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2017 Vol. 14, No. 25 Published: 2017-09-05

	4	Effects of formononetin on proliferation and apoptosis of human bladder cancer cells T739 and its mechanism
		LIU Qing1 LIANG Meihua2 ZHANG Xing2 LI Zhengzhao3 CAO Jun1
		Objective To study the effect of formononetin on the proliferation and apoptosis of human bladder cancer cells T739 cells, and discuss the mechanism. Methods Different contents of 0, 15, 30, 60 μmol/L formononetin were added to T739 cells. CCK8 assay was applied to determine the effect of formononetin on proliferation of T739 cells. Apoptosis was analyzed by flow cytometry and Hoechst33258 staining. The expressions of GSK-3β, Axin and β-catenin proteins in T739 cells were determined by Western Blot. Results Different contents of 15, 30, 60 μmol/L formononetin treatments suppressed the proliferation of T739 cells in a time- or dose-dependent manner (P < 0.05), and the apoptotic rates of formononetin-treated T739 cells for 48 hours were increased in a dose-dependent manner (P < 0.05). In addition, Hoechst 33258 staining revealed that the apoptotic cells of formononetin-treated T739 were increased in a dose-dependent manner. Further, Western blot results showed that formononetin significantly up-regulated the protein levels of GSK-3β and Axin in a dose-dependent manner (P < 0.05), while the protein level of β-catenin was inhibited (P < 0.05). Conclusion Formononetin exerts inhibitory growth effect and induced apoptosis on human bladder cancer of T739 cells. The underlyng mechanism involved may be associated with activating GSK-3β and Axin expressions and inhibiting β-catenin activity in T739 cells.
		2017 Vol. 14 (25): 4-7 [Abstract] ( 241 ) HTML (1 KB) PDF (816 KB) ( 96 )

	8	Optimization of formulation of Heparin and Inositol Nicotinate Cream by central composite design-response surface method
		MA Hongda CUI Yaling WU Qiong JIA Hui HOU Mingxiao
		Objective To optimize formulation of Heparin and Inositol Nicotinate Cream by central composite design-response surface method. Methods The model of paw edema of mice and the blood flow of rats measured by laser Doppler flowmetry (LDF) were chosen as the pharmacodynamic screening index. With the amount of Heparin, Inositol Nicotinate and penetration enhancers azone were as independent variables, the swelling inhibition rate and the blood perfusion were as the comprehensive pharmacodynamic index. Design-Expert 7.0 software was used for the experimental value, and response surface methodology was used to optimize the Heparin, Inositol Nicotinate and azone using central composite design-response surface method. The prediction was carried out through comparing the observed and predicted with the two-dimension overlaying contour and the three-dimension response surfaces. Results Heparin, Inositol Nicotinate and Azone were proved to have synergistic effectsby central composite design-response surface method. Optimal formulaiton was as following: Heparin 8000 U, Inositol Nicotinate 200 mg and Azone 600 mg. Conclusion Central composite design-response surface methodology is convenient and highly predictive in optimizing formulation of Heparin and Inositol Nicotinate Cream, which can be offered in the scientific methods and experimentation.
		2017 Vol. 14 (25): 8-12 [Abstract] ( 173 ) HTML (1 KB) PDF (1375 KB) ( 91 )

	13	Effects of flavonoids extract from Pteris multifida Poir on photoaged skin of mice
		CHEN Jiaming ZHANG Meiqin CHEN Ning LUO Xu YANG Suming CHEN Yongbei XIE Chengwen
		Objective To investigate the specific repairing effects of flavonoids extract from Pteris multifida Poir on photoaged skin of mice caused by ultraviolet irradiation, and to provide a theoretical basis for the medicinal use of this plant. Methods Forty damaged model mice with photoaging caused by ultraviolet irradiation were selected, according to the gender, they were divided into group A (no treatment), group B (smeared normal saline), group C (smeared normal saline + vitamin C), group D (smeared normal saline + flavonoids rutin extract), with 10 mice in each group. Follow-up observation of 10 days, the differences of surface evaluation of roughness (SER), surface evaluation of scales (SESC), surface evaluation of wrinkles (SEW), percentage of healed area, microvessel density (MVD), skin healing time, scab time and fluff generated time among the four groups were compared. Results In the 7th and 10th days, the SER, SESC, and SEW in group A, B, and C were all significantly higher than those of group D (all P ＜ 0.05), the percentage of healed area and MVD were significantly lower than those of group D (all P ＜ 0.05). The skin healing time, scab time and fluff generated time in group A, B, C were significantly shorter than those of group D (all P ＜ 0.05), and the results of each index in group A were maximum, and the results of each index in group D were minimum. Skin histopathologic examination showed that, the skin collagen fibre in group A showed no regular fracture, the emptiness of the dermis in group B was enlarged gradually, the epidermis of group C was relatively intact, the epidermis of group D had better recovery conditions and collagen fibers were also more than other groups. Conclusion Biological flavonoids rutin substances contribute to the repair of photoaged skin, reflected in the skin appearance and internal organizational structure, the efficacy is better than vitamin C, which can greatly enhance the skin healing time.
		2017 Vol. 14 (25): 13-16 [Abstract] ( 223 ) HTML (1 KB) PDF (988 KB) ( 54 )

	17	Influence of Yisui Shengxue Granules on mRNA expression of C/EBPα, GM-CSF, GM-CSFRα and MAFB in bone marrow cells of mice irradiated by 60Co-γ rays
		YUE Zhujun1 WANG Wenjuan2 JIA Fuxia2 WANG Jiajia2 MA Yun2 WANG Li'na2 ZHANG Qunxiu2
		Objective To study the influence of Yisui Shengxue Granules on CCAAT/enhancer binding protein α (C/EBPα), granulocyte-macrophage colon stimulating factor (GM-CSF), granulocyte-macrophage colon stimulating factor receptor alpha (GM-CSFRα) and transcription factor MAFB mRNA expression in bone marrow cells of mice irradiated by 60Co-γ rays, and to explore its mechanism of promoting bone marrow hematopoiesis. Methods Seventy-eight male Kunming mice were randomly divided into normal control group, model group, granulocyte-colony stimulating factor (G-CSF) group, low-dose, middle-dose and high-dose Yisui Shengxue Granules group. Two days before modeling, mice in low-dose, middle-dose and high-dose Yisui Shengxue Granules group received 12, 6, 3 g/(kg·d) Yisui Shengxue Granules ig respectively. On modeling day except normal control group, mice were established by 60Co-γ ray in other five groups. The 2nd day after modeling, mice in G-CSF group received 30 μg/(kg·d) G-CSF by injection, mice in normal control group and model group received the same volume distilled water, mice in low-dose, middle-dose and high-dose Yisui Shengxue Granules group received the same way as before modeling, the course lasted 14 days. Bone marrow cells were counted. The mRNA expression of C/EBPα, GM-CSF, GM-CSFRα and MAFB in BM cells was analyzed by real-time fluorescent quantitative polymerase chain reaction. Results The data showed that, Yisui Shengxue Granules could increase the count of bone marrow cells of mice irradiated by 60Co-γ rays (all P ＜ 0.05), and up-regulate the mRNA expression of GM-CSF, GM-CSFRα and MAFB in BM cells (all P ＜ 0.05). The effect of low-dose Yisui Shengxue Granules group was the best. Conclusion These results suggest that Yisui Shengxue Granules can promote bone marrow hematopoiesis, the mechanism may have some relation to up-regulating the mRNA expression of GM-CSF, GM-CSFRα and MAFB in BM cells.
		2017 Vol. 14 (25): 17-22 [Abstract] ( 186 ) HTML (1 KB) PDF (1334 KB) ( 91 )

	23	The analysis of the efficacy and prognosis of hemodynamic and inflammatory mediators in patients with multiple dysfunction syndrome after wasp stinging poisoning treated by continuous veno-venous hemofiltration
		YANG Jun LI Bin▲
		Objective To study the effect of continuous veno-venous hemofiltration (CVVH) on patients with multiple organ dysfunction syndrome (MODS) after wasp sting poisoning. Methods The clinical data of 48 cases with MODS after wasp sting poisoning in Center Hospital of Jiangjin District from October 2010 to October 2016 were retrospectively analyzed. They were divided into experimental group (24 cases) and control group (24 cases) according to the hemopurification program. All the patients were treated by blood perfusion (HP); then the experimental group was treated by CVVH, and the control group was treated by intermittent hemodialysis (IHD). One week after treatment, the curative effect and prognosis of the two groups were evaluated and compared. Results After treatment, the scores of APACHE II and MODS in the experimental group were lower than those in the control group (P < 0.05). The change of hemodynamic indexes in the experimental group was better than that in the control group (P < 0.05). The IL-6 level in the experimental group was lower than that in the control group (P < 0.05). The SOFA score in the experimental group was lower than that in the control group (P < 0.05). Conclusion CVVH can remarkably remove the inflammatory media, improve the hemodynamic level and prognosis of patients with MODS after wasp sting poisoning, which is worthy of clinical application.
		2017 Vol. 14 (25): 23-25,37 [Abstract] ( 142 ) HTML (1 KB) PDF (1054 KB) ( 71 )

	26	Study on anti-inflammatory and analgesic effects of Caulopyhllum robustum
		LI Xiaochun WANG Lifang XU Changgen FAN Baojuan
		Objective To investigate the anti-inflammatory and analgesic effects of Caulopyhllum robustum water extract. Methods The mice were randomly by weight divided into model group (CMC-Na), positive control group, Caulopyhllum robustum water extract low-dose, medium-dose and high-dose groups (3, 9, 27 g/kg, calculated by crude drug), each group had 10 mice. They were given relevant medicine intragastrically, once a day, for consecutive 7 d. The xylene-induced ear edema method was used to determine the degree of ear edema. Paper-induced granuloma model was used to determine the inhibition ratio of granulation tissue hyperplasia, the anti-inflammatory activity of Caulopyhllum robustum water extract was investigated. The pain incubation period and the number of writhing within 15 minutes were determined by acetic acid writhing method. Pain thresholds of mice were determined by hot-plate test before and after medication 30, 60, 90, 120 minutes, the analgesic effect of Caulopyhllum robustum water extract was investigated. Results Compared with model group, Caulopyhllum robustum water extract medium-dose and high-dose groups could restrain the degree of ear edema of mice (P ＜ 0.05 or P ＜ 0.01); the high-dose group could decrease the dry weight of granulation tissue (P ＜ 0.05). Caulopyhllum robustum water extract medium-dose and high-dose groups could prolong the pain incubation period, decrease the number of writhing in mice within 15 minutes (P ＜ 0.05 or P ＜ 0.01), and extended pain thresholds of mice 30, 60 minutes after medication (P ＜ 0.05 or P ＜ 0.01), the high-dose group could also extend pain thresholds of mice 90, 120 minutes after medication (P ＜ 0.05 or P ＜ 0.01). Conclusion Caulopyhllum robustum water extract possesses anti-inflammatory and analgesic effects.
		2017 Vol. 14 (25): 26-29 [Abstract] ( 183 ) HTML (1 KB) PDF (689 KB) ( 142 )

	30	The relationship between beige fat and disease and its significance
		MA Lei LI Lingyi YANG Zhonghan▲
		Besides energy-stocking white adipose tissue, there are two types of thermogenic adipose tissues including classical brown adipose tissue and beige adipose tissue. Human classical brown adipose tissue may regress by adulthood and almost disappear, which is distinct from rodent animal life-through existence. Beige adipocytes sporadically reside with white adipocytes and emerge in response to certain environmental cues, such as chronic cold exposure, excess catecholamine or β-adrenergic stimulation. Beiging of adipose tissue may play a potential role in developing an attractive therapeutic target for obesity and obesity-associated diseases, including type 2 diabetes. In this paper, we review, analyze and summarize the present research on the beige fat and obesity, diabetes, fatty liver, tumor and other diseases, for the further research and application of beige adipose tissue.
		2017 Vol. 14 (25): 30-33 [Abstract] ( 263 ) HTML (1 KB) PDF (549 KB) ( 95 )

	34	Research status on knowledge-attitude-belief-practice of traditional Chinese medicine health care in the elderly
		ZHOU Ping1 SONG Jie2
		Population aging is a major social problem in today′s world and healthy aging is one of important research topics in China's aging problems. The traditional Chinese medicine health care in our country can promote the health of the elderly well. The current situation and influencing factors of knowledge-attitude-belief-practice of traditional Chinese medicine health care in the elderly are summarized in this paper and the national traditional Chinese medicine health care status were deeply analyzed. Based on the relationship between the health literacy and health outcomes, the author advised the elderly people should improve the health level and the quality of the life through the living health care, sports health care, emotional health care, technical heath care and diet heath care.
		2017 Vol. 14 (25): 34-37 [Abstract] ( 188 ) HTML (1 KB) PDF (549 KB) ( 73 )

	38	Study development of Peroxiredoxins in tumors
		ZENG Wei1，2 XIAO Tao1 CAI Anlie2
		Peroxiredoxins (Prdx) is one kind of antioxidant enzymes in cells which can catalysis oxidation-reduction reactions to balance the level of hydrogen peroxide. They can also act as an important regulator in oxidation-reduction signal pathway, which is important for signal transduction and metabolism in cells. Many studies have showed that Prdx family plays different roles in tumors. Because of the change oftumor gene groups, their expressions changed, with the change of oxidation-reduction signal pathway. These changes lead to the influence of biological actions of tumors, offering new ideas of treatment of tumors. Therefore, we make a short conclusion of study about Prdx in tumors, in order to find a new way to treat tumors.
		2017 Vol. 14 (25): 38-41,57 [Abstract] ( 191 ) HTML (1 KB) PDF (880 KB) ( 56 )

	42	Research progress of clinical application on intra-aortic balloon pump
		YU Tao1 LI Yan2 HUANG Huan1 CAO Xuelei1 YIN Zuomin2▲
		Intra-aortic balloon pump counterpulsation (IABP) is widely used in acute myocardial infarction patients combined with cardiogenic shock and refractory cardiac failure and the patients who need angioplasty and coronary artery bypass grafting (CABG). Remarkable effect of IABP has been achieved in clinical application. However, there have still been controversies on clinical indications and application time of IABP. This article summarizes the current clinical situation of IABP.
		2017 Vol. 14 (25): 42-45 [Abstract] ( 222 ) HTML (1 KB) PDF (578 KB) ( 120 )

	46	Research on evaluation tools of capacity in medical and health field
		MAO Xin1 YANG Yue2 ZHANG Hezhan1▲
		"Capacity" and "evaluation" being the key words, literatures in medicine and health field have been searched and the evaluation tools of capacity have been studied according to the steps of the establishment of indicator system, including selection and establishment of the indicators, determination of the weights and data analysis and statistics. The combination of Delphi method and analytic hierarchy process is currently most widely used. The most appropriate and most efficient evaluation tool should be selected based on the object.
		2017 Vol. 14 (25): 46-50 [Abstract] ( 156 ) HTML (1 KB) PDF (554 KB) ( 71 )

	51	Values of procalcitonin and serum amyloid A and C reactive protein in acute infection of Brucella
		Aoduntuoya Qiqige
		Objective To investigate procalcitonin (PCT), serum amyloid A (SAA) and C reactive protein (CRP) in the diagnosis of acute infection of Brucella. Methods From January 2014 to January 2016, in Affiliated Hospital of Inner Mongolia Medical University, 100 patients with acute brucellosis infection were selected, according to whether patients developed liver function injury (ALI) or not, all patients were divided into an ALI group (n = 39) and a non ALI group (n = 61). The values of PCT, SAA and CRP in diagnosing ALI in patients with acute infection of Brucella were studied. Results Compared with the non ALI group, levels of glutamic-pyruvic transaminase, glutamic-pyruvic transaminase, total bilirubin, direct bilirubin, PCT, SAA and CRP in ALI group were higher, the differences were statistically significant (P < 0.01). The area under the curve of PCT, SAA and CRP in the diagnosis of ALI in patients with acute Brucella infection were 0.879, 0.858 and 0.737 (P < 0.05). Conclusion PCT and SAA have good diagnostic values in the diagnosis of ALI in patients with acute brucellosis infection.
		2017 Vol. 14 (25): 51-53 [Abstract] ( 158 ) HTML (1 KB) PDF (507 KB) ( 86 )

	54	Effect of hyperhomocysteinemia on urokinase intravenous thrombolytic therapy in patients with acute cerebral infarction
		LI Weizhou
		Objective To investigate the relationship between hyperhomocysteinemia (HHcy) and intravenous thrombolytic therapy of urokinase in patients with acute cerebral infarction. Methods From Apirl 2012 to May 2015, in Yunfu City People's Hospital, 91 patients with acute cerebral infarction were selected, the plasma homocysteine (Hcy) concentration was measured and they were divided into HHcy group (48 cases) and non-HHcy group (43 cases). All patients were treated with intravenous thrombolytic therapy of urokinase, the treatment time was 2 weeks, the neurological deficits, clinical treatment effect, daily living ability, vascular recanalization and incidence of adverse reactions were observed. Results The NIHSS scores of the two groups before treatment were not statistically significant (P > 0.05). The NIHSS scores of the two groups at 12 h, 48 h and 7 d were significantly lower than those before treatment (P < 0.05), these of non-HHcy group were lower than those of HHcy group at the same time (P < 0.05),these of the two groups at 48 h were lower than those at 12 h (P < 0.05), these of the two groups at 7 d were lower than those at 48 h (P < 0.05). The effective rate of non-HHcy group was significantly lower than that of HHcy group (P < 0.05), and the total effective rate of non-HHcy group was significantly lower than that of HHcy group (P < 0.05). The life self-care rate of non-HHcy group was significantly higher than that of HHcy group (P < 0.05). The recanalization rate of non-HHcy group was significantly higher than that of HHcy group (P < 0.05). The incidence of adverse reactions in HHcy group was significantly higher than that in non-HHcy group (P < 0.05). Conclusion The using of urokinase intravenous thrombolysis in the treatment of acute cerebral infarction, non-HHcy patients can significantly improve neurological deficits, improve daily living ability and clinical treatment.
		2017 Vol. 14 (25): 54-57 [Abstract] ( 676 ) HTML (1 KB) PDF (512 KB) ( 33 )

	58	Analysis of effect of antibiotic bronchoalveolar lavage on patients with severe bacterial pneumonia
		XIANG Zhi HE Jianbin HE Wei XIE Maofeng
		Objective To investigate and analyze of the effect of antibiotic bronchoalveolar lavage on pulmonary function and inflammatory mediators in patients with severe bacterial pneumonia. Methods From January 2015 to November 2016, in Huaihua First People's Hospital, 60 patients with severe bacterial pneumonia were selected, according to the random number table method, they were divided into observation group and control group, with 30 cases in each group. The control group was treated with antibiotics by intravenous administration, and the observation group was treated with antibiotic by bronchoalveolar lavage on the basis of the control group. The lung function index of forced epiratory volume in one second (FEV1), peak expiratory flow rate (PEFR) and max volume value (MVV), the inflammatory factor of lipopolysaccharide (LPS), tumor necrosis factor-2 (TNF-2) and interleukin-6 (IL-6) before and after treatment in two groups were compared. Results Before the treatment, the FEV1, PEFR, MVV in two groups were compared, the differences were not statistically significant (P > 0.05), after the treatment, the FEV1, PEFR, MVV in two groups were significantly better than before the treatment, the differences were statistically significant (P < 0.05), and observation group were significantly better than the control group, the differences were statistically significant (P < 0.05). Before the treatment, the LPS, TNF-2 and IL-6 in two groups were compared, the differences were not statistically significant (P > 0.05), after the treatment, the LPS, TNF-2 and IL-6 in two groups were significantly better than before the treatment, the differences were statistically significant (P < 0.05), and observation group were significantly better than the control group, the differences were statistically significant (P < 0.05). Conclusion Application of antibiotic bronchoalveolar lavage in the treatment of elderly patients with severe bacterial pneumonia can effectively improve the patient's lung function, effectively control and alleviate the lung inflammation, the application of treatment have good clinical effect, and it′s worthy of further clinical application.
		2017 Vol. 14 (25): 58-60,72 [Abstract] ( 199 ) HTML (1 KB) PDF (866 KB) ( 70 )

	61	Association of obstructive sleep apnea-hypopnea syndrome with the serum hormone in females
		SHEN Ying1 YANG Jing1 DONG Deqiong2
		Objective To analyze the risk factors of obstructive sleep apnea-hypopnea syndrome(OSAHS) in females, and the relationship between sex hormones and OSAHS. Methods From January 2013 to December 2015, in Affiliated Hospital of Zunyi Medical College, 173 females OSAHS were selected, and 346 health femal were selected as control at the same time. The demographic, sex hormones, and PSG related variables were selected and analyzed. Results The Logistic analysis results showed that menopause (OR = 1.89, 95%CI = 1.28-2.80), hypertension (OR = 3.39, 95%CI = 2.11-5.45), high neck circumfrence (OR = 1.72, 95%CI = 1.54-1.92), high BMI (OR = 1.25, 95%CI = 1.06-1.48) and PRL (OR = 1.39, 95%CI = 1.19-1.61) were risk factors of OSAHS (P < 0.05); the FSH (OR = 0.90, 95%CI = 0.88-0.91), LH (OR = 0.79, 95%CI = 0.75-0.82), E2 (OR = 0.92, 95%CI = 0.87-0.97), TT (OR = 0.13, 95%CI = 0.05-0.33) and P(OR = 0.95, 95%CI = 0.89-0.99) were protective factor of OSAHS (P < 0.05). Pearson correlation analysis showed that the FSH, LH, E2 and TT values showed negative association with AHI and TS90% (r < 0, P < 0.01), but the PRL and P values displayed positive association (r > 0, P < 0.01). FSH, LH, E2 and TT values expressed a positive correlation with LSaO2 (r > 0, P < 0.01), PRL and P values showed negative correlation (r < 0, P < 0.01). Conclusion FSH, LH, PRL, E2, P and TT have correlation with risk of OSAHS, and the menopause, hypertension, neck circumference and BMI were risk factors of OSAHS.
		2017 Vol. 14 (25): 61-64 [Abstract] ( 202 ) HTML (1 KB) PDF (488 KB) ( 49 )

	65	Effect of Dexmedetomidine combined with Ropivacaine on hemodynamics of hypertensive patients underwent operation with local anesthesia
		WANG Yifeng1,2 YANG Changming2 ZHOU Qin1 SHEN Cheng1 WANG Long1▲
		Objective To observe the effect of Dexmedetomidine combined with Ropivacaine on hemodynamics of hypertensive patients underwent selective operation with local anesthesia. Methods 60 hypertensive female who underwent selective breast mass (diameter＜2.5 cm, parts≤3) resection in Renmin Hospital of Wuhan University from March 2015 to March 2016 were randomly divided into three groups. Patients in group A were given intravenous administration of Dexmedetomidine combined with 0.5% Ropivacaine local anesthesia; patients in group B were given intravenous administration of Dexmedetomidine combined 1% Lidocaine local anesthesia; patients in group C were given intravenous administration of saline combined with 0.5% Ropivacaine local anesthesia. The hemodynamic changes were recorded at the time that patients went into the operating room (T0), beginning of the operation (T1), 15 min after the start of the operation (T2) and the end of the operation (T3); while the analgesic onset time, analgesic effect, time of duration and adverse reactions of the patients in the three groups were compared. Results The systolic blood pressure, diastolic blood pressure and heart rate of patients in group A and B at the time point T1-T3 were significantly lower than those at T0 (P ＜ 0.05). Compared with group C, the systolic blood pressure, diastolic blood pressure and heart rate of patients in group A and B were significantly lower at the time point T1-T3 (P ＜ 0.05). Compared with group B, the anesthesia onset time and duration of analgesia were longer, and the VAS scores were lower at 4, 6, 8 h after operation in both of the group A and C (P ＜ 0.05). Conclusion Dexmedetomidine combined with Ropivacaine local anesthesia for breast mass resection in patients with hypertension is a safe and accurate method, which has more stable hemodynamics and better postoperative analgesic effect.
		2017 Vol. 14 (25): 65-68 [Abstract] ( 180 ) HTML (1 KB) PDF (563 KB) ( 95 )

	69	Clinical application of Propofol in emergency tracheal intubation of patients with multiple trauma outside the hospital
		LI Dongxu LIU Li▲ DI Caiying ZHAO Liya LIU Chunyan JING Xiao
		Objective To observe the application effect of Propofol in emergency tracheal intubation of patients with multiple trauma outside the hospital. Methods 194 cases of patients with multiple trauma need emergency tracheal intubation outside the hospital in Shijiazhuang Emergency Center from October 2013 to June 2015 were analyzed retrospectively. According to the methods of anesthesia, patients were divided into three groups. 65 cases in group A were given intravenous injection of Propofol before intubation; 65 cases in group B were given 2% Lidocaine Hydrochloride intratracheal superficial anesthesia before intubation; 64 cases in group C were intravenous Diazepam before intubation. Intubation preparation time, intubation completion time, pharyngeal reflectivity, one-time intubation success rate were recorded. The heart rate (HR) and blood pressure [systolic blood pressure (SBP) and diastolic blood pressure (DBP)] at before drug use (T0), endotracheal intubation immediately (T1), 1 min after intubation (T2), 3 min after intubation (T3), 5 min after intubation (T4) were observed. Results Compared with group B, the intubation preparation time, intubation completion time were shorter and the one-time intubation success rate was higher in group A (P < 0.05). Compared with group C, the intubation preparation time, intubation completion time were shorter, the one-time intubation success rate was higher, and the pharyngeal reflectivity was lower in group A (P < 0.05). Compared with T0, in the three groups at T1 the HR, SBP and DBP decreased, and in group A the decreasing was significant (P ＜ 0.05); at T2 the HR, SBP and DBP of the three groups increased, and in group B the increasing was significant (P ＜ 0.05). Conclusion Propofol intravenous injection can obviously shorten the intubation preparation time and intubation completion time, improve the success rate of intubation. Three kinds of drugs can suppress the cardiovascular response to tracheal intubation, but the effect of Propofol inhibits the changes of hemodynamic during endotracheal intubation is better.
		2017 Vol. 14 (25): 69-72 [Abstract] ( 226 ) HTML (1 KB) PDF (601 KB) ( 48 )

	73	Effects of Oxycodone Hydrochloride combined with Parecoxib Sodium on patients after retroperitoneal laparoscopic radical nephrectomy
		ZHAN Huiming HUANG Juanjuan CHEN Jingli
		Objective To investigate the effect of Oxycodone Hydrochloride combined with Parecoxib Sodium on patient-controlled intravenous analgesia (PCIA) with Sufentanil in patients after retroperitoneal laparoscopic radical nephrectomy. Methods 60 patients with kidney cancer scheduled for elective retroperitoneal laparoscopic radical surgery under general anesthesia and accepted PCIA from May to August 2016 in the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, were randomly divided into 3 groups: control group (group S); Parecoxib Sodium group (group P) and Oxycodone Hydrochloride combined with Parecoxib Sodium (group O) group according to random number table, each group had 20 cases. Group S received intravenous normal saline 5 mL 30 min before incision and 30 min before the end of the operation. Group P received intravenous Parecoxib Sodium 40 mg 30 min before incision. Group O received intravenous Parecoxib Sodium 40 mg 30 min before incision and received intravenous Oxycodone Hydrochloride 0.1 mg/kg 30 min before the end of the operation. The three groups were all given PCA with Sufentanil until 48 h after surgery. The visual analogue scale (VAS), Ramsay sedation score at 0.5, 6, 12, 24, 48 h after operation, Shufentanil consumption and effective compressions number of PCA, the side effects and patient satisfaction were recorded. Results The VAS scores were significantly lower at each time points after operation in group P and group O compared with group S (P < 0.05); the VAS scores were significantly lower at 0.5, 6, 12 h in group O compared with group P (P < 0.05); there were no significantly differences in VAS scores at 24, 48 h between group O and group P (P > 0.05). The Ramsay sedation score was higher at 0.5 h after operation in group O compared with group P and group S (P < 0.05). The effective compressions numbers of PCA were significantly less in group P and group O than in group S (P < 0.05), group O were less than group P (P < 0.05). The Shufentanil consumption of PCA in group P and group O were less than group S (P < 0.05). The patients' satisfaction rates were higher in group P and group O than in group S (P < 0.05), group O was higher than group P (P < 0.05). There was no significant difference in side effects among the three groups (P > 0.05). Conclusion Oxycodone Hydrochloride can be safe and effective used for postoperative analgesia, combined with Parecoxib Sodium can improve the effect of PCA with Sufentanil in patients after retroperitoneal laparoscopic radical nephrectomy.
		2017 Vol. 14 (25): 73-76,93 [Abstract] ( 215 ) HTML (1 KB) PDF (1066 KB) ( 95 )

	77	Application of CT 3D reconstruction measurement in the placement of bronchial occlusive device in newborn′s air passage
		XU Yingyi SONG Xingrong TAN Yonghong LIU Wei PAN Yongying
		Objective To explore the application of CT 3D reconstruction measurement in the placement of bronchial occlusive device in newborn′s air passage. Methods 28 cases of newborns underwent limited one-lung ventilation surgery in Guangzhou Women and Children Medical Center from January 2015 to September 2016 were selected as the subjects. They were randomly and evenly divided into the traditional group and CT group according to the placement mode of bronchial occlusive device. Bronchial occlusive device of the traditional group was placed in the blind-mate way namely with manual controlled breathing resistance combined with auscultation localization, while bronchial occlusive device of the CT group was placed guided by the CT 3D reconstruction measurement data. Two groups of children were compared for SpO2, EtCO2, PaO2 and PaCO2 at the time of double-lung ventilation (T1), immediate one-lung ventilation (T2), 10 min after one-lung ventilation (T3) and 10 min after pulmonary collapse (T4). Localization time of placement, pulmonary collapse time, pulmonary collapse quality, intraoperative catheter and the shift times of bronchial occlusive device before the operation were observed and counted. Air passage mucosal damage was evaluated by fibreoptic bronchoscope after operation. Results There were no statistical differences between two groups of children in SpO2, EtCO2, PaO2 and PaCO2 at T1 (P > 0.05). Compared with the traditional group, SpO2 and PaO2 increased at T2 and T3, while EtCO2 and PaCO2 decreased in CT group (P < 0.05). Compared with the traditional group, localization time and pulmonary collapse time were decreased, pulmonary collapse quality was improved, and air passage mucosal damage was decreased in CT group (P <
		2017 Vol. 14 (25): 77-80 [Abstract] ( 206 ) HTML (1 KB) PDF (563 KB) ( 51 )

	81	Clinical comparison between paravertebral nerve block and interscalene groove brachial plexus block combined with superficial cervical plexus block in surgical anesthesia for clavicle fracture
		HE Feng BAI Jianyun▲ HUO Jianzhen LIU Hongfei
		Objective To investigate the clinical effect of paravertebral nerve block (PCNB) and interscalene groove brachial plexus block (IGBPB) combined with superficial cervical plexus block (SCPB) in surgical anesthesia for clavicle fracture. Methods 76 patients with clavicle fractures underwent operation in the Second Hospital of Yulin City from October 2010 to October 2013 were selected. According to anesthesia plan, patients were divided into two groups, each group had 38 cases. Patients in the control group were treated with IGBPB+SCPB. Patients in the observation group were treated with PCNB+SCPB. Changes of heart rate and non-invasive blood pressure, nerve block condition, surgical anesthetic effect, complications were compared between the two groups. Results There were no significant differences in heart rate and non-invasive blood pressure at time of before anesthesia, skin incision, fracture restoration between the two groups (P > 0.05). There were no significant differences in nerve block improvement rates of C5, C6, T2 between the two groups (P > 0.05); nerve block improvement rate of C4 in the observation group was significantly lower than that in the control group (P < 0.05); nerve block improvement rates of C7, C8, T1 in the observation group were significantly higher than that in the control group (P < 0.05). Excellent rate of surgical anesthesia in the observation group was higher than that in the control group (P < 0.05). Incidence of complication in the observation group was significantly higher than that in the control group (P < 0.05). Conclusion PCNB+SCPB and IGBPB+SCPB are effective anesthesia methods in surgical anesthesia for clavicle fracture. Anesthesia effect of PCNB+SCPB is better, which has higher complete block rate in innervation area.
		2017 Vol. 14 (25): 81-84 [Abstract] ( 198 ) HTML (1 KB) PDF (561 KB) ( 26 )

	85	Comparative study on chromatic value of all facial regional sites in different disease conditions of patients with chronic hepatitis
		MA Yun1 WANG Xiaojun2 JIA fuxia1
		Objective To explore the differences of chromatic values of all facial regional sites in different disease conditions of patients with chronic hepatitis. Methods Three hundred and eighty-eight cases of patients with chronic hepatitis treated in Beijing You'an Hospital, Capital Medical University from March 2009 to December 2015 were collected as observation group, while 325 cases of healthy people composed of college students and teachers were recruited as control group. The three-level color positioning method set up by professor Wang Hongmo was used to take facial distribution, the Lab color method was used to detect the Lab values of facial regional sites of five zang viscera. Through one-way analysis of variance, the Lab values of patients with chronic hepatitis in two groups and different disease conditions (light, medium, heavy) were compared. Results The "L" values of heart, spleen, kidney, liver, lung of all regional sites in the observation group were all lower than those of control group, which were decreased gradually as the disease got worse, the differences were all statistically significant (P ＜ 0.05), among which, the decrease of liver regional site was more significant and sustained. The differences of "a" values of heart, spleen, kidney, liver, lung of all regional sites in different disease conditions of patients with chronic hepatitis were statistically significant (P ＜ 0.05), within a certain degree of lesions, the "a" values of heart, spleen, kidney, liver, lung of facial regional sites in observation group were higher than those of control group. Within a certain degree of lesions, the "b" values of heart, liver, lung of regional sites had changes, but the value changes showed no obvious rules. Conclusion With the degree of illness deepens, the facial chromatic values will show corresponding pathological changes, especially in the values changes reflected on the lightness of facial color and red or green feelings.
		2017 Vol. 14 (25): 85-88 [Abstract] ( 162 ) HTML (1 KB) PDF (751 KB) ( 64 )

	89	The clinical efficacy of Tongyang Quyu Decoction with combination chemotherapy scheme in the treatment of Her-2 positive breast cancer
		HE Na′na WANG Qiaolin CHEN Yin
		Objective To investigate the clinical efficacy of Tongyang Quyu Decoction with combination chemotherapy scheme in the treatment of human epidermal growth factor receptor 2 (Her-2) positive breast cancer. Methods 150 cases with Her-2 positive breast cancer received in Traditional Chinese Medicine Hospital from May 2013 to May 2016 were divided into control group (75 cases) and observation group (75 cases) by random number table. The control group was treated with trastuzumab based chemotherapy, while the observation group was treated with Tongyang Quyu Decoction assisted with combination chemotherapy scheme. The two groups were treated for 18 weeks. The TCM Syndrome scores of breast cancer patients, quality of life scale (FACT-B) score, blood rheology, serum level of cardiac troponin (cTnI), heart fatty acid binding protein (H-FABP), interleukin -6 (IL-6) and tumor necrosis factor -a (TNF- alpha) and poison side effect difference in patients were compareds. Results The objective response rate and clinical benefit rate in the observation group were significantly higher than those in the control group (P < 0.05). The TCM Syndrome scores in the observation group after treatment were significantly lower than those in the control group (P < 0.05). The physiological status, family status, emotional status, social function, additional attention index FACT-B score in the observation group were lower than those in the control group (P < 0.05). Whole blood viscosity, whole blood viscosity, whole blood low shear viscosity, plasma viscosity, cTnI, H-FABP, IL-6 and TNF- levels of the observation group after treatment were significantly lower than those of the control group (P < 0.05). The incidence rate of observation group was lower than that of the control group (P < 0.05). Conclusion The treatment of Her-2 positive breast cancer with Tongyang Quyu Decoction with combination chemotherapy scheme can effectively control the progress of disease, have better clinical treatment effect and improve the quality of life of patients.
		2017 Vol. 14 (25): 89-93 [Abstract] ( 197 ) HTML (1 KB) PDF (766 KB) ( 104 )

	94	Analysis of medicine law on treating bronchiectasis by professor Zhang Zhongde based on TCM inheritance support system
		JIN Lianshun1 ZHU Hongfa1 SONG Ping1 ZHANG Tong2 HUANG Shouxie1 WANG Yuanyuan1 YANG Rongyuan1
		Objective To analyze the medication experience, medicine law and characteristics of composition of professor Zhang Zhongde's treatment of bronchodilator. Methods The medical records in General Institute of Guangdong Provincial TCM Hospital (Dade Road) and Ersha Island Branch of Guangdong Provincial TCM Hospital from July 2014 to June 2015 of Professor Zhang Zhongde 's treatment of Fei Luo Zhang in TCM or bronchodilator in western medicine were collected. After entering the "TCM inheritance support system (V2.5 edition)", the software integration rule analysis, improved mutual information method, complex system entropy clustering and other data mining methods were adopted to analyze drug use frequency, drug compatibility, group characteristics, combined with the experts' reviews. Results A total of 93 prescriptions were analyzed and 91 Chinese medicines were found. The frequency of using various drugs and the association rules between drugs were analyzed. Sixteen core compositions, such as Fructus Schisandrae Chinensis_Nodus Nelumbinis Rhizomatis_Radix Asteris and other fifteen compositions, were evolved. And seven of core compositions, such as Fructus Schisandrae Chinensis_Nodus Nelumbinis Rhizomatis_Radix Asteris_Cortex Moutan Radicis_Radix Paeoniae Rubra and other six prescriptions, were evolved. Conclusion The results of using traditional Chinese medicine inheritance support system are consistent with the characteristics of expert clinical application, therefore, the traditional Chinese medicine inheritance support system can be used for analyzing and summarizing experts' clinical experience.
		2017 Vol. 14 (25): 94-97,118 [Abstract] ( 189 ) HTML (1 KB) PDF (806 KB) ( 102 )

	98	Evaluation on the effect of the new management mode of inheritance of traditional Chinese medicine based on SECI model
		WANG Yuling1 BAI Xiaoxu1 ZHAO Xi1 GAO Yujin1 LI Tingting1 WEN Yinping2 ZHANG Hong3▲ XU Xisheng3
		Objective To explore and evaluate the effect of the new management mode for inheritance of traditional Chinese medicine. Methods From January 2014 to January 2017, the inheritance persons of the first session in Fangshan Traditional Medical Hospital of Beijing were selected as the research objects. The SECI knowledge transformation model was introduced into the management of inheritance of traditional Chinese medicine. Through the way of learning with the teacher, clinical practice, learning together, participation in training, reading classics together, writing articles, setting up professional periodicals, undertaking research projects, revising management measures, the socialization, externalization, integration and internalization of the implicit knowledge of Chinese medicine were promoted. Before and after the inheritance, a self-designed questionnaire was used to conduct a questionnaire survey on the tutors and students. Results Total 12 times of hospital training and 17 times of out of hospital training were organized, 1 item of municipal continuing medical education projects was completed. Tutors and students got excellent results in the hospital and national competition of Treatise on Febrile Diseases. 4 issues of professional periodicals and 1 academic compilation were published. 16 items of scientific research were declared. Work programs of inheritance were revised. Management system of inheritance was improved. 21 times of supervision and assessment were completed. The inheritance of district level was developed based on the inheritance of hospital level. Survey results showed that the professional ability of students was significant enhanced before and after inheritance (P ＜ 0.05). There were no significant differences in the basic knowledge, clinical ability, scientific research level of students (P > 0.05). There were no significant differences in the teaching level, clinical level and scientific research level of tutors (P > 0.05). Conclusion It is feasible to introduce SECI model into the management of inheritance of traditional Chinese medicine, which can improve teaching effect, promote the inheritance and development of Chinese medicine knowledge, accelerate the cultivation of talents of Chinese medicine.
		2017 Vol. 14 (25): 98-101,122 [Abstract] ( 158 ) HTML (1 KB) PDF (777 KB) ( 34 )

	102	Clinical effect of acupuncture in the treatment of hyperuricemia
		LU Xinling1 LI Ruiling1 SHEN Weidong2▲
		Objective To investigate the improved effect of acupuncture on the uric acid metabolism(UA) in the patients with hyperuricemia. Methods Sixty patients with hyperuricemia treated in the Nephrology Clinic and Acupuncture Clinic of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from September 2015 to December 2016 were chosen. According to the random number table method, the patients were divided into control group and treatment group, with 30 cases in each group. Both groups were given basic treatment: low purine diet, abstaining from alcohol, proper exercises, and taking more water to keep urine volume at 2000-3000 mL per day, which was useful for UA excretion. On basis of basic treatment, the treatment group was given acupuncture on bilateral píshù, shènshù, zúsānlǐ, sānyīnjiāo, yīnlíngquán, fēnglóng, three times a week, once 30 min. One month was as a course, total for 2 courses. The clinical efficacy and the level changes of UA, blood urea nitrogen (BUN) and creatinine (Cr) before and after treatment in the two groups were compared. Results The total effective rate of treatment group was 93.33%, which was higher than that of control group (46.67%), the difference was statistically signficant (P ＜ 0.05). After treatment, the level of UA in the treatment group was lower than that before treatment (P ＜ 0.05), while BUN, Cr had no statistically signficant differences compared with those before treatment (P ＞ 0.05). The level of UA after treatment in the treatment group was lower than that of control group (P ＜ 0.05), while there were no statistically signficant differences of BUN, Cr between the two groups after treatment (P ＞ 0.05). Conclusion The acupuncture can reduce the patients' UA metabolism, protect the renal function, so as to treat hyperuricemia.
		2017 Vol. 14 (25): 102-105 [Abstract] ( 236 ) HTML (1 KB) PDF (758 KB) ( 84 )

	106	Effect research of five-note therapy in the treatment of acute earlier acute stage of migraine with syndrome of liver Yang ascending hyperactively
		LYU Weihua TI Guixiang LYU Xia LYU Pin▲
		Objective To observe the clinical effect of five-note therapy on acute earlier acute stage of migraine with syndrome of liver Yang ascending hyperactively. Methods 90 patients with acute earlier acute stage of migraine with syndrome of liver Yang ascending hyperactively in Guang′anmen Hospital, China Academy of Traditional Chinese Medicine from June 2015 to April 2017 were selected, and they were divided into two groups according to random number table, with 45 cases in each group. The control group was treated with acupuncture at regular acupoints for 30 min; the treatment group was treated with five-note therapy on the base of control group for 30 min. After treatment, headache VAS score of 1 hour, 2 hours, 4 hours and 24 hours between two groups were observed and curative effect of two groups were evaluated. The levels of serum 5-HT and CGRP were compared between the two groups. Adverse reactions were observed between the two groups. Results After treatment, the total efficiency of control group was 80.0%, 95.6% in the treatment group, the difference was statistically significant between the treatment group and control group (P < 0.05). After treatment, The VAS scores at each time point between the two groups were significantly lower than those before treatment, with statistically significant difference (P < 0.05), but there was no significant difference between the two groups (P > 0.05). There were no obvious changes in blood and urine routine, liver and kidney function before and after treatment between the two groups (P > 0.05). After treatment, the serum level of 5-HT in the two group were significantly higher than those before treatment, the levels of CGRP were significantly lower than those before treatment, with statistically significant difference (P < 0.05), and after treatment, the levels of serum 5-HT and CGRP of treatment group were significantly better than those of the control group, with statistically significant difference (P < 0.05). There were no obvious adverse reactions among the three groups. Conclusion Five-note therapy combined with conventional acupuncture can improve the acute earlier acute stage of migraine with syndrome of liver Yang ascending hyperactively, and have no obvious adverse reaction, high safety, and is worthy of popularization and application.
		2017 Vol. 14 (25): 106-109 [Abstract] ( 208 ) HTML (1 KB) PDF (758 KB) ( 41 )

	110	Study on traditional Chinese medication rules for lumbar spinal stenosis based on data mining
		LYU Haoyuan1 XIANG Qingdong2 XIAO Qiangbing1,3,4 ZHU Zhangshuai5 JIANG Chenhui1 LIU Caiping1
		Objective To explore the medication regularities of Chinese medicine in the treatment of lumbar spinal stenosis by data mining techniques. Methods The related clinical literatures about Chinese medicine in the treatment of lumbar spinal stenosis were revealed from CNKI, Wanfang, VIP, PubMed, Embase and Medline, the data was analyzed statistically. Results Among the collected prescriptions, herbs types were used, the commonly used herbs, medicine pair, medicine groups, new formula and clustering situations were excavated by further analysis. Conclusion This paper finds new medication rules of Chinese medicine in the treatment of lumbar spinal stenosis, which provides guidance for the use of traditional Chinese medicine of lumbar spinal stenosis.
		2017 Vol. 14 (25): 110-114 [Abstract] ( 177 ) HTML (1 KB) PDF (1006 KB) ( 110 )

	115	Effect of Jianpi Yishen Tongdu Decoction on the bone density and balance function of patients with senile osteoporosis with syndrome of Yang deficiency of spleen and kidney
		ZHENG Youxin1 ZHENG Jinxian2 HU Wanyun1 ZHANG Xiaozhao1 ZHONG Shengcai1
		Objective To observe the effect of Jianpi Yishen Tongdu Decoction on bone mineral density and balance function of patients with senile osteoporosis with syndrome of Yang deficiency of spleen and kidney. Methods From February 2014 to July 2014, 120 patients with senile osteoporosis with syndrome of Yang deficiency of spleen and kidney treated in Qinghai Renji Hospital were divided into Chinese medicine group and control group by random number table, with 60 cases in each group. The patients in both groups were treated with Calcium D. Besides, the Chinese medicine group was treated by Jianpi Yishen Tongdu Decoction, the control group was treated by Salmon Calcitonin. Both groups were treated a course of 4 weeks, with 3 sessions. Meanwhile, the clinical efficacy, BBS, TUG and BMD of patients in the two groups were observed. Results Eleven cases of Chinese medicine group were lost, fourteen cases of control group were lost. The clinical efficacy in the Chinese medicine group was 93.9%, and 87.0% in the control group, with no statistical significance (P > 0.05). Compared with before treatment, in both of the two groups after treatment, the BMD levels were significantly increased, and the BBS scores were significantly increased (P < 0.05). The score of TUG was decreased in Chinese medicine group, and which was lower than the control group, with statistically significant difference（P < 0.05）.Conclusion Jianpi Yishen Tongdu Decoction can relief clinical symptoms, increase BMD and improve the balance ability of of patients with senile osteoporosis.
		2017 Vol. 14 (25): 115-118 [Abstract] ( 241 ) HTML (1 KB) PDF (754 KB) ( 46 )

	119	Study on the clinical effect and mechanism of Shugan Huazhuo Decoction in treating diabetes mellitus complicated with nonalcoholic fatty liver disease
		LI Yue MIAO Qiuli ZHANG Wenrui▲
		Objective To observe the clinical effect of Shugan Huazhuo Decoction on patients with diabetes mellitus combined with nonalcoholic fatty liver disease (NAFLD), in order to study its mechanism. Methods From June 2015 to January 2017, 80 patients with diabetes mellitus combined with NAFLD treated in the First Hospital of Jilin University were selected and divided into control group and observation group by random number table, with 40 cases in each group. The control group was treated with Polyene Phosphatidylcholine Capsule, while the observation group was treated with Polyene Phosph atidy leholine Capsule Shugan Huazhuo Decoction. The liver function, lipid metabolism and insulin resistance in the two groups were compared. Results After treatment, the levels of aspartate aminotransferase, alanine aminotransferase, glutamyl transpeptidase, transforming growth factor-β1 (TGF-β1), total cholesterol triglyceride, low density lipoprotein cholesterol (LDL-C), fasting insulin and insulin resistance index (HOMA-IR) were significantly decreased, with statistically significant difference (P < 0.05). Compared with the control group after treatment, except for the levels of LDL-C and fasting blood glucose (FPG), the other indexes in the observation group were significantly lower, with statistically significant difference (P < 0.05). The effective rate of the observation group was significantly higher than that of the control group, with statistically significant difference (P < 0.05). Conclusion The clinical effect of Shugan Huazhuo Decoction on patients with diabetes mellitus combined with NAFLD is accurate, and its mechanism may be related to improve blood lipid metabolism, reduce insulin resistance.
		2017 Vol. 14 (25): 119-122 [Abstract] ( 246 ) HTML (1 KB) PDF (756 KB) ( 132 )

	123	Discussion of 4 classification methods of colonic morphology reconstruction in irritable bowel syndrome
		XUE Runguo1 XUAN Jianxin2 CUI Bing3 SU Bin1 XIN Hong4 CUI Baoji1 LI Jianhui1
		Objective To discuss the practical application value of colonic morphology reconstruction (CTC) in irritable bowel syndrome (IBS). Methods From January 2014 to January 2016, in Chengde Central Hospital, 110 patients with IBS were selected. all patients were given colonic morphology reconstruction by MSCT, they were divided into 4 types by CTC data: length type, twisted type, spastic type and inability type, The correlativity of all the clinical symptoms of different types of IBS was analyzed. Results The results showed 27 cases (24.55%) were length type, 22 cases (20.00%) were distorted type, 37 cases (33.64%) were spasticity type and 24 cases (21.82%) were weakness type, colon curvature and total length of 4 types were compared, the differencea were statistically significant (P < 0.05), constipation, incomplete defecation, stimulated diarrhea and abdominal distension of 4 types were compared, the differencea were statistically significant (P < 0.05). The lengthy type was positively correlated with constipation (r = 0.943, P < 0.05), distortion was positively correlated with poor defecation (r = 0.876, P < 0.05), spasticity was positively correlated with postganglionic diarrhea (r = 0.815, P < 0.05), and insufficiency was positively correlated with bloating (r = 0.973, P < 0.05). Conclusion IBS can be subdivided into four types by MSCT reconstruction, and each type has typical clinical symptoms, which can provide experimental basis for clinical diagnosis and treatment.
		2017 Vol. 14 (25): 123-126 [Abstract] ( 239 ) HTML (1 KB) PDF (707 KB) ( 56 )

	127	Application value of TCD foam test in screening and curative effect evaluation of migraine patients with patent foramen ovale
		MA Li WANG Juanjuan▲ LIU Yingying
		Objective To analyze the application value of TCD foam test in screening and curative effect evaluation of migraine patients with patent foramen ovale. Methods From January to December 2016, in Yan'an University Affiliated Hospital, 80 migraine patients were selected as the MA group, there were 51 patients of migraine aura (MA), 29 patients of migraine aura (MO)，30 healthy persons carried physical examination were selected as control group, TCD foaming test was carried in both two groups, and the MA group was given the esophagus echocardiography, head CT examination in addition, the percutaneous puncture in sealing treatment was carried among patients who diagnosed as patent foramen ovale and agreed to percutaneous puncture seal treatment, and the effect of intervention plugging treatment was observed by TCD foaming test, conventional chest cardiac echocardiography, head CT examination 1 and 3 months postoperative. Results TCD foaming test showed that, there were 37 patients with right-to-left shunt in the MA group, and they were confirmed by the esophagus echocardiography, including 13 cases were grade Ⅱ, 19 cases were grade Ⅲ, and 15 cases were grade Ⅳ; in control group, 5 cases were grade Ⅱ, 2 cases were grade Ⅲ, and no grade Ⅳ case, RLS shunt situation of two groups were compared, the difference was statistically significant (P < 0.05). 20 patients (13 patients with MA, 7 patients with MO) were given the intervention plugging treatment,and the operation of all patients were successful, postoperative migraine symptoms of 12 patients were disappeared, and symptoms of 5 patients were improved, TCD foaming test showed that 3 patients were still with right-to-left shunt 3 months postoperative, but migraine symptoms of patients decreased significantly compared with before the treatment, but symptoms of 2 patients recovered after Valsalva action, 1 patient was grade Ⅳ before and after surgery. Head CT examination showed that no new infarction lesions was found. Conclusion Intervention plugging treatment can obviously improve the symptoms of patent foramen ovale patients combined with migraine, TCD foam test has important application value in screening and curative effect evaluation in migraine patients combined with migraine, and it is worthy of clinical popularization and application.
		2017 Vol. 14 (25): 127-130 [Abstract] ( 245 ) HTML (1 KB) PDF (464 KB) ( 93 )

	131	Application value of beam arm test in diagnosis of subclavian steal
		LI Liang1 XIU Junqing2▲
		Objective To evaluate the value of beam arm test in the diagnosis of symptomatic subclavian steal by Doppler ultrasound. Methods From August 2014 and January 2017, in China Academy of Chinese Medical Sciences Guang'anmen Hospital, 62 patients confirmed subclavian artery stenosis by digital subtraction angiography (DSA), magnetic resonance angiography (MRA) or computer tomography angiography (CTA) were selected,the direction, velocity of bilateral subclavian artery and vertebral artery the resistance index of vertebral artery were measured, the changes of spectrum shape were observed after beam arm test. Results There were totally 20 cases were steal blood,18 cases were partial steal in blood, 20 cases were occult steal in blood, and 4 cases were no obvious steal blood; 17 cases of occult steal images were converted into partial steal after brachial beam test. Conclusion Ultrasound can accurately diagnose the degree of subclavian artery stenosis by observing the direction of vertebral artery blood flow and the characteristics of blood flow spectrum; beam arm test is a useful supplement to ultrasonic diagnosis.
		2017 Vol. 14 (25): 131-133 [Abstract] ( 182 ) HTML (1 KB) PDF (456 KB) ( 72 )

	134	Assessing the clinical value of serum amyloid A protein and C-reactive protein on the diagnosis of children with Mycoplasma pneumoniae infection
		LI Pan1 YANG Jian2 CAO Huicai1
		Objective To investigate the clinical value of serum amyloid A protein (SAA) and C-reactive protein (CRP) on diagnosis of children with Mycoplasma pneumoniae (Mp) infection. Methods From January to December 2016, in East Branch of Baoding First Central Hospital, the data of 159 hospitalized children with pulmonary infection were retrospectively analyzed, including 124 Mp infection children (Mp infection group), 35 bacterial infection children (bacterial infection group), 20 healthy children were selected as control group at the same period. The level of SAA and CRP in three groups were detected and analyzed, ROC was used to analyze. Resluts SAA and CRP in three groups were compared, the difference was statistically significant (P < 0.05), the SAA and CRP of bacterial infection groups were higher than other groups (P < 0.05), the SAA and CRP of MP infection group were higher than control group (P < 0.05), but the SAA/CRP of each group was compared, the difference was not statistically significant (P > 0.05). The area under the ROC of SAA and CRP on the diagnosis of MP infection was 0.95 and 0.33, the bacterial infection was 0.88 and 0.86. Conclusion SAA has higher accuracy on the diagnosis of MP and bacterial infection; CRP has higher accuracy on the diagnosis of bacterial infection, it is insignificant for the clinical value of distinguishing and diagnosis the children with MP infection. SAA can be used for distinguishing and diagnosing the children with MP infection and should be extensively used for clinical practice; the clinical value of CRP on diagnosis the children with MP infection still need a deep research.
		2017 Vol. 14 (25): 134-137 [Abstract] ( 259 ) HTML (1 KB) PDF (472 KB) ( 72 )

	138	Students development of information management major in traditional Chinese medicine university based on competency model
		LI Xuebo MI Li
		With the development of the information technology in traditional Chinese medicine (TCM) industry, the demand of information human resource in TCM is increasing. The information management (IM) major in TCM university should give the students a higher-quality development. The IM majors in TCM universities have different fundamentals, education directions and strategies. Many universities pay less attention to the practice education and comprehensive quality development towards the job demand, so the gap between the human resource demand and university education is coming up. This paper analyzes the problems in the education of IM majors in universities of TCM, and has investigated 27 employers of the graduated students of IM major in Shandong University of TCM to build a competency model and refined the competency elements from 5 aspects of professional knowledge, application ability, team capacity, self-development ability and stress management. Based on this model, this paper discusses the students development strategy as below: emphasizing multidisciplinary cross connection and process teaching, innovating teaching organization, and developing non-intellectual factors.
		2017 Vol. 14 (25): 138-140,151 [Abstract] ( 176 ) HTML (1 KB) PDF (809 KB) ( 28 )

	141	Clinical teaching discussion of the standardized training of residents in General Surgery
		LI Yandong1 DING Xiyan2▲ REN Qiang1 REN Chunhong3
		Currently the standardized training of residents is an important part of medical education in our country, and the indispensable stage of improving the quality of clinicians, cultivating high-quality talents of clinical medicine. General surgery as the basic subject of surgery, is a broad and holistic clinical subject, occupies a pivotal position in the standardized training of residents. Currently clinical work is busy, especially undergraduates and graduates teaching in teaching hospital. The standardized training of residents is the top priority in teaching, how to do well for its teaching is always the hot spot of the study. This paper discusses the topic combined with the effects of the standardized training of residents in General Surgery of Affiliated Hospital of Beihua University.
		2017 Vol. 14 (25): 141-143 [Abstract] ( 206 ) HTML (1 KB) PDF (458 KB) ( 47 )

	144	Effects of the foldable medication table on the safety of clinical medication of nursing students
		MAO Chun1 KONG Lingyu1▲ MA Hongmei2 ZHANG Qian3 ZHANG Xiaohong1
		Objective To explore the influence of the foldable medication table on clinic medication safety of nursing students, so as to reduce mistakes that a trainee can make. Methods Nursing students of Hubei University of Arts and Science training in Xiangyang Central Hospital were selected as research objects, 61 grade 2013 as experimental group, 63 grade 2012 as control group. Using advantages of school and hospital, the foldable medication table was made by double qualified teachers. The experimental group were required to use the foldable medication table during the internship, the control group did not. Medication errors, drug errors (contraindications) and drug-related disputes during the internship between two groups were analyzed. Results Incidence rate of medication errors, drug errors (contraindications) between two groups were compared, with statistical differences (P ＜ 0.05). The experimental group was seen to improve apparently in medication safety. Conclusion The foldable medication table made by this research group is close to the clinic, significantly reducing the trainee from clinical medication errors, which medical schools and hospitals deserve.
		2017 Vol. 14 (25): 144-146 [Abstract] ( 184 ) HTML (1 KB) PDF (488 KB) ( 67 )

	147	Improving the hospital office efficiency with mobile office
		YANG Liu LIU Yanting
		With the popularization of mobile phone, the mobile health care and the mobile office are integrating into our lives gradually. The mobile health care requires that the hospital improves the management standards as well as the service, and promote the information public administration, which has been a crucial task. Currently, the level of using information in the hospitals is unsatisfactory; and the traditional information construction has defects the high investment but hard to use. This article uses the public administration as the point combining the experience of applying “Dingtalk” software in Beijing Tongren Hospital, Capital Medical University to explore how to improve the management standards by using the mobile internet technology.
		2017 Vol. 14 (25): 147-151 [Abstract] ( 153 ) HTML (1 KB) PDF (447 KB) ( 130 )

	152	The effects of early rehabilitation nursing on the prognosis of postoperative develepment dislocationg of the hip
		HU Xiaoyun WANG Xiaolei LI Lianyong
		Objective To analyze the effects of early rehabilitation care on the prognosis of postoperative develepment dislocationg of the hip (DDH). Methods From December 2014 to December 2016, 90 children with DDH treated by surgery in Shengjing Hospital of China Medical University were selected and divided into control group and observation group by random number table, with 45 cases in each group. After operation, the control group was treated by routine nursing, the observation group was treated by early rehabilitation nursing. The postoperative efficacy, complications and degree of pain, lower limb motor function and daily life of two groups were compared. Results The clinical curative effect of the observation group was higher than that of the control group, with statistically significant difference (P < 0.05). The incidence rates of asphyxiation, pressure sores, incisions and respiratory infections in the observation group were lower than those in the control group, with statistically significant difference (P < 0.05). In two groups, the FMA and Barthel scores after operation were higher than those before operation, the VAS score after surgery was lower than that before surgery, and the change of the observation group was more evident, with statistically significant difference (P < 0.05). Conclusion Early rehabilitation nursing can improve the clinical effect of postoperative children with DDH, reduce complication incidence rate, relieve pain, and improve function of lower extremity and activity of daily living.
		2017 Vol. 14 (25): 152-154,158 [Abstract] ( 156 ) HTML (1 KB) PDF (620 KB) ( 61 )

	155	Effect of systemic nursing intervention on the activities of daily living during postoperative rehabilitation in patients with acute severe craniocerebral trauma
		ZHANG Xiaojia1 SHANG Helan2 WANG Ligang3
		Objective To explore and analyze the effect of systemic nursing intervention on the activities of daily living during postoperative rehabilitation in patients with acute severe craniocerebral trauma. Methods Ninety cases of patients with acute severe craniocerebral trauma admitted to the First Affiliated Hospital of Harbin Medical University from January 2015 to January 2017 were selected and divided into routine nursing group and systemic nursing group by random number table, with 45 cases in each group. The nursing satisfaction of relatives of the patients, the scores of national institute of health stroke scale (NIHSS), activity of daily living (Barthel index), the scores of clinical neurological function of craniocerebral trauma and the incidence of complications between the two groups were compared. Results The nursing satisfaction rate of relatives of the patients in the systemic nursing group (93.33%) was higher than that of routine nursing group (77.78%), with statistically significant difference (P ＜ 0.05). After nursing intervention, the scores of NIHSS and clinical neurological function of craniocerebral trauma in the two groups were all lower than those before nursing intervention, the Barthel index was higher than that before nursing intervention, the differences were all statistically significant (all P ＜ 0.05), the indexes above in the systemic nursing group were improved more significantly compared with those of routine nursing group, the differences were all statistically significant (all P ＜ 0.05). The incidence of complications in the systemic nursing group (6.67%) was lower than that of routine nursing group (17.78%), with statistically significant difference (P ＜ 0.05). Conclusion The systemic nursing intervention can increase the nursing satisfaction of relatives of patients with acute severe craniocerebral trauma, improve the neurologic impairment, promote the activity of daily living, reduce the incidence of complications.
		2017 Vol. 14 (25): 155-158 [Abstract] ( 166 ) HTML (1 KB) PDF (607 KB) ( 30 )

	159	Study on the systematic nursing intervention model of patients with laryngeal cancer based on the improvement of medical treatment experience
		JI Jianmin
		Objective To study the effect of systematic nursing intervention to improve the feelling patients with laryngeal cancer. Methods From December 2013 to December 2016, 70 patients with laryngeal cancer in Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Hebei North University were selected as the research object. According to random number table method, they were divided into control group (35 cases) and observation group (35 cases). The control group was treated by hospital general nursing, and the observation group was treated by systematic nursing intervention. The nursing satisfaction, scores of life quality, SAS and SDS, and self care ability after discharge were evaluated. Results Before intervention, there were no significant differences in the scores of emotion, role function, social function, physical function, cognitive ability between the two groups (P > 0.05); after intervention, the scores in the two groups were increased, and the scores in the observation group were higher than those in the control group (P < 0.05). The patients' satisfaction rate of the observation group was higher than that of the control group (P < 0.05). Before intervention, the scores of SAS and SDS in the two groups were not statistically significant (P > 0.05); after intervention, the scores in the two groups were decreased, and the scores in the observation group were lower than those in the control group (P < 0.05). The self care ability after discharge of the control group was lower than that of the observation group (P < 0.05).Conclusion Systematic nursing intervention model can improve quality of life, unhealthy emotions and self-care ability after discharge of patients with laryngeal cancer.
		2017 Vol. 14 (25): 159-162 [Abstract] ( 174 ) HTML (1 KB) PDF (647 KB) ( 37 )

	163	Effect of JCI standard combined with fast-track care on postoperative hospital infections in patients with hepatic echinococcosis
		LI Mei1 ZHANG Qian1 Ayifuhan·Ahan2 SHAO Li1
		Objective To investigate the effect of JCI standard combined with fast-track care on postoperative hospital infections in patients with hepatic echinococcosis. Methods According to random number table, 60 postoperative patients with hepatic cystic echinococcosis were divided into JCI standard combined with fast-track care group and JCI group, with 30 cases in each group. They were hospitalized in the First Affiliated Hospital of Xinjiang Medical University from December 2016 to March 2017. The 3-,7- and 10-day incidence rates of incision infection, respiratory tract infection and urinary infection were compared between the two groups respectively, and the patients′ satisfaction of the two groups were also compared. Results The 3-,7- and 10-day incidence rates of incision infection, respiratory tract infection and urinary infection in the JCI standard combined with fast-track care group were lower than those in the JCI group (P ＜ 0.05). The improvement of patients′ satisfaction in the JCI standard combined with fast-track care group was higher than that in the JCI group (P ＜ 0.05). Conclusion JCI standard combined with fast-track care can reduce the incidence of hospital infection and alleviate the sufferings of patients with hepatic cystic echinococcosis.
		2017 Vol. 14 (25): 163-166 [Abstract] ( 186 ) HTML (1 KB) PDF (652 KB) ( 46 )

	167	Influences of multidisciplinary team model nursing intervention for the treatment compliance, cancer-related fatigue, anxiety and depression in elderly patients with advanced lung cancer accompanied with bone metastasis
		Ami′na·Quhai1 HAN Jizhen2 MA Ling1 ZHANG Yan1
		Objective To investigate the influences of multidisciplinary team model nursing intervention for the treatment compliance, cancer-related fatigue, anxiety and depression in elderly patients with advanced lung cancer accompanied with bone metastasis. Methods One hundred and twenty-four cases of elderly patients with advanced lung cancer accompanied with bone metastasis met with the inclusive criteria treated in Tumor Hospital Affiliated to Xinjiang Medical University from January 2015 to December 2016 were selected as research objects, and they were randomly divided into the control group and the observation group by random number table, with 62 cases in each group. The control group was given conventional nursing, while the observation group was given multidisciplinary team model nursing intervention. The revised Piper fatigue scale (PFS), self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to evaluate the status of cancer-related fatigue, anxiety and depression. The treatment compliance between two groups was compared. Results After nursing intervention, the treatment compliance (including taking medicine on time, rational diet, reasonable exercises and timely reexamination) in the observation group was all higher than the control group, the differences were all statistically significant (all P ＜ 0.05). After intervention, the scores of PFS (including emotion, severity of behavior, perception and cognition) in the observation group were all lower than those before intervention, and the scores of indexes above in the observation group were lower than those of control group, the differences were statistically significant (all P ＜ 0.05). After intervention for 1, 2, 3 months, the scores of SAS and SDS in the two groups were all lower than those before intervention, and the scores in the observation group were lower than those of control group, the differences were statistically significant (all P ＜ 0.05). Conclusion Multidisciplinary team model nursing intervention in elderly patients with advanced lung cancer accompanied with bone metastasis has good application effects, which can enhance the treatment compliance, improve cancer-related fatigue, alleviate negative emotions of anxiety and depression, it is worthy of clinical promotion and application.
		2017 Vol. 14 (25): 167-170 [Abstract] ( 185 ) HTML (1 KB) PDF (646 KB) ( 51 )

	171	Effect of comprehensive nursing intervention on the compliance and quality of life in patients with chronic renal insufficiency
		WANG Jiqiao YAO Li XU Tianhua
		Objective To explore and analyze the effect of comprehensive nursing intervention on the compliance and quality of life in patients with chronic renal insufficiency. Methods Ninety cases of patients with chronic renal insufficiency admitted to Department of Nephrology, the First Hospital of China Medical University from January 2015 to January 2017 were selected and divided into control group and observation group by random number table, with 45 cases in each group. The control group was given routine nursing, on basis of routine nursing, the observation group was added with comprehensive nursing intervention. The nursing compliance, indexes of renal function (including urea nitrogen, creatinine, serum albumin, hemoglobin) and quality of life (including the physical function, role function, cognitive function, emotional function and social function) between two groups were compared. Results The nursing compliance rate in the observation group (93.33%) was higher than that of control group (75.56%), with statistically significant difference (P ＜ 0.05). After nursing intervention, the indexes of renal function in the two groups were all higher than those before intervention, and the indexes above in the observation group were improved more significantly, with statistically significant differences (P ＜ 0.05). After nursing intervention, the scores of quality of life in the two groups were all higher than those before intervention, and the scores above in the comprehensive nursing group were improved more significantly, with statistically significant differences (P ＜ 0.05). Conclusion Comprehensive nursing intervention can enhance the nursing compliance of patients with chronic renal insufficiency, promote the recovery of renal function, improve the quality of life.
		2017 Vol. 14 (25): 171-173,177 [Abstract] ( 187 ) HTML (1 KB) PDF (618 KB) ( 93 )

	174	Application effect of goal attainment theory in health education for the elderly in hospital
		XU Xu MA Hongmei CHEN Jiangning ZHANG Songlian
		Objective To investigate the application effect of goal attainment theory in health education for the elderly in hospital. Methods Eighty cases in Renmin Hospital of Wuhan University were given to health education with the guidance of goal attainment theory from November 2015 to January 2016. Three questionnaire including health knowledge assessment, health-promoted behavior investigation, degree of satisfaction were used to assess application effect. Results The scores of health knowledge and health-promoted behavior were improved after the application of goal attaining theory in health education, with statistically significant difference (P < 0.05); the satisfaction degree was improved, while the difference was not statistically significant (P > 0.05). Conclusion Application of goal attaining theory to health education for elderly patients in hospital can improve health knowledge of patients, bulid healthy lifestyle and enhance the effect of health education.
		2017 Vol. 14 (25): 174-177 [Abstract] ( 176 ) HTML (1 KB) PDF (644 KB) ( 74 )

	178	The application of clinical nursing pathway in the perioperative period of patients with primary glaucoma
		XIE Liaoqi LYU Juying LYU Ronghui ZHAO Jifei▲
		Objective To analyze the application of clinical nursing pathway in the perioperative period of patients with primary glaucoma. Methods The clinical data of 110 patients with primary glaucoma in the the First People′s Hospital of Xianyang from February 2014 to March 2017 were analyzed by retrospective study. They were divided into routine nursing group (50 cases) and clinical nursing path group (60 cases), according to different nursing intervention. The visual acuity level, IOP, the central retinal blood flow and the scores of cognitive and life quality were compared. Results After nursing, the visual acuity level, EDV, PSV, the scores of cognitive and life quality in the two groups were increased, while the intraocular pressure level and RI were decreased, with statistically significant difference (P < 0.05). Excepted the visual acuity level, other indicators of the clinical nursing path group were better than the routine nursing group after nursing, with statistically significant difference (P < 0.05). Conclusion The clinical nursing pathway applied in the perioperative period of patients with primary glaucoma can improve vision，decrease IOP，accelerate ocular blood vascular system and increase the scores of cognitive and life quality. So it is worthy of clinical application.
		2017 Vol. 14 (25): 178-181 [Abstract] ( 217 ) HTML (1 KB) PDF (802 KB) ( 47 )

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