|
|
|
| Diagnosis value of serum laminin and hyaluronic acid in liver fibrosis |
| ZHANG Xindi LI Weijuan GAO Ya′ni SHAN Dongfeng LI Shaochen |
| Department of Nuclear Medicine, People's Hospital of Langfang City, Hebei Province, 065000, China |
|
|
|
Abstract Objective To investigate the diagnosis value of serum laminin and hyaluronic acid in hepatic fibrosis. Methods From February 2015 to February 2017, in People's Hospital of Langfang City, 120 patients diagnosed with chronic hepatitis B were selected, amond them, mild hepatitis patients were 35 cases, moderate hepatitis patients were 30 cases, serious hepatitis patients were 25 cases, liver cirrhosis were 30 cases, and 30 healthy physical examinees were selected as normal control at the same time. The serum of patients and physical examinees were collected, laminin was tested by magnetism particulate, hyaluronic acid was tested by chemiluminiscence, liver tissue of patients were punctured for pathology examination, degree of fibrosis was determined, the relationship between the serum laminin and hyaluronic acid levels with the degree of liver fibrosis was analyzed. Results Laminin of mild hepatitis was compared with normal control, the difference was not statistically significant (P > 0.05). Laminin of moderate, serious hepatitis and liver cirrhosis patients showed gradually rising, that of liver cirrhosis patients was the highest, it was (190.77±38.65) ng/L, and these were higher than that of normal control, the differences were statistically significant (P < 0.05). Serum hyaluronic acid levels of chronic hepatitis patients were higher than that of normal contol, the difference was statistically significant (P < 0.05), serum hyaluronic acid levels of mild, moderate, serious hepatitis and liver cirrhosis patients showed gradually rising, the differences were statistically significant (P < 0.05). The serum hyaluronic acid levels of liver cirrhosis S1, S1, S3, S4 stage showed gradually rising, and these were compared with S0 stage, the differences were statistically significant (P < 0.05). Conclusion Serum laminin and hyaluronic acid can reflect the degree of liver fibrosis, with diagnostic value.
|
|
|
|
|
|
[1] 中华医学会肝病学分会，中华医学会感染病学分会.慢性乙型肝炎防治指南[J].中华传染病杂志，2011，32（4）：405-406.
[2] 林占洲，谭斌，周华坚，等.拉米夫定联合阿德福韦酯与恩替卡韦单药治疗乙型肝炎肝硬化48周疗效对比研究[J].临床合理用药杂志，2011，4（3C）：10-11.
[3] 江山，李芳.小柴胡汤对肝纤维化大鼠的抗肝纤维化作用[J].中药药理与临床，2013，29（1）：17-18.
[4] Wiens A，Lenzi L，Venson R，et al. Comparative efficacy oforal nucleoside or nucleotide analog monotherapy used inchronic hepatitis B：a mixed-treatment comparison metaanalysis [J]. Pharmacotherapy，2013，33（2）：144-145.
[5] 陈丹丹，龚作炯.小柴胡汤治疗慢性乙型肝肝炎肝纤维化的临床研究[J].现代中西医结合志，2011，20（31）：890-891.
[6] 滕晓英，周新刚，孙磊，等.细化慢性肝炎肝纤维化分期标准在药物疗效评定中的应用[J].中华肝脏病杂志，2013， 21（4）：67-68.
[7] 徐微.肝纤维化指标检测在替比夫定联合扶正化瘀胶囊治疗慢乙肝患者中的价值[J].中国实验诊断学，2013，17（12）：2245-2247.
[8] 韩新令，冯文玉，朱玉红，等.胆管部分梗阻致肝纤维化大鼠模型的建立[J].中华全科医学，2011，9（5）：678-679.
[9] Rawat S，Clippinger AJ，Bouchard MJ. Modulation ofapoptotic signaling by the hepatitis B virus X protein [J]. Viruses，2012，4（11）：2945-2946.
[10] 包永星，娄繁，赵化荣，等.骨髓间充质干细胞对大鼠急性放射性肝损伤修复的研究[J].中华放射医学与防护杂志，2010，30（1）：22-25.
[11] 熊亚波.乙型肝炎合并肝硬化术后并发症的危险因素[J].中国医药导报，2012，9（16）：63-64.
[12] 何建伟，曹薇薇，李静，等.甲胎蛋白异质体3 及其比值对原发性肝癌和肝硬化的鉴别诊断价值研究[J].中国全科医学，2012，15（8）：234-235.
[13] 程红新，杨晓萍，蒋雅红，等.E-钙粘蛋白和MMP-9在肾间质纤维化大鼠肾组织中的表达及其意义[J].临床和实验医学杂志，2011，10（3）：123-124.
[14] 肖蕾，王云莲，艾力江·吐尔逊，等.血清透明质酸、Ⅳ型胶原、层粘连蛋白与大鼠放射性肝纤维化的相关性研究[J].中华全科医学，2015，13（1）：18-19.
[15] 陈小玲，焦晓多，伍勇.肝癌患者血清中透明质酸、层粘蛋白、Ⅵ型胶原的测定及临床意义[J].临床和实验医学杂志，2010，9（14）：234-235.
[16] Friedrich-Rust M，Buggisch P，de Knegt R J，et al. Acoustic radiation force impulse imaging for non-invasive assessment of liver fibrosis in chronic hepatitis B [J]. J Viral Hepat，2013，20（4）：240-241.
[17] 王同兴，于卫叶.联合检测血清PCⅢ，HA，LN对肝纤维化的诊断价值[J].医学信息，2016，29（28）：89-90.
[18] 贺希，杨硕，牛子长，等.肝脏瞬时弹性成像和血清肝纤维化指标对肝移植术后肝纤维化的诊断价值研究[J].传染病信息，2015，28（4）：223-224.
[19] 陆明海，张军艳，杨宏伟.乙型肝炎肝硬化血清纤维化指标和肝功能相关性研究[J].医学综述，2015，21（24）：89-90.
[20] 武婷，李嘉.慢性丙型病毒性肝炎患者抗病毒期间血清肝纤维化指标的变化[J].中国临床药理学杂志，2016， 32（15）：90-91.
[21] 张卫军，王瑞霞.肝硬化应用生化检验项目的价值与检验结果分析[J].中国现代医生，2017，55（11）：91-93. |
|
|
|
