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2017 Vol. 14, No. 24
Published: 2017-08-25
 
 
4 Change of flash electroretinogram in rats with experimental autoimmune uveitis
LIU Zhengfeng1 GUO Dadong2 LI Jiao3 SUN Yuanyuan1 LIU Bin1 BI Hongsheng2,3▲
Objective To observe the changes of flash visual evoked potential (F-VEP) and flash electroretinogram (F-ERG) in experimental autoimmune uveitis (EAU) rats. Methods 12 female Lewis rats (6-8 weeks old) were randomly divided into the control group and the experimental group with a random number table method. Each group included 6 rats. EAU models were induced by injection of interphotor-eceptor retinoid binding protein (IRBP, 1177-1191) supplemented with complete Freund adjuvant (CFA) and tuberculin (TB) at footpads, napes and back of the body; while another 6 rats without any treatment were used as normal controls. After EAU induction for 8 days, both EAU and control rats were examined by Fundus, fundus fluorescein angiography (FFA), optical coherence tomography (OCT), F-VEP and F-ERG techniques, respectively. Results Compared with those in control group, the results of rats in EAU group determined by fundus photograph, OCT and FFA had no apparent alterations after induction for 8 days, and no significant difference in F-VEP measurement was found between the two groups (P ＞ 0.05), however, there was a significant difference for the result of F-ERG between EAU and control groups (P < 0.05). Conclusion The F-ERG in EAU rats has been apparent changed after EAU induction for 8 days, indicating that the retinal cells have been damaged.
2017 Vol. 14 (24): 4-7,12 [Abstract] ( 164 ) HTML (1 KB)  PDF (984 KB)  ( 50 )
8 Influencing factor of clinical progress and prognosis of anterior choroidal artery blood supply area infarction
TONG Yanna CHENG Zhe DUAN Honglian SONG Zhaohui ZHANG Weidong DU Mingyan MENG Fanhua GENG Xiaokun▲
Objective To explore the possible mechanism and the prognosis of progressive infarction in the anterior choroidal artery (AChA) territory. Methods 113 patients with infarction in the AChA territory, admitted to Beijing Luhe Hospital from June 2014 to February 2016, confirmed by brain computed tomography (CT) or magnetic resonance imaging (MRI) were retrospectively analyzed. All the patients enrolled were divided into two groups: progressive infarction group (49 cases) and no progressive infarction group (64 cases). Cerebral infarction related risk factors were collected and cerebral vascular evaluations were done in all the patients. Then cerebral infarction related risk factors and cerebral vascular conditions were compared between two groups in order to explore the causes and mechanisms of the progressive infarction. All the patients were followed up for 6 months and the prognosis were compared between two groups. Results Patients with hypertension, diabetes and hyperlipidemia (known as "three high disease") were obviously more in the progressive infarction group than in the no progressive infarction group (P = 0.039). Patients with heart disease were also significantly more in the progressive infarction group (P = 0.027). The national institute of health stroke scale (NIHSS) score of patients in the progressive infarction group were higher at discharge, and patients in the progressive infarction group had worse prognosis than those in no progressive infarction group. Conclusion Neurological deterioration is frequent in the AChA infarction. "Three high disease", heart disease and carotid atherosclerotic plaque and (or) stenosis are associated with the progress of AChA infarcts. Patients with progressive AChA infarction has worse prognosis than those with no progressive AChA infarction.
2017 Vol. 14 (24): 8-12 [Abstract] ( 168 ) HTML (1 KB)  PDF (779 KB)  ( 37 )
13 Performance evaluation of magnetic bead nucleic acid extraction in real-time fluorescence quantitative PCR detection system for plasma EBV-DNA
ZHENG Yuhong1 ZHONG Fengjin1 CHEN Yansong1 LIN Yingying1 XIAO Zhenzhou1 PAN Jianji2 LIN Shaojun2 GUO Qiaojuan2 CHEN Yan1▲
Objective To evaluate the application performance of magnetic bead nucleic acid extraction method in real-time fluorescence quantitative PCR detection for plasma Epstein-Barr virus (EBV) DNA. Methods Automated magnetic bead method was used to extract nucleic acid, and combined real-time fluorescence quantitative PCR assays for quantitative EBV-DNA. The detection performance of the method was evaluated by using the third-party reference materials. In addition, 100 patients with NPC were selected, and the plasma EBV-DNA was quantitatively detected by magnetic beads method and boiling method. The correlation between the two methods was analyzed. Results In the automated magnetic bead method-based real-time fluorescence quantitative PCR detection system for EBV-DNA, the repeatability precision of the low, medium and high were all <3/5 TEa (TEa = target ± 0.4 lg), and the intermediate precision were all < 4/5 Tea. In the range of 5.4×101 - 5.4×105 U/mL, there had good linear relationship. The minimum detection limit was about 3.334×101 U/mL. And the concentration of Hb interference in plasma was lower than 8.667 g/L, the results of magnetic bead test were not significantly affected. The detection results between magnetic bead method and boiling method were linearly related, and the qualitative coincidence rate was 83%. Conclusion The detection of plasma EBV-DNA by automated magnetic bead nucleic acid extraction method can achieve good detection performance.
2017 Vol. 14 (24): 13-16,24 [Abstract] ( 385 ) HTML (1 KB)  PDF (751 KB)  ( 124 )
17 Study on the effect of Xiaotan Sanjie Recipe on apoptosis of colon cancer stem-like cells and its related mechanism
ZHOU Yuqi1,2 ZHANG Yingcheng1 WEI Pinkang1▲ YE Min1▲
Objective To investigate effect of Xiaotan Sanjie Recipe on apoptosis of colon cancer stem-like cells (CCSCs) and its related mechanism. Methods The CCSCs were induced from colon cancer cell line HCTl16 in serum-free medium. The expressions of CD44 were detected to identify CCSCs. The lyophilized powder of Xiaotan Sanjie Recipe Extract was dissolved in cell culture fluid, so as to make preserving fluid of Xiaotan Sanjie Recipe. CCSCs were treated with different concentrations of Xiaotan Sanjie Recipe (0.125, 0.25, 0.5, 1.0 mg/mL) for 72 h. The effects of different concentrations of Xiaotan Sanjie Recipe for CCSCs were detected by Annexin-V/PI staining combined with flow cytometry. The expression changes of Bax, Bcl-2 protein after drug intervention were detected by Western blot. Results HCT116 cells formed cancer stem cell spheres in serum-free medium. The proportion of CD44 cells in cell spheres was (49.69±1.89)%. Xiaotan Sanjie Recipe could induce the cell apoptosis, the apoptosis rate was statistically significant different compared with the control group (0 mg/mL) (P ＜ 0.05), the apoptotic effects showed concentration-dependent. After application of Xiaotan Sanjie Recipe, the expression of pro-apoptotic protein Bax of Bcl-2 family was increased, meanwhile the expression of anti-apoptotic protein Bcl-2 was decreased. The effect was more pronounced in 0.5 mg/mL and 1.0 mg/mL concentration groups. Conclusion CCSCs are successfully induced from HCT116 colon cancer cell line. Xiaotan Sanjie Recipe can induce CCSCs in a dose-dependent manner, the mechanism may be related to the increased expression of pro-apoptotic protein Bax and decreased expression of anti-apoptotic protein Bcl-2.
2017 Vol. 14 (24): 17-20 [Abstract] ( 212 ) HTML (1 KB)  PDF (1095 KB)  ( 79 )
21 Efects of Eucommia ulmoides oliver flavones on apoptotic of pediatric hemangioma endothelial cells
LI Yang1 LIU Guoliang2 YAO Yuan2 ZHANG Ning2▲ GUO Wei3▲
Objective To study the influence of Eucommia ulmoides oliver flavones (EUOF) on apoptosis of infantile hemangioma endothelial cell. Methods Infantile hemangioma endothelial cells were cultured in vitro. The cells was divided into blank groups (normal cultivate infantile hemangioma endothelial cells), high dose group of EUOF (50 μg/mL EUOF treatment infantile hemangioma endothelial cells), the middle dose group (5 μg/mL EUOF treatment infantile hemangioma endothelial cells), the low dose group (0.5 μg/mL EUOF treatment children hemangioma endothelial cells), then cultured for 72 hours, MTT method detected cell vitality. The TUNEL method detected apoptosis of cells; Western blot method detected expression levels of apoptosis related proteins Bax, Bcl-2 and caspase-9 in infantile hemangioma endothelial cell. Results Compared to the blank group, infantile hemangioma endothelial cell proliferation could inhibit in EUOF middle dose group, high dose group, the differences were statistically significant (P < 0.05). The rate of apoptosis in high dosages group and middle dosages group rose, the differences were statistically significant (P < 0.05); the expression of Bax in high dose group rose, differences were statistically significant (P < 0.01). The expression of caspase-9 potein in the high dose group middle dose group and low dose group rose, the differences were statistically significant (P < 0.05). The expression of bcl-2 in high dose group, middle dose group decreased, the differences were statistically significant (P < 0.05). Conclusion EUOF can inhibit the the expression of Bcl-2 protein and promote the expression of Bax and caspase-9 in infantile hemangioma endothelial cells, that is expected to be an effective therapeutic agent in the disease of hemangioma.
2017 Vol. 14 (24): 21-24 [Abstract] ( 179 ) HTML (1 KB)  PDF (766 KB)  ( 52 )
25 Study on the effects of Trichostatin A on behaviors and expression of brain-derived neurotrophic factor in model rats with depression
LI Kun1 SUN Guoping2 LU Haozhong2 SUN Zhongguo2
Objective To investigate the effects of Trichostatin A on behaviors and expression of brain-derived neurotrophic factor (BDNF) in model rats with chronic unpredictable mild stress-induced depression (CUMS). Methods Forty adult male SD rats were randomly divided into normal control group, model group, Fluoxetine group and Trichostatin A group. The model of depression was established with alternative unpredictable stress combining isolated living conditions. The rat ethological changes were assessed by body weight, sucrose consumption and open field test. The protein expressions of BDNF and phosphorylated cAMP responsive element binding protein (p-CREB) were measured by Western blot. Results After modeling for 21 days, the body weight, sucrose consumption, horizontal motion and vertical motion scores in model group were significantly lower than those of normal control group (P ＜ 0.05); however, these ethological indexes in Fluoxetine group and Trichostatin A group were obviously increased compared with those of model group (P ＜ 0.05). The results of Western blot showed that the expression of BDNF and p-CREB in model group were significantly lower than those of normal control group (P ＜ 0.05), while the expression of BDNF and p-CREB in Fluoxetine group and Trichostatin A group were significantly higher than those of model group (P ＜ 0.05). Conclusion Trichostatin A can effectively improve depression-like behaviors in CUMS model rats, its anti-depressive effect may be attributed to up-regulation of the CREB-BDNF signaling pathway.
2017 Vol. 14 (24): 25-29 [Abstract] ( 227 ) HTML (1 KB)  PDF (867 KB)  ( 86 )
30 Effect of 99Tc Methylene Diphosphonate Injection on postoperative prognosis and quality of life after neurosurgery
HAN Shuqin ZHAO Lin HU Shi WANG Baoguo▲
Objective To observe the effects of 99Tc Methylene Diphosphonate Injection on postoperative prognosis and quality of life after neurosurgery. Methods From December 2015 to February 2016, in Sanbo Brain Hospital, 80 patients underwent neurosurgery were selected, they were divided into 99Tc Methylene Diphosphonate Injection group and control group by random number table method, with 40 cases in each group. 99Tc Methylene Diphosphonate Injection group were given intravenously 4 sets of 99Tc Methylene Diphosphonate Injection after anesthetic induction and successive 4 d daily after surgery, control group were given the same volume of saline. Index of anesthesia recovery period, pain intensity, fatigue, degree of comfort, subsided time of head and facial edema, drainage time, time of suture removal and time of discharge were assessed after surgery were recorded. Results The pain scores of patients in 99Tc Methylene Diphosphonate Injection group from the 1st day to the morning of 5th day were lower than control group, the differences were statistically significant (P < 0.05). The weary degree in 99Tc Methylene Diphosphonate Injection group from 1st to 3rd day were lower than control group, comfort degree in 99Tc Methylene Diphosphonate Injection group were high than control group, the differences were statistically significant (P < 0.05). The sitting up time, leaving bed activity time, independent walk time and taking out stitchesand, discharge time in two groups were compared, the differences were not statistically significant (P > 0.05), The edema time of head and face and drainage time in 99Tc Methylene Diphosphonate Injection group were shorter than control group, the differences were statistically significant (P < 0.05). Conclusion The application of 99Tc Methylene Diphosphonate Injection in patients experiencing craniotomy can obviously increase the degree of comfort, improve appetite, relieve fatigue and postoperative pain, accelerate edema recession, and improve the quality of life after neurosurgery.
2017 Vol. 14 (24): 30-33 [Abstract] ( 191 ) HTML (1 KB)  PDF (644 KB)  ( 37 )
34 The study of protective effects of EGCG on oxidative -induced apoptosis in myocardial cells
YANG Rui DONG Zhuo WANG Mengqi XU Lei▲
Objective To discuss the protective effects and possible mechanisms of epigallocatechin gallate (EGCG) in oxidative damage of rat H9C2 cells induced by oxidative stress. Methods H9C2 cells were random grouped after subcultured. There were negative control group (cultured with normal nutrient solution), H2O2 injury group (incubated with 100 μmol/L H2O2 for 12 h), EGCG low dose group (incubated with 10 μmol/L EGCG for 24 h then cultured with 100 μmol/L H2O2 for 12 h) and EGCG high dose group (incubated with 100 μmol/L EGCG for 24 h then cultured with 100 μmol/L H2O2 for 12 h). Cell viability were tested by MTT colorimetric detection, apoptotic cell morphology was observed by Hochest33258 staining, apoptosis rate was detected by flow cytometry, expression of apoptosis-related factors Caspses-3 and Caspase-9 were tested by colorimetric detection. Results The cell survival rate increased to 66.68% and 78.63% after treated with 10 μmol/L and 100 μmol/L EGCG compared with H2O2 injury group (57.33%), with statistically significant difference (P < 0.05). Hoechst33258 dying and flow cytometry technology results showed that cell apoptosis rate dropped gradually after treated with different concentration of EGCG with H2O2 injury group, with statistically significant difference (P < 0.05). Besides, the expression of Caspase-3 and Caspase-9 were inhibited after treated with EGCG. Conclusion EGCG effective inhibit H9C2 cells oxidative damage by inhibiting the expression of Caspses-3 and Caspase-9, which provide reliable experimental basis for the treatment of injuries in myocardial cells.
2017 Vol. 14 (24): 34-37 [Abstract] ( 171 ) HTML (1 KB)  PDF (799 KB)  ( 48 )
38 Progress and prospect of health education nursing research on mild cognitive impairment in community
SHI Yirong HU Hui▲ WANG Ling AI Yating DONG Xinxiu SUN Kaili LI Mengying
Mild cognitive impairment (MCI) is an internationally recognized pre-dementia state, because the early symptoms are not obvious, often mistaken for normal aging caused by. If not intervened, MCI may eventually develop into Alzheimer disease. Practice has proved that having misconceptions and beliefs about disease of MCI patients is one of the leading causes of disease delay diagnosis and treatment. Because early symptoms of MCI are not obvious, many MCI patients hide in the community. It is important to have MCI health education in the community. This paper reviews the needs of MCI community health education, the characteristics of community service needs of MCI patients, the contents, forms, specific measures and effects of MCI community health education, and puts forward some suggestions, which provide guidance and reference for future health education of MCI.
2017 Vol. 14 (24): 38-41,91 [Abstract] ( 146 ) HTML (1 KB)  PDF (1093 KB)  ( 72 )
42 18F-FDG PET imaging in Parkinson's disease
CHEN Zhilin WANG Xijin
Parkinson's disease is a common neurological degenerative disease, early diagnosis and differential diagnosis are the most difficult points toneurologist. With the development of functional imaging, 18F labelled fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging has become an important tool for Parkinson's disease. This artical first review the current analytic approaches to 18F-FDG PET imaging data and then discuss how 18F-FDG PET studies have advanced understanding of the relation between the clinical symptoms and brain metabolism of Parkinson's disease. In addition,the value of 18F-FDG PET imaging in differential diagnosis, early diagnosis,the evaluation of treatment effects and the future development direction are also reviewed.
2017 Vol. 14 (24): 42-45 [Abstract] ( 186 ) HTML (1 KB)  PDF (687 KB)  ( 44 )
46 History, problem and prospect of cervical cancer FIGO staging system
WANG Tong WU Yumei
Cervical cancer staging-system is the first designed staging system for gynecological cancer and the only system has not been changed to surgical-pathological system. Through reviewing the designed history of cervical cancer can understand the persistent problems of the clinical staging system. Recently exploration of surgical-pathological system for cervical cancer is hot point. More accuracy imaging examination methods such as PET-CT, MRI, CT are used to detect metastatic lymph nodes in patients with cervical cancer, specially surgical pelvic and paraaortic lymphadenectomy or lymph nodes biopsy (including laparotomy, abdominal and Robotic-Assisted) being applied in cervical cancer surgical-pathologic staging and scoring system explore a new and accuracy assessment way.
2017 Vol. 14 (24): 46-49 [Abstract] ( 178 ) HTML (1 KB)  PDF (685 KB)  ( 41 )
50 Research progress on Cetuximab and Bevacizumab in first and second-line treatment on advanced colorectal cancer
DUAN Jiawen1 WU Xueliang1 NIU Yuchun2 QU Ming1 XUE Jun1
In China, the incidence of CRC is reportedly increasing over time. The treatment options including surgery, chemotherapy and radiotherapy, which are available depending mostly on disease stage. However, patients with advanced CRC have lost the chance of surgery，may also have  a worse life because of chemotherapy and radiotherapy. With more and more studies on targeted therapy, such as Bevacizumab and Cetuximab, may shines a light for the patients with CRC. Chemotherapy combined with targeted therapy has become a new direction for the treatment of advanced CRC. Moreover, the association between tumor location and targeted therapy has become a hot topic. This review focuses on the progress of monoclonal antibody in the first-and second-tier treatment of advanced CRC and the effect of the left and right half colon on the efficacy of targeted drugs.
2017 Vol. 14 (24): 50-53 [Abstract] ( 146 ) HTML (1 KB)  PDF (690 KB)  ( 55 )
54 Native application of Morita psychotherapy in China
LI Fengzhan LU Huijie YANG Qun SHI Wanghong▲
Morita psychotherapy has been arisen for nearly a hundred years and treated many clients effectively, but it has been also found some shortcomings during local practices. It indicates that local practice should take into account the local characteristics, which following the principle of "foster strengths and circumvent weaknesses, various forms, learn widely from others' strong points, advance with the times" in the concrete implementation. For the selecting of treatment object, it should be targeted the person who has self-aware and Morita Characterand eliminate the object of non-psychological treatment. Specific treatment process should be built a good relationship which based on the trust. Therapist communicate with client should follow three aspects: what is the problem, the mechanism and solution of the problem, and help clients live through "empathy period, let nature take its course and cultivate period", and realize the goal of coexisting with the symptoms eventually.
2017 Vol. 14 (24): 54-57 [Abstract] ( 175 ) HTML (1 KB)  PDF (727 KB)  ( 31 )
58 Research progress on luteoloside in Lonicerae Japonicae Flos
YANG Lijun1 WANG Dandan1 ZHANG Yunfei1 WU Hongjie1 CHEN Dazhong1 SHI Lang2
Lonicerae Japonicae Flos is commonly used in clinical medicine, with the function of clearing away heat and toxic materials and antiviral, which is widely used in the treatment of various clinical diseases. Luteoloside and chlorogenic acid were added to the 2005 edition of Chinese Pharmacopoeia as the indicators of the quality control of Lonicerae Japonicae Flos. In this paper, six extraction methods such as solvent extraction, ultrasonic extraction, flash extraction, ultra-high pressure extraction, supercritical fluid extraction and ultrasonic-assisted extraction were summarized, and macroporous resin column chromatography purification method, the molecular imprinting technology purification method and polyamide column chromatography method were used to separate luteoloside from Lonicerae Japonicae Flos by reviewing the related literatures in recent years, and it made a summary of the protective effect of respiratory system, the cardiovascular system, anti-bacterial, anti-inflammatory, antiviral, anti-tumor, anti-aging skin and anti-ischemic biological activities of luteoloside in Lonicerae Japonicae Flos in order to provide reference for further development and utilization of Lonicerae Japonicae Flos.
2017 Vol. 14 (24): 58-61 [Abstract] ( 170 ) HTML (1 KB)  PDF (694 KB)  ( 239 )
62 Research progress on the effective constituents and pharmacological activities of Ilex kudingcha C.J. Tseng
WEI Xiaojie1 YIN Huihui1 MENG Fei1 ZHAO Wu1 LIU Wei1 JIANG Yuanming1 QIN Zhenhua1 SUN Jianhua1 CHEN Hailan2
Ilex kudingcha C.J. Tseng is widely used as a traditional pharmacy in our country, which is rich in triterpenes, flavonoids, polyphenolic, volatile oil, polysaccharide and many other effective constituents, with the health-care and medicinal effects of prevention and treatment of cardiovascular disease, antioxidation, reducing blood fat and anti-virus. In order to develop and utilize its medicinal value, this paper presents a review of the recent progress in chemical constituents and pharmacological activities to provide references for the development and further study of Ilex kudingcha C.J. Tseng.
2017 Vol. 14 (24): 62-65 [Abstract] ( 237 ) HTML (1 KB)  PDF (694 KB)  ( 210 )
66 Advance of connexin 43 and connexin 43-formed channels in the spinal cord injury
ZHANG Shuangshuang HU Ji▲ HUANG Jinxiu XIE Lijie LIU Jiao
Connexin 43 are integral membrane proteins which span the plasma membrane four times, and widely distributed in the central nervous system. Connexin 43 can form hemi channels and gap junctions which provides a direct cytoplasmic pathway between contacting cells. In the spinal cord injury, the levels of connexin 43 mRNA and protein obviously up-regulated. Also, the permeability of the hemichannels and gap junctions increased, which form a well-known pathway for the release of intracellularmetabolites and the entry of extracellularsubstances, that can play major roles in the secondary injury by the way of aggravating the inflammatory response, disruption of blood-spinal cord barrier, and neuronal death. In addition, the blockers of connexin 43 channels and other methods which regulate the expression of connexin 43 and the permeability of connexin 43 channels can act obvious protective effects in the spinal cord injury. This review discusses the latent injury mechanisms induced by connexin 43 and connexin 43 channels in the spinal cord injury, and relevant treatments on the basis of it.
2017 Vol. 14 (24): 66-69 [Abstract] ( 298 ) HTML (1 KB)  PDF (688 KB)  ( 25 )
70 A study on pension intention and influencing factors among the youth and the middle-aged people in Guangzhou
HAO Yanping1 WANG Juan2
Objective To explore the pension intentions of the youth & middle-aged people in Guangzhou and their willingness for their elders′ pension arrangements, in order to provide basis for creating a pension environment in line with the will of the elderly in the future. Methods The pension intention and the influencing factors were investigated among 251 people aged 15-59 years, who were conveniently sampled in Haizhu District, Yuexiu District and Liwan District in Guangzhou from February to June 2016. Enumeration data was analyzed by Chi Square test. Multivariate analysis was performed by using unconditional Logistic regression model. Results About 84% (211 cases) respondents prefered old in place. One-child, unwilling to live together with their own children, more affordable to pension costs, and not intimate community relations were factors which impacted their own pension intention among the youth and the middle-aged people (P < 0.05), but not gender, age differences (P ＞ 0.05). One-child, relatively high capability of pension cost, nursing facilities′ reputation and rich entertainment lives in nursing facilities were factors which impacted the willingness for their elders′ pension arrangements (P < 0.05). Conclusion Home endowment or family endowment is preferred by the youth and middle-aged people. The government should focus on creating social services matching with the needs of different pension models for different people.
2017 Vol. 14 (24): 70-73 [Abstract] ( 172 ) HTML (1 KB)  PDF (447 KB)  ( 154 )
74 Evaluation of life quality of the rural elderly with chronic diseases measured by health survey questionnaire and its influencing factors
REN Tingting1 JIANG Zhigang2 LIU Yingqing1 LIU Jiayuan3 WANG Hongyang3 PENG Xiaobo3 ZHAO Yixi3 ZHOU Aiming3
Objective To investigate the life quality of rural elderly patients with chronic diseases in Tongzi County of Zunyi City, and to explore its influencing factors. Methods Cluster random sampling method was used to select survey respondents. The life quality of 304 rural older people with chronic diseases in Tongzi County were investigated by EQ-5D from July to September in 2016. The influencing factors of life quality according to general demography characteristics were discussed. Results EQ-5D index and mean score of EQ-VAS among rural elderly people with chronic diseases in Tongzi County were (0.70±0.13) and (61.87±10.41) points. Univariate analysis showed that there were statistically significant differences in EQ-5D index and EQ-VAS score among the elderly with different labor situation and chronic diseases (P < 0.05). The multiple-linear regression analysis showed that labor situation and physical exercise were influencing factor of action capability (P < 0.05); labor situation and offspring's company were influencing factors of self-care (P < 0.05); ages and suffered from chronic diseases were influencing factors of daily activities (P < 0.05); marital status and suffered from chronic diseases were influencing factors of pain/discomfort (P < 0.05); physical exercise and offspring's company were influencing factors of anxiety/depression (P < 0.05). Conclusion The rural elderly with chronic diseases have poorer quality of life. The influencing factors include chronic illness, offspring's company, labor situation, marital status, physical exercise. An important way to improve the quality of life of the rural elderly with chronic diseases is to strengthen the prevention and treatment of chronic diseases.
2017 Vol. 14 (24): 74-77 [Abstract] ( 192 ) HTML (1 KB)  PDF (408 KB)  ( 33 )
78 Correlation study of cystatin C and insulin resistance in type 2 diabetes mellitus patients with non-alcoholic fatty liver
MO Xiaoqing HUANG Chun SONG Qingqing CHEN Wenjun HE Ningning
Objective To investigate the association between cystatin C and insulin resistance in type 2 diabetes mellitus (T2DM) patients with non-alcoholic fatty liver disease (NAFLD). Methods According to the results of ultrasonography detection of liver, 65 cases with T2DM in Central People′s Hospital of Zhanjiang from October 2013 to October 2015 were divided into two groups, including 29 cases of T2DM patients with NAFLD (T2DM+NAFLD group) and 36 cases of only T2DM (T2DM group). The levels of cystatin C and insulin resistance and correlation in both groups were analyzed. Results The levels of cystatin C and insulin resistance in T2DM+NAFLD group were higher than those in T2DM group, the differences were statistically significant (P ＜ 0.05). The correlation coefficient of cystatin C and insulin resistance in T2DM+NAFLD group was 0.79, while the correlation coefficient between cystatin C and insulin resistance in T2DM group was 0.43(P < 0.05). Conclusion Cystatin C and insulin resistance in T2DM with NAFLD group is positively correlated, and more prone to insulin resistance.
2017 Vol. 14 (24): 78-80 [Abstract] ( 216 ) HTML (1 KB)  PDF (370 KB)  ( 186 )
81 Occurrence and influencing factor analysis of different parts of plaque in patients with type 2 diabetes mellitus
HUANG Nana1 CHEN Shulin2
Objective To investigate occurrence and influencing factor analysis of different parts of plaque in patients with type 2 diabetes mellitus. Methods 1325 patients with type 2 diabetes mellitus in Endocrinology Department of Yantai Yuhuangding Hospital from December 2015 to March 2017 were selected. According to Doppler ultrasound results, all patients were stratified into two groups: no plaque group (271 cases) and plaque group (1054 cases). Then plaque group was divided into carotid artery plaque subgroup (141 cases), lower extremity artery plaque subgroup (247 cases) and multi-postion artery plaque subgroup (666 cases). Multiple factor Logistic regression was used to analyze risk factors of the formation of atherosclerotic plaques. Results Total prevalence of peripheral arterial lesion was 79.55% (1054/1325), the carotid arterial lesions was 10.64% (141/1325) and the lower extremity arterial disease was 18.64% (247/1325). Age, hypertension were the common risk factors in different parts of the plaque; gender, TG and HbA1c level were specific risk factors for the formation of lower extremity artery plaque (OR=3.293, 1.727, 1.989). LDL-C level was unique risk for carotid artery plaque formation (OR=1.716). Conclusion In patients with type 2 diabetes mellitus, the occurrence of vascular lesion in different parts is different, the lower extremity arteries lesions are higher than those in the carotid arteries. The risk factors in different parts of atherosclerosis are not all the same. LDL-C level is mainly affect the carotid artery plaque. Gender, TG and HbA1c are unique risk factors for the formation of lower extremity artery atherosclerosis plaque.
2017 Vol. 14 (24): 81-84,134 [Abstract] ( 170 ) HTML (1 KB)  PDF (825 KB)  ( 45 )
85 Clinical analysis of postoperative sepsis after flexible ureteroscope lithotripsy
ZHANG Zhihong1 JIN Shihua1 HUANG Huagang2 ZHOU Jianfang2 GUO Hongfeng1 JIN Lianchao1 WANG Gang1 LI Ningchen1
Objective To analyze the related factors, clinical diagnosis and treatment of postoperative sepsis after flexible ureteroscope lithotripsy and explore its prevention and treatment measures. Methods Clinical data of 25 patients with sepsis in 786 cases of ureteroscopic holmium laser lithotripsy in two urinary centers from November 2010 to December 2016 were retrospectively analyzed. Hospital stay, anti-infection treatment time, clinical outcome were observed. Preoperative conventional urine culture and drug sensitivity test were performed in all the patients. Double J tubes were indwelled for 7-10 days. Intraoperative intravenous antibiotics were routinely applied. OLYMPUS F3.6/9.9 flexible ureteroscope and Power Suite100W holmium laser were used for lithotripsy. Results 16 cases showed positive results of preoperative urine culture, the operation time was 55-175 min, an average of (94±11) min; hospital stay was 13-28 days, an average of (14.4±1.5) days; postoperative anti-infective treatment time was 3-10 days, the average of (4.1±1.5) days. 11 patients were with severe sepsis after surgery, 9 patients were with septic shock, of which 7 cases were refered to ICU. Conclusion Preoperative, intraoperative and postoperative control are critical for prevention and treatment of sepsis. Early detection of clinical signs and proper treatment is the key to the successful management of postoperative sepsis after flexible ureteroscope lithotripsy.
2017 Vol. 14 (24): 85-87 [Abstract] ( 182 ) HTML (1 KB)  PDF (339 KB)  ( 14 )
88 Simulated analysis of older intertrochanteric fractures based on finite element method
HE Xiangxin1 LI Pengfei1 LIN Ziling2 SUN Wentao1 CHEN Xinmin1 LIANG Ziyi1
Objective For the blank of finite element model about intertrochanteric fracture, the fracture model of the intertrochanteric fracture based on the finite element analysis softwares, to provide experimental basis for the prevention and treatment of intertrochanteric fracture. Methods From March to April 2017, in First Affiliated Hospital of Guangzhou University of Chinese Medicine, 1 elderly patient with intertrochanteric fracture was selected, the CT image data of the uninjured side was collected, the Mimics software was used to grow the contralateral area, fill the cavity, edit and rebuild the contralateral proximal femur model. Next, preprocessed it by Geomagic studio 2013. Data were imported in Hypermesh 14.0 and LS-DYNA software for meshing, and defining material properties. The failure parameters and interfacial properties were set. The load and force boundary constraints simulating the falling were simulated. The model of intertrochanteric fracture was calculated, then, the Hyper-View 14.0 software was used to check the results. Results The inside of proximal femur was the first appeared stress concentration, under the continuous stress it began to break, fracture line stretched from intside to outside of the upper, ultimately Evans Ⅰ intertrochanteric fracture model would be gained. Conclusion The finite element analysis method based on LS-DYNA software can simulate the dynamic fracture of the intertrochanteric fracture veritably, it provides experimental reference to reveal the mechanism and guides the prevention and the treatment of intertrochanteric fractures.   
2017 Vol. 14 (24): 88-91 [Abstract] ( 284 ) HTML (1 KB)  PDF (579 KB)  ( 119 )
92 Effect comparison of fixation technique of minirnally invasive plate osteosynthsis and open reduction and internal fixation in treatment of tibia shaft fracture
GOU Bo1 ZHANG Jinkang2 XIE Xiaomin1▲ QI Wenbing1 BAI Minghua1
Objective To discuss the effect of fixation technique of minirnally invasive plate osteosynthsis and open reduction and internal fixation in the treatment of tibia shaft fracture. Methods From January 2015 to March 2017, in Baoji Hospital of Traditional Chinese Medicine, 60 patients with tibia shaft fracture were selected, they were divided into two groups according to the treatment, observation group (30 cases) and control group (30 cases). Patients in the control group were treated with open reposition imfixation, and patients in the observation group were treated with minirnally invasive plate osteosynthsis. The operation time, intraoperative blood loss, degree of pain, healing time, and the incidence of complications of patients were compared between the two groups; treatment effect of the two groups were compared. Results The operation time of observation group was shorter than that of the control group, but the difference was not statistically significant (P > 0.05). The intraoperative blood loss and healing time of the observation group were significantly less than those of the control group, the differences were statistically significant (P < 0.05). 1, 3, 7 days after surgery, the VAS scores of observation group were lower those that of the control group, and the differences were statistically significant (P < 0.05). Postoperative internal fixation loosening, malformation, infection, lower limb ischemia necrosis were the main complications, total incidence of complications in the observation group were significantly lower than those of the control group, the difference were statistically significant (P < 0.05); the excellence rate of the observed group was significantly higher than that of the control group, the difference was statistically significant (P < 0.05). Conclusion Compared with open reduction and internal fixation, minirnally invasive plate osteosynthsis in the treatment of tibia shaft fracture can obviously reduce the intraoperative blood loss, shorten the healing time, reduce the degree of postoperative pain, is safe and effective, and worthy of clinical application.
2017 Vol. 14 (24): 92-95 [Abstract] ( 212 ) HTML (1 KB)  PDF (580 KB)  ( 136 )
96 Effects of hypoxia on mechanism of TH17 in spinal tuberculosis recurrence
Suonan′angxiu CAO Zhenyu QI Tengmin ZHOU Jingyuan LI Ming AN Yuxiu TANG Weidong HAN Guodong
Objective To discuss the effect of TH17 cells and cytokines on the recurrence of spinal tuberculosis was evaluated in hypoxic environment. Methods From September 2015 to January 2017, in Qinghai People's Hospital, 46 patients with spinal tuberculosis were selected, they were divided into primary group (27 cases) and recurrence group (19 cases) according to clinical manifestation and laboratory examination. TH17 cells and cytokines including IL-6, IL-1β, IL-23, TNF-α, IFN-γ in patients and the CCL20, CCL22, CCL27 were detected. The relationship of chemotactic index of Th17 cells and the Th17 expression of CCR receptor and CCL ligand were evaluated. Results Compared with primary group, the percentage of TH17 cells increased significantly of patients in recurrence group (P < 0.05), the content of cytokines including IL-6, IL-1, IL-23, TNF-α increased significantly (P < 0.01), the content of IFN-γ decreased (P < 0.01). The concentration of CCL20, CCL22 and CCL27 from recurrent group were significantly higher than primary group (P < 0.01), immunofluorescence staining and scanning quantitative analysis showed that the expression of CCL20, CCL22 and CCL27 in bone cells of patients in recurrent group were higher than in primary group (P < 0.01), cell morphology was similar with the the staining results of primary group. Conclusion Th17 cells can be used for the diagnosis of tuberculosis and tuberculosis recurrence, differentiation of tuberculosis courses and evaluation of immune function of patients. IL-6, IL-1β, IL-23, TNF-α, IFN-γ, CCL20, CCL22, CCL27, CCR receptors and CCL ligands can be used as a new diagnostic marker for the recurrence of spinal tuberculosis in hypoxia, and for the early diagnosis of tuberculosis recurrence.
2017 Vol. 14 (24): 96-101 [Abstract] ( 189 ) HTML (1 KB)  PDF (611 KB)  ( 16 )
102 Effect of hydrotherapy combined with fumigation on swelling and pain of limb fracture after operation
HAN Liang LI Shugang▲ GUO Pengfei ZHANG Yuming
Objective To investigate the effect of hydrotherapy combined with fumigation on swelling and pain of limb fracture after operation. Methods From January 2015 to January 2017, in Xuzhou Central Hospital, 148 patients with limb fracture after operation were selected and divided into two groups,  control group (74 cases) was treated with hydrotherapy, experiment group (74 cases) was treated with herbal fumigation on the basis of the control group, the degree of swelling, pain, joint mobility score, serum bone metabolism index, callus growth score, and the clinical effect after the treatment were compared. Results The total effective rate in the control group was lower than that in the experiment group, the differences were statistically significant (P < 0.05); compared with before treatment, the degree of swelling, pain VAS score and near joint activity score lower in two groups after treatment were lower, the differences were statistically significant (P < 0.01), and that in the experiment group were lower than the control group, the differences were statistically significant (P < 0.01); serum levels of alkaline phosphatase, bone morphogenetic protein-2, osteocalcin and type Ⅰ procollagen carboxyl terminal peptide in two groups after treatment were higher, the differences were statistically significant (P < 0.01), and that in the experiment group were higher than the control group, the differences were statistically significant (P < 0.05 or P < 0.01); the amount of callus, callus density, callus edge, and the score of the broken edge in two groups after treatment were higher, the differences were statistically significant (P < 0.01), and that in the experiment group were higher than the control group, the differences were statistically significant (P < 0.01). Conclusion Hydrotherapy combined with fumigation can significantly reduce the postoperative swelling, pain and joint movement disorders of limbs fracture, improve the level of bone formation related indicators, promote callus growth and fracture healing.
2017 Vol. 14 (24): 102-105 [Abstract] ( 196 ) HTML (1 KB)  PDF (583 KB)  ( 66 )
106 Effect of comprehensive emergency care of abnormal pregnancy for improvement the prognosis of pregnant women and fetus
LI Yan1 WANG Dan2▲ LIU Bingyu2 LIU Yisi2
Objective To explore the effect of comprehensive emergency care of abnormal pregnancy for improvement the prognosis of pregnant women and fetus. Methods 90 cases of patients with abnormal pregnancy hemorrhage treated in Shengjing Hospital of China Medical University from April 2015 to April 2017 were selected. According to the admission time sequence, patients were divided into the control group (from April 2015 to April 2016) and the observation group (from May 2016 to April 2017), each group had 45 cases. The control group was given routine emergency care, the observation group was given comprehensive emergency care. The time of delivery, bleeding amount of delivery, reduction of glycosylated hemoglobin, length of hospital stay, pregnancy outcome and nursing satisfaction were compared between the two groups. Results Compared with the control gorup, the time of delivery, bleeding amount of delivery, reduction of glycosylated hemoglobin, length of hospital stay were shorter or lower in the observation group, with statistically significant differences (P < 0.05). Compared with the control gorup, the cesarean section rate and gestation induced labor rate were lower, the natural vaginal delivery rate and fetal survival rate were higher in the observation group, with statistically significant differences (P < 0.05). The satisfaction rate of the observation group was higher than that of the control gorup, with statistically significant difference (P < 0.05). Conclusion Application of comprehensive emergency nursing for patients with abnormal pregnancy hemorrhage can enhance the quality of clinical nursing service, improve the prognosis of pregnant women and fetal.
2017 Vol. 14 (24): 106-109 [Abstract] ( 179 ) HTML (1 KB)  PDF (649 KB)  ( 73 )
110 Comparative study on the clinical efficacy of laparoscopic assisted vaginal hysterectomy and abdominal hysterectomy in the treatment of benign uterine lesions and its influence on the pelvic floor function
XU Pu MA Jiehua ZHANG Lei
Objective To compare the clinical efficacy of laparoscopic assisted vaginal hysterectomy and abdominal hysterectomy in the treatment of benign uterine lesions and its influence on the pelvic floor function. Methods One hundred and thirty cases of patients with benign uterine lesions admitted to Department of Gynecology, Nanjing Maternity and Child Health Hospital from March 2016 to March 2017 were selected and divided into two groups by random number table, with 65 cases in each group. The control group was given abdominal hysterectomy, while the observation group was given laparoscopic assisted vaginal hysterectomy. The operative conditions, sexual quality of life, stress indexes and incidence of pelvic floor dysfunction of patients in the two groups were compared and analyzed. Results After treatment, intraoperative blood loss of observation group were less than the control group, the operative time, postoperative exhaust time and postoperative activity time in observation group were shorter than the control group, the differences were statistically significant(P ＜ 0.05). The total score of female sexual function index in observation group was higher than the control group, the difference was statistically significant (P ＜ 0.05), the scores of self-rating anxiety scale in observation group were lower than those before treatment and the control group, the differences were statistically significant(P ＜ 0.05). After treatment, the white blood cell count and the levels of serum cortisol, interleukin-6 and C-reactive protein in observation group were lower than the control group, the differences were statistically significant (P ＜ 0.05). There were no statistically significant differences on the incidence of pelvic floor dysfunction between the two groups (P ＞ 0.05). Conclusion Laparoscopic assisted vaginal hysterectomy can effectively reduce intraoperative blood loss, shorten the operative time and postoperative activity time, relieve anxiety and stress response.
2017 Vol. 14 (24): 110-113 [Abstract] ( 183 ) HTML (1 KB)  PDF (652 KB)  ( 23 )
114 Clinical analysis of two kinds of cystic-like liver tumors in children with similar appearance and different prognosis
YU Jiaole1,2 CHEN Zhifeng2
Objective To analyze the clinical manifestations, imaging features, treatment and prognosis of two rare cystic-like hepatic tumors: undifferentiated embryonal sarcoma (UES) and mesenchymal hamartoma (MH). Methods The clinical manifestations, imaging features, treatment and prognosis of four patients diagnosed as UES and MH in Department of Paediatrics & Adolescent Medicine, Queen Mary Hospital, the University of Hong Kong from January 1990 to December 2015 were analyzed. Results The patients diagnosed as UES and MH had 2 cases respectively and all were confirmed by pathological examination, the onset of age were from 11 months to 15 years old, and 3 of them were female. Two cases of patients with MH were only presented with abdominal distension without constitutional symptoms. One patient with UES had abdominal distension accompanied by abdominal pain, fever, anorexia and weight loss. There were no significant laboratory abnormal results in the four patients except one MH patient, who had mild elevated liver parenchymal enzymes and alpha-fetoprotein. Both ultrasonography and CT-scan showed cystic and/or solid lesions in all patients. Two patients with MH received tumor excision surgery, one patient with UES received hepatic trisegmentectomy and the other one patient underwent hemi-hepatectomy. Two patients with UES received chemotherapy after surgery(IRS-Ⅳ protocol). One patient with UES died of relapse after nine years of treatment and others achieved long-term survival. Conclusion MH and UES has similar clinical manifestations and imaging appearance. Due to the difference in prognosis, it is easy to be misdiagnosed. Surgical biopsy and excision remains mandatory to confirm the diagnosis and guide the subsequent treatment. Early diagnosis plus timely surgery and chemotherapy regime can significantly improve the prognosis of UES.
2017 Vol. 14 (24): 114-117,129 [Abstract] ( 245 ) HTML (1 KB)  PDF (710 KB)  ( 47 )
118 Expression of signal transducer and activators of transcription 3 and Twist basic helix-loop-helix transcription factor 1 in epithelial ovarian cancer
HONG Li1▲ YANG Jiang1▲ XING Hui2 LU Danhua1 TANG Jianming1 LI Bingshu1 GUO Fengqin1
Objective To investigate the expression of signal transducer and activators of transcription 3 (STAT3) and Twist basic helix-loop-helix transcription factor 1(Twist1) in epithelial ovarian cancer, and to analyze the relationship between the expression dysregulation and the occurrence and development of ovarian cancer. Methods The tissue of 49 cases with epithelial ovarian cancer and 14 cases with ovarian benign tumor taken surgery in Renmin Hospital of Wuhan University from March 2015 to December 2016 were collected. The expression of STAT3 and Twist1 protein was examined by immunohistochemistry streptavidin peroxidase conjugated method, the expression differences of which in early ovarian cancer and advanced ovarian cancer were compared and analyzed by Pearson correlation analysis. Results The positive expression rates of STAT3 and Twist1 in ovarian cancer were significantly higher than those of ovarian benign tumor, the differences were statistically significant (P ＜ 0.05). The positive expression rates of STAT3 and Twist1 in the advanced ovarian cancer were higher than those of early ovarian cancer, the differences were statistically significant (P ＜ 0.05). The positive expression of Twist1 in early ovarian cancer and advanced ovarian cancer was both positively correlated with STAT3(r = 0.653, 0.798, all P ＜ 0.05). Conclusion The expression of STAT3 and Twist1 plays an important role in the occurrence, development and deterioration of ovarian cancer, the positive expression rate has correlation with FIGO stage of ovarian cancer, and the mechanism may be achieved through epithelial-mesenehymal transition.
2017 Vol. 14 (24): 118-121 [Abstract] ( 244 ) HTML (1 KB)  PDF (701 KB)  ( 119 )
122 Effects of WeChat health education on compliance and outcome of inhaled corticosteroid treatment in children with asthma
WU Zhonghua SHI Mingfang▲
Objective To explore the effect of WeChat health education on the compliance and outcome of inhaled corticosteroid treatment in children with asthma. Methods A total of 112 children with moderate bronchial asthma in Outpatient Department of Pediatrics of the First People's Hospital of Yibin from March 2015 to May 2017 were selected as research objects. All patients were divided into observation group and control group by random number table, with 56 cases in each group. The control group received routine education, the observation group was given WeChat health education on the basis of the control group. After intervention for 12 weeks, the inhaled corticosteroid compliance, asthma control level and lung function [including forced vital capacity (FVC), forced expiratory volume in one second (FEV1), peak expiratory flow (PEF), 25% forced expiratory flow (FEF25%), 50% forced expiratory flow (FEF50%), 75% forced expiratory flow (FEF75%)] were compared between the two groups. Results After 12 weeks intervention, the inhaled corticosteroid compliance in the observation group was higher than the control group, the asthma control level was better than the control group, the differences were statistically significant (all P ＜ 0.05). The indicators of lung function in the observation group were all higher than those before intervention (all P ＜ 0.05); there were no statistically significant differences on all indicators of lung function before and after intervention in the control group (P ＞ 0.05); after intervention, the indicators of lung function in the observation group were higher than those in the control group, there were statistically significant differences (all P ＜ 0.05). Conclusion The intervention of WeChat health education on children with asthma can promote the compliance of corticosteroid inhalation treatment, improve the level of asthma control and the lung function.
2017 Vol. 14 (24): 122-125 [Abstract] ( 197 ) HTML (1 KB)  PDF (703 KB)  ( 117 )
126 Effect of health education based on IKAP theory for hepatitis B virus interruption from mother to child transmission of patients in the middle and later period of pregnancy
TIAN Hongwei ZHANG Kun DONG Jiawei LIU Xiaojing DONG Zhenghong WANG Ruimin DONG Surong
Objective To explore the effect of health education based on IKAP theory for hepatitis B virus (HBV) interruption from mother to child transmission of patients in the middle and later period of pregnancy. Methods 97 cases of patients with HBV in the middle and later period of pregnancy treated in the Fifth Hospital of Shijiazhuang City from March 2015 to March 2016 were divided into the control group (48 cases) and the observation group (49 cases) randomly. The control group was given traditional health education, and the observation group was given health education based on IKAP theory. Knowledge of HBV interruption from mother to infant transmission, positive rate of hepatitis B surface antigen (HBsAg) in neonates with different months, anti-HBs positive rate and nursing satisfaction were compared between the two groups. Results The knowledge of HBV transmission path, basic knowledge of hepatitis B, interruption methods from mother to child transmission, knowledge of disinfection and isolation, and the awareness of treatment notes in the observation group were significantly higher than those in the control group (P < 0.05). HBsAg positive rates of 0 month and 6 months of newborns in the observation group were significantly lower than those in the control group (P < 0.05). There were no significant differences in anti-HBs positive rates of different-month ages and HBsAg positive rate of one month age (P > 0.05). The satisfaction degree of the observation group was significantly higher than that of the control group (P < 0.05). Conclusion IKAP theory applied into health education for patients with HBV in the middle and later period of pregnancy, can improve the awareness rate of interruption from mother to child transmission of HBV, and reduce the vertical transmission rate of HBV, with obvious intervention effect and high patients′ satisfaction. It has certain application value.
2017 Vol. 14 (24): 126-129 [Abstract] ( 176 ) HTML (1 KB)  PDF (705 KB)  ( 93 )
130 Clinical study of nasal biphasic positive airway pressure ventilation in the treatment of respiratory distress syndrome of preterm infants
GAO Zibo HAN Liangrong PAN Zhaojun ZHAO Yuxiang ZHANG Wenjie MIAO Yequan WU Rong▲
Objective To observe the clinical effect of nasal biphasic positive airway pressure ventilation (nBiPAP) in the treatment of respiratory distress syndrome (RDS) of premature infants. Methods 78 cases of RDS preterm children who were hospitalized in Neonatal Medical Center, Huai′an Maternal and Child Health Care Center Affiliated to Yangzhou University Medical School and treated with non-invasive positive pressure auxiliary ventilation from July 2016 to February 2017 were selected. According to the ventilation mode, patients were divided into the nCPAP group (n = 37) and nBiPAP group (n = 41). The ventilation parameters, blood gas analysis at 0, 12, 24, 48, 72 h of ventilate, auxiliary ventilation time, ventilation failure rate, noninvasive ventilation time and complications were compared between the two groups. Results ①With the prolongation of ventilation time, the levels of inhaled oxygen (FiO2) and positive end expiratory pressure (PEEP) in the two groups gradually decreased. There were no significant differences in FiO2 and PEEP between the two groups at 0 h and 72 h (P > 0.05), but there were significant differences between the two groups at 12, 24, 48 h, the nBiPAP group were lower than the nCPAP group (P < 0.05). ②With the prolongation of ventilation time, the levels of PCO2 in the two groups gradually decreased. There were no significant differences in PCO2 between the two groups at 0 h and 72 h (P > 0.05), but there were significant differences between the two groups at 12, 24, 48 h, the nBiPAP group were lower than the nCPAP group (P < 0.05). With the prolongation of ventilation time, the levels of P/F and PaO2/PAO2 in the two groups gradually increased. There were no significant differences in P/F and PaO2/PAO2 between the two groups at 0 h and 72 h (P > 0.05), but there were significant differences between the two groups at 12, 24, 48 h, the nBiPAP group were higher than the nCPAP group (P < 0.05). ③There were no significant differences in ventilation failure rate, noninvasive ventilation time and complications between the two groups (P > 0.05). Conclusion nBiPAP is effective in the treatment of RDS of preterm infants, and it has certain advantages compared with nCPAP.
2017 Vol. 14 (24): 130-134 [Abstract] ( 186 ) HTML (1 KB)  PDF (710 KB)  ( 38 )
135 Risk factors of gestational diabetes mellitus and its influence on pregnancy outcome
WANG Jinfeng
Objective To investigate the risk factors of gestational diabetes mellitus and its influence on pregnancy outcome. Methods Sixty cases of pregnant women with gestational diabetes admitted to Department of Obstetrics and Gynecology, Suzhou Science and Technology Town Hospital ("our hospital" for short) from June to December 2016 were selected as observation group, 50 cases of normal pregnant women admitted to our hospital at the same period were selected as control group, the pregnancy outcome was compared between the two groups. At the same time, the obstetric risk factors of patients with gestational diabetes, such as pregnancy, maternal, abortion were analyzed. Results The incidence of pregnancy-induced hypertension, polyhydramnios, postpartum hemorrhage, cesarean section in the observation group was higher than those in the control group, the differences were statistically significant (P ＜ 0.05). The incidence of fetal macrosomia, premature delivery, fetal distress in the observation group was higher than those in the control group, the differences were statistically significant (P ＜ 0.05). Multi factor Logistic regression analysis showed that, the age, the times of pregnancy, the number of abortions and the weight gain during pregnancy were the risk factors of the obstetric risk factors (P ＜ 0.05). Conclusion Maternal and neonatal outcomes in women with gestational diabetes is poor. Age, pregnancy times, abortion times, weight gain during pregnancy are the risk factors of gestational diabetes mellitus, it is necessary to give active obstetric intervention to reduce the occurrence of gestational diabetes.
2017 Vol. 14 (24): 135-138 [Abstract] ( 176 ) HTML (1 KB)  PDF (700 KB)  ( 82 )
139 Meta-analysis of lung ultrasound for the diagnosis of neonatal respiratory distress syndrome
ZHANG Ying1 LI Peng2▲
Objective To evaluate the diagnostic value of lung ultrasound for neonatal respiratory distress syndrome (NRDS) by Meta-analysis. Methods PubMed, Cochrane library, Embase, Springer, CNKI and Wanfang Database were searched from database establishment to April 2017 to gathering articles according to the inclusion and exclusion criteria of diagnostic research. QUADAS2 was used to evaluate the quality of articles included. Meta-Disc 1.4 software was applied for the statistical analysis to evaluate the diagnostic value of lung ultrasound for NRDS. Results A total of 7 articles involving 673 cases were included. Random effect model was adopted for statistical analysis. The sensitivity was 0.99 (95%CI 0.98-1.00); the specificity was 0.96 (95%CI 0.93-0.98); the pooled positive likelihood ratio was 20.51 (95%CI 6.05-69.54); the pooled negative likelihood ratio was 0.03 (95%CI 0.01-0.06); the pooled odds ratio was 1024.52 (95%CI 306.35-3426.31); the area under SROC was 0.9956, the standard error was 0.0083. Conclusion The lung ultrasound has a relatively high diagnostic value for NRDS.
2017 Vol. 14 (24): 139-142 [Abstract] ( 162 ) HTML (1 KB)  PDF (1054 KB)  ( 104 )
143 Effects of cataract surgery with torsional ultrasound mode and small incision extracapsular cataract extraction in Lifeline Express
ZHOU Dan LU Hai▲ TAO Jing GUO Hongwen SUN Junye
Objective To evaluate effects of cataract surgery with torsional ultrasound mode and small incision extracapsular cataract extraction at Liaoyuan station in Lifeline Express. Methods From May to August 2016, 1209 cases (1209 eyes) of cataract surgeries at Liaoyuan station in Lifeline Express were retrospectively evaluated. Phacoemulsification with torsional ultrasound mode were performed in 1122 cases and extracapsular cataract extraction through a small incision in 87 cases. The preoperative and postoperative data of treated eyes, operative procedures and surgical complications were recorded. Results There was a significant difference between the uncorrected visual acuity of the first post-operative day with the best corrected visual acuity before operation (P < 0.01). The main intraoperative complication included: hyphema in 14 eyes (1.16%), posterior capsule rupture in 17 eyes (1.41％), suspensory ligament rupture in 6 eyes (0.50%), vitreous fluxion in 16 eyes (1.32%) and Descemet′s membrane detachment in 20 eyes (1.65%).The early period postoperative complications included: cornea edema in 181cases (15.0%), intraocular hypertension in 35 cases (2.90%), exudation in anterior chamber in 3 cases (0.25%), leakage of the wound in 2 cases (0.17%) and pupil capture of intraocular lens in 5 eyes(0.41%). Conclusion Both phacoemulsification with torsional ultrasound mode and extracapsular cataract extraction through a small incision are safe and effective in large-scale cataract surgery in Lifeline Express and may provide improvement of visual acuity in cataract patients.
2017 Vol. 14 (24): 143-146 [Abstract] ( 165 ) HTML (1 KB)  PDF (396 KB)  ( 91 )
147 Effect, relevant clinical indicators and prognosis analysis of Low Molecular Heparin combined with Prednisone in the treatment of children with nephrotic syndrome
TIAN Jianmei1 LIU Xiaowei2
Objective To analyze the clinical effects, relevant indicators and prognosis of Low Molecular Heparin Combined with Prednisone in the treatment of children with nephrotic syndrome. Methods Clinical data of 84 children confirmed to be with nephrotic syndrome in Affiliated Hospital of Inner Mongolia Medical University were analyzed from January 2016 to January 2017, and they were divided into two groups according to different treatment methods applied: 42 cases were given only Low Molecular Heparin for treatment as control group, while the other 42 children were treated with Low Molecular Heparin combined with Prednisone as observation group. The clinical indicators including coagulation indicators, total cholesterol, plasma albumin and 24-h proteinuria, renal function after prognosis, and life quality were compared between two groups for one month after treatment. Results The time for activation of partial thromboplastin and prothrombin, incidence rate of adverse reactions between two groups were compared, with no statistical differences (P > 0.05). After treatment, serum total cholesterol and 24-h proteinuria levels of observation group were both lower than those of control group, and plasma albumin of observation group was higher than that of control group, the differences were statistically significant (P < 0.01). After treatment, the creatinine clearance rate and quality of life scores in observation group were higher than those in control group, urea nitrogen, serum creatinine in observation group were lower than those in control group, the differences were statistically significant (P < 0.01). Conclusion Children with nephrotic syndrome are treated with Low Molecular Heparin combined with Prednisone, these treatment will improve the curative effect, and reduce adverse reaction, but also promote the prognosis effect. Therefore, this therapy is significant value to be popularized in clinical application and for research.
2017 Vol. 14 (24): 147-150 [Abstract] ( 180 ) HTML (1 KB)  PDF (352 KB)  ( 23 )
151 Clinical effect of integrated traditional Chinese and western medicine therapy in the treatment of chronic pelvic inflammatory disease and its impact on related inflammatory factors and hemorheology
FENG Wei1 MA Jianwen2 LYU Ruihuang1
Objective To investigate the clinical effect of integrated traditional Chinese and western medicine therapy on chronic pelvic inflammatory disease and its impact on related inflammatory factors and hemorheology. Methods Sixty-two patients with chronic pelvic inflammatory disease treated in Urumqi Maternal and Child Health Hospital from January 2016 to January 2017 were randomly divided into control group (antibiotic intravenous drip) and experimental group (antibiotic combined with traditional Chinese medicine decoction) by random number table, with 31 cases in each group. The TCM syndrome effect of the two groups was compared, and the levels of tumor necrosis factor-α (TNF-α), high sensitive C-reactive protein (hs-CRP), interleukin-2 (IL-2) and the hemorheology changes of the two groups before and after treatment were observed. Results After treatment, the TCM syndrome effect in the experimental group was better than that in the control group (P ＜ 0.05); the levels of whole blood viscosity, plasma viscosity, haematocrit and erythrocyte sedimentation rate in the two groups were significantly decreased compared with before treatment (P ＜ 0.05), and the experimental group was significantly lower than those of control group (P ＜ 0.05); the levels of TNF-α, hs-CRP and IL-2 of two groups were significantly improved compared with before treatment (P ＜ 0.05), and the improvement of the experimental group was significantly better than the control group (P ＜ 0.05). Conclusion The clinical effect of traditional Chinese medicine decoction combined with antibiotic in the treatment of chronic pelvic inflammatory disease is significant, which can effectively alleviate the inflammatory reactions and improve the indexes of hemorheology, and it has high clinical application value.
2017 Vol. 14 (24): 151-154 [Abstract] ( 177 ) HTML (1 KB)  PDF (384 KB)  ( 45 )
155 One uremia case with induced encephalopathy after applying Linezolid
ZHOU Jianghui1 WU Kunzhe2 XU Xiaohua1
 In the clinical work, 1 uremic case in China-Japan Union Hospital of Jilin University during the application of Linezolid was observed and studied. The patient′s death occurred, because of related encephalopathy and despite all treatment. In this case, it could be concluded that patients with uremic were likely to lead to the accumulation of Linezolid. The dose and time of taken Linezolid should be reduced when it was necessarily used. Otherwise there will be serious adverse consequences, even cause the patient′s death. In clinical practice, additional attention should be paid to this scenario.
2017 Vol. 14 (24): 155-157 [Abstract] ( 170 ) HTML (1 KB)  PDF (558 KB)  ( 137 )
158 The influence of taoism for the development of the traditional health-care P.E. course of universities of Chinese medicine
LIU Jiali WANG Bin
Traditional health-care P.E. course is the precious cultural heritage in our country. It is the characteristics course of universities of Chinese medicine. The article mainly discusses the Taoism positive impact on the development of traditional health-care P.E. course of universities of Chinese medicine from the aspects of traditional things, the natural rule, the motion of the Tao, the combination of dynamic and static state, respecting life and spirit, dedicating to the gentle, and preservation constitution and mentality. The research suggests that Taoism has laid a theoretical healthy foundation for the traditional health-care P.E. course development
2017 Vol. 14 (24): 158-161 [Abstract] ( 221 ) HTML (1 KB)  PDF (733 KB)  ( 47 )
162 Research of present situation and development trend of wisdom medical in Shandong Province
LI Xiumin DIAO Lijuan DING Ming
Wisdom medical is alleviating the prominent medical problemsthrough cloud computing, internet of things, large data and other technologies. With the continuous development of information technology and modern medicine, wisdom medical service model have become the highest goal of medical and health development. At present, Chinese medical information construction is in the stage of changing from clinical information to regional medical information, and wisdom medical construction is still in the process of development. This paper discusses the concept and development status of wisdom medical from the related research results in recent years. It focuses on the characteristics of wisdom medical and the specific application and problems in Shandong Province. It analyzes the prospect of wisdom medical development and put forward relevant suggestions, which can provide reference for the further development of wisdom medical.
2017 Vol. 14 (24): 162-165 [Abstract] ( 225 ) HTML (1 KB)  PDF (759 KB)  ( 52 )
166 Study on employment forecasting of graduates of traditional Chinese medicine based on C4.5 and random forest algorithm
TANG Yan WANG Ping
Chinese medicine institutions of employment channels is relatively narrow, graduates have great employment pressure. How to accurately predict the employment of students, to help them, so that they can early employment is a very important university work. Based on C4.5 decision tree algorithm, this paper generates employment decision tree, determines the important influencing factors of employment and predicts the employment situation. And further use the random forest algorithm to improve the accuracy of employment forecast. This paper provides a new method for the employment of Chinese medicine colleges and universities, and has practical application value.
2017 Vol. 14 (24): 166-169 [Abstract] ( 205 ) HTML (1 KB)  PDF (1142 KB)  ( 80 )
170 Research on the evaluation of the financial performance of medical scientific research projects
WEI Wei RUAN Peng PENG Yun ZHAO Jianjun
The financial quality evaluation of scientific research projects is often a weak link in the project acceptance, and the scientific evaluation method is helpful to guide the scientific and technical personnel to make reasonable use of scientific research funds and promote the effective development of scientific research work. This paper analyzes the problems and difficulties in the financial management of scientific research projects, and puts forward the indexes of overrun and balance evaluation, the proportion of each project, the evaluation of tolerance at the time of acceptance, the evaluation of market conditions, the evaluation of project completion and so on, meanwhile it establishes a mathematical evaluation model.
2017 Vol. 14 (24): 170-172,181 [Abstract] ( 205 ) HTML (1 KB)  PDF (856 KB)  ( 48 )
173 Analysis of medication regularity of Professor Huang Chunlin in treatment of gout based on data mining
ZHOU Min ZOU Chuan LIN Qizhan HUANG Chunlin
Objective To analyze medication rule of Professor Huang Chunlin in the treatment of hyperuricemia with traditional Chinese medicine inheritance assistant system software. Methods 72 cases of gout and prescription 256 treated by Professor Huang Chunlin in Guangdong Province Traditional Chinese Medical Hospital during the period from November 2015 to December 2016 were input onto "TCM Inheritance Assistance Platform". The drug used characteristics and prescription-formulating principle of Professor Huang Chunlin in the treatment of gout were summarized by the unsupervised data mining method of association rules, improved mutual information method, complex system entropy clustering. Results A total of 256 prescriptions were analyzed for 72 patients with gout enrolled in the study. The frequency of drug use and the association between drugs were determined. The basic prescriptions and 8 new prescriptions including plantago asiatica, smilax glabra, rhizoma atractylodis, cortex phellodendri and etc. for the treatment of gout of Professor Huang Chunlin were excavated. Conclusion Clearing away heat and promoting diuresis, eliminating phlegm and freeing channels, tonifying the liver and kidney as the basic treatment, Professor Huang Chunlin selected coix seed, cortex phellodendri, achyranthes bidentata, smilax glabra, rhizoma atractylodis, radix astragali, radix rehmanniae and other Chinese herbs to treat patients with the integration of syndrome identifying and disease diagnosing. The traditional Chinese medicine inheritance assistance system will play a very important auxiliary role in inheriting the experience of famous TCM doctor, summarizing the experience of clinicians and finding new drugs of traditional Chinese medicine.
2017 Vol. 14 (24): 173-177 [Abstract] ( 211 ) HTML (1 KB)  PDF (901 KB)  ( 98 )
178 The application of PBL model based on improving clinical communication ability in nursing English teaching
WANG Dan YAO Zhuang DONG Xiaohong▲
Objective To introduce PBL teaching into nursing English teaching, in order to improve the ability of clinical English communication. Methods 86 nursing students of Heilongjiang University Chinese Medicine Jiamusi College were selected as the subjects. 45 students of class 1 were selected as the experimental group. 41 students of class 2 were selected as the control group. After 16 weeks, the changes of experimental group and control group from the questionnaire and English test aspects were compared. Results The scores of the medical vocabulary, listening clinical medical text, nursing recording and clinical nurse patient communication test in the experimental group were higher than those in the control group, with statistically significant difference (P < 0.05). Conclusion PBL teaching methods based on clinical communication can effectively improve the students' English interesting and participation, master more English medicine vocabulary and improve the English clinical conversation ability, which can be applied in college nursing English teaching.
2017 Vol. 14 (24): 178-181 [Abstract] ( 175 ) HTML (1 KB)  PDF (865 KB)  ( 43 )
186 Analysis of the prevalence of fatty liver in a scientific research unit
YANG Hongning
Objective To understand the prevalence of fatty liver in Document Information Center, Chinese Academy of Sciences ("our unit" for short), and provide evidence for effective preventive measures. Methods The abnormal situation of fatty liver in health examination in September 2015 in our unit was analyzed. Results The number of health examination was 498, the number of fatty liver was 151, the detection rate was 30.32%. The male had a higher detection rate than female. The highest detection rate was 49.76% for the age group over 50 years old, and the retired staff had higher detection rates than the researchers and graduate students. The detection rate of hyperlipidemia and hyperglycemia in patients with liver disease was higher than that in non-fatty liver patients (P < 0.05). Conclusion The prevalence of fatty liver is closely related to gender, age, hyperlipidemia and hyperglycemia. Regular medical examinations are important for early detection, diagnosis and prevention of fatty liver.
2017 Vol. 14 (24): 186-188 [Abstract] ( 223 ) HTML (1 KB)  PDF (775 KB)  ( 52 )
189 A case report of Castleman's disease of the posterior mediastinum and literature review
YE Jingting1 LI Wenhui1 CAO Qianqian2 SHU Yusheng3▲
Vascular follicular lymphadenopathy, also known as Castleman 's Disease (CD), giant lymph node hyperplasia, it is a rare cause of chronic lymphoproliferative dysplasia, mainly characterized by chronic progressive lymphadenopathy. The disease misdiagnosis rate is higher, the diagnosis depends on pathological examination. The case is a 46-year-old male patients, due to physical examination found mediastinal lumps a year, newly diagnosed as "posterior mediastinal tumor; teratoma?", intended thoracoscopic assisted mediastinal tumor resection. Because the surgery is difficult to remove lumps, bleeding more, the surgery decided to thoracotomy and successful removal of the mass. Postoperative pathology of vascular follicular lymphadenopathy, hyaline type, follow-up 10 months no recurrence of evidence. Although the operation of the case is satisfactory, but if the diagnosis can be clear before surgery and understand the characteristics of the tumor can reduce the damage caused by patients during surgery, so we review the relevant literature, analysis,and have a summary.
2017 Vol. 14 (24): 189-192 [Abstract] ( 196 ) HTML (1 KB)  PDF (1296 KB)  ( 42 )
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