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2018 Vol. 15, No. 17
Published: 2018-06-15
 
 
4 Anti-oxidative damage effect on PC12 cells transfected with human ApoE3 gene
ZHAO Rui YAO Liqing
Objective To observe the effect of human ApoE3 gene high expression on the apoptosis of rat adrenal pheochromocytoma PC12 cells. Methods The pEGFP plasmid containing human ApoE3 gene and pEGFP plasmid were transfected with PC12 cells, and PC12 cell line was established that could stably express human ApoE3 gene and pEGFP plasmid through continuous screening. PC12 cells were allocated into 4 groups: normal control group, H2O2 group (cultured with 400 μmol/L H2O2 for 4 hours), liposome group (pEGFP transfection and H2O2 culture) and ApoE3 group (ApoE3 transfection and H2O2 culture). Cell survival was tested by CCK-8 method, cell apoptosis was detected by Hochest33258. Results Compared with the normal control group, cell survival rate was decreased in the other three groups (P ＜ 0.05), while cell apoptotic was increased. The differences in the indexes mentioned above were not significant between H2O2 group and liposome group(P ＞ 0.05). The cell survival rate was higher in the ApoE3 group, compared with H2O2 group and H2O2+liposome group (P ＜ 0.05); the apoptosis was obviously lower in the ApoE3 group, compared with the H2O2 group and H2O2+liposome group. Conclusion The overexpression of ApoE3 gene has a great protective effect on the oxidative damage of PC12 cell mediated by H2O2.
2018 Vol. 15 (17): 4-6,11 [Abstract] ( 232 ) HTML (1 KB)  PDF (568 KB)  ( 157 )
7 Expression of intestinal sweet taste receptors and incretin secretion in diabetic rats
QIAN Cheng1 FENG Rilu1 WU Bin2 MA Jing1
Objective To observe the expression of sweet taste receptors (STRs) and downstream molecules in the ileum and gut hormone secretion in diabetic rats. Methods SD rats (CON group), zucker diabetic fatty (ZDF group) rats and STZ-induced diabetic rats (STZ group) were involved in this study (n = 7). The rats in each group were received an intragastric glucose tolerance test. Blood samples were taken for measurement of blood glucose, plasma insulin and GLP-1 concentrations. One week later, small intestinal tissue was collected and expression of STRs was detected by RT-PCR. Results T1R3 and α-gustducin in the ileum of ZDF group were down-regulated than those of CON and STZ group (P < 0.05). Fasting and postprandial glucose concentrations in STZ group were higher than CON and ZDF group at 0, 15, 30, 60, 120 min (P < 0.01). Fasting and postprandial plasma insulin and GLP-1 levels were higher in ZDF group than CON and STZ group (P < 0.05 or P < 0.01). Conclusion The ileum expression of T1R3 and its downstream signaling molecules is disordered in ZDF rats, indicating that the expression of intestinal STRs is related to glucose metabolism. The mechanism underneath it still needs further investigation.
2018 Vol. 15 (17): 7-11 [Abstract] ( 206 ) HTML (1 KB)  PDF (805 KB)  ( 241 )
12 Expression and clinical significance of SLC19A3 in breast cancer and effects of Bufalin on the expression of SLC19A3: analysis based on the data-mining from bioinformatics
LI Dan1 YU Tao2,3 LI Jing1 ZHANG Fan1 ZENG Junfen1 PENG Yan1
Objective To analyze the expression and its clinical significance of SLC19A3 gene in breast cancer and to explore the effects of Bufalin on the expression of SLC19A3 in breast cancer cells. Methods The datasets about breast cancer and effects of Bufalin on breast cancer cell were retrieved from Oncomine and GEO database, and the datasets were deeply mined and analyzed with literature. SLC19A3 mRNA expression between normal group and breast cancer group as well as correlation with prognosis were analyzed. Meanwhile, the effect of Bufalin on the expression level of SLC19A3 gene in breast cancer cells was also analyzed. Results The expression of SLC19A3 gene in breast cancer tissues was significantly higher than that of breast normal tissues through mining and analyzing the 9 datasets about SLC19A3 gene in breast carcinoma from Oncomine database (P ＜ 0.05). Survival analysis showed that the disease-free survival of breast cancer patients with higher expression of SLC19A3 gene was significantly better than the patients with lower expression of SLC19A3, and the prognosis of patients with high expression of SLC19A3 gene was better (P ＜ 0.05). Finally, the mRNA expression of SLC19A3 gene was up-regulated by Bufalin in the datasets of GSE85871 through mining the GEO database (P ＜ 0.01). Conclusion SLC19A3 gene is under-expressed in breast cancer and its expression level is related to the prognosis of breast cancer, which may be a new target of effects of Bufalin on breast cancer cells.
2018 Vol. 15 (17): 12-16 [Abstract] ( 238 ) HTML (1 KB)  PDF (922 KB)  ( 154 )
17 The gene phenotype, protein expression of TP53 gene in Uygur′s esophageal carcinoma and its correlation with prognosis
Abudoushalamu·Abudoureheman1 Madinyet·Niyaz2 ZHANG Haiping1 Julaiti·Ainiwaer1 Abudouaini·Tuerhong1 ZHANG Liwei1 Ilyar·Shayhedin1 Idiris·Awut1
Objective To study the TP53 gene deletion and p53 protein expression level in Uygur′s esophageal carcinoma, and its correlation with prognosis of Uygur esophageal cancer patients. Methods Sixty-seven cases of Uygur esophageal squamous cell carcinoma treated by radical resection from December 2009 to June 2013 in Department of Thoracic Surgery, the First Affiliated Hospital of Xinjiang Medical University were selected. TP53 gene deletion and p53 protein expression was detected respectively by fluorescence in situ hybridization and immuno-histo-chemistry  methods. The relationship of TP53 gene deletion and p53 protein expression with clinicopathological factors and postoperative survival rate was analyzed. Results In the highly differentiated group, the deletion rate of TP53 gene was 15.00%, which of moderate and poorly differentiation group was 40.43%, the difference was statistically significant (P ＜ 0.05). There was no significant difference of the deletion rate of TP53 gene in different tumor invasion depth and lymph node metastasis status (P ＞ 0.05). There was no significant difference of the degree of p53 protein expression in different degrees of tumor differentiation, tumor invasion depth and lymph node metastatis status (P ＞ 0.05). Conclusion There is a certain correlation between TP53 gene deletion and the differentiation degree of esophageal carcinoma tumor, but the relationship with the survival has not been determined. The TP53 gene deletion and p53 protein expression level cannot be seen as the prognostic biomarkers of Uygur patients with esophageal cancer. Therefore, larger sample capacity is needed for in-depth exploration and determination.
2018 Vol. 15 (17): 17-20 [Abstract] ( 226 ) HTML (1 KB)  PDF (497 KB)  ( 27 )
21 Research progress of long non-coding RNAs in ischemia reperfusion injury of important tissue and organs
WANG Yi LIANG Jiuqing SUN Huilin YANG Dan ZHANG Liangqing▲ HU Zhe▲
In recent years, more and more studies have suggested that long non-coding RNAs (lncRNAs) can participate in the vital movement of all kinds of cells and the emergence and development of many diseases. However, the regulating effects of lncRNA in the pathological process of ischemia-reperfusion injury (IRI) have not been clarified. To further understand the role of these lncRNAs in IRI will help to know about the molecular regulatory network after IRI, which has great significance for seeking new biomarkers and therapeutic targets of IRI, protecting important tissue and organs, and improving the clinical prognosis of patients. This paper reviews the currently known effects of lncRNA in the IRI of important organs of heart, brain, liver, kidney and lung, and summarizes some lncRNAs those have not been researched deeply, so as to provide direction for future deeper mechanism research.
2018 Vol. 15 (17): 21-24 [Abstract] ( 257 ) HTML (1 KB)  PDF (459 KB)  ( 102 )
25 Research progress of indocyanine green-loaded nanomaterials in tumor diagnosis and therapy
HAN Cuiping1,2 HANG Yinhui1 ZHANG Dujuan1 DING Jiazheng1 WANG Keying1
Indocyanine green (ICG) is a biocompatible near-infrared fluorescent dye that can be used in many fields such as tumor imaging and potothermal therapy. But its low stability, rapid metabolism and low cell uptake limited its efficient use. The rapid development of nanotechnology provids a solution platform for this problem. Multifunctional ICG-loaded nanomaterials have many advantages in controlling the release of drugs, improving the biological stability of drugs, enhancing the availability and targeting of drug delivery, etc. It has great application prospect in the field of early diagnosis and treatment of tumor. In this paper, the properties and characteristics of ICG-loaded nanomaterials are summarized, and their latest research progress in the field of multi-modal imaging diagnosis, combined therapy and combined therapy under the guidance of multi-modal imaging application is reviewed.
2018 Vol. 15 (17): 25-27,31 [Abstract] ( 369 ) HTML (1 KB)  PDF (472 KB)  ( 240 )
28 The mechanisms of oxidative stress damage on sperms and protection
LI Tiantian1 ZHANG Xingying1 LI Lianqin2▲
The occurrence of infertility is increasing with the rapid mode of work, change of life style and environmental pollution. The main cause of male infertility is abnormal sperms including asthenospermia, oligospermia, azoospermia and sperm malformation. One of the mechanisms that causes abnormal sperms is the increasing of reactive oxygen species level, which results in the oxidative damage on the DNA, lipid and mitochondria of sperms. In addition to the supplement of vitamin E, vitamin C and Chinese herbal medicine, good life habits and proper physical exercises will help to enhance self antionxidant capacity and improve the quality of sperms.
2018 Vol. 15 (17): 28-31 [Abstract] ( 252 ) HTML (1 KB)  PDF (460 KB)  ( 135 )
32 Effect of menstrual volume on the premenstrual symptoms and coping styles of female nursing students in a city
XU Na1 ZHANG Yongai1 ZHAO Jiang2 YUE Huijuan3 ZHANG Haimiao1
Objective To understand the relationship between premenstrual symptoms and coping styles in female nursing students with different menstrual volume, in order to provide scientific basis for female nursing students' health care work. Methods Through multistage stratified cluster random sampling, 1061 female nursing students from 4 grades in 3 medical universities were recruited from September to December in 2017. Self-made questionnaire, menstrual symptoms scale and menstrual coping styles scale were used and the data were analyzed by SPSS 18.0. Results There were significant differences in premenstrual symptoms among female nursing students with different menstrual volume(P < 0.05). There were significant differences in menstrual coping styles such as general processing, positive behavior and positive cognition among female nursing students with different menstrual volume (P < 0.01). While there were no significant differences in negative behavior among female nursing students with different menstrual volume (P > 0.05). Conclusion The female nursing students with different menstrual volume have different premenstrual symptoms and menstrual coping styles. Health guidance should be provided according to the health status of female nursing students.
2018 Vol. 15 (17): 32-35,39 [Abstract] ( 231 ) HTML (1 KB)  PDF (467 KB)  ( 111 )
36 Survey on the elderly endowment models selection and its influencing factors in Sichuan
LIU Zhenfan1，2 LI Xin1 DONG Wenju1 SHUI Wenting1 LONG Lin1,2 TIAN Xiaobing3
Objective To understand the elderly endowment models selection and its influencing factors in Sichuan. Methods From July 2016 to July 2017, the convenience sampling method was used to analyze the influencing factors and endowment model selection among the 1053 elder people in Nanchong, Deyang, Guangyuan, Guangan, Dazhou, Mianyang, six regions of Sichuan by self-designed questionnaire. Results Among the 1053 people, the percentages of elder people selected community home care，institution endowment and family endowment were 6.9％, 9.2％ and 83.9％,respectively. In the analysis of single factor, the endowment models selection was influenced by gender, cultural degree, permanent residence, monthly income, relationship satisfaction with the children, the number of children, and the number of old-age pension resources (P < 0.05). In multiple factor Logistic regression analysis, the more older, the less educated, living in village and satisfied with their children′s relationship, the more were willing to accept family endowment; the elder people with fewer children were more likely to be accept institution endowment; while the elderly with the more sources of old-age care expenses were more likely to be accept community home care （P < 0.05）. Conclusion Constrained by a variety of factors, family endowment is still the main endowment models. In the weakening of the family function and the surge of pension demand, building a suitable endowment models to meet the demand of the elderly endowment, rational utilization of resources endowment, implementation "health Sichuan 2030" healthy aging has play a positive role.
2018 Vol. 15 (17): 36-39 [Abstract] ( 263 ) HTML (1 KB)  PDF (454 KB)  ( 99 )
40 Clinical effect of long-term aerobic exercise combined with Guizhi Fuling Capsules in treatment of carotid atherosclerosis
LI Jianbing1 YANG Jianquan2
Objective To explore the clinical efficacy of long-term aerobic exercise combined with Guizhi Fuling Capsules in the treatment of carotid atherosclerosis. Methods From January 2016 to January 2017, in the Affiliated Hospital of Xi′an Medical University, 186 patients with hypertensive carotid atherosclerosis were selected, according to the random number table method, they were divided into control group A (simple long-term aerobic exercise), control group B (simple Guizhi Fuling Capsules treatment) and test group C (combined therapy of aerobic exercise and Guizhi Fuling Capsules), with 62 cases in each group. The blood pressure level, blood lipid level and the thickness of carotid artery (CIMT) and plaque area in the three groups were compared. Results After the treatment, the diastolic pressure and systolic pressure level in test group C were significantly lower than the control group A and the control group B, the differences were statistically significant (P < 0.05); the levels of total cholesterol, triglyceride and low density lipoprotein in test group C were significantly lower than the control group A and control B group, the high density lipoprotein was significantly higher than the control A group and the control B group, the differences were statistically significant (P < 0.05); the CIMT and plaque area after treatment in the test group C was significantly smaller than the control group A and control group B, the differences were statistically significant (P < 0.05). Conclusion The long-term aerobic exercise combined with Guizhi Fuling Capsules can effectively improve the blood pressure and lipid metabolism of the patients, reduce the thickness of the carotid artery and the area of the plaque, and the clinical effect is significant.
2018 Vol. 15 (17): 40-43 [Abstract] ( 731 ) HTML (1 KB)  PDF (455 KB)  ( 138 )
44 Clinical study of QT dispersion, heart rate variability and ventricular late potentials in patients with aortic arch calcification maintenance hemodialysis
WU Chuhai ZHU Shiyan CHENG Zhuo
Objective To investigate the clinical significance of QT dispersion, heart rate variability and ventricular late potentials in patients with aortic arch calcification maintenance hemodialysis. Methods From January 2014 to December 2017, in the Third Affiliated Hospital of Guangdong Medical University, 52 patients with maintenance hemodialysis were selected, according to whether with or without aortic arch calcification, patients were divided into calcification group (35 cases) and non-calcification group (17 cases). The basic clinical indexes, QT dispersion, heart rate variability index and ventricular late potentials in two groups were compared. Results Compared with the non-calcification group, the average age of the patients in the calcification group was more, the mean duration of dialysis was longer, and the mean pulse pressure difference was higher, the differences were statistically significant (P < 0.05). The QTd, Q-Tcd and E/E' in the calcification group were significantly higher than those in the non-calcification group, the differences were statistically significant (P < 0.05) . There was no significant difference in EF between the two groups (P > 0.05). The LFn value and LF/HF ratio in the calcification group were significantly lower than those in the non-calcification group, the differences were statistically significant (P < 0.05). There was no significant difference in HFn values between the two groups (P > 0.05). Conclusion Maintaining calcification of the aortic arch in hemodialysis patients can causes changes of cardiac QT dispersion, reduced heart rate variability, in order to make a greater likelihood of ventricular late potentials in patients.
2018 Vol. 15 (17): 44-47 [Abstract] ( 233 ) HTML (1 KB)  PDF (490 KB)  ( 79 )
48 Effects of platelet parameters on incidence of major adverse cardiac events in patients with acute myocardial infarction after primary percutaneous interventional therapy
WANG Wenbin JIAN Hongwei CHENG Guojie TANG Xuehong LI Xin
Objective To explore the relationship between platelet parameters and the incidence of major adverse cardiac events (MACE) in STEMI patients treated with percutaneous coronary intervention (PCI), and evaluate the predictive efficacy of each platelet parameter on MACE events. Methods From July 2013 to July 2017, the clinical data of 365 STEMI patients treated with primary PCI in the Daxing District People's Hospital were retrospectively analyzed. The date of MACE patient during the follow-up were recorded. According to the follow-up results, they were divided into two groups: MACE group (144 cases) and no MACE group (211 cases). The differences in baseline data and platelet parameters between the two groups were compared. Results There were significant differences between the two groups in age, hypertension history, platelet count, mean platelet volume and platelet distribution width (P < 0.05). Logistic regression analysis showed that MPV was independently associated with short-term MACE in acute STEMI after primary PCI (OR = 4.54, 95%CI: 1.11-18.47, P = 0.035). The sensitivity and specificity of MPV in predicting MACE were 72.9 % and 72.7%, respectively. Conclusion The increase in MPV is associated with recent MACE in STEMI patients after primary PCI and may be an independent predictor of the short-term prognosis of such patients.
2018 Vol. 15 (17): 48-51 [Abstract] ( 208 ) HTML (1 KB)  PDF (562 KB)  ( 166 )
52 Effect of rehabilitation intervention on functional recovery and common complications in severe ischemic stroke patients
FU Pingping1 JIN Peiying2 JIANG Ying1 XIE Wenlong1 HE Fengxiang1
Objective To research the effect of rehabilitation intervention for severe patients with acute ischemic stroke in neurological function, motor function , activities of daily living, and the occurrence of pulmonary infection and shoulder pain. Methods From January 2016 to September 2017, in EICU, Huzhou Central Hospital, 96 patients with were acute ischemic stroke treated were selected, according to random number table method, they were divided into three groups according to random number table method, with 32 cases in each group. The severe rehabilitation group received rehabilitation treatment when they were in hospital at the first day, the early rehabilitation group received rehabilitation treatment when the sign of life was smooth after 48 hours, the conventional rehabilitation group received rehabilitation 2 weeks after they came in hospital. The outcome measures included the National Institute of health stroke scale (NIHSS), modified Barthel index (MBI) and Fugl-Meyer motor assessment scale (FMA) performed seperately when they were in hospital first day, after treatment 1 month and 3 months. The common complications of  pulmonary infection and shoulder pain were accumulated during 3 months. Results The NIHSS, MBI, FMA scores after treatment 1 month and 3 months in the three groups were compared with those at the time of admission, the differences were statistically significant (P < 0.01). The NIHSS, MBI, and FMA scores in the severe rehabilitation group and early rehabilitation group were compared with the conventional rehabilitation group after treatment 1 month and 3 months, the differences were statistically significant (P < 0.01). During the 3 months of treatment, the frequencies of common complications of pulmonary infection and shoulder pain in the severe rehabilitation group were 21 and 3, in the early rehabilitation group were 28 and 9, and in the conventional rehabilitation group were 39 and 13. Conclusion The rehabilitation intervention for severe patients with acute ischemic stroke can effectively improve the neurological function, motor function and activities of daily living, and decrease the occurrence of the common complications of pulmonary infection and shoulder pain. Mastering the indications, standard individual rehabilitation treatment is practicable, though the patients with acute ischemic stroke are especially severe.
2018 Vol. 15 (17): 52-55 [Abstract] ( 211 ) HTML (1 KB)  PDF (483 KB)  ( 80 )
56 Influence of swallowing rehabilitation training under standard swallowing function evaluation on rehabilitation effect in stroke patients with swallowing dysfunction
MA Junting YUAN Yan▲
Objective To investigate influence of swallowing rehabilitation training under standard swallowing function evaluation on rehabilitation effect in stroke patients with swallowing dysfunction. Methods From January 2011 to December 2016, in Liaocheng People′s Hospital, 104 patients with dysphagia after stroke were selected, according to the random digital table method, they were divided into the control group and observation group, with 52 cases in each group. The control group received routine rehabilitation training, observation group received swallowing rehabilitation training under standard swallowing function evaluation. Swallowing function and speech function were evaluated before and after rehabilitation training, and the nutrition indexes were detected, the clinical efficacy and adverse events in two groups were compared. Results After the rehabilitation training, the levels of albumin, hemoglobin, transferrin, prealbumin, total cholesterol, triglyceride in two groups increased compared with before rehabi litation, and those in the study group were better than those in the control group, the differences were statistically significant (P < 0.01). After rehabilitation training, the scores of Burke, NHISS and SSA in both groups decreased compared with before rehabi litation, VESS increased, and these in the study group were better than those in the control group, the differences were statistically significant (P < 0.01). After rehabilitation training, in the Watian drinking water test, the drinking time and choking phlegm times in two groups significantly decreased, and these in the study group were better than those in the control group, the differences were statistically significant (P < 0.05). The treatment efficiency in the study group was higher than that in the control group, the difference was statistically significant (P < 0.05). The rate of adverse events in the study group was lower than that in the control group, the difference was statistically significant (P < 0.05). Conclusion Swallowing rehabilitation training under standard swallowing function evaluation can improve rehabilitation effect in stroke patients with swallowing dysfunction, which is worthy of clinical use.
2018 Vol. 15 (17): 56-60,64 [Abstract] ( 244 ) HTML (1 KB)  PDF (547 KB)  ( 211 )
61 Prognosis factors of transient ischemic attack within 7 days
DONG Min1 CHE Zhenyong2▲ ZHAO Jianting2 WANG Huimin2
Objective To explore the factors of affecting the prognosis after transient ischemic attack (TIA) within 7 d. Methods From June 2015 to June 2016, in Xinxiang Central Hospital, 56 patients with TIA and were examined by perfusion-weighted imaging (PWI) and diffusion-weighted imaging (DWI) within 24 hours after onset were selected, there was no cerebral ischemia in DWI images. Meanwhile, the ABCD2 score was applied, the incidence of patients with cerebral infarction within 7 d were followed-up and observed. Results 23 cases (41.1%) had cerebral infarction in 56 patients with TIA within 7 d. The incidence of cerebral infarction in the low risk group of ABCD2 score was lower than that in the middle risk group and the high risk group within 7 d, the middle risk group was lower than the high risk group, the differences were statistically significant (P < 0.05). The incidence of cerebral infarction in the patients with positive MR-PWI examination was significantly higher than that in the negative patients within 7 d, the differences were statistically significant (P < 0.05). Logistic regression analysis showed that PWI positive (OR = 2.998, 95%CI: 1.456-6.172, P = 0.003), ABCD2 score (OR = 3.765, 95%CI: 1.193-11.878, P = 0.024), intracranial vascular stenosis (OR = 4.743, 95%CI: 2.109-10.667, P = 0.000) and atrial fibrillation (OR = 3.051, 95%CI: 1.185-7.855, P = 0.021) were risk factors of cerebral infarction of TIA within 7 d. Conclusion Positive magnetic resonance perfusion imaging, ABCD2 score, intracranial vascular stenosis and atrial fibrillation are important prognostic factors of TIA diseases.
2018 Vol. 15 (17): 61-64 [Abstract] ( 209 ) HTML (1 KB)  PDF (534 KB)  ( 60 )
65 Efficiency of combination therapy with Jiannao Zhichou Granules and Tiapride in children with tourette syndrome
YANG Shenghai1 WANG Liwen1 WANG Jun1 XU Cuijuan1 WAN Fuqin1 GUO Jian2
Objective To observe the clinical efficacy of combination therapy with Jiannao Zhichou Granules and Tiapride in children with Tourette syndrome (TS). Methods Children with TS diagnosed in outpatient of Children′s Hospital affiliated to Children′s Hospital, Capital Institute of Pediatrics were collected from March to November in 2015, which were randomly divided into treatment group and control group, with 30 cases in each group. The control group was treated with monotherapy of Tiapride, and the treatment group was treated with combination therapy with Jiannao Zhichou Granules and Tiapride. They were treated for 12 weeks. The daily dosage of Tiapride in the two groups were recorded, the Yale global tic severity scale (YGTSS) before and after treatment and the treatment efficiency in the two groups were compared. Results The daily dosage of Tiapride in the treatment group was lower than that in the control group (P < 0.05). The YGTSS scores at 4, 8 and 12 weeks after treatment in both groups were lower than that before treatment in the same group (P < 0.05), besides after treatment, the YGTSS scores in the treatment group at 4, 8 and 12 weeks after treatment were lower than those in the control group at the same time (P < 0.05). There was no statistically significant difference between the two groups in treatment efficiency (P > 0.05). Conclusion Combination therapy with Jiannao Zhichou Granules and Tiapride cannot significantly improve the treatment efficiency, while it can reduce the daily dosage of Tiapride and the YGTSS score clearly, compared with monotherapy of Tiapride.
2018 Vol. 15 (17): 65-67,71 [Abstract] ( 253 ) HTML (1 KB)  PDF (531 KB)  ( 117 )
68 Impact of subclinical hypothyroidism on the insulin resistance and lipid profiles of PCOS patients
YIN Dongmei1 RUAN Xiangyan1▲ TIAN Xuanxuan1 LU Yongjun2
Objective To evaluate the characteristics of insulin resistance and lipid metabolism of PCOS patients with SCH. Methods A total of 200 patients with PCOS were recruited at the Department of Endocrinology, Beijing Obstetrics and Gynecology Hospital from September 2015 to October 2016. And they were divided into two groups: 41 cases of subclinical hypothyroidism (SCH-PCOS group) as study group and 159 cases of normal thyroid function (EU-PCOS group) as control group. The clinical features, sex hormone levels, fasting insulin levels and serum lipids between the groups were investigated. Results Body mass index (BMI), fasting insulin (FIN) and homeostatic model assessment -insulin resistance (HOMA-IR ) were higher than those in SCH-PCOS group (P ＜ 0.05). Lipid metabolism was slightly abnormal, but the difference was not statistically significant (P > 0.05). Conclusion The analysis indicates that PCOS complicated with SCH patients have more severe obesity and insulin resistance than those with normal thyroid functions.
2018 Vol. 15 (17): 68-71 [Abstract] ( 197 ) HTML (1 KB)  PDF (521 KB)  ( 342 )
72 The effect of hydrodissection with diluted pituitrin on ovarian function after laparoscopic operation on unilateral ovarian endometriosis cyst
PAN Zhuo1 HU Chang′e2 SU Jingjing3
Objective To explore the effect of hydrodissection with diluted pituitrin on ovarian function after laparoscopic operation on unilateral ovarian endometriosis cyst. Methods Sixty patients with unilateral ovarian endometriosis cyst underwent laparoscopic cystectomy in Panjin People′s Hospital from March 2015 to January 2017 were selected. According to operation methods, they were divided into three groups: pituitrin group (group A), physiological saline group (group B) and electro surgical instruments group (group C), with 20 cases in each group. The operation time, hemoglobin and anti-müllerian hormone (AMH) values before and after operation were compared. Results There were no significant differences among the three groups in operation time, hemoglobin value before and after operation (P ＞ 0.05). After operation for 1, 3, 6 months, the levels of serum AMH in the three groups were all lower than those before operation, the differences were statistically significant (P ＜ 0.05). After operation for 1, 3, 6 months, there were no significant differences in the serum AMH value between group A and group B (P ＞ 0.05), but the indices of both groups were higher than that of group C (P ＜ 0.05). Conclusion The ovarian reserve function will be reduced after laparoscopic cystectomy for unilateral ovarian endometriosis cyst, and the reserve function can be protected by hydrodissection with diluted pituitrin.
2018 Vol. 15 (17): 72-75 [Abstract] ( 201 ) HTML (1 KB)  PDF (543 KB)  ( 140 )
76 Effects of Yinzhihuang Granules and microecologics agents on pathological jaundice of newborn
LI Yan
Objective To explore the clinical efficacy of Yinzhihuang Granules and microecologics agents on pathological jaundice of newborn. Methods Seventy-five neonates with pathological jaundice treated in Department of Pediatrics, the People's Hospital of Dachang Hui Autonomous County in Langfang City from October 2015 to June 2017 were selected. They were divided into control group (37 cases) and observation group (38 cases) according to random number table. Both groups were given conventional treatment and oral Yinzhihuang Granules, the observation group was given oral microecologics of Bacillus Cereus Tablets besides the conventional treatment for 1 week. The indices were compared before and after treatment in the two groups, including clinical efficacy, serum bilirubin concentration, serum related indicators, jaundice fade time and adverse events. Results After treatment, the total effective rate in the observation group (100.00%) was significantly higher than that in the control group (91.89%) (P ＜ 0.05); after treatment, the serum bilirubin in the observation group was significantly lower than that before treatment and more lower than the control group. Compared with control group, daily decrease of bilirubin was more remarkable and the jaundice fade time was shorter in the observation group, the difference was statistically significant (P ＜ 0.05). After treatment, the hematological parameters such as alanine aminotransferase, total bile acid and total bilirubin in the observation group turned better than those before treatment, which were better than those in the control group (P ＜ 0.05). No serious adverse reactions occurred during treatment. Only one case of mild diarrhea occurred in the observation group and recovered after symptomatic treatment that did not affect the treatment. Conclusion The combination of microecologics of bacillus cereus with Yinzhihuang Granules in the treatment of pathological jaundice of newborn can significantly improve the therapeutic effect, shorten the courses of pathological jaundice of newborn, optimize the serum jaundice related indicators, and does not increase the adverse reactions in children, with good treatment safety, it is worthy of promotion and application in clinic.
2018 Vol. 15 (17): 76-79 [Abstract] ( 711 ) HTML (1 KB)  PDF (513 KB)  ( 103 )
80 Clinical efficacy comparison of different dose-intensity SOX in neoadjuvant chemotherapy for advanced gastric cancer
SHEN Xu′ning ZHU Yi PENG Yuping
Objective To investigate the clinical efficacy of Oxaliplatin + SOX at different doses of chemotherapy in neoadjuvant chemotherapy for advanced gastric cancer. Methods From November 2011 to December 2016, 66 patients with advanced gastric cancer received neoadjuvant chemotherapy of SOX regimen in the Department of Gastrointestinal Surgery, the First Hospital of Jiaxing City were selected as the research subjects and divided into the standard dose intensity group (31 cases, Oxaliplatin:130 mg/m2, d1; SOX:60 mg/d, d1-14) and low dose group (35 cases, Oxaliplatin:104 mg/m2, d1; SOX:50 mg/d, d1-14) by draw method. The clinical efficacy, surgical conditions, adverse reactions to chemotherapy, survival time under the different doses of intensity SOX were analyzed. Results There were no statistically significant differences in the total clinical effective rate, the tumor control rate and R0 resection rate (all P ＞ 0.05). The incidences of thrombocytopenia and peripheral neurotoxicity in the standard dose intensity group were all significantly higher than those of low dose group, with statistically significant differences (all P ＜ 0.05). Follow-up was performed in 55 patients with gastric cancer underwent R0 resection. There were no statistically significant differences in 1 year and 3 years survival rate (all P ＞ 0.05). The median survival time in both groups was 33 months. Conclusion Compared with the standard dose intensity SOX regimen, the low dose SOX has the same efficacy and long-term efficacy for patients with gastric cancer requiring neoadjuvant chemotherapy and has greater safety.
2018 Vol. 15 (17): 80-84 [Abstract] ( 1112 ) HTML (1 KB)  PDF (611 KB)  ( 85 )
85 Effect of synchronous iodine-125 seed strand implantation and transcatheter arterial chemoembolization in the treatment of primary hepatocellular carcinoma combined with portal vein main tumor thrombus
LIN Jiejun LU Lijie JIN Xiaojun BAO Luowen
Objective To evaluate the clinical effect of synchronous iodine-125(125I) seed strand implantation and transcatheter arterial chemoembolization (TACE) in the treatment of primary hepatocellular carcinoma combined with portal vein main tumor thrombus (PVTT). Methods From July 2013 to December 2016, 21 patients with hepatocellular carcinoma complicated by PVTT in Wenzhou Central Hospital were selected as the research subjects. Intravenous metal stents and 125I seed strips were implanted in sequential TACE therapy and all patients were followed up. Results A total of 21 portal vein stents were implanted and 10-18 particles per person. All patients were successfully implanted portal vein stents and 125I particle strips, with 100% success rate. No serious complications related to surgery occurred. A total of 38 times in 21 patients received TACE treatment, with an average of （1.8±0.9） times. There were no statistically significant differences in total bilirubin, prothrombin time, albumin and leukocyte counts between preoperative and postoperative of 30 d （P ＞ 0.05）. The mean survival time of patients was （389.1±79.9）d and the median survival time was 358.0 d. The cumulative survival rates of 90, 180 d and 360 d were 95.2%, 66.7% and 47.6%, respectively. The stent patency rates were 100.0%, 76.2% and 57.0%, respectively. Conclusion The clinical effect of synchronous 125I seed strand implantation and transcatheter arterial chemoembolization in the treatment of primary hepatocellular carcinoma combined with portal vein main tumor thrombus is better. It is worthy of clinical promotion and application．
2018 Vol. 15 (17): 85-88 [Abstract] ( 753 ) HTML (1 KB)  PDF (731 KB)  ( 117 )
89 Association between -592C＞A polymorphism within gene promoter region of interleukin-10 and susceptibility of cervical cancer: a meta-analysis
GUO Chong1 ZHANG Zhijun2
Objective To study the association between -592C＞A polymorphism within gene promoter region of interleukin-10 (IL-10) and susceptibility of cervical cancer. Methods The relevant literatures about -592C＞A polymorphism within gene promoter region of IL-10 and susceptibility of cervical cancer of PubMed, Embase, Web of SCI, CNKI and Wanfang from inception to March 2018 were searched. After the data of literatures met with inclusion criteria was extracted, taking OR value and 95% confidence interval as effect indicators, STATA 14.0 software was used to make meta analysis, and the occurrence of bias, sensibility, accumulation analysis were detected. Results Ten published studies including 3149 patients with cervical cancer and 2237 normal controls were enrolled. The results of meta analysis showed that in the total population, no significant association between IL-10 -592C＞A polymorphism and susceptibility of cervical cancer was found. After that, the subgroup analysis aiming at multiple factors showed that -592C＞A polymorphism within gene promoter region of IL-10 had significant correlation with the occurrence of cervical cancer in European (P ＜ 0.05). Conclusion The changes of -592C＞A polymorphism within IL-10 gene may increase the risk of suffering from cervical cancer in European.
2018 Vol. 15 (17): 89-93,105 [Abstract] ( 242 ) HTML (1 KB)  PDF (1149 KB)  ( 61 )
94 Clinical efficacy of Oxaliplatin combined with Tegafur, Gimeracil and Oteracil Potassium in the treatment of advanced colorectal cancer
MA Tianfei TANG Yu
Objective To investigate the effects of Oxaliplatin combined with Tegafur, Gimeracil and Oteracil Potassium in the treatment of patients with advanced colorectal cancer. Methods The clinical data of 86 patients with advanced colorectal cancer admitted to Liaoning Cancer Hospital & Institute from March 2013 to January 2015 was analyzed retrospectively, and they were divided into observation group (46 cases) and control group (40 cases) according to the difference of chemotherapy regimen. The observation group was given Oxaliplatin combined with Tegafur, Gimeracil and Oteracil Potassium. The control group was given Oxaliplatin combined with Capecitabine, 21 d was as a course, both groups were treated for 6 courses. The clinical effective rate, disease control rate, long-term prognosis, the incidence of adverse reactions and the levels of tumor markers before and after treatment between the two groups were compared. Results The clinical effective rate (58.70%) and disease control rate (71.74%) in the observation group were significantly higher than those in the control group (35.00%, 50.00%) (P ＜ 0.05); Log-rank test showed that the risk of death in the observation group was significantly lower than that in the control group (χ2 = 3.952, P ＜ 0.05). The total incidence of adverse reactions (above 3 levels) in the observation group (10.87%) was significantly lower than that of the control group (27.50%) (P ＜ 0.05). After treatment, the levels of tumor markers such as carcino-embryonic antigen (CEA), alpha fetoprotein (AFP), cancer antigen 19-9 (CA19-9) and thymidine kinase 1 (TK-1) in the two groups were significantly lower than those before treatment, which of the observation group were significantly lower than those of the control group, the differences were statistically significant (P ＜ 0.05). Conclusion The efficacy and safety of Oxaliplatin combined with Tegafur, Gimeracil and Oteracil Potassium in the treatment of advanced colorectal cancer are good, which can effectively decrease the levels of tumor markers and improve the prognosis of patients.
2018 Vol. 15 (17): 94-97 [Abstract] ( 268 ) HTML (1 KB)  PDF (653 KB)  ( 132 )
98 Clinical effects of total mesorectal excision with pelvic autonomic nerve preservation by laparoscopy in male patients with middle and low rectal cancer
XU Yongshi LONG Yunzhi HU Keke
Objective To explore the clinical safety and efficacy of total mesorectal excision (TME) with pelvic autonomic nerve preservation (PANP) by laparoscopy in male patients with middle and low rectal cancer. Methods From October 2014 to October 2016, a total of 112 patients diagnosed with middle and low rectal cancer (AJCC clinical stages Ⅰ～Ⅲ) in No.169 Hospital of PLA were selected as the research subjects. All the patients reserved TME+PANP. They were divided into the control group and the observation group by random number table,  with 56 cases in each group. The control group received open surgery and the observation group adopted laparoscopy. The mean operation time, blood loss, drainage volume, indwelling time, gastrointestinal function recovery time and activity time on ground, successful rate of operation and incidence of perioperative complications were compared between the two groups. The scores visual analogue scale (VAS) after operation of 1, 3 d and 7 d were compared between the two groups. The rates of erectile dysfunction, ejaculatory dysfunction, voiding dysfunction and local recurrence were compared between the two groups after at least one year follow-up. Results There was no statistically significant difference in the mean operation time between the two groups (P ＞ 0.05). The blood loss, drainage volume, indwelling time, gastrointestinal function recovery time and activity time in observation group were all significantly lower than those of control group, with statistically significant differences (P ＜ 0.05). There were both 100% successful rate of operation in the two groups, but the incidence of complications in the observation group was lower than that of control group, after operation of 1, 3 d and 7 d, VAS scores in observation group were all lower than those of control group, with statistically significant differences (P ＜ 0.05). The rates of erectile dysfunction, ejaculatory dysfunction and voiding dysfunction in the observation group were all lower than those of control group, with statistically significant differences (P ＜ 0.05). There was no statistically significant difference in the local recurrence rate between the two groups (P ＞ 0.05). Conclusion There is better clinical safety and efficacy of TME+PANP with laparoscopy in male patients of middle and low rectal cancer. It is worthy of clinical promotion and application.
2018 Vol. 15 (17): 98-101 [Abstract] ( 168 ) HTML (1 KB)  PDF (612 KB)  ( 112 )
102 Influence of short term concurrent chemoradiotherapy combined with Temozolomide on the survival situations of patients with glioblastoma
GAO Jinbao LI Wende YU Bin LI Yunjun CHEN Lihua▲
Objective To investigate the influence of short term concurrent chemoradiotherapy combined with Temozolomide on the survival situations of patients with glioblastoma. Methods Sixty-five patients with glioblastoma receiving surgery treatment in the Affiliated Bayi Brain Hospital of Army General Hospital from June 2011 to June 2015 were selected as the research objects. According to the different treatments, the patients were divided into short term concurrent radiotherapy combined with Temozolomide group (combined group, 23 cases), short term concurrent radiation group (21 cases) and Temozolomide group (21 cases). The short term efficacy, progression free survival (PFS), overall survival (OS) and adverse reactions of the three groups were observed. In addition, the survival curves of the three groups were drawn. Results After treatment, the objective remission rate (ORR) in the combined group (56.52%) was significantly higher than that of short term concurrent radiation group (19.05%) and Temozolomide group (21.81%) (P ＜ 0.05). There was no statistically significant difference of ORR between short term concurrent radiation group and Temozolomide group (P ＞ 0.05). There was no statistically significant difference of the disease control rate (DCR) among the three groups (P ＞ 0.05). There was statistically significant difference of the median PFS among the three groups (P ＞ 0.05). There was no statistically significant difference of the median OS among the three groups (P ＜ 0.05). The rate of adverse reactions among the three groups had no significant difference(P ＞ 0.05). Conclusion Short term concurrent radiation combined with Temozolomide can improve the postoperative remission rate of patients with glioblastoma and prolong the survival period.
2018 Vol. 15 (17): 102-105 [Abstract] ( 251 ) HTML (1 KB)  PDF (688 KB)  ( 45 )
106 Diagnostic value of p504s, ck5/6 and p63 expression level in benign prostatic hyperplasia and prostate cancer
ZHANG Ying1 WANG Xizhe1 ZHOU Lu1 DING Fen′gan2▲
Objective To study the diagnostic value of alpha methylacyl coenzyme A racemase (p504s), cytokeratin5/6 (ck5/6) and p63 in benign prostatic hyperplasia (BPH) and prostate cancer. Methods Immunohistochemical staining method was used to detect the expression of p504s, ck5/6 and p63 in 120 cases of prostate biopsy specimens that collected in Department of Pathology, Huishan People's Hospital of Wuxi City and Xishan People′s Hospital of Wuxi City from January 2012 to December 2017. In the 120 cases, 70 cases were prostate cancer (prostate cancer group), 50 cases were BPH (BPH group). 65 cases of patients with prostate acinic cell carcinoma were divided into three subgroups according to the Gleason classification standard: ≤6 scores group (20 cases), 7-8 scores group (26 cases) and ≥9 scores group (19 cases). The product of staining intensity and percentage of positive cells was compared among these groups. Statistical software SPSS 15.0 was used to analyze the results. Results The expression rate of p504s in the prostate cancer group was 91.43%, 64.28% (45/70) were strongly positive. Only 5 cases of BPH group were p504s weakly positive, and the expression rate was 10.00%. The positive rate of ck5/6 expression in prostate cancer group was 11.43% (8/70), and all of them were weakly positive. 90.00% (45/50) of BPH group were ck5/6 positive expression, and 84.00% (42/50) were positive expression above medium intensity. The positive rate of p63 expression in prostate cancer group was 8.57% (6/70), and all of them were weakly positive. 92.00% (46/50) of BPH group were p63 positive, and 82.00% (41/50) were positive expression above medium intensity. There was a significant difference in the expression of p504s, ck5/6 and p63 in the two groups (P ＜ 0.05). There was a significant difference in the expression intensity of p504s in ≤6 score group, 7-8 score group and ≥9 score group (P ＜ 0.05). The expression intensity of p504s in 7-8 score group and ≥9 score group were significantly higher than that in ≤6 score group (P ＜ 0.05). The expression intensity of p504s in 7-8 score group and ≥9 score group had no significant difference (P ＞ 0.05). There was no significant difference in the expression intensity of ck5/6 and p63 among three types of benign prostatic hyperplasia tissues, which included partial atrophy of glands, complete atrophy of glands, and hyperplasia of basal cells (P ＞ 0.05). There were 3 cases of ck5/6 deletion, and 2 cases of p63 expression deletion in the glandular partial atrophy. There were 2 cases of ck5/6 expression deletion, and 2 cases of p63 expression deletion in the complete atrophy of glands. Conclusion The expression of p504s is highly expressed in the prostate cancer tissue, while the expression of p63 and ck5/6 is decreased significantly. The expression intensity of p504s is enhanced with the degree increase of Gleason classification. It is suggested that the combined detection of p504s, ck5/6 and p63 has good application value in the diagnosis of prostate cancer and BPH.
2018 Vol. 15 (17): 106-109 [Abstract] ( 303 ) HTML (1 KB)  PDF (653 KB)  ( 66 )
110 Application of Multi-parameter MRI in the diagnosis of prostate cancer
HUA Ting RUAN Jianping GUAN Qing XU Yu▲ TANG Guangyu
Objective To investigate the application value of multi-parameter magnetic resonance imaging (MRI) in the diagnosis of prostate cancer. Methods The clinical data of 75 patients with suspected prostate cancer admitted to the Shanghai Tenth People′s Hospital of Tongji University from August 2016 to August 2017 were retrospectively analyzed. Multi-parameter [diffusion-weighted imaging (DWI), H magnetic resonance spectroscopy (1H-MRS) and dynamic contrast enhanced MRI (DCE-MRI)] MRI examinations were performed. The apparent diffusion coefficient (ADC), CC/C of 1H-MRS, DCE-MRI volume transfer constant (Ktrans), rate constant (Kep), extravascular extracellular volume fraction (Ve) and initial area under the curve (iAUC) were compared between patients with prostate cancer and patients with benign prostate lesions. The value of multi-parameter MRI in the diagnosis of prostate cancer was evaluated, referring to the results of postoperative pathological examination. Results The sensitivity, specificity and accuracy of multi-parameter MRI in the diagnosis of prostate cancer were 88.46%, 82.61% and 86.67%, respectively. The ADC value of patients with prostate cancer was significantly lower than that of those with benign prostate lesions, while CC/C, Ktrans, Kep, Ve and iAUC were significantly larger than those of patients with benign prostate lesions, the differences were statistically significant (P < 0.01). The AUC, sensitivity and specificity of multi-parameter MRI for benign and malignant prostate lesions were higher than those of single-parameter MRI. Conclusion Multi-parameter MRI is of certain value in the differential diagnosis of prostate cancer. It can be used as an effective and accurate method for the diagnosis of benign and malignant prostate lesions.
2018 Vol. 15 (17): 110-113 [Abstract] ( 259 ) HTML (1 KB)  PDF (816 KB)  ( 39 )
114 Value of cardiac motion quantification on evaluation of left ventricular short axis myocardial function in patients with polycystic ovary syndrome associated with insulin resistance 
DU Qigen MI Xiangqin XU Hongwei SHANG Weimin ZHOU Liping CHEN Wei▲
Objective To investigate the clinical value of myocardial motion quantification (CMQ) in the assessment of left ventricular short-axis myocardial motion in patients with polycystic ovary combined with insulin resistance (PCOS-IR). Methods From February 2016 to February 2017, in the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, 55 patients with PCOS-IR were selected (PCOS-IR group), at same time, 55 age matched healthy women were selected (control group). Waist-to-hipratio(WHR), body mass index (BMI), Systolic pressure (SBP), diastolic pressure (DBP), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), fasting blood glucose (FPG), fasting plasma insulin (FINS), homeostasis model assessment for IR index (HOMA-IR), and all subjects underwent routine echocardiography to measure left ventricular end-diastolic dimension (LVDd) and left ventricular end-systolic diameter (LVDs), end-diastolic interventricular septum thickness (IVSTd), end diastolic left ventricular posterior wall thickness (LVPWTd), left ventricular ejection fraction (LVEF), early diastolic blood flow peak velocity (E), late diastolic blood flow peak velocity (A), Mitral annular early diastolic motion peak velocity (Em), calculate E/A and E/Em, measured E peak deceleration time (DT), isovolumic relaxation time (IVRT) of two groups were compared. CMQ technique was used to trace tracing of myocardial trajectory, and left ventricular short axis mitral valve level, papillary muscle level and apical horizontal systolic radial peak strain (RS) and systolic circumferential peak strain (CS); acquired apical level, the peak velocity of systolic rotation angle in mitral valve level is calculated, and the left ventricular twist angle of two groups were calculated. Results The prevalence of WHR, FINS, HOMA-IR, LDL-C, BMI, metabolic syndrome in PCOS-IR group were higher than control group, the differences were statistically significant (P < 0.05). There was no significant difference in age, SBP, DBP, FPG, HDL-C, TG between the PCOS-IR group and the control group (P > 0.05). Compared with the control group, DT, IVRT, E/Em increased, and Em decreased in PCOS-IR group, the differences were statistically significant (P < 0.05). There was no significant difference in LVDd, LVDs, IVSTd, LVPWTd, LVEF, E, A, E/A between the PCOS-IR group and the control group (P > 0.05). Compared with the control group, the subendocardial, epicardial and global apical peak rotation angle and the left ventricular peak torsion angle increased in PCOS-IR group, the differences were statistically significant (P < 0.05). There was no significant difference in the peak rotation angle of the subendocardial, epicardium and the basement of the whole body (P > 0.05). Compared with the control group, most of the segments in the PCOS-IR group had decreased RS, and some segments only had a decreasing trend, but the differences were not statistically significant (P > 0.05). There was no significant reduction in CS in all segments, and the differences were not statistically significant (P > 0.05). Conclusion The left ventricular torsional motion is enhanced in PCOS-IR patients, and the radial motion is reduced, but the circular motion is not significantly decreased. CMQ technology can detect early abnormal left ventricular short-axis movement in patients with PCOS-IR, and provide clinical help for timely intervention.
2018 Vol. 15 (17): 114-118 [Abstract] ( 205 ) HTML (1 KB)  PDF (717 KB)  ( 47 )
119 Application of Wumei Xiaoshi Granule combined with ferrous sulfate in the treatment of iron deficiency anemia of spleen-stomach deficiency
ZHOU Zhenhuan LI Jun FAN Hua LU Chunying
Objective To observe the effect of Wumei Xiaoshi Granule combined with ferrous sulfate in the treatment of iron deficiency anemia (IDA) of spleen-stomach deficiency. Methods From May 2015 to May 2017, in Langfang TCM Hospital, 92 patients with IDA of spleen-stomach deficiency were divided into treatment group (n = 46) and control group (n = 46) according to the random number table. The control group was treated with ferrous sulfate tablets, the treatment group was treated with Wumei Xiaoshi Granule 20 min before ferrous sulfate tablets, 30 d for a course of treatment. The efficacy, blood routine examination, iron metabolism and side effects were observed. Results There was no significant difference in the curative effect between the two groups (P > 0.05). However, the blood routine test and iron metabolism in the treatment group were significantly improved compared with the control group, the differences were statistically significant (P < 0.05). Conclusion Wumei Xiaoshi Granule combined with ferrous sulfate in the treatment of IDA of spleen-stomach deficiency can significantly improve the anemia symptoms, increase the body iron reserve and reduce the stimulation effect, and the effect is better than ferrous sulfate only.
2018 Vol. 15 (17): 119-122 [Abstract] ( 211 ) HTML (1 KB)  PDF (694 KB)  ( 50 )
123 Effect of Shenmai Injection on microvascular density and quality of life of hepatic carcinoma patients with arterial infusion chemotherapy
WANG Bo1 WANG Youqing1 MAO Kui1▲ CHEN Long1 SUN Weijian2
Objective To explore the effect of Shenmai Injection on microvascular density and quality of life of hepatic carcinoma(HCC) patients with arterial infusion chemotherapy. Methods From January 2015 to January 2017, in the First People's Hospital of Linhai City and the Second Affiliated Hospital of Wenzhou Medical University, 90 HCC patients treated with arterial infusion chemotherapy were collected, according to random number table method, patients were divided into control group and observation group, with 45 cases in each group, all patients were treated with arterial perfusion chemotherapy, the observation group was given Shenmai injection on the basis of the control group, immunohistochemical expression of VEGF and MVD were analyzed, and the quality of life was evaluated. Results The positive staining was not uniform of VEGF and MVD in the two groups, and the control group was darker, and the observation group was shallower. The expression of VEGF and MVD in HCC in the observation group was significantly lower than that in the control group, and the differences were statistically significant (P < 0.01). The overall quality of life of the observation group was better than that of the control group, the difference was statistically significant (P < 0.05). Conclusion Shenmai Injection can obviously improve the prognosis of hepatic carcinoma patients with arterial infusion chemotherapy, effectively restrain VEGF expression of the liver tissue, reduce the density of blood vessels and MVD, thereby inhibit tumor angiogenesis, improve the quality of life, which is worth promoting.
2018 Vol. 15 (17): 123-126,142 [Abstract] ( 796 ) HTML (1 KB)  PDF (935 KB)  ( 46 )
127 Clinical effect of Atorvastatin combined with Ezetimibe in the treatment of atherosclerotic non occlusive mesenteric ischemia
YANG Zhensheng1 QIU Xiaolei1 CHEN Yingyu2 CAI Weibiao3 LIU Shaohui4▲
Objective To investigate the clinical effect of Atorvastatin combined with Ezetimibe in the treatment of atherosclerotic non occlusive mesenteric ischemia and its effect on the levels of blood lipid, inflammatory factors, vascular endothelial function. Methods One hundred and sixty patients with atherosclerotic non occlusive mesenteric ischemia from May 2015 to May 2017 in the First People's Hospital of Foshan City were selected and divided into observation group and control group according to random number table method, with 80 cases in each group. The control group was treated with Atorvastatin treatment, on basis of which, the observation group was added with Ezetimibe, and 80 healthy volunteers matched with the other two groups in age and sex were selected as health group. The blood lipid level, inflammation indices, vascular endothelial function of the three groups were compared and analyzed after treatment for 8 weeks. Results Before treatment, the levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and triglyceride (TG) in the observation group and the control group were higher than those in the healthy group (P ＜ 0.05), and the level of high density lipoprotein cholesterol (HDL-C) was lower than that of the healthy group. There was no significant difference between the observation group and the control group (P ＞ 0.05). The levels of TC, LDL-C and TG in the observation group and the control group decreased significantly after treatment. The observation group was significantly lower than the control group (P ＜ 0.05) and close to the level of the healthy group. The levels of HDL-C in the observation group and the control group were higher than those before treatment, and the increase of the observation group was more obvious, the difference was statistically significant (P ＜ 0.05). Before treatment, the levels of hypersensitivity C reaction protein (hs-CRP) and metalloproteinase -9 (MMP-9) in the observation group and the control group were higher than those in the healthy group (P ＜ 0.05). There was no significant difference in the levels of hs-CRP and MMP-9 between the observation group and the control group (P ＞ 0.05). The levels of hs-CRP and MMP-9 in the observation group and the control group were lower than those before treatment, and the level of the observation group was significantly lower than that of the control group, which was significantly lower than the control group, the difference was statistically significant (P ＜ 0.05). Before treatment, the levels of NO and FMD in the observation group and the control group were lower than those in the healthy group(P ＜ 0.05). There were no significant differences in the levels of nitric oxide (NO) and vascular endothelial function (FMD) between the observation group and the control group (P ＞ 0.05). Compared with those before treatment, the levels of NO and FMD in the observation group and the control group were significantly increased, and the control group increased more obviously, the difference was statistically significant (P ＜ 0.05). After treatment, there were no significant differences in blood lipid level, inflammatory markers and vascular endothelial function between the observation group and the healthy group (P ＞ 0.05). Conclusion Atorvastatin combined with Ezemab can reduce the levels of blood lipid, inflammatory factors and improve vascular endothelial function.
2018 Vol. 15 (17): 127-130 [Abstract] ( 232 ) HTML (1 KB)  PDF (698 KB)  ( 122 )
131 Study on time of compression hemostasis by puncture point after interventional operation through radial artery puncture
NI Shuyu1 DU Dehua2▲
Objective To analyze the influence of puncture point compression and hemostasis time after radial artery puncture on patients, summarize the experience of controlling hemostasis time. Methods From July 2016 to May 2017, in Department of Cardiovascular Medicine, Qianjiang Central Hospital, 164 patients treated with interventional therapy were selected. According to the random number table method, they were divided into the experiment group and the control group, with 82 cases in each group. All patients were given routine nursing, while the control group received conventional compression after operation. When the compression time reached 4 h, the first circle of adhesive tape was removed, when the compression time reaches 24 h, remove second circles of adhesive tape; the experiment group received conventional compression after operation, and when the compression time reached 4 h, the first circle of adhesive tape was removed, when the compression time reached 8 h, remove second circles of adhesive tape. The bleeding, hematoma and other related complications were compared in the two groups, and the time of hospitalization, bed time, hospitalization expenses and the index of satisfaction were compared and analyzed in the two groups. Results Two patients withdrew from experiment group, three patients withdrew from control group. The incidence of puncture site bleeding in the experiment group was 2.50%, that in the control group was 2.53%, two groups were compared, the difference was not statistically significant (P > 0.05). The incidence of other related adverse reactions in the experiment group (2.50%) was significantly lower than that in the control group (12.66%), the difference was statistically significant (P < 0.05). In the experiment group, the bed time [(1.6±0.6) d] and the nursing care satisfaction of the puncture point [(8.4±1.2) scores] were compared with those in the control group [(2.3±0.8) d and (7.5±1.5)score], the differences were statistically significant (P < 0.05). In the experiment group, the hospitalization time [(3.4±1.1) d] and the hospitalization cost[ (21.3±4.3) thousand yuan] were compared with those in the control group [(3.5±1.2) d, (22.5±4.8)thousand yuan], the differences were statistically significant (P < 0.05). Conclusion Second laps of glue can not increase the risk of bleeding after puncture point 8 hours after percutaneous radial artery puncture, but it can reduce the incidence of other related adverse reactions, shorten the bed time and improve the patients' satisfaction.
2018 Vol. 15 (17): 131-134 [Abstract] ( 267 ) HTML (1 KB)  PDF (692 KB)  ( 80 )
135 Effect of calcitriol combined with compound Flumethasone in treatment of psoriasis vulgaris patients and influences on serum levels of interleukin 6, 17 and 23
CHEN Gengming WANG Jinyun HUANG Guoqiang
Objective To investigate the clinical effect of Calcitriol combined with compound Flumethasone in the treatment of psoriasis vulgaris (PV) patients and the influences on the serum levels of interleukin 6, 17 and 23 (IL-6, IL-17, IL-23). Methods From March 2015 to November 2016, in Department of Dermatology and Venereal Diseases, Jieyang People's Hospital, 80 PV patients were selected, they were divided into single drug group and combined group by random digital table method, with 40 cases in each group. The single drug group was treated with compound Flumetasone, while the combined group was given Calcitriol on the base of the single drug group. The severity index (PASI) and the total area percentage of skin lesions before and after treatment and the clinical efficacy in the two groups were compared, and the levels of serum IL-6, IL-17 and IL-23 were detected and compared before and after treatment, then the safety and recurrences were compared. Results After treatment, the PASI scores and total area percentage of skin of two groups were significantly lower than those before treatment, and these of the combined group were significantly lower than those of the single drug group, the differences were statistically significant (P < 0.05). The total effective rate of the combined group was significantly higher than that of the single drug group, the differences were statistically significant(P < 0.05). After treatment, the levels of serum IL-6, IL-17 and IL-23 in the two groups were significantly lower than those before treatment, these of combined group were significantly lower than those of the single drug group, the differences were statistically significant (P < 0.05). There was no significant difference in the incidence rates of total adverse reactions between the combined group and the single drug group during the treatment (P > 0.05), and the recurrence rate of the combined group within 1 year after treatment was significantly lower than that of the single drug group, the difference was statistically significant (P < 0.05). Conclusion Calcitriol combined with compound Flumethasone for the treatment of PV can significantly improve the clinical efficacy, significantly reduce the serum levels of IL-6, IL-17 and IL-23, reduce the recurrence, and there is no obvious increase in adverse reactions, which has the value of popularization.
2018 Vol. 15 (17): 135-138 [Abstract] ( 337 ) HTML (1 KB)  PDF (704 KB)  ( 60 )
139 Curative efficacy of granulocyte colony-stimulating factor in combination with entecavir in patients with hepatitis B virus related acute-on-chronic liver failure at early stage and its influences on levels of AngⅡ, TNF-α, and IL-10
TIAN Yuqiu ZHOU Ning JIANG Yongfang
Objective To investigate the curative efficacy of granulocyte colony-stimulating factor in combination with entecavir in patients with hepatitis B virus related acute-on-chronic liver failure (ACLF) at early stage and its influences on levels of angiotensin Ⅱ (AngⅡ), tumor necrosis factor α (TNF-α), interleukin 10 (IL-10). Methods From January 2016 to June 2017, in Department of Infedtious Diseases, Xiangya No.2 Hospital of Central South University, 84 patients with hepatitis B virus related ACLF at early stage were collected, according to random number table, they were divided into the control group and the observation group, with 42 cases in each group. Besides conventional treatments, the control group was treated with entecavir, while the observation group was treated with granulocyte colony-stimulating factor in combination with entecavir. Curative efficacy, levels of indices of liver function, AngⅡ, TNF-α and IL-10 were compared between the two groups. Results The total therapeutic efficacy ratio in the observation group was statistically higher than that in the control group, the difference was statistically significant (P < 0.05). Compared with the control group, the observation group had lower level of total bilirubin and higher levels of albumin, prothrombin activity after treatment, the differences were statistically significant (P < 0.05). After treatment, compared with the control group, the observation group had lower levels of AngⅡ, TNF-α and higher level of IL-10, the differences were statistically significant (P < 0.05). Conclusion Granulocyte colony-stimulating factor in combination with Entecavir has well application effect in patients with hepatitis B virus related ACLF at early stage with a high therapeutic efficacy ratio. And it can effectively improve liver function, reduce level of AngⅡ and improve inflammatory reaction.
2018 Vol. 15 (17): 139-142 [Abstract] ( 194 ) HTML (1 KB)  PDF (384 KB)  ( 127 )
143 Clinical efficacy comparation of two different intestine preparation on patients with colorectal cancer underwent elective operation
JIN Xianzhen GOU Ya'nan CUI Xijuan LIAO Chunyan QIAO Li′na
Object To explore the clinical efficacy of two methods commonly used in preoperative bowel preparation on patients with colorectal cancer. Methods From January 2016 to June 2017, 231 patients with colorectal cancer underwent surgical treatment in Department of General Surgery, the First Affiliated Hospital of Xi'an Jiaotong University were selected and randomly divided into two groups according to the random number table, of which 117 cases in the experimental group and 114 cases in the control group. The experimental group was given compound polyethylene glycol electrolyte for intestinal preparation before operation, while the control group was given soapy water enema. The intestinal cleanliness score, patients' discomfort degree, serum inflammatory index and electrolytes changes, postoperative recovery of intestinal function were observed. Results There were no statistically significant differences in the intestinal cleanliness score, serum leukocyte level potassium and chloride level, postoperative recovery time of intestinal function, postoperative exhaust time, postoperative defecation time and incidence of abdominal infection(P ＞ 0.05). However, the incidence of nausea, abdominal distension or abdominal pain in the experimental group was lower than that of control group in the process of bowel preparation, the serum sodium level in the experimental group was significantly higher than that of control group, with statistically significant differences (P ＜ 0.05). Conclusion Compared with the traditional method of bowel preparation, oral administration with compound polyethylene glycol electrolyte has a more positive effect, and can reduce the degree of discomfort and the incidence of electrolyte imbalance, which is worth promotion and application.
2018 Vol. 15 (17): 143-146 [Abstract] ( 209 ) HTML (1 KB)  PDF (611 KB)  ( 47 )
147 The application of comprehensive nursing intervention in postoperative patients with senile diabetic cataract
ZHU MeiLin WANG Lin
Objective To explore the clinical effect of comprehensive nursing intervention in senile patients with diabetic cataract. Methods From August 2014 to April 2016, 86 patients with senile diabetic cataract in the First Affiliated Hospital of Harbin Medical University were selected as the research objects and divided into the control group and the observation group by random number table, with 43 cases in each group. The control group was given with routine nursing intervention, while the observation group was given comprehensive nursing intervention in the bases of the control group. The blood glucose level, visual acuity value, nursing satisfaction, the hospitalization time and the total incidence of complications between the two groups were compared. Results After nursing, the visual acuity value in the observation group was significantly higher than that of control group, the nursing satisfaction rate was higher than that of control group, the blood glucose level, the total incidence of complications and hospitalization time in the observation group were all significantly lower than those of control group, with statistically significantly differences (P ＜ 0.05). Conclusion The clinical effect of comprehensive nursing intervention in senile patients with diabetes after cataract surgery is obvious, which can effectively promote the visual acuity and blood glucose, improve the nursing satisfaction, reduce the postoperative complications. It is worthy of clinical promotion and application.
2018 Vol. 15 (17): 147-150 [Abstract] ( 240 ) HTML (1 KB)  PDF (611 KB)  ( 93 )
151 Effect of chiropractic therapy in hospitalized patients with lower extremity fractures
LIU Jing
Objective To study the effect of chiropractic therapy on complications and negative emotions of patients with lower extremity fracture during hospitalization. Methods A total of 94 patients with lower extremity fractures in Liaocheng Traditional Chinese Medicine Hospital from May 2015 to May 2017 were selected as the research objects and divided into the experimental group and the control group according to the random number table, with 47 cases in each group. The control group was given routine nursing care and the experimental group was given chiropractic therapy on the basis of routine group. The nursing satisfaction of the patients was evaluated by the Newcastle care satisfaction scale compiled by Thomas et al. The treatment efficacy of bloating, constipation and urinary retention were compared between the two groups. Self-rating anxiety scale and self-rating depression scale were applied to evaluate the degree of anxiety and depression before and after intervention. Results The total satisfaction rate in the experimental group was higher than that of control group, with statistically significant difference (P ＜ 0.05). The total effective rate of abdominal distension, constipation and urinary retention in the experimental group were all higher than those of control group, with statistically significant differences (P ＜ 0.05). After intervention, the scores of anxiety and depression in the experimental group were all lower than those of control group, with statistically significant differences (P ＜ 0.05). Conclusion Chiropractic therapy can effectively improve the patients' negative emotion and bloating, constipation, urinary retention during postoperative bed rest. It is worthy of clinical promotion and application.
2018 Vol. 15 (17): 151-153,158 [Abstract] ( 186 ) HTML (1 KB)  PDF (626 KB)  ( 61 )
154 Research of clinical pathway application in perioperative management of procedure for prolapse and hemorrhoids in patients with hemorrhoids
GUO Minghao
Objective To discuss the application of rational clinical pathway in the perioperative management of procedure for prolapse and hemorrhoids (PPH) in patients with hemorrhoids. Methods From January 2014 to December 2016, 200 patients underwent PPH therapy in the Department of Proctology, South District Guang'anmen Hospital, China Academy of Chinese Medical Sciences were divided into the study group and the control group according to the random number table, with 100 cases in each group. The study group applied the clinical pathway management and the control group applied the routine diagnosis and treatment. The safety, clinical efficacy, average length of hospital stay, average hospitalization cost and patient satisfaction were compared between the two groups. Results There were no significant differences in the safety and clinical efficacy between the two group (P ＞ 0.05).The average hospital stay and the average hospitalization cost in the study group were lower than those of control group, the satisfaction rate in the study group was higher than that of control group, with highly statistically significant differences (P ＜ 0.01). Conclusion Clinical pathway as a scientific medical care model applied in PPH of the perioperative management is practical and has certain scientific value and positive social significance. It can improve the level of diagnosis and treatment and is worthy of promotion.
2018 Vol. 15 (17): 154-158 [Abstract] ( 196 ) HTML (1 KB)  PDF (582 KB)  ( 140 )
159 Effect of prone position ventilation on hemodynamics in patients with acute respiratory distress syndrome
WANG Caihong WANG Nan ZHANG Xiumin▲
the Second Department of Intensive Care Unit, Xinjiang Uygur Autonomous Region People′s Hospital, Xinjiang Uygur Autonomous Region, Urumqi   830000, Chinapine position (P ＞ 0.05). After prone position ventilation, 15.63% patients showed skin mucosal injury, 6.25% blood pressure decreased, 6.25% vomited stomach contents, 71.88% had no adverse reactions and 9.38% had no response. Conclusion Prone position ventilation can improve oxygenation in patients with ARDS, promote airway sputum drainage, have no obvious influence on hemodynamics. The gravity dependence and heterogeneity of ARDS patients are corrected. The safety is good. It is worthy of clinical promotion and application.
2018 Vol. 15 (17): 159-162 [Abstract] ( 267 ) HTML (1 KB)  PDF (611 KB)  ( 109 )
163 Effect of continuous nursing care education on negative emotions and life quality in patients with colorectal cancer after radical operation
ZHANG Lin QIAN Jiang
Objective To investigate the influence of continuous nursing care education on negative emotions and life quality in patients with colorectal cancer after radical operation. Methods A total of 98 patients with colorectal cancer after radical operation in Department of General Surgery, Branch of Zhejiang Hospital from Janary 2016 to Janary 2017 were selected and divided into the experimental group and the control group by random number table, with 49 cases in each group. The control group was given the conventional nursing, while the experimental group was given continuous nursing care education on the basis of control group. The compliance of patients was compared between the two groups. Self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to evaluate the negative emotions of the patients before and after nursing. The score of life quality and the nursing satisfaction after 6 months hospital discharge were compared between the two groups. Results The compliance in the experimental group was significantly higher than that of control group, with statistically significant difference (P ＜ 0.05). After nursing, the scores of SAS and SDS in the experimental group were significantly lower than those of control group, with statistically significant differences (P ＜ 0.05); the scores of appetite, spiritual condition, sleep quality, family understanding, knowledge of cancer and daily life in the experimental group were all significantly higher than those of control group, with statistically significant differences (all P ＜ 0.05). After 6 months hospital discharge, the nursing satisfaction in the experimental group was significantly higher than that of control group, with statistically significant difference (P ＜ 0.05). Conclusion Continuous nursing health education can improve the compliance of patients with colorectal cancer after radical operation, reduce negative emotions and improve the quality of life.
2018 Vol. 15 (17): 163-166 [Abstract] ( 205 ) HTML (1 KB)  PDF (573 KB)  ( 88 )
167 Study on hospice care from the perspective of traditional Chinese medicine thought of benevolence
PU Yalou1 ZHANG Honglei2 ZHI Xiaoxu3 MENG Aifeng3
With the popularization and application of new medical model in our country, hospice care is the active development in the future medical system. The viewpoints of traditional Chinese medicine thought of benevolence have practical significance to solve the contradiction between supply and demand of hospice care、the lack of care skills for medical staff and the weak social support. This article aims to study the current situation and dilemma of the development of hospice care under the perspective of traditional Chinese medicine thought of benevolence. It is suggested that medical staff should follow the “people-oriented” concept of benevolence, pay attention to the mind of patients and their families, and improve their medical ethics, promote social integrity and the development of hospice care career.
2018 Vol. 15 (17): 167-170 [Abstract] ( 251 ) HTML (1 KB)  PDF (549 KB)  ( 240 )
171 Exploration of the safety of aminoglycosides once daily by clinical pharmacist
LIU Jinchun ZHANG Haixia MENG Xiangyan GE Weihong▲
Objective To evaluate the safety of aminoglycoside antibiotics once daily with clinical pharmacists tracking the entire treatment process. Metheds From September 2015 to August 2016, in Institute of Antibiotics, Shanghai Huashan Hospital, 30 patients who used once daily aminoglycoside antibiotics were selected, clinical pharmacist participated in the formulation of treatment strategies, and monitored the adverse effects of aminoglycosides. Clinical pharmacists observed the serum creatinine, blood urea nitrogen and hearing of the patients before and after using aminoglycosides. Results The serum creatinine and serum urea nitrogen in 30 patients after treatment with aminoglycoside antibiotics had no significant change compared with that before treatment, and the differences were not statistically significant (P > 0.05). In addition, none of the 30 patients appeared ototoxicity or neuromuscular blockade. Conclusion Under the supervision of clinical pharmacists, once daily using of aminoglycoside antibiotics and control the infusion rate according to the instructions have a better safety, and the incidence of nephrotoxicity, ototoxicity, neuromuscular blockage and other adverse reactions is low.
2018 Vol. 15 (17): 171-174 [Abstract] ( 216 ) HTML (1 KB)  PDF (579 KB)  ( 36 )
175 Clinical effect of hip strength training combined with rehabilitation therapy on athletes patellofemoral joint pain syndrome
WU Xiaomao1 YANG Jianquan2
Objective To explore the clinical effect of hip joint strength training combined with rehabilitation therapy on athlete's patellofemoral joint pain syndrome. Methods From January 2016 to December 2017, in Xi＇an Hospital of Sports Trauma, 80 sportsmen with patellofemoral joint pain syndrome were selected, according to the random number table, they were divided into the observation group and the control group,  with 40 cases in each group. The control group was given conventional rehabilitation treatment, the observation group was given hip joint strength training on the basis of routine rehabilitation treatment. The pain degree, patellofemoral joint function and knee flexion and muscle strength between in two groups before and after treatment were compared. Results Before the treatment, there was no statistically significant difference in the VAS scores of walking up and down stairs, jumping between the two groups (P > 0.05); after the treatment, the VAS scores of walking up and down stairs, jumping in the two groups were lower than before the treatment, the differences were statistically significant (P < 0.05); after treatment, the VAS scores of walking up and down stairs, jumping in the observation group were lower than the control group, the differences were statistically significant (P < 0.05). Before the treatment, there was no statistically significant difference in Kujala scores between the two groups (P > 0.05), after the treatment, the Kujala scores in two groups were higher than before the treatment, the differences were statistically significant (P < 0.05); after treatment, the Kujala scores in the observation group were higher than the control group, the differences were statistically significant(P < 0.05). Before the treatment, there was no significant difference in the peak torque of the four head muscles and the popliteal muscle peak at angular velocity 60°/s and 120°/s between two groups (P > 0.05); after treatment, the peak torque of the four head of the femoral muscle and the popliteal muscle peak at angular velocity 60°/s and 120°/s in two groups were higher than before the treatment, the differences were statistically significant (P < 0.05); after treatment, the peak torque of the four head muscles of the femoral four head and the popliteal muscle peak at angular velocity 60°/s and 120°/s in the observation group were higher than the control group, the differences were statistically significant (P < 0.05). Conclusion Hip strength training combined with rehabilitation therapy can significantly improve the pain symptoms of patellofemoral pain syndrome athletes, it can improve the patellofemoral joint function and knee flexion strength significantly, it is great significance to the recovery of athletes' competitive level.
2018 Vol. 15 (17): 175-178 [Abstract] ( 215 ) HTML (1 KB)  PDF (550 KB)  ( 125 )
179 Experience of endocrinology in standardized training of general practitioners
JIA Yumei FAN Hui▲
Nowadays the general practitioners standardized training is an important part of the training of resident doctors in Beijing. But the training teachers in endocrinology and general practitioners may lack of general medical science theory and they are unfamiliar with general medical work features, it leads to the general training models are similar to the training of endocrine specialist. Therefore, the teachers should put general medical science theory into the whole training, be clear with the tasks and pay more attention to the trainings of general practitioner abilities. Though the training the general practitioners could strengthen the emergency treatment and recognition, provide guidance for common endocrine diseases management in the elderly people. At the same time, the application of “Balint group” is benefit to improve doctor-patient communication, and reasonable evaluation method should be used in general practitioner training assessment. Lastly the construction of the endocrinology teacher staff should be strengthen, which can further improve the standardized general practitioner training.
2018 Vol. 15 (17): 179-181 [Abstract] ( 225 ) HTML (1 KB)  PDF (689 KB)  ( 92 )
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