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| Value of cardiac motion quantification on evaluation of left ventricular short axis myocardial function in patients with polycystic ovary syndrome associated with insulin resistance |
| DU Qigen MI Xiangqin XU Hongwei SHANG Weimin ZHOU Liping CHEN Wei▲ |
| Department of Ultrasound, Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Heilongjiang Province, Harbin 150000, China |
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Abstract Objective To investigate the clinical value of myocardial motion quantification (CMQ) in the assessment of left ventricular short-axis myocardial motion in patients with polycystic ovary combined with insulin resistance (PCOS-IR). Methods From February 2016 to February 2017, in the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, 55 patients with PCOS-IR were selected (PCOS-IR group), at same time, 55 age matched healthy women were selected (control group). Waist-to-hipratio(WHR), body mass index (BMI), Systolic pressure (SBP), diastolic pressure (DBP), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), fasting blood glucose (FPG), fasting plasma insulin (FINS), homeostasis model assessment for IR index (HOMA-IR), and all subjects underwent routine echocardiography to measure left ventricular end-diastolic dimension (LVDd) and left ventricular end-systolic diameter (LVDs), end-diastolic interventricular septum thickness (IVSTd), end diastolic left ventricular posterior wall thickness (LVPWTd), left ventricular ejection fraction (LVEF), early diastolic blood flow peak velocity (E), late diastolic blood flow peak velocity (A), Mitral annular early diastolic motion peak velocity (Em), calculate E/A and E/Em, measured E peak deceleration time (DT), isovolumic relaxation time (IVRT) of two groups were compared. CMQ technique was used to trace tracing of myocardial trajectory, and left ventricular short axis mitral valve level, papillary muscle level and apical horizontal systolic radial peak strain (RS) and systolic circumferential peak strain (CS); acquired apical level, the peak velocity of systolic rotation angle in mitral valve level is calculated, and the left ventricular twist angle of two groups were calculated. Results The prevalence of WHR, FINS, HOMA-IR, LDL-C, BMI, metabolic syndrome in PCOS-IR group were higher than control group, the differences were statistically significant (P < 0.05). There was no significant difference in age, SBP, DBP, FPG, HDL-C, TG between the PCOS-IR group and the control group (P > 0.05). Compared with the control group, DT, IVRT, E/Em increased, and Em decreased in PCOS-IR group, the differences were statistically significant (P < 0.05). There was no significant difference in LVDd, LVDs, IVSTd, LVPWTd, LVEF, E, A, E/A between the PCOS-IR group and the control group (P > 0.05). Compared with the control group, the subendocardial, epicardial and global apical peak rotation angle and the left ventricular peak torsion angle increased in PCOS-IR group, the differences were statistically significant (P < 0.05). There was no significant difference in the peak rotation angle of the subendocardial, epicardium and the basement of the whole body (P > 0.05). Compared with the control group, most of the segments in the PCOS-IR group had decreased RS, and some segments only had a decreasing trend, but the differences were not statistically significant (P > 0.05). There was no significant reduction in CS in all segments, and the differences were not statistically significant (P > 0.05). Conclusion The left ventricular torsional motion is enhanced in PCOS-IR patients, and the radial motion is reduced, but the circular motion is not significantly decreased. CMQ technology can detect early abnormal left ventricular short-axis movement in patients with PCOS-IR, and provide clinical help for timely intervention.
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