抗生素支气管肺泡灌洗治疗重症老年细菌性肺炎的疗效分析

Abstract
Figure/Table
References (26)
Related Citation (15)

Download: PDF (866 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate and analyze of the effect of antibiotic bronchoalveolar lavage on pulmonary function and inflammatory mediators in patients with severe bacterial pneumonia. Methods From January 2015 to November 2016, in Huaihua First People's Hospital, 60 patients with severe bacterial pneumonia were selected, according to the random number table method, they were divided into observation group and control group, with 30 cases in each group. The control group was treated with antibiotics by intravenous administration, and the observation group was treated with antibiotic by bronchoalveolar lavage on the basis of the control group. The lung function index of forced epiratory volume in one second (FEV1), peak expiratory flow rate (PEFR) and max volume value (MVV), the inflammatory factor of lipopolysaccharide (LPS), tumor necrosis factor-2 (TNF-2) and interleukin-6 (IL-6) before and after treatment in two groups were compared. Results Before the treatment, the FEV1, PEFR, MVV in two groups were compared, the differences were not statistically significant (P > 0.05), after the treatment, the FEV1, PEFR, MVV in two groups were significantly better than before the treatment, the differences were statistically significant (P < 0.05), and observation group were significantly better than the control group, the differences were statistically significant (P < 0.05). Before the treatment, the LPS, TNF-2 and IL-6 in two groups were compared, the differences were not statistically significant (P > 0.05), after the treatment, the LPS, TNF-2 and IL-6 in two groups were significantly better than before the treatment, the differences were statistically significant (P < 0.05), and observation group were significantly better than the control group, the differences were statistically significant (P < 0.05). Conclusion Application of antibiotic bronchoalveolar lavage in the treatment of elderly patients with severe bacterial pneumonia can effectively improve the patient's lung function, effectively control and alleviate the lung inflammation, the application of treatment have good clinical effect, and it′s worthy of further clinical application.

Key words： Severe bacterial pneumonia Elderly patients Bronchoalveolar lavage Antibiotics Pulmonary function Inflammatory mediators

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	XIANG Zhi HE Jianbin HE Wei XIE Maofeng

Cite this article:

XIANG Zhi HE Jianbin HE Wei XIE Maofeng. Analysis of effect of antibiotic bronchoalveolar lavage on patients with severe bacterial pneumonia[J]. 中国医药导报, 2017, 14(25): 58-60,72.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I25/58

[1] 罗维贵，许杰，揭志军，等.抗生素支气管肺泡灌洗对重症老年细菌性肺炎患者肺功能及炎症介质的影响[J].医学文选，2005，24（4）：463-465.
[2] 邵艳梅.细菌性肺炎患者支气管肺泡灌洗液和血清中CRP、PCT的相关性[J].医药前沿，2013，11（33）：209.
[3] 陈花，唐荣昌，刘杰，等.支气管肺泡灌洗联合局部抗生素治疗支气管扩张并发感染治疗效果分析[J].吉林医学，2016，37（10）：2474-2475.
[4] 亢国良.支气管肺泡灌洗联合局部抗生素治疗支气管扩张并发感染临床分析[J].中国实用医药，2014，12（18）：112-113.
[5] 彭瑞芳.支气管肺泡灌洗联合局部抗生素治疗支气管扩张并发感染的临床观察[J].临床合理用药杂志，2014，9（16）：102-103.
[6] 胡艳东.支气管肺泡灌洗联合局部抗生素治疗支气管扩张并发感染的有效性探究[J].中国现代药物应用，2015， 9（24）：188-189.
[7] 杨茜.支气管肺泡灌洗联合局部抗生素治疗支气管扩张并发感染的效果观察[J].中国现代药物应用，2014，6（6）：129-130.
[8] 王丽英.重症肺部感染应用纤支镜支气管肺泡灌洗并局部抗生素治疗的临床观察[J].医疗装备，2015，11（16）：39-40.
[9] 陈亚利，戴华.创伤及术后重症肺部感染者纤支镜支气管肺泡灌洗术80例疗效观察[J].四川医学，2009，30（7）：1074-1076.
[10] 管彩虹，楼雅芳，陈旭燕，等.纤维支气管镜灌洗与常规治疗对重症肺部感染合并肺不张的疗效分析[J].中国内镜杂志，2014，20（6）：612-615.
[11] 顾文东，吕卫兵，赵勤峰，等.支气管肺泡灌洗在重症肺炎患者治疗中的价值临床研究[J].航空航天医学杂志，2016，27（8）：949-951.
[12] 张建军.炎症介质对脑损伤患者呼吸机相关性肺炎的早期诊断和预测[D].石家庄：河北医科大学，2014：25-28.
[13] 李艳丽.纤支镜下肺泡灌洗治疗难治性肺炎的疗效探析[J].临床肺科杂志，2016，9（2）：293-295.
[14] 蔡远玲.支气管肺泡灌洗对难治性肺炎的疗效观察[J].中国实用医药，2016，11（18）：7-9.
[15] 刘武胜，李如梅，宋志峰，等.重症肺炎患者肺泡灌洗液的炎症因子动态变化特点及临床意义[J].临床肺科杂志，2016，21（5）：831-834.
[16] 陈建丽，徐超，李振华，等.经支气管镜肺泡灌洗治疗卒中相关性肺炎的疗效观察[J].中国继续医学教育，2016， 8（9）：109-110.
[17] 倪楠，林琳.支气管肺泡灌洗治疗老年重症肺炎的临床疗效观察[J].中华老年多器官疾病杂志，2016，15（1）：34-37.
[18] 何悦成.支气管肺泡灌洗在重症肺炎患者的价值[J].中国保健营养，2016，26（20）：271-272.
[19] 李芝兰.支气管肺泡灌洗在重症肺炎患者治疗中的价值研究[J].中国实用医刊，2016，43（14）：25-27.
[20] 蔡林再，王成存，谢五菊，等.纤支镜下支气管肺泡灌洗在治疗重症肺炎中的可行性分析[J].医学理论与实践，2016，29（7）：895-896.
[21] 徐洪建.支气管肺泡灌洗加注抗生素治疗肺脓肿24例分析[J].基层医学论坛，2017，21（10）：1166-1168.
[22] 谭经福，叶永青，杨龙峰，等.内科常规治疗联合支气管肺泡灌洗治疗支气管扩张并感染[J].现代诊断与治疗，2016，27（10）：1773-1775.
[23] 何悦成.支气管肺泡灌洗在重症肺炎患者的价值[J].中国保健营养，2016，26（20）：271-272.
[24] 王涛.支气管内全身麻醉下结核性胸膜炎胸膜剥脱术中行小剂量局部支气管肺泡灌洗的疗效观察[J].中国医药指南，2017，15（3）：130.
[25] 陈肖华，凌宙贵，唐贞明，等.比较3种采样方法在下呼吸道感染病原学诊断的价值[J].临床肺科杂志，2017， 22（4）：649-652.
[26] 张振安，张风林，董晓娜，等.支气管镜下肺泡灌洗治疗支气管扩张合并感染的疗效研究[J].中国医学装备，2015，（12）：111-114.