一氧化氮合成酶对豚鼠形觉剥夺性近视抑制作用研究

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Abstract Objective To observe the effect of nitric oxide on formation of deprivation myopia (FDM) in guinea pig, in order to investigate the regulation of nitric oxide on retinopathy of myopia. Methods Guinea pigs were used to establish the FDM model. They were divided into group A (FDM-untreated), group B (FDM induced 10-day), group C (FDM induced 20-day), group D (FDM induced 10-day plus NOS inhibitor injected), group E (FDM induced 20-day plus NOS inhibitor injected), group F (FDM induced 10-day plus melatonin injected), group G (FDM induced 20-day plus melatonin injected), with 15 guinea pigs in each group. The myopic refraction, axial length in each group and expression level of iNOS in the retina of guinea pigs were observed. Results Compared to group A, myopia increased and the axial length prolonged significantly, and the level of iNOS increased obviously in FDM-induced group, with statistically significant difference (P < 0.05). Compared to FDM-induced group, the level of iNOS significantly reduced (P < 0.05), and the degree of myopia and the axial length were severely inhibited in guinea pigs treated with FDM plus NOS inhibitor injected. Conclusion The expression of iNOS in retina in FDM guinea pigs increases, while NOS inhibitor can effectively inhibite the occurrence of myopia. The synthesis of nitric oxide promotes FDM in guinea pig.

Key words： Form-deprivation myopia iNOS NOS inhibitor Guinea pigs

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	ZHANG Wenlong XU Chen CHEN Jun

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ZHANG Wenlong XU Chen CHEN Jun. The suppression effect of nitric oxide synthetase on formation of deprivation myopia in guinea pig[J]. 中国医药导报, 2017, 14(23): 22-24,47.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I23/22

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