electroacupunctrue is effective for neuropathic painrelated to the secretion of endorphins. At early stage of neuropathic pain,2 Hz/50 μs electroacupuncture is advisable, while at late stage of neuropathic pain, different parameter combinations electroacupuncture is similar efficacious.
2017 Vol. 14 (23): 18-21 [Abstract] ( 168 ) HTML (1 KB)  PDF (845 KB)  ( 77 )
22 The suppression effect of nitric oxide synthetase on formation of deprivation myopia in guinea pig
ZHANG Wenlong XU Chen CHEN Jun
Objective To observe the effect of nitric oxide on formation of deprivation myopia (FDM) in guinea pig, in order to investigate the regulation of nitric oxide on retinopathy of myopia. Methods Guinea pigs were used to establish the FDM model. They were divided into group A (FDM-untreated), group B (FDM induced 10-day), group C (FDM induced 20-day), group D (FDM induced 10-day plus NOS inhibitor injected), group E (FDM induced 20-day plus NOS inhibitor injected), group F (FDM induced 10-day plus melatonin injected), group G (FDM induced 20-day plus melatonin injected), with 15 guinea pigs in each group. The myopic refraction, axial length in each group and expression level of iNOS in the retina of guinea pigs were observed. Results Compared to group A, myopia increased and the axial length prolonged significantly, and the level of iNOS increased obviously in FDM-induced group, with statistically significant difference (P < 0.05). Compared to FDM-induced group, the level of iNOS significantly reduced (P < 0.05), and the degree of myopia and the axial length were severely inhibited in guinea pigs treated with FDM plus NOS inhibitor injected. Conclusion The expression of iNOS in retina in FDM guinea pigs increases, while NOS inhibitor can effectively inhibite the occurrence of myopia. The synthesis of nitric oxide promotes FDM in guinea pig.
2017 Vol. 14 (23): 22-24,47 [Abstract] ( 225 ) HTML (1 KB)  PDF (958 KB)  ( 25 )
25 Study on preparation and osteogenic effects of BMP-2-loaded PLGA microspheres with a sustained control release
WU Yongheng ZHANG Zijun HUANG Yan ZHAO Wen
Objective To research the physical characteristics of novel bone morphogenetic factor-2 (BMP-2)-loaded poly (lactic-co-glycolic acid) (PLGA) microspheres with a sustained control release of BMP-2 for bone induction and the influence ossification in vitro and in vivo. Methods The BMP-2-loaded PLGA microspheres through double emulsion method was prepared, and  the physiological properties of microspheres was investigated, including particle size and loading and encapsulation rates of BMP-2, and the release profile of BMP-2. The effects of BMP-2-loaded microspheres on the proliferation and differentiation of bone marrow mesenchymal stem cells (BMSCs) in vitro and the ectopic bone formation inside the mouse thigh muscle were studied. Results The average size of PLGA particles loaded with BMP-2 was (242.2±31.3) μm with smooth surface. BMP-2 released from microspheres displayed a biphasic release profile. BMSCs cultured with BMP-2-loaded microspheres showed the fastest proliferation rate among all groups (P < 0.05). The proliferation rate of BMSCs was dose-dependent on BMP-2 (P < 0.05). Ectopic bone formation in the mouse thigh muscle was observed after injection of BMP-2-loaded-microspheres. A large number of trabecular bone appeared with emerging bone marrow cavity 4 weeks after the injection. Conclusion The new method to prepare PLGA microspheres loaded with BMP-2 has a sustained control release rate, which can promote the proliferation and differentiation of BMSCs in vitro and ectopic bone formation in vivo. BMP-2-loaded PLGA microsphere holds high potential for wide application in bone tissue regeneration.
2017 Vol. 14 (23): 25-28 [Abstract] ( 198 ) HTML (1 KB)  PDF (885 KB)  ( 101 )
29 Research progress of ultrasound and microbubble mediated stem cell in the treatment of myocardial infarction
ZHANG Jie MU Yuming
The method of using stem cells to repair infarcted myocardium has great potential. But there are a series of questions with simple exogenous transplantation, such as immunological rejection, transmission of pathogens, storage, packing and more, the stem cells can′t home to the targeted area efficiently. As a novel gene delivery system, ultrasound-targeted microbubble destruction has been widely used for recruiting stem cells and gene therapy for its advantages of noninvasiveness, low immunogenicity, repeatability, spatial target specificity, etc. This article reviewes the methods of ultrasound and microbubble mediated stem cell in the treatment of myocardial infarction.
2017 Vol. 14 (23): 29-32 [Abstract] ( 179 ) HTML (1 KB)  PDF (422 KB)  ( 38 )
33 Research progress of the correlation between RAS gene polymorphism and diabetes mellitus associated with hypertension
HOU Lina1，2 BI Lifu1，2 SU Xiulan1
Diabetes mellitus and hypertension are polygenetic hereditary diseases, and the correlation of their genes has become a focus in academic research. This summary presents a review of literatures reported at home and abroad between the renin-angiotens in system gene polymorphism and diabetes mellitus with hypertension.
2017 Vol. 14 (23): 33-35 [Abstract] ( 189 ) HTML (1 KB)  PDF (418 KB)  ( 50 )
36 Advances in seed cells in cartilage tissue engineering
ZHANG Zhijin QUAN Renfu YUE Zhenshuang ZHU Fangbing
Tissue engineering cartilage repair tissue engineering technology is applied to the clinical one of the most feasible research field, and the seed cell is cartilage tissue engineering research and clinical application of the basic elements and the primary link. In this paper, combining the domestic and foreign research results, the research status of seed cells in cartilage defects repairing tissue engineering was reviewed. The characteristics, sources, species and culture of seed cells are reviewed in order to provide the basis for the further development of cartilage tissue engineering.
2017 Vol. 14 (23): 36-39 [Abstract] ( 213 ) HTML (1 KB)  PDF (450 KB)  ( 45 )
40 Study on the preference of patients for medical treatment based on the conjoint analysis and the enlightenment to the graded medical treatment
ZHI Simin XU Huaifu
Objective To study the patients′ preferences, provide suggestions on guiding patients for medical treatment reasonably and perfecting graded medical treatment. Methods From February 13th to March 3rd, 2017, a questionnaire was designed by conjoint analysis, in order to conduct the questionnaire survey on 194 patients totally, who were from the First People′s Hospital of Zhengzhou, He′nan Provincial People′s Hospital and others total of 6 medical institutions. Conjoint analysis of data was conducted by SPSS 19.0. Results The results of conjoint analysis showed the patients were sensitive to the quality of care mostly, followed by the level of medical institutions. The patients got the highest utility value based on the analog combination, which included general hospital, just waiting for 30 min, good service quality, cost of 120 RMB and 85% reimbursement rate. Conclusion At present, patients have lower confidence in community health institutions. Patients need to improve blindness in medical treatment. Differentiated health care policy has little incentive for patients. As a result, it is suggested that graded medical treatment should be improved from the aspects of the community hospital development, health education and medical institutions, etc..
2017 Vol. 14 (23): 40-43 [Abstract] ( 186 ) HTML (1 KB)  PDF (481 KB)  ( 111 )
44 Risk factors analysis of recent prognosis of patients with ST-elevation myocardial infarction after percutaneous coronary intervention
WANG Yin
Objective To analyze the risk factor of recent prognosis of patients with ST-elevation myocardial infarction after percutaneous coronary intervention (PIC). Methods The clinical data of 130 patients with ST-elevation myocardial infarction treated after PCI in Traditional Chinese Medicine Hospital of Baoji City from January 2012 to January 2017 were retrospectively analyzed. They were divided into two groups according to the recent prognosis: MACE group (48 cases) and non-MACE group (82 cases). Sex, age, body mass index, Killip classification, complications, LVEF, hs-CRP, NT-proBNP, kidney function and other clinical data of patients were eliminated; the influencing factors of the recent prognosis of patients with ST-elevation myocardial infarction after PIC were analyzed by multi-factor Logistic regression model analysis. Results Single factor analysis showed that, there was no statistically significant difference in the sex, age, body mass index, Killip classification, area of infarction, and the proportion of patients with hyperlipemia, hypertension, stroke and LVEF < 40% between the two groups (P > 0.05); the proportion of patients with diabetes mellitus, number of stenosed coronary vessel ≥ 1, hs-CRP > 4 mg/L, NT-pro BNP > 3600 pmol/L, HbA1c ≥ 6.5%, SCr > 133 mmol/L, GFR < 90 mL/(min·1.73 m2),and level of Hb of patients between the two groups had statistically significant difference (P < 0.05). Logistic regression analysis showed that, hs-CRP, HbA1c, GFR, Hb, NT-proBNP were the influence factors of MACE in patients with st-elevation myocardial infarction (P < 0.05). Conclusion hs-CRP, HbA1c, GFR, Hb, NT-proBNP are risk factors of major adverse cardiovascular events of patients with ST-elevation myocardial infarction after PCI; the clinical should carry corresponding treatment, to improve the prognosis of patients.
2017 Vol. 14 (23): 44-47 [Abstract] ( 190 ) HTML (1 KB)  PDF (432 KB)  ( 162 )
48 Clinical effect of Simvastatin combined with Ezetimibe in the regulate lipid of patients with coronary heart disease
LI Minfeng LUO Qiulin TANG Qianmei▲
Objective To analyse the clinical effects of Simvastatin combined with Ezetimibe in the treatment of patients with coronary heart disease and its influence for TC, LDL-C, ApoB. Methods From October 2015 to October 2016, 96 patients with coronary heart disease in the Third Branch of Chongqing People's Hospital were selected and divided into control group (48 cases) and observation group (48 cases). The control group was treated by Simvastatin, while the observation group was treated by Simvastatin combined with Ezetimibe. Three months after treatment, the compliance rate and adverse drug reactions of two groups were compared, and the changes of serum cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and apolipoprotein (ApoB) levels were measured before and after treatment between two groups. Results The levels of TC, LDL-C and ApoB in the observation group were lower than those in the control group (P < 0.05). The rate of blood lipid in the observation group was higher than that in the control group, with statistically significant difference (P < 0.05). The incidence of adverse reactions in the observation group was higher than that in the control group, but the difference was not statistically significant (P > 0.05). Conclusion Simvastatin combined with Ezetimibe for coronary heart disease has a good effect in the regulate lipid, which has a high achievement rate of serum lipid and safety of medication.
2017 Vol. 14 (23): 48-51 [Abstract] ( 196 ) HTML (1 KB)  PDF (415 KB)  ( 138 )
52 Study on the relationship between carotid atherosclerosis and serum LTB4, MMP-9 levels in patients with acute cerebral infarction
MA Honggang1 ZHU Feifei2 WANG Yaxian1
Objective To study the relationship between serum levels of leukotriene B4 (LTB4), matrix metallopeptidase 9 (MMP-9) and the degree of arteriosclerosis in the patients with acute cerebral infarction. Methods From January 2014 to January 2016, 200 patients with acute cerebral infarction were selected. They were divided into carotid atherosclerosis group (143 cases) and control group (57 cases), according to whether there exist carotid atherosclerosis. Then, the patients in the carotid atherosclerosis group were divided into intima thickening group (22 cases), plaque group (67 cases) and carotid artery stenosis group (54 cades), according to the degree of intimal thickening. The levels of serum LTB4, MMP-9 in the groups were compared. Results The levels of serum LTB4, MMP-9 in the carotid atherosclerosis group were obviously higher than those in the control group, with statistically significant difference (P < 0.05). The expression in the carotid artery stenosis group was significantly higher than that in the carotid plaque group and intima thickening group, and Spearman correlation test showed the levels of LTB4 and the MMP-9 were positively related to severity of carotid atherosclerosis (P < 0.05). Conclusion The levels of serum LTB4 and MMP-9 are positively correlated with the carotid atherosclerosis and the degree in patients with acute cerebral infarction.
2017 Vol. 14 (23): 52-55 [Abstract] ( 172 ) HTML (1 KB)  PDF (435 KB)  ( 41 )
56 The study of intravenous thrombolysis for different TOAST subtype of minor ischaemic stroke
ZHU Haibao YANG Jing SHEN Yongling QI Limin FENG Li ZHANG Guanwen SANG Xiaoyi CHENG Ruinian
Objective To analysis safety and short-term prognosis of rt-PA intravenous thrombolysis treatment in different TOAST subtype of minor ischaemic stroke. Methods From November 2013 to January 2016, 256 patients with mild ischaemic stroke in Chengde Central Hospital were selected. 136 patients were treated with rt-PA intravenous thrombolysis (intravenous thrombolysis group), and 120 patients were treated with oral drugs (non thrombolysis group), the patients in the two groups were divided by TOAST etiology. 90 days after treatment, the scores of NIHSS and mRS, the cerebral hemorrhage rate, death rate, recurrence rate were observed, besides the NIHSS score of 0-1 and mRS of 0-1 were defined as good outcomes. Results The proportion of good outcomes in the intravenous thrombolysis group was higher than that of the non thrombolysis group, the recurrence rate was lower than that of the non thrombolysis group, with statistically significant difference (P < 0.05). And the proportion of good outcomes in the LAA subgroup who were treated with rt-PA intravenous thrombolysis was higher and the recurrence rate was lower (P < 0.05). Conclusion rt-PA intravenous thrombolysis can improve the proportion of good outcomes in the patients with minor ischaemic stroke in 90 days, especially LAA subtype, reduce the recurrence rate, and it has good safety.
2017 Vol. 14 (23): 56-59 [Abstract] ( 222 ) HTML (1 KB)  PDF (406 KB)  ( 91 )
60 Application of child to child health education nursing model on following up school-age children with asthma
HA Haixia LIU Hui LI Juan▲ YANG Guanshan
Objective To explore the effect of child to child health education nursing model on following up school-age children with asthma. Methods Ninety-seven school-age children with asthma received treatment in the Outpatient Department of Ankang Hospital of Chinese Medicine were selected as research objects, among whom, 48 children from August 2014 to March 2015 were set as control group, 49 children from April to October 2015 were set as observation group. Both groups received conventional health education, on basis of which, the observation group was taken child to child health education nursing model. The asthma control level, pulmonary function and the quality of life of the two groups before intervention and after intervention within one week were evaluated. Results After intervention, the scores of childhood asthma control test (C-ACT), the percentage of peak expiratory flow accounted for predicted value (PEF%) and the percentage of forced expiratory volume in the first second accounted for predicted value (FEV1%) in the two groups were all significantly higher than those before intervention, and the observation group were significantly higher than those of the control group (P ＜ 0.05); in terms of quality of life, the scores of emotional function, symptom, activity of pediatric asthma quality of life questionnaire (PAQLQ) after intervention in the observation group were all higher than those before intervention and those of the control group after intervention (P ＜ 0.05); meanwhile, the frequency of acute attack and the frequency of hospitalization during the intervention time in the observation group were significantly less than those of the control group (P ＜ 0.05). Conclusion Child to child health education nursing model is conducive to promote the self-management of school-age children with asthma for the diseases, improve the clinical therapeutic effect and enhance the quality of life.
2017 Vol. 14 (23): 60-63 [Abstract] ( 240 ) HTML (1 KB)  PDF (448 KB)  ( 67 )
64 Randomized controlled clinical observation on zang-fu viscera acupoint pressure therapy in the treatment of infantile anorexia
RUI Na PENG Zhengping PAN Lu
Objective To observe the clinical effects of zang-fu viscera acupoint pressure therapy in the treatment of infantile anorexia. Methods Eighty children with anorexia treated in Outpatient Department of Pediatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences from July 2013 to July 2016 were chosen and randomly divided into viscera massage group and medicine group according to the random number table, each group had 40 cases. Viscera massage group was treated with viscera acupoint pressure therapy, while medicine group was given Jianwei Xiaoshi Oral Solution. The clinical efficacy and TCM syndrome scores of the two groups were observed and compared. Results The total effective rate was 97.5% in viscera massage group and 80.0% in the medicine group, there was statistically significant difference between the two groups (P ＜ 0.05). After treatment, the total scores of TCM syndrome and the scores of main symptoms (appetite, food intake, mealtime) and the secondary symptoms (complexion, abdominal distension, spirit, thirsty, defecation, nausea and vomiting) in the viscera massage group were all lower than those before treatment, the differences were all statistically significant (P ＜ 0.05). The scores of complexion and thirsty in medicine group before and after treatment were not statistically significant (P ＞ 0.05), the scores of the other symptoms in the medicine group before and after treatment were all statistically significant (P ＜ 0.05).  After treatment, the total scores of TCM syndrome and the scores of main symptoms and the secondary symptoms in the viscera massage group were all lower than those of medicine group, the differences were all statistically significant (P ＜ 0.05). Conclusion Zang-fu viscera acupoint pressure therapy show good effects on infantile anorexia, which can significantly improve the appetite of children and increase the food intake, and it has good effects in improving the other gastrointestinal symptoms.
2017 Vol. 14 (23): 64-66,70 [Abstract] ( 162 ) HTML (1 KB)  PDF (854 KB)  ( 132 )
71 Observation of short-term efficacy, toxic side effects and survival situation of TACE combined with Tegafur Gimeracil Oteracil Potassium in treatment of primary hepatic carcinoma
QIN Wenban LI Yongbiao TANG Chaoli LU Wenxi ZHOU Cui
Objective To study the influence of short-term efficacy, toxic side effects and survival time of TACE combined with oral Tegafur Gimeracil Oteracil Potassium on treatment of primary hepatic carcinoma. Methods From February 2013 to January 2014, in Chongzuo People's Hospital, 50 patients with primary hepatic carcinoma admitted into the hospital were divided into two groups by random number table, with 25 cases in each group. Simple treatment group was given TACE, and association group was given Tegafur Gimeracil Oteracil Potassium on the basis of treatment of simple treatment group. Patients of two groups were given follow-up investigation, and short-term efficacy, toxic side effects, survival situation within 3 years and survival quality of two groups were compared. Results The short-term effective rate, survival rate of 1, 2, 3 years and survival time of association group were 84.00%, 84.00%, 68.00%, 44.00%, (17.63±1.85) months, which were significantly higher than 56.00%, 52.00%, 32.00%, 16.00%, (10.52±1.74) months of simple treatment group (P < 0.05 or P < 0.01); the total incidence of toxic side effects in association group was 4.00%, which was significantly lower than 40.00% in simple treatment group, and there was statistical difference (P < 0.01); the scores of each survival quality of association group were significantly higher than those of simple treatment group, and there were statistical difference (P < 0.01). Conclusion TACE combined with oral Tegafur Gimeracil Oteracil Potassium in treatment of patients with primary hepatic carcinoma can significantly increase short-term efficacy, reduce toxic side effects, lengthen survival time and improve survival quality, which is worthy of further promotion.
2017 Vol. 14 (23): 71-74,79 [Abstract] ( 193 ) HTML (1 KB)  PDF (704 KB)  ( 98 )
75 The effect of thoracoscopic and laparoscopic esophagectomy combined with TP chemotherapy on serum tumor-related factors and survivin protein expression of esophageal cancer patients
LIANG Min FU Maoyong WANG Lie LIANG Weiwei ZHANG Xiaoyan
Objective To explore the effect of thoracoscopic and laparoscopic esophagectomy combined with TP chemotherapy on serum tumor-related factors and survivin protein expression of esophageal cancer patients. Methods 100 cases of esophageal cancer patients treated in Affiliated Hospital of North Sichuan Medical College from August 2010 to August 2013 were selected. All patients were divided into control group and observation group according to the random number table method, thoracoscopic and laparoscopic esophagectomy was used in control group (50 cases), TP chemotherapy before surgery on the basis of control group was applied in observation group (50 cases). The surgery time, intraoperative bleeding, postoperative activity time, incidence rate of complication and prognosis between two groups were observed. Serum tumor markers [soluble major histo-compatibility complex class Ⅰ chain-related protain A (sMICA), transcription factor YY1 (YY1), cytokeratin 19 fragment antigen21-1 (Cyfra21-1)], malignant biological markers of serum tumors [matrix metalloprotein-9 (MMP-9), CD44v, vascular endothelial growth factor (VEGF)] and serum survivin protein of two groups were compared. Results The sMICA, YY1, Cyfra21-1, MMP-9, CD44v, VEGF, survivin protein of two groups after treatment were lower than before treatment (P < 0.05). The sMICA, YY1, Cyfra21-1, MMP-9, CD44v, VEGF, survivin protein of observation group after treatment were lower than those of control group (P < 0.05). The intraoperative bleeding of observation group was less than that of control group (P < 0.05). The postoperative activity time of observation group was shorter than that of control group (P < 0.05). There was no significant difference in operation time between two groups (P > 0.05). The incidence rate of postoperative complication in control group was significantly higher than that in observation group (P < 0.05). 3-year survival rate of control group was significantly lower than that of observation group (P < 0.05). Conclusion Thoracoscopic and laparoscopic esophagectomy combined with TP chemotherapy can significantly decrease the levels of serum tumor-related factors and serum survivin protein expression. Efficacy is significant, the incidence rate of complication is low. It is worthy of clinical promotion.
2017 Vol. 14 (23): 75-79 [Abstract] ( 209 ) HTML (1 KB)  PDF (614 KB)  ( 44 )
80 Influence of Paclitaxel and Nedaplatin concurrent late course accelerated hyperfractionated radiotherapy combined with high-frequency hyperthermia in vitro on curative effect and survival rate of patients with locally advanced esophageal cancer
LIU Lihua1 CAI Jundong1 LIU Yanqin2 ZHENG Yumei1 WANG Haisheng3 DING Baiying1 LI Xiaodong1 LIU Jing4 QIAO Weichao1 DONG Xinhong1
Objective To explore the influence of Paclitaxel and Nedaplatin concurrent late course accelerated hyperfractionated radiotherapy combined with high frequency hyperthermia in vitro on curative effect and survival rate of patients with locally advanced esophageal cancer. Methods From August 2011 to July 2012, in Chengde Tumour Hospital, 144 patients with locally advanced esophageal cancer were selected, and they were divided into control group (72 cases) and observation group (72 cases) according to the random number table method. The control group was treated with Paclitaxel and Nedaplatin concurrent late course accelerated hyperfractionated radiotherapy, and the observation group was given ombined with hyperthermia in vitro on the basis of the control group. The rapeutic effect and survival rate in the two groups were contrasted, and toxic and side effects in the two groups were observed. Results The total effective rate of the combination group (86.11%) was significantly higher than that of the control group (62.50%), the difference was statistically significant (P < 0.05). The side effects during the treatment occured in two groups, two groups were compared, the difference was not statistically significant (P > 0.05). Survival rates of 1, 2, 3, 4 years in the observation group (70.83%, 55.56%, 45.83%, 38.89%) were significantly higher than those in the control group (55.56%, 40.27%, 29.17%, 22.22%), the differences were statistically significant (P < 0.05). Conclusion The effect is better of Paclitaxel and Nedaplatin concurrent late course accelerated hyperfractionated radiotherapy combined with hyperthermia in vitro on patients with locally advanced esophageal cancer, with high survival rate. It has a certain promotion value.
2017 Vol. 14 (23): 80-83 [Abstract] ( 215 ) HTML (1 KB)  PDF (694 KB)  ( 57 )
84 Clinical significance of miR-21, miR-155 and miR-210 and their correlation with pathological features of lymphoma
FENG Xiaoyun YAN Lingling
Objective To investigate the clinical significance of miR-21, miR-155 and miR-210 and their correlation with the pathological features of lymphoma. Methods 62 cases of pathologically confirmed lymphoma patients from December 2014 to December 2016 in Nantong Tumor Hospital were chosen as the research objectes. Expression of miR-21, miR-155 and miR-210 in lymphoma tissues and normal lymph tissues was determined respectively. And the correlation of age, gender, immunophenotype, MYC gene and B cell lymphoma 6 protein (BCL-6) with miR were also analyzed. Results The miR-21, miR-155 and miR-210 in lymphoma tissues were higher than those in normal lymph tissues, the differences were statistically significant (P ＜ 0.05). The miR-21, miR-155, miR-210 of NK/T cell lymphoma, mucosa -associated lymphoma in immunological typing were higher than those of DLBCL, miR-21, miR-155, miR-210 of normal arrangement in MYC gene were higher than those of gene rearrangement, miR-21, miR-155 of expression in BCL-6 protein were lower than those of non-expression, the differences were statistically significant (P ＜ 0.05). The miR-21 and miR-155 were associated with immunophenotyping, MYC gene and BCL-6 protein expression in lymphoma patients, miR-210 expression was associated with immune classification and MYC gene in patients with lymphoma (P ＜ 0.05). Conclusion The miR-21, miR-155 and miR-210 participates in the development and progression of lymphoma, the high expression of miR may influence the prognosis of patients with lymphoma. The expression of miR-21, miR-155 and miR-210 in clinic has certain guiding significance for the follow-up treatment and prognosis.
2017 Vol. 14 (23): 84-87 [Abstract] ( 187 ) HTML (1 KB)  PDF (645 KB)  ( 28 )
88 Clinical analysis of malignant pleural effusion in non-small cell lung cancer treated with different doses of Recombinant Human Endostatin Injection and Cisplatin thoracic perfusion
WANG Hua ZHAO Ya′ning▲ ZHANG Bin
Objective To explore clinical effect of malignant pleural effusion in non-small cell lung cancer treated with different doses of Recombinant Human Endostatin Injection and Cisplatin thoracic perfusion. Methods Clinical data of 76 patients with malignant pleural effusion in non-small cell lung cancer in Baoji Central Hospital of Shaanxi Province from February 2012 to January 2017 were retrospectively analyzed. All patients were divided into treatment group Ⅰ (36 cases) and treatment group Ⅱ (40 cases) according to different treatment methods. The lung function, blood gas analysis and quality of life scores were observed before and after treatment in both groups. The short-term efficacy and toxicity between two groups were observed. Results FEV1, FEV1%Pred, FEV1/FVC, PaO2, physical function, mental function, social function, common symptoms scores of treatment group Ⅰ and treatment group Ⅱ after treatment were higher than before treatment, PaCO2 was lower than before treatment, the differences were statistically significant (P < 0.05). FEV1, FEV1%Pred, FEV1/FVC, PaO2, physical function, mental function, social function, common symptoms scores of treatment group Ⅱ after treatment were higher than those of treatment group Ⅰ, PaCO2 was lower than treatment group Ⅰ, the differences were statistically significant (P < 0.05). The remission rate of short-term effect in treatment group Ⅱ was higher than that in treatment group Ⅰ, the difference was statistically significant (P < 0.05). There were no significant differences in incidence rate of gastrointestinal symptoms, myelosuppression, fever, chest pain and cardiac toxicity between two groups (P > 0.05). Conclusion Lung function and life quality of Recombinant Human Endostatin Injection (60 mg) and Cisplatin perfusion in the treatment of non-small cell lung cancer patients with malignant pleural effusion are well recovered. The effect is obvious, it is worthy of clinical promotion and application.
2017 Vol. 14 (23): 88-91,106 [Abstract] ( 216 ) HTML (1 KB)  PDF (1060 KB)  ( 85 )
92 Application of semipronation in thoracic laparoscopy for esophageal cancer
TANG Honghua LU Xiuying JIANG Xiaofang JIN Hailong LIU Lu
Objective To explore the application of semipronation in thoracic laparoscopy for esophageal cancer. Methods From Apirl 2013 to October 2014, in Sichuan Cancer Hospital, 106 esophageal cancer patients with two methods of the radical operation of esophageal cancer were selected, and they were divided into test group and control group by random number table， patients in two groups were given semiprone position and positive side position when separating the tumor and cleaning up mediastinal lymph nodes respectively. The BP, HR and AP before and after the body position were monitored. The surgical field exposure, operation time and the degree of comfort effect of body position intervention were discussed. Results After the operation position changed，the blood pressures were lower than before in the test group，but those were higher in the control group (P < 0.05). The air pressures after position change were higher than those before in two groupd (P < 0.05), and the heart rate had no obvious change in the two groups (P > 0.05). The operation time of the test group was significantly shorter than that of the control group (P < 0.05). The comfort score of the test group was significantly higher than that of the control group (P < 0.05). The operation field quality of the test group was higher than that of the control group (P < 0.05). Conclusion The semipronation can not only fully expose the surgical field,but also maintain satisfactory hemodynamics.In conclusion,the semipronation can shorten the operation time as well as ensure the safety of patients.    
2017 Vol. 14 (23): 92-95 [Abstract] ( 221 ) HTML (1 KB)  PDF (644 KB)  ( 82 )
96 Analysis of neurocognitive impairment characteristic in alcohol-dependent patients with aggressive behavior
ZHOU Xiafeng1 ZHOU Xuhui1 GUO Yujun1 YANG Jun1 HUANG Saiping1 ZHANG Li2▲
Objective To study the characteristics of neurocognitive impairment in alcohol-dependent patients with aggressive behavior. Methods 100 patients with alcohol dependence were enrolled in Brain Hospital of Hu′nan Province from January 2015 to January 2016. The patients were divided into two groups according to the explicit behavior attack scale. The 50 patients with aggressive behavior were considered as the observation group, 50 patients without aggressive behavior were considered as the control group. According to the Wechsler adult intelligence scale, Stroop test and Wisconsin card sorting test, the cognitive function impairment, memory function, attention and executive function of the two groups were compared. Results The mean score of Wechsler adult intelligence scale and memory quotient in the observation group were significantly lower than those of the control group, the differences were statistically significant (P < 0.05). The ST-CW test score and the ST-C test score in the observation group were significantly lower than those of the control group, the differences were statistically significant (P < 0.05). The working memory capacity score and the cognitive transfer ability score of the observation group were significantly lower than those of the control group, the differences were statistically significant (P < 0.05). Conclusion Alcohol-dependence can impair the cognitive function of the patients. The neurocognitive dysfunction of alcohol-dependence patients with aggressive behavior is more serious. Most patients show the reduction of memory function, attention and executive function. Cognitive impairment of consciousness is also an important factor that leads to aggressive behavior in patients.
2017 Vol. 14 (23): 96-98 [Abstract] ( 202 ) HTML (1 KB)  PDF (702 KB)  ( 110 )
99 Analysis of prognosis in pulmonary tuberculosis patients combined with acute respiratory failure by mechanical ventilation treatment
LIU Qiuyue1 ZHANG Zongde2 LUO Baojian1 HAN Fen1 PAN Liping2 WU Endong1 LI Qi3▲
Objective To discuss the high risk factor contributing to death in pulmonary tuberculosis patients combined with acute respiratory failure. Methods Clinical data of 120 pulmonary tuberculosis patients combined with acute respiratory failure in Beijing Chest Hospital, Capital Medical University from January 2012 to May 2016 were analyzed retrospectively. The patients were divided into the survival group and the death group according to clinical outcome. The observed data were identified by χ2/t test and multivariate Logistic analysis. Results There were 59 cases in 120 pulmonary tuberculosis patients combined with respiratory failure treated by mechanical ventilation died in ICU, the fatality rate was 49.20%. Independent predictive factors of mortality included the APACHE Ⅱ score, initial respiratory rate, lactic acid, C-reactive protein and PaO2/FiO2 at 24 hours after mechanical ventilation (P < 0.05). Conclusion Patients with high APACHE Ⅱ scores, high respiratory rate, high serum lactate and C-reactive protein levels, and low PaO2/FiO2 at 24 hours after mechanical ventilation have high fatality rates and poor prognosis.
2017 Vol. 14 (23): 99-102 [Abstract] ( 253 ) HTML (1 KB)  PDF (717 KB)  ( 67 )
103 Clinical observation of antegrade lavage of intestine in operation of acute intestinal obstruction
ZHANG Li1 YU Linchong2 CHEN Xingyuan3 FAN Xiaohua1 LIANG Xuemin1
Objective To investigate the clinical effect and safety of colonic lavage in one-stage resection and anastomosis of acute intestinal obstruction. Methods From January 2012 to December 2015, in Department of Anorectal Surgery in Guangdong Province Traditional Chinese Medical Hospital, 60 patiens with acute intestinal obstruction treated were selected and retrospectively analyzed. They were divided into colonic lavage group and convention operation group according to different operation methods, with 30 cases in each group. Patients in the colonic lavage group underwent closed intestinal antegrade cleansing irrigation and stage Ⅰ resection and anastomosis. The convention operation group had no intraoperative lavage, and the other treatment was the same as the colonic lavage group. The incidence of anastomotic leakage, intraoperative infection, abdominal abscess and other complications were recorded and the complication rate were calculated respectively. The operation time and the recovery time for anal exsufflation were observed and recorded. Results Compared with the conventional surgery group, the operation time and the recovery time for anal exsufflation in colonic lavage group were longer, the differences were not statistically significant (P > 0.05); the incidence of anastomotic leakage, intraoperative infection, abdominal abscess and other complications decreased significantly in the colonic lavage group, the differences were statistically significant (P < 0.05); hospitalization time of colonic lavage group were significantly shortened, the differences were statistically significant (P < 0.05). Conclusion "Colonic lavage+Ⅰstage resection and anastomosis" in the treatment of acute intestinal obstruction with satisfactory clinical effect and high safety can reduce the incidence of postoperative complications, and shorten the hospitalization time, it is worthy of further promotion and optimization.
2017 Vol. 14 (23): 103-106 [Abstract] ( 210 ) HTML (1 KB)  PDF (660 KB)  ( 110 )
107 Mutations in HBV reverse transcriptase region in patients with chronic hepatitis B after nucleot(s)ide analogues withdrawal
LI Quanshuang1,2 DENG Yanchao1,2▲ CHENG Xing2 PEI Yunfeng2 ZHOU Jing2 SHEN Hongyan1,2 XU Zhan1,2
Objective To investigate the mutation of hepatitis B viurs DNA reverse transcriptase in chronic hepatitis B patients with relapse after nucleot(s)ide analogues withdrawal. Methods From January 2014 to January 2016, in Xuzhou Central Hospital, 110 serum samples of patients with chronic hepatitis B were collected. Patients took nucleoside (acid) drugs for more than 6 months; due to various reasons, patients after withdrawal of the disease recurrence. HBV resistance mutation sites and genotypes were detected by PCR- reverse dot blot hybridization. Results There were 62 drug resistant mutations, the detection rate was 56.36%; including 36 cases of rtL180M (32.73%), 24 cases of rtM204I (21.82%), 24 cases of rtM204V (21.82%), 14 cases of rtA181V (12.73%); the number of patients with drug resistance was 58 cases (52.73%), and the main patterns of mutation were L180M+M204I/V, M204I, A181V. Drug resistance rates of Lamivudine (LMV), telbivudine (LDT), adefovir dipivoxil (ADV) was 52.73%, 22.73%, 14.55% respectively; there were 43 patients with entecavir resistance risk (39.09%) among them. 24 patients were resistant to LMV and LDT, the ratio was 21.82%; 14 patients were resistant to LMV and ADV, the ratio was 12.73%; 2 patients were resistant to LMV, LDT, ADV, the ratio was 1.82%. Mutations in the HBV RT region were independent of age, sex, genotype (P > 0.05). Conclusion The incidence of drug resistance mutation in chronic hepatitis B patients with relapse after withdrawal was higher; it is necessary to detect the mutations in chronic hepatitis B patients with relapse after withdrawal, so as to provide basis for clinical treatment.
2017 Vol. 14 (23): 107-110 [Abstract] ( 210 ) HTML (1 KB)  PDF (714 KB)  ( 62 )
111 Diagnosis value of serum laminin and hyaluronic acid in liver fibrosis
ZHANG Xindi LI Weijuan GAO Ya′ni SHAN Dongfeng LI Shaochen
Objective To investigate the diagnosis value of serum laminin and hyaluronic acid in hepatic fibrosis. Methods From February 2015 to February 2017, in People's Hospital of Langfang City, 120 patients diagnosed with chronic hepatitis B were selected, amond them, mild hepatitis patients were 35 cases, moderate hepatitis patients were 30 cases, serious hepatitis patients were 25 cases, liver cirrhosis were 30 cases, and 30 healthy physical examinees were selected as normal control at the same time. The serum of patients and physical examinees were collected, laminin was tested by magnetism particulate, hyaluronic acid was tested by chemiluminiscence, liver tissue of patients were punctured for pathology examination, degree of fibrosis was determined, the relationship between the serum laminin and hyaluronic acid levels with the degree of liver fibrosis was analyzed. Results Laminin of mild hepatitis was compared with normal control, the difference was not statistically significant (P > 0.05). Laminin of moderate, serious hepatitis and liver cirrhosis patients showed gradually rising, that of liver cirrhosis patients was the highest, it was (190.77±38.65) ng/L, and these were higher than that of normal control, the differences were statistically significant (P < 0.05). Serum hyaluronic acid levels of chronic hepatitis patients were higher than that of normal contol, the difference was statistically significant (P < 0.05), serum hyaluronic acid levels of mild, moderate, serious hepatitis and liver cirrhosis patients showed gradually rising, the differences were statistically significant (P < 0.05). The serum hyaluronic acid levels of liver cirrhosis S1, S1, S3, S4 stage showed gradually rising, and these were compared with S0 stage, the differences were statistically significant (P < 0.05). Conclusion Serum laminin and hyaluronic acid can reflect the degree of liver fibrosis, with diagnostic value.
2017 Vol. 14 (23): 111-113,121 [Abstract] ( 196 ) HTML (1 KB)  PDF (718 KB)  ( 113 )
114 Association between aspartate aminotransferase and metabolic syndrome
HUANG Dan JIA Zhongping BAI Xueqin LI Liyun XU Junfeng
Objective To explore the association of aspartate transaminase (AST) with metabolic syndrome (MS) and its components, in order to provide scientific basis for the early diagnosis of MS. Methods Individuals taken continuous physical examination in Physical Examination Center of Beijing Xiaotangshan Hospital from January 2012 to December 2015 were recruited in the study. Pearson correlation was used to analyze the correlation of baseline AST with MS and its components. The subjects were divided into four groups according to the baseline AST quartile (AST 1-4, from AST lowest to highest). Generalized estimation equation was applied for data analysis. Results There were 2003 males, average of (45.52±14.33) years old; and 2050 females, average age of (42.39±11.72) years old. The incidence of MS was 0.94% in the four years. The average baseline (2012 year) AST level [(19.24±0.12) U/L] was significantly lower than individuals in 2015 [(20.99±0.15) U/L], with statistically significant difference (P ＜ 0.05). Pearson analysis and adjustment of age and other components of MS showed that there were positive correlations between AST and FPG, TG (P < 0.01). Generalized estimation equation revealed that increased AST was positively correlated to the higher risk of MS after age and sex being adjusted (OR=1.00793, 95%CI:1.00351-1.01236, P=0.00043). Conclusion AST is closely correlated with MS and its components, and it can be used as a predictor of MS.
2017 Vol. 14 (23): 114-117 [Abstract] ( 179 ) HTML (1 KB)  PDF (689 KB)  ( 100 )
118 Establishment of scoring system in differential diagnosis of Crohn's disease and intestinal tuberculosis based on quantltative and quatltative analysis of histological evaluation
HU Baoying YUAN Shuai▲ ZHOU Haihua
Objective To establish an effective differential diagnostic model of Crohn's disease (CD) and intestinal tuberculosis (ITB) based on quantltative and quatltative analysis of histological evaluation. Methods 66 patients (35 cases of CD, 31 cases of ITB) were precisely diagnosed according to the current criteria. Quantltative (fissuring ulcers, crypt abscess, thickened submucosa, non-caseating granulomas, caseating granuloma) and quatltative (the number of granuloma in each section, the number of lymphoid aggregation in 10 high power field) histological evaluation of the two groups were collected. Variables were analyzed by univariate analysis first, then by multivariae Logistic regression analysis. A differential diagnosis model was developed based on the Logistic regression model and the scoring system was established in accordance with assigning of the value of each variable β in the model. Application efficiency of the diagnostic scoring system was tested by calculating area under the receiver operating characteristic (ROC) curve. Results The non-caseating granulomas, the number of granuloma in each section, and the number of lymphoid aggregation in 10 high power field were included in the multivariate Logistic regression model. Area under the ROC curve of the diagnostic score scheme was 0.762 (95%CI 0.630-0.895). Conclusion The differential scoring system based on quantltative and quatltative analysis of histological evaluation provides a new and effective method for differential diagnosis between CD and ITB.
2017 Vol. 14 (23): 118-121 [Abstract] ( 172 ) HTML (1 KB)  PDF (763 KB)  ( 52 )
122 Clinical effect of Ulinastatin combined with early continuous renal replacement therapy in the treatment of severe acute pancreatitis and its influence on CRP and IL-6
CHEN Xin CHENG Qipeng
Objective To investigate the clinical curative effect of Ulinastatin combined with early continuous renal replacement therapy in the treatment of severe acute pancreatitis. Methods 60 cases of patients with severe acute pancreatitis treated in Peking University Shougang Hospital from January 2015 to January 2016 were selected and divided into the combined group and the control group by random number table, each group had 30 cases. Patients of the two groups were treated with fasting, continuous gastrointestinal decompression, fluid infusion, somatostatin, anti-inflammatory, improving minicirculation; according to the condition, giving early enteral nutrition; noninvasive or invasive mechanical ventilation respiratory; giving Ulinastatin injection. Patients in the combined group were treated with continuous renal replacement therapy at the same time, continuous treatment of 14 days. The clinical efficacy of the two groups was compared, and the changes of CRP and IL-6 in the two groups before treatment and after treatment for 1, 3, 7 days were compared and analyzed. Results The total effective rate of the combined group was 93.3%, the total effective rate of the control group was 70.0%, there was statistically significant difference between the two groups (P < 0.05). There were no statistically significant differences in CRP and IL-6 levels before treatment between the two groups (P > 0.05). After treatment for 1, 3, 7 days, the CRP and IL-6 levels of the two groups were significantly lower than before treatment, and the CRP and IL-6 levels of the combined group were significantly lower than those of the control group, the differences were statistically significant (P < 0.05). Conclusion Ulinastatin combined with continuous renal replacement therapy in the treatment of severe acute pancreatitis can significantly improve the clinical efficacy, improvepatients′ inflammatory state by decreasing CRP and IL-6 levels, which is conducive to promote the recovery of the disease. 
2017 Vol. 14 (23): 122-125 [Abstract] ( 186 ) HTML (1 KB)  PDF (657 KB)  ( 91 )
126 Meta-analysis of the association between STAT6 gene polymorphism and asthma susceptibility
ZOU Fenfang ZHANG Jianpeng GAO Hongmei JIAO Hongbin▲
Objective To further explore the genetic association between rs324011 of STAT6 and asthma susceptibility through Meta-analysis. Methods Literature search was performed in PubMed, EMBASE, CNKI and Wanfang Database till the date of December 2016. Odds ratio (OR) and 95% confidence interval (95%CI) were calculated to assess the strength of association between rs324011 and asthma. Results A total of 9 studies comprising 2247 cases and 2940 controls were included in our analysis. Significant associations between rs324011 and asthma were observed that TT genotype might increase the risk of asthma in recessive model and additive model (OR=1.32, 95%CI 1.10-1.58, P=0.003 for TT vs CC+CT; OR=1.34, 95%CI 1.10-1.63, P=0.004 for TT vs CC). No similar association was observed in other models. Conclusion The polymorphism rs324011 in STAT6 is a susceptibility loci of asthma. TT genotype may increase the risk of asthma, especially in the Caucasian population.
2017 Vol. 14 (23): 126-129 [Abstract] ( 177 ) HTML (1 KB)  PDF (901 KB)  ( 46 )
130 Clinical effect of Paclitaxel combined with bronchial endoscopy intervention in treatment of benign hypertrophic scar stenosis
GUO Peng
Objective To analyze the clinical effect of Paclitaxel combined with bronchial endoscopy intervention in the treatment of benign hypertrophic scar stenosis. Methods From May 2014 to May 2016, in Zhejiang Tumor Hospital, 40 patients with hypertrophic scar stenosis were selected, they were divided into Paclitaxel combined with bronchial endoscopy intervention treatment group (combined treatment group, 20 cases) and single bronchial endoscopy intervention treatment group (single treatment groups, 20 cases), sectional areas, shortness of breath, dyspnea index scores, pulmonary functions, clinical efficacy, incidences of adverse reactions of the two groups were statistically analyzed. Results compared with single group, in combined group, the airway diameter and cross-sectional area were significantly higher (P < 0.05), the dyspnea score was significantly lower (P < 0.05), the proportions of dyspnea grade 0, grade Ⅰwere significantly higher (P < 0.05), the proportions of dyspnea grade Ⅲ, grade Ⅳ were significantly lower (P < 0.05), the total treatment efficiency was significantly higher than the single treatment group (P < 0.05), the FEV1, VC, MVV, MMEF were significantly higher (P < 0.05). Conclusion The clinical effect of Paclitaxel combined with bronchial endoscopy intervention in the treatment of benign hypertrophic scar stenosis is better than single bronchial endoscopy intervention treatment.
2017 Vol. 14 (23): 130-133,151 [Abstract] ( 177 ) HTML (1 KB)  PDF (1115 KB)  ( 39 )
134 Study of serotype distribution and drug resistance of Streptococcus pneumonia
CHEN Tao
Objective To investigate the serotype distribution and antimicrobia1 resistance of Streptococcus pneumoniae isolated from clinical specimens in Xindu District of Chengdu City, in order to provide evidence for the vaccine application and rational use of antimicrobial agents in clinic. Methods Streptococcus pneumoniae isolated from clinical specimens of People's Hospital of Xindu District in Chengdu City from January 2014 to December 2015 were collected. Capsule swelling test was used for serotype analysis. ATB Expression drug sensitivity analysis system of Biomerieux was used for antibiotic sensitivity test. Results 62 strains and 14 type of Streptococcus pneumoniae isolated through the capsule swelling test, mainly included 19A (32.3%), 19F (25.8%), 6B (12.9%), 23F (8.1%), 9V (4.8%), 4 (4.8%), accounted for 87.1% (54/62) of all typed bacteria. The coverage of these serotypes was 87.1% by PCV7，100% by PPV23. Drug sensitivity test showed these bacteria had high sensitive rates to Vancomycin, Levofloxacin, Dalfopristin, Cefotaxime, Chloramphenicol, Penicillin and Amoxicillin, which had high resistance rates to Erythromycin, Sulfamethoxazole, Clindamycin, Tetracycline. Conclusion The main epidemic serotypes of Streptococcus pneumoniae are 19A, 19F, 6B, 23F, 9V, 4 in Xindu District of Chengdu City. The PCV7 vaccine coverage is high, while PPV23 covers all serotypes, indicating its appropriateness for vaccination. Antibiotics should be used rationally according to drug sensitivity results, in order to prevent the spread of drug-resistant strains
2017 Vol. 14 (23): 134-136 [Abstract] ( 187 ) HTML (1 KB)  PDF (521 KB)  ( 45 )
137 Analysis of the medication situation of neuroprotective agents from 2010 to 2015 in 6 cities of our country
WANG Huiyuan YANG Li ZHAO Zhigang▲
Objective To study the neuroprotective agents utilization in 6 cities (Beijing, Tianjin, Shanghai, Guangzhou, Hangzhou, Chengdu) of China from 2010 to 2015, in order to provide basis for promoting the rational use of drugs and medical resources. Methods "Hospital prescription analysis cooperation project" was used for data collection. The average daily cost value (DDDc), drug utilization index (DUI), serial number ratio (B/A value) and medication combination were calculated. Results The drugs that ranked in the front of DDDc were basically similar kinds in different regions. Those drugs were all general types, including Brain Nucleoside Carnosine, Edaravone, Ganglioside, Fasudil and Mouse Nerve Growth Factor. These drugs were frequently used with high cost and heavy economic burden. There were 3 kinds of drugs with the DUI > 1.0, which were Gangliosides, Mouse Nerve Growth Factor and Deproteinized Calf blood Serum. These drugs were excessive use in clinic and they were not rational used. The neuroprotective agents were most given by the single way, the double combination therapy had increased from 5.29% in 2010 to 14.89% in 2015. Conclusion There are excessive use of neuroprotective agents in these regions. The rational use of neuroprotective agents is deserved more attention.
2017 Vol. 14 (23): 137-143 [Abstract] ( 158 ) HTML (1 KB)  PDF (551 KB)  ( 44 )
144 The application of PDCA method in liver-protective agents management
SONG Dongsheng
Objective To discuss the effect of PDCA method application in liver-protective agents management. Methods The application of liver-protective agents in the First People's Hospital of Guangyuan City from July 2014 to July 2016 were analyzed, of which, 100 cases of patients treated with liver-protective agents given no PDCA management method from July 2014 to July 2015 were selected as the control group, 100 cases of patients treated with liver-protective agents given PDCA management method from August 2015 to July 2016 were selected as the observation group. The scores of medicine management, adverse drug reaction rate, life quality scores, error rate of batch number management, error rate of drug dispensing, satisfaction of the two group were compared. Results The scores of storage environment, sorting placement, preservation method, date processing of liver-protective agents in the observation group were significantly higher than those in the control group (P < 0.05). The incidence of anaphylactic reaction, cardiovascular system injury, gastrointestinal tract injury, renal function injury, nervous system injury of the observation group were significantly lower than those of the control group (P < 0.05). Before the treatment of liver-protective agents, the scores of physical function, charactar status, social function, mental health of the two groups had no statistically significant differences (P > 0.05). After treatment, the scores of physical function, charactar status, social function, mental health of the two groups were all higher than those of before treatment, of which the observation group were significantly higher than those of the control group (P < 0.05). The error rates of batch number management and drug dispensing of the observation group were significantly lower than those of the control group (P < 0.05), while the satisfaction rate was higher than that of the control group (P < 0.05). Conclusion The application of PDCA method in liver-protective agents management can improve the management quality of drugs, decrease adverse drug reaction rate, increase life quality and satisfaction of patients. It is worthy of clinical application.
2017 Vol. 14 (23): 144-147,167 [Abstract] ( 188 ) HTML (1 KB)  PDF (914 KB)  ( 69 )
148 Effects of mindfulness based cognitive therapy on quality of life and sleep status in end-stage renal disease patients with renal transplantation
CHEN Ping
Objective To explore the effects of mindfulness based cognitive therapy (MBCT) on quality of life and sleep status in end-stage renal disease patients with renal transplantation. Methods 60 patients with end-stage renal disease underwent renal transplantation from January 2011 to January 2017 in the First Affiliated Hospital of Harbin Medical University were divided into observation group and control group according to random number table, with 30 cases in each group. The patients in control group were treated by routine nursing, and the patients in observation group were treated by MBCT based on the routine nursing. Before nursing and one month after nursing, self-rating depression scale (SDS) and self-rating anxiety scale (SAS) were used to evaluate the emotion of anxiety and depression in two groups; after one month nursing, the Pittsburgh sleep quality index scale (PSQI) was used to evaluate sleep status in two groups patients. And the scale of quality of life in emotional function, physical function, social function, role function score and quality of life were evaluated. Results One month after nursing, the SDS score and SAS score in observation group were significantly decreased, only SAS score in control group was significantly decreased; and the SDS score and SAS score in the observation group were decreased more than those in the control group, with statistically significant difference (P < 0.01); the PSQI score and total score in the observation group were lower than those in the control group, with statistically significant difference (P < 0.01); the score of emotional function, physical function, social function, role function and overall quality of life in the observation group were significantly higher than those in the control group, with statistically significant difference (P < 0.05). Conclusion MBCT can alleviate depression and anxiety, improve sleep quality, and improve the quality of life in patients with end-stage renal disease underwent renal transplantation.
2017 Vol. 14 (23): 148-151 [Abstract] ( 164 ) HTML (1 KB)  PDF (626 KB)  ( 80 )
152 Application of full-time patrol class in neonatal intensive care unit
LEI Na DONG Jianying▲ XU Duanchen WANG Ruijuan LI Hui CAO Fangfang
Objective To discuss the application effect of full-time patrol class in neonatal intensive care unit. Methods Two thousand two hundred and thirteen cases of children in Department of Premature and Neonatal Care Unit, Bayi Children's Hospital Affiliated to Army General Hospital were selected as research objects. According to the admission time, 1106 cases of children before setting full-time patrol class from January to June 2015 were taken as conventional group and 1107 cases of children after setting full-time patrol class from July to December 2015 were taken as improved group. The incidence of clinical adverse events, success rate of rescue, satisfaction rate of doctors for nursing care were compared. Results The total incidence of clinical adverse events in improved group was 16.16%, which was significantly lower than that of conventional group (33.99%), the difference was highly statistically significant (P ＜ 0.01). The success rate of rescue in the improved group was 98.0%, which was significantly higher than that of the conventional group (93.8%), the difference was highly statistically significant (P ＜ 0.01). The satisfaction rate of doctors for nursing care in the conventional group and improved group was 89.1% and 95.2% respectively, the difference was highly statistically significant (P ＜ 0.01). Conclusion The application of full-time tour class in neonatal intensive care unit can ensure the safety of medical care and promote the healthy development of the hospital, which is worthy of promotion in neonatal intensive care unit.
2017 Vol. 14 (23): 152-155 [Abstract] ( 179 ) HTML (1 KB)  PDF (621 KB)  ( 85 )
156 The effect of integrated medical treatment and nursing model in community elderly care
LI Mo PANG Xiuming DU Jinxiang CHEN Jing ZHAO Jian▲
Objective To observe the application effect of integrated medical treatment and nursing model in community elderly care. Methods From January to June 2016, 75 old people were respectively chosen from two local communities. The elderly from Yuejin Community Health Service Center were selected as the observation group, which were treated by integrated medical treatment and nursing model. The elderly from Liaoyuan Community Health Service Center were selected as control group, which were received routine nursing. 6 months after nursing, the quality of life score, nursing satisfaction and nursing effect of the elderly in the two groups were compared. Results Before nursing, there was no significant difference between the two groups in the score of quality of life (P > 0.05); after nursing, the quality of life score in the two groups were significantly higher than that before nursing (P < 0.05), and the score in observation group was significantly higher than that in the control group (P < 0.05). The rates of self-care ability, nursing knowledge awareness, health and safety awareness and mental health in observation group were better than those in control group (P < 0.05), and the nursing satisfaction in observation group was significantly higher than that in control group (P < 0.05). Conclusion The integrated medical treatment and nursing model can improve the quality of life, and promote the development of the model of community nursing care.
2017 Vol. 14 (23): 156-158,174 [Abstract] ( 142 ) HTML (1 KB)  PDF (603 KB)  ( 14 )
159 Effects of continuous nursing of responsibility model for the chemotherapy compliance, cancer-related fatigue and disease perception control in elderly patients with advanced non-small cell lung cancer
Ayiguli·Maimaiti1 TONG Wanyun2
Objective To observe the effects of continuous nursing of responsibility model for the chemotherapy compliance, cancer-related fatigue and disease perception control in elderly patients with advanced non-small cell lung cancer (NSCLC). Methods Sixty elderly patients with advanced NSCLC received chemotherapy in Department of Pulmonary Medicine, Cancer Hospital Affiliated to Xinjiang Medical University ("our hospital" for short) from January to November 2015 were taken as control group. 60 elderly patients with advanced NSCLC received chemotherapy in our hospital from January to November 2016 were taken as observation group. The control group was given conventional continuous nursing, the observation group was given continuous nursing of responsibility model. The levels of chemotherapy compliance, cancer-related fatigue and disease perception control between the two groups were compared. Results The chemotherapy compliance of observation group was better than that of control group, the difference was statistically significant (P ＜ 0.05). The scores of emotion, severity of behavior, perception and cognition of revised Piper fatigue scale in observation group were all lower than those of control group, the differences were statistically significant (P ＜ 0.05). The scores of consequence, personal control, treatment control, focus, emotional statement and identification of symptoms of brief-illness perception questionnaire in observation group were all higher than those of control group, the differences were statistically significant (P ＜ 0.05), while there were no statistically significant differences of the scores of periodicity and disease consistency between the two groups (P ＞ 0.05). Conclusion Continuous nursing of responsibility model in elderly patients with advanced NSCLC has good application effects, which can enhance the chemotherapy compliance, improve cancer-related fatigue and increase the levels of disease perception control, it is worthy of clinical application.
2017 Vol. 14 (23): 159-162 [Abstract] ( 197 ) HTML (1 KB)  PDF (589 KB)  ( 18 )
163 The application status of family participatory nursing model in nursing field
JIA Yuling MA Hongmei WU Jiaojiao LIAO Chunxia CHEN Yuan
The family participatory nursing model is derived from the family-centered care, which emphasizing that by taking family members who are willing to take care into the care team, then teaching and training them a series of knowledge and basic skills, nurses can help family members take better care of patients in hospitals, homes, or communities. This model is widely used in the care of premature infants in the neonatal intensive care unit. However, with the changes of the medical environment and the demand for medical treatment, this model is gradually applied in various fields of nursing. This study reviews the application status of family participatory nursing model in pediatrics, geriatrics, oncology, psychiatry, intensive care unit, aims to provide reference for the application and development of family participatory nursing model.
2017 Vol. 14 (23): 163-167 [Abstract] ( 188 ) HTML (1 KB)  PDF (630 KB)  ( 62 )
168 Effects of oral nursing intervention based on evidence-based theory on nursing satisfaction of patients with chemotherapy oral ulcer
LIU Jing WANG Yunjun
Objective To explore the effects of oral nursing intervention based on evidence-based theory on nursing satisfaction of patients with chemotherapy oral ulcer. Methods The clinical data of 80 cases of patients with chemotherapy oral ulcer in Cangzhou People's Hospital from January 2015 to January 2017 were retrospectively analyzed, the patients were divided into conventional nursing group and evidence-based nursing group, with 40 cases in each group. The conventional nursing group was given conventional oral nursing intervention, the evidence-based theory group was given oral nursing intervention based on evidence-based theory. The degree of oral ulcer, clinical curative effects, nursing satisfaction of the two groups were analyzed statistically. Results After nursing intervention, the oral ulcer degree of the evidence-based nursing group was significantly better than conventional nursing group, the difference was statistically significant (P ＜ 0.05). The total nursing effective rate of evidence-based nursing group was 90.0%, which was significantly higher than that of conventional nursing group (62.5%), the difference was statistically significant (P ＜ 0.05). The scores of health education, service attitude and initiative, love and communication scores and nursing satisfaction total score of nursing satisfaction rating scale in evidence-based nursing group were significantly higher than those of conventional nursing group (P ＜ 0.05). Conclusion Oral nursing intervention based on evidence-based theory is more effective than conventional oral nursing intervention on improving the nursing satisfaction of patients with chemotherapy oral ulcer, which is worthy of promotion and application in clinic.
2017 Vol. 14 (23): 168-170 [Abstract] ( 149 ) HTML (1 KB)  PDF (580 KB)  ( 45 )
171 Effect of details in nursing on quality of life of low-birth-weight children with congenital heart disease
WANG Juan BAI Xue▲
Objective To investigate the effect of details in nursing on quality of life of low-birth-weight children with congenital heart disease. Methods 80 cases of low-birth-weight children with congenital heart disease underwent operation in Yan′an People′s Hospital from June 2013 to June 2016 were divided into the experimental group and the control group by random number table, with 40 cases in each group. Children in the control group were treated by routine nursing, and children in the experimental group were continually treated by detailed nursing. The FLACC score, the rate of indications and the satisfied situation 36 hours after operation were recorded and compared between two groups. The quality of life after nursing for 1 month was compared between two groups. Results 36 hours postoperatively, the FLACC pain score of children in the experimental group was significantly lower than that in the control group (P < 0.01), the average hospitalization time in the experimental group was significantly shorter than that in the control group (P < 0.01), the incidence of complications in the experimental group was significantly lower than that in the control group (P < 0.01), degree of patients′ families satisfied was significantly higher than the control group (P < 0.01). Postoperative nursing for 1 month, the quality of life obviously improved in the control group and experimental group, and patients′ quality of life score were much higher in various fields including physical field, psychological field, the social domain and the environmental field (P < 0.01). Conclusion Detailed nursing using in low-birth-weight children with congenital heart disease can effectively promote postoperative recovery of patients, and improve the quality of life, which is worthy popularizing in clinical application.
2017 Vol. 14 (23): 171-174 [Abstract] ( 148 ) HTML (1 KB)  PDF (591 KB)  ( 65 )
175 Effect of Bushen Huoxue Decoction in treating amenorrhea caused by polycystic ovary syndrome with syndrome of kidney deficiency and blood stasis
NIU Jingyun1 HOU Lihui2 LI Yan2 WANG Ying2 QU Yufang3
Objective To observe the clinical efficacy of Bushen Huoxue Decoction in treating amenorrhea caused by polycystic ovary syndrome (PCOS) with syndrome of kidney deficiency and blood stasis. Methods A total of 20 patients with amenorrhea caused by PCOS with syndrome of kidney deficiency and blood stasis treated in Outpatient Department of Gynecology and Reproductive Medicine of Hospital of Integrated Traditional Chinese and Western Medicine in Zhejiang Province from March to July 2014 were collected, all patients were treated with Bushen Huoxue Decoction for 3 months. The menstrual status, TCM syndromes, clinical signs and levels of sex hormones of the patients before and after treatment were statistically analyzed. Results After 3 months of treatment, the scores of TCM syndromes, the body weight, body mass index (BMI), hirsutism scores, the percentage of acanthosis nigricans, serum luteinizing hormone (LH) and the ratio of LH/follicle stimulating hormone (FSH) were all decreased significantly compared with those before treatment, the differences were all statistically
2017 Vol. 14 (23): 175-178 [Abstract] ( 185 ) HTML (1 KB)  PDF (412 KB)  ( 44 )
179 The format exploration of English instruction of Chinese medicinal product
LIU Ming1 WANG Shun2 HUANG Shuming3
First, through questionnaire investigation among experts, this paper explored the documents and materials one must rely on when writing English instruction format of Chinese medicinal products (CMPs). Then, through retrieving and summarizing the problems of the instruction writing raised by the papers commenting on the format writing in CNKI, and through comparing the laws and regulations of U.S. FDA on prescription drug labeling, we reached the conclusion that when a CMP is exported to the countries where the product is regarded as a drug, drug instruction format should be taken as English instruction according to the laws and regulations of these target countries. Furthermore, this paper explored how to write the format of an English instruction of a Chinese medicinal product when it is regarded as a dietary supplement, through reviewing and analyzing related labeling rules and regulations of U.S.FDA on dietary supplements, combining the labeling examples of five famous international health care products companies.
2017 Vol. 14 (23): 179-181 [Abstract] ( 193 ) HTML (1 KB)  PDF (527 KB)  ( 107 )
Copyright © Editorial Board of 中国医药导报
Supported by:Beijing Magtech