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| Clinical significance of miR-21, miR-155 and miR-210 and their correlation with pathological features of lymphoma |
| FENG Xiaoyun YAN Lingling |
| Department of Laboratory, Nantong Tumour Hospital, Jiangsu Province, Nantong 226361, China |
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Abstract Objective To investigate the clinical significance of miR-21, miR-155 and miR-210 and their correlation with the pathological features of lymphoma. Methods 62 cases of pathologically confirmed lymphoma patients from December 2014 to December 2016 in Nantong Tumor Hospital were chosen as the research objectes. Expression of miR-21, miR-155 and miR-210 in lymphoma tissues and normal lymph tissues was determined respectively. And the correlation of age, gender, immunophenotype, MYC gene and B cell lymphoma 6 protein (BCL-6) with miR were also analyzed. Results The miR-21, miR-155 and miR-210 in lymphoma tissues were higher than those in normal lymph tissues, the differences were statistically significant (P ＜ 0.05). The miR-21, miR-155, miR-210 of NK/T cell lymphoma, mucosa -associated lymphoma in immunological typing were higher than those of DLBCL, miR-21, miR-155, miR-210 of normal arrangement in MYC gene were higher than those of gene rearrangement, miR-21, miR-155 of expression in BCL-6 protein were lower than those of non-expression, the differences were statistically significant (P ＜ 0.05). The miR-21 and miR-155 were associated with immunophenotyping, MYC gene and BCL-6 protein expression in lymphoma patients, miR-210 expression was associated with immune classification and MYC gene in patients with lymphoma (P ＜ 0.05). Conclusion The miR-21, miR-155 and miR-210 participates in the development and progression of lymphoma, the high expression of miR may influence the prognosis of patients with lymphoma. The expression of miR-21, miR-155 and miR-210 in clinic has certain guiding significance for the follow-up treatment and prognosis.
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