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The relationship between beige fat and disease and its significance |
MA Lei LI Lingyi YANG Zhonghan▲ |
Department of Biochemistry, Zhongshan Medical College, Sun Yat-sen University, Guangdong Province, Guangzhou 510080, China |
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Abstract Besides energy-stocking white adipose tissue, there are two types of thermogenic adipose tissues including classical brown adipose tissue and beige adipose tissue. Human classical brown adipose tissue may regress by adulthood and almost disappear, which is distinct from rodent animal life-through existence. Beige adipocytes sporadically reside with white adipocytes and emerge in response to certain environmental cues, such as chronic cold exposure, excess catecholamine or β-adrenergic stimulation. Beiging of adipose tissue may play a potential role in developing an attractive therapeutic target for obesity and obesity-associated diseases, including type 2 diabetes. In this paper, we review, analyze and summarize the present research on the beige fat and obesity, diabetes, fatty liver, tumor and other diseases, for the further research and application of beige adipose tissue.
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