急性脑梗死患者颈动脉硬化与血清LTB4、MMP-9表达水平的相关性研究

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Abstract Objective To study the relationship between serum levels of leukotriene B4 (LTB4), matrix metallopeptidase 9 (MMP-9) and the degree of arteriosclerosis in the patients with acute cerebral infarction. Methods From January 2014 to January 2016, 200 patients with acute cerebral infarction were selected. They were divided into carotid atherosclerosis group (143 cases) and control group (57 cases), according to whether there exist carotid atherosclerosis. Then, the patients in the carotid atherosclerosis group were divided into intima thickening group (22 cases), plaque group (67 cases) and carotid artery stenosis group (54 cades), according to the degree of intimal thickening. The levels of serum LTB4, MMP-9 in the groups were compared. Results The levels of serum LTB4, MMP-9 in the carotid atherosclerosis group were obviously higher than those in the control group, with statistically significant difference (P < 0.05). The expression in the carotid artery stenosis group was significantly higher than that in the carotid plaque group and intima thickening group, and Spearman correlation test showed the levels of LTB4 and the MMP-9 were positively related to severity of carotid atherosclerosis (P < 0.05). Conclusion The levels of serum LTB4 and MMP-9 are positively correlated with the carotid atherosclerosis and the degree in patients with acute cerebral infarction.

Key words： Leukotriene B4 Matrix metallopeptidase 9 Carotid arteriosclerosis

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	MA Honggang1 ZHU Feifei2 WANG Yaxian1

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MA Honggang1 ZHU Feifei2 WANG Yaxian1. Study on the relationship between carotid atherosclerosis and serum LTB4, MMP-9 levels in patients with acute cerebral infarction[J]. 中国医药导报, 2017, 14(23): 52-55.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I23/52

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