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| Analysis of prognosis in pulmonary tuberculosis patients combined with acute respiratory failure by mechanical ventilation treatment |
| LIU Qiuyue1 ZHANG Zongde2 LUO Baojian1 HAN Fen1 PAN Liping2 WU Endong1 LI Qi3▲ |
1.Department of Intensive Care Unit, Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing Chest Hospital, Capital Medical University, Beijing 101149, China;
2.Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing Chest Hospital, Capital Medical University, Beijing 101149, China;
3.Department of Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing Chest Hospital, Capital Medical University, Beijing 101149, China |
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Abstract Objective To discuss the high risk factor contributing to death in pulmonary tuberculosis patients combined with acute respiratory failure. Methods Clinical data of 120 pulmonary tuberculosis patients combined with acute respiratory failure in Beijing Chest Hospital, Capital Medical University from January 2012 to May 2016 were analyzed retrospectively. The patients were divided into the survival group and the death group according to clinical outcome. The observed data were identified by χ2/t test and multivariate Logistic analysis. Results There were 59 cases in 120 pulmonary tuberculosis patients combined with respiratory failure treated by mechanical ventilation died in ICU, the fatality rate was 49.20%. Independent predictive factors of mortality included the APACHE Ⅱ score, initial respiratory rate, lactic acid, C-reactive protein and PaO2/FiO2 at 24 hours after mechanical ventilation (P < 0.05). Conclusion Patients with high APACHE Ⅱ scores, high respiratory rate, high serum lactate and C-reactive protein levels, and low PaO2/FiO2 at 24 hours after mechanical ventilation have high fatality rates and poor prognosis.
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