盐酸羟考酮联合帕瑞昔布钠对后腹腔镜肾癌根治术患者的影响

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Abstract Objective To investigate the effect of Oxycodone Hydrochloride combined with Parecoxib Sodium on patient-controlled intravenous analgesia (PCIA) with Sufentanil in patients after retroperitoneal laparoscopic radical nephrectomy. Methods 60 patients with kidney cancer scheduled for elective retroperitoneal laparoscopic radical surgery under general anesthesia and accepted PCIA from May to August 2016 in the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, were randomly divided into 3 groups: control group (group S); Parecoxib Sodium group (group P) and Oxycodone Hydrochloride combined with Parecoxib Sodium (group O) group according to random number table, each group had 20 cases. Group S received intravenous normal saline 5 mL 30 min before incision and 30 min before the end of the operation. Group P received intravenous Parecoxib Sodium 40 mg 30 min before incision. Group O received intravenous Parecoxib Sodium 40 mg 30 min before incision and received intravenous Oxycodone Hydrochloride 0.1 mg/kg 30 min before the end of the operation. The three groups were all given PCA with Sufentanil until 48 h after surgery. The visual analogue scale (VAS), Ramsay sedation score at 0.5, 6, 12, 24, 48 h after operation, Shufentanil consumption and effective compressions number of PCA, the side effects and patient satisfaction were recorded. Results The VAS scores were significantly lower at each time points after operation in group P and group O compared with group S (P < 0.05); the VAS scores were significantly lower at 0.5, 6, 12 h in group O compared with group P (P < 0.05); there were no significantly differences in VAS scores at 24, 48 h between group O and group P (P > 0.05). The Ramsay sedation score was higher at 0.5 h after operation in group O compared with group P and group S (P < 0.05). The effective compressions numbers of PCA were significantly less in group P and group O than in group S (P < 0.05), group O were less than group P (P < 0.05). The Shufentanil consumption of PCA in group P and group O were less than group S (P < 0.05). The patients' satisfaction rates were higher in group P and group O than in group S (P < 0.05), group O was higher than group P (P < 0.05). There was no significant difference in side effects among the three groups (P > 0.05). Conclusion Oxycodone Hydrochloride can be safe and effective used for postoperative analgesia, combined with Parecoxib Sodium can improve the effect of PCA with Sufentanil in patients after retroperitoneal laparoscopic radical nephrectomy.

Key words： Oxycodone Hydrochloride Parecoxib Sodium Sufentanil Patient controlled analegsia Laparoscopic Kidney cancer

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	ZHAN Huiming HUANG Juanjuan CHEN Jingli

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ZHAN Huiming HUANG Juanjuan CHEN Jingli. Effects of Oxycodone Hydrochloride combined with Parecoxib Sodium on patients after retroperitoneal laparoscopic radical nephrectomy[J]. 中国医药导报, 2017, 14(25): 73-76,93.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I25/73

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