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| Meta-analysis of the association between STAT6 gene polymorphism and asthma susceptibility |
| ZOU Fenfang ZHANG Jianpeng GAO Hongmei JIAO Hongbin▲ |
| Department of Respiratory Medicine, General Hospital of Chinese People′s Armed Police Force, Beijing 100039, China |
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Abstract Objective To further explore the genetic association between rs324011 of STAT6 and asthma susceptibility through Meta-analysis. Methods Literature search was performed in PubMed, EMBASE, CNKI and Wanfang Database till the date of December 2016. Odds ratio (OR) and 95% confidence interval (95%CI) were calculated to assess the strength of association between rs324011 and asthma. Results A total of 9 studies comprising 2247 cases and 2940 controls were included in our analysis. Significant associations between rs324011 and asthma were observed that TT genotype might increase the risk of asthma in recessive model and additive model (OR=1.32, 95%CI 1.10-1.58, P=0.003 for TT vs CC+CT; OR=1.34, 95%CI 1.10-1.63, P=0.004 for TT vs CC). No similar association was observed in other models. Conclusion The polymorphism rs324011 in STAT6 is a susceptibility loci of asthma. TT genotype may increase the risk of asthma, especially in the Caucasian population.
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