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| Research progress of long non-coding RNAs in ischemia reperfusion injury of important tissue and organs |
| WANG Yi LIANG Jiuqing SUN Huilin YANG Dan ZHANG Liangqing▲ HU Zhe▲ |
| Anesthesiology Department, Affiliated Hospital of Guangdong Medical University, Guangdong Province, Zhanjiang 524000, China |
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Abstract In recent years, more and more studies have suggested that long non-coding RNAs (lncRNAs) can participate in the vital movement of all kinds of cells and the emergence and development of many diseases. However, the regulating effects of lncRNA in the pathological process of ischemia-reperfusion injury (IRI) have not been clarified. To further understand the role of these lncRNAs in IRI will help to know about the molecular regulatory network after IRI, which has great significance for seeking new biomarkers and therapeutic targets of IRI, protecting important tissue and organs, and improving the clinical prognosis of patients. This paper reviews the currently known effects of lncRNA in the IRI of important organs of heart, brain, liver, kidney and lung, and summarizes some lncRNAs those have not been researched deeply, so as to provide direction for future deeper mechanism research.
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