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| The effect of thoracoscopic and laparoscopic esophagectomy combined with TP chemotherapy on serum tumor-related factors and survivin protein expression of esophageal cancer patients |
| LIANG Min FU Maoyong WANG Lie LIANG Weiwei ZHANG Xiaoyan |
| Department of Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College, Sichuan Province, Nanchong 637000, China |
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Abstract Objective To explore the effect of thoracoscopic and laparoscopic esophagectomy combined with TP chemotherapy on serum tumor-related factors and survivin protein expression of esophageal cancer patients. Methods 100 cases of esophageal cancer patients treated in Affiliated Hospital of North Sichuan Medical College from August 2010 to August 2013 were selected. All patients were divided into control group and observation group according to the random number table method, thoracoscopic and laparoscopic esophagectomy was used in control group (50 cases), TP chemotherapy before surgery on the basis of control group was applied in observation group (50 cases). The surgery time, intraoperative bleeding, postoperative activity time, incidence rate of complication and prognosis between two groups were observed. Serum tumor markers [soluble major histo-compatibility complex class Ⅰ chain-related protain A (sMICA), transcription factor YY1 (YY1), cytokeratin 19 fragment antigen21-1 (Cyfra21-1)], malignant biological markers of serum tumors [matrix metalloprotein-9 (MMP-9), CD44v, vascular endothelial growth factor (VEGF)] and serum survivin protein of two groups were compared. Results The sMICA, YY1, Cyfra21-1, MMP-9, CD44v, VEGF, survivin protein of two groups after treatment were lower than before treatment (P < 0.05). The sMICA, YY1, Cyfra21-1, MMP-9, CD44v, VEGF, survivin protein of observation group after treatment were lower than those of control group (P < 0.05). The intraoperative bleeding of observation group was less than that of control group (P < 0.05). The postoperative activity time of observation group was shorter than that of control group (P < 0.05). There was no significant difference in operation time between two groups (P > 0.05). The incidence rate of postoperative complication in control group was significantly higher than that in observation group (P < 0.05). 3-year survival rate of control group was significantly lower than that of observation group (P < 0.05). Conclusion Thoracoscopic and laparoscopic esophagectomy combined with TP chemotherapy can significantly decrease the levels of serum tumor-related factors and serum survivin protein expression. Efficacy is significant, the incidence rate of complication is low. It is worthy of clinical promotion.
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