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| Clinical study of nasal biphasic positive airway pressure ventilation in the treatment of respiratory distress syndrome of preterm infants |
| GAO Zibo HAN Liangrong PAN Zhaojun ZHAO Yuxiang ZHANG Wenjie MIAO Yequan WU Rong▲ |
| Neonatal Medical Center, Huai′an Maternal and Child Health Care Center Affiliated to Yangzhou University Medical School, Jiangsu Province, Huai′an 223001, China |
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Abstract Objective To observe the clinical effect of nasal biphasic positive airway pressure ventilation (nBiPAP) in the treatment of respiratory distress syndrome (RDS) of premature infants. Methods 78 cases of RDS preterm children who were hospitalized in Neonatal Medical Center, Huai′an Maternal and Child Health Care Center Affiliated to Yangzhou University Medical School and treated with non-invasive positive pressure auxiliary ventilation from July 2016 to February 2017 were selected. According to the ventilation mode, patients were divided into the nCPAP group (n = 37) and nBiPAP group (n = 41). The ventilation parameters, blood gas analysis at 0, 12, 24, 48, 72 h of ventilate, auxiliary ventilation time, ventilation failure rate, noninvasive ventilation time and complications were compared between the two groups. Results ①With the prolongation of ventilation time, the levels of inhaled oxygen (FiO2) and positive end expiratory pressure (PEEP) in the two groups gradually decreased. There were no significant differences in FiO2 and PEEP between the two groups at 0 h and 72 h (P > 0.05), but there were significant differences between the two groups at 12, 24, 48 h, the nBiPAP group were lower than the nCPAP group (P < 0.05). ②With the prolongation of ventilation time, the levels of PCO2 in the two groups gradually decreased. There were no significant differences in PCO2 between the two groups at 0 h and 72 h (P > 0.05), but there were significant differences between the two groups at 12, 24, 48 h, the nBiPAP group were lower than the nCPAP group (P < 0.05). With the prolongation of ventilation time, the levels of P/F and PaO2/PAO2 in the two groups gradually increased. There were no significant differences in P/F and PaO2/PAO2 between the two groups at 0 h and 72 h (P > 0.05), but there were significant differences between the two groups at 12, 24, 48 h, the nBiPAP group were higher than the nCPAP group (P < 0.05). ③There were no significant differences in ventilation failure rate, noninvasive ventilation time and complications between the two groups (P > 0.05). Conclusion nBiPAP is effective in the treatment of RDS of preterm infants, and it has certain advantages compared with nCPAP.
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