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| Research progress of indocyanine green-loaded nanomaterials in tumor diagnosis and therapy |
| HAN Cuiping1,2 HANG Yinhui1 ZHANG Dujuan1 DING Jiazheng1 WANG Keying1 |
1.School of Medical Imaging, Xuzhou Medical University, Jiangsu Province, Xuzhou 221000, China；
2.Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Jiangsu Province, Xuzhou 221000, China |
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Abstract Indocyanine green (ICG) is a biocompatible near-infrared fluorescent dye that can be used in many fields such as tumor imaging and potothermal therapy. But its low stability, rapid metabolism and low cell uptake limited its efficient use. The rapid development of nanotechnology provids a solution platform for this problem. Multifunctional ICG-loaded nanomaterials have many advantages in controlling the release of drugs, improving the biological stability of drugs, enhancing the availability and targeting of drug delivery, etc. It has great application prospect in the field of early diagnosis and treatment of tumor. In this paper, the properties and characteristics of ICG-loaded nanomaterials are summarized, and their latest research progress in the field of multi-modal imaging diagnosis, combined therapy and combined therapy under the guidance of multi-modal imaging application is reviewed.
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