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| Assessing the clinical value of serum amyloid A protein and C-reactive protein on the diagnosis of children with Mycoplasma pneumoniae infection |
| LI Pan1 YANG Jian2 CAO Huicai1 |
1.Clinical Laboratory, East Branch of Baoding First Central Hospital, Heibei Province, Baoding 071000, China;
2.Clinical Cytogenetics Laboratory, Baoding Maternal and Child Health Hospital, Heibei Province, Baoding 071000, China |
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Abstract Objective To investigate the clinical value of serum amyloid A protein (SAA) and C-reactive protein (CRP) on diagnosis of children with Mycoplasma pneumoniae (Mp) infection. Methods From January to December 2016, in East Branch of Baoding First Central Hospital, the data of 159 hospitalized children with pulmonary infection were retrospectively analyzed, including 124 Mp infection children (Mp infection group), 35 bacterial infection children (bacterial infection group), 20 healthy children were selected as control group at the same period. The level of SAA and CRP in three groups were detected and analyzed, ROC was used to analyze. Resluts SAA and CRP in three groups were compared, the difference was statistically significant (P < 0.05), the SAA and CRP of bacterial infection groups were higher than other groups (P < 0.05), the SAA and CRP of MP infection group were higher than control group (P < 0.05), but the SAA/CRP of each group was compared, the difference was not statistically significant (P > 0.05). The area under the ROC of SAA and CRP on the diagnosis of MP infection was 0.95 and 0.33, the bacterial infection was 0.88 and 0.86. Conclusion SAA has higher accuracy on the diagnosis of MP and bacterial infection; CRP has higher accuracy on the diagnosis of bacterial infection, it is insignificant for the clinical value of distinguishing and diagnosis the children with MP infection. SAA can be used for distinguishing and diagnosing the children with MP infection and should be extensively used for clinical practice; the clinical value of CRP on diagnosis the children with MP infection still need a deep research.
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