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The mechanisms of oxidative stress damage on sperms and protection |
LI Tiantian1 ZHANG Xingying1 LI Lianqin2▲ |
1.Department of Obstetrics and Gynecology, Binzhou Medical University, Shandong Province, Yantai 264003, China;
2.Department of Reproductive Medicine, Yantai Affiliated Hospital of Binzhou Medical University, Shandong Province, Yantai 264100, China |
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Abstract The occurrence of infertility is increasing with the rapid mode of work, change of life style and environmental pollution. The main cause of male infertility is abnormal sperms including asthenospermia, oligospermia, azoospermia and sperm malformation. One of the mechanisms that causes abnormal sperms is the increasing of reactive oxygen species level, which results in the oxidative damage on the DNA, lipid and mitochondria of sperms. In addition to the supplement of vitamin E, vitamin C and Chinese herbal medicine, good life habits and proper physical exercises will help to enhance self antionxidant capacity and improve the quality of sperms.
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[1] Kuksal N,Chalker J,Mailloux RJ. Progress in understanding the molecular oxygen paradox-function of mitochondrial reactive oxygen species in cell signaling [J]. Biol Chem,2017,398(11):1209-1227.
[2] Mao X,Gu C,Chen D,et al. Oxidative stress-induced diseases and tea polyphenols [J]. Oncotarget,2017,8(46):81649-81661.
[3] Ollero M,Gil-Guzman E,Lopez MC,et al. Characterization of subsets of human spermatozoa at different stages of maturation:implications in the diagnosis and treatment of male infertility [J]. Hum Reprod,2001,16(9):1912-1921.
[4] 张俏忻,肖颖秀,程碧珍.白细胞异常增加对精液质量及氧化应激的影响[J].国际检验医学杂志,2016,37(6):826-727,730.
[5] Dorostghoal M,Kazeminejad SR,Shahbazian N,et al. Oxidative stress status and sperm DNA fragmentation in fertile and infertile men [J]. Andrologia,2017,49(10):12762.
[6] Moazamian R,Polhemus A,Connaughton H. Oxidative stress and human spermatozoa:diagnostic and functional significance of aldehydes generated as a result of lipid peroxidation [J]. Mol Hum Reprod,2015,21(6):502-515.
[7] Fraczek M,Hryhorowicz M,Gill K,et al. The effect of bacteriospermia and leukocytospermia on conventional and nonconventional semen parameters in healthy young normozoospermic males [J]. J Reprod Immunol,2016,118:18-27.
[8] Ni K,Steger K,Yang H,et al. A comprehensive investigation of sperm DNA damage and oxidative stress injury in infertile patients with subclinical,normozoospermic,and astheno/oligozoospermic clinical varicocoele [J]. Andrology,2016,4(5):816-824.
[9] Li J,Barranco I,Tvarijonaviciute A,et al. Seminal plasma antioxidants are directly involved in boar sperm cryotolerance [J]. Theriogenology,2018,107:27-35.
[10] Muratori M,Tamburrino L,Marchiani S,et al. Investigation on the origin of sperm DNA fragmentation:role of apoptosis,immaturity and oxidative stress [J]. Mol Med,2015,21(1):109-122.
[11] Taken K,Alp HH,Eryilmaz R,et al. Oxidative DNA damage to sperm cells and peripheral blood leukocytes in infertile men [J]. Med Sci Monit,2016,22:4289-4296.
[12] Kaur S,Saluja M,Bansal MP. Bisphenol A induced oxidative stress and apoptosis in mice testes:Modulation by selenium [J]. Andrologia,2017.Doi:10.1111/and.12834.
[13] O'Flaherty C,Matsushita-Fournier D. Reactive oxygen species and protein modifications in spermatozoa [J]. Biol Reprod,2017,97(4):577-585.
[14] Treulen F,Uribe P,Boguen R,et al. Mitochondrial permeability transition increases reactive oxygen species production and induces DNA fragmentation in human spermatozoa [J]. Hum Reprod,2015,30(4):767-776.
[15] Amaral A,Louren?觭o B,Marques M,et al. Mitochondria functionality and sperm quality [J]. Reproduction,2013, 46(5):R163-174.
[16] Dorostghoal M,Kazeminejad SR,Shahbazian N,et al. Oxidative stress status and sperm DNA fragmentation in fertile and infertile men [J]. Andrologia,2017,49(10):e12762.
[17] Aprioku JS,Ugwu TC. Comparative evaluation of the impact of subacute exposure of smokeless tobacco and tobacco smoke on rat testis [J]. Int J Reprod Med,2015, 2015(1):676 245.
[18] 蔡文伟,江楠.男性不育患者精液活性氧与精子参数的关系研究[J].预防医学2017,29(3):264-265,268.
[19] Tang Z,Ding W,Wang L,et al. Protective effect of vitamin E on methyl methanesulfonate-induced teratozoospermia in adult Sprague-Dawley rats [J]. Mol Med Rep,2015,12(3):4422-4426.
[20] Rezaie AH,Razi M,Amniattalab A,et al. Co-administration of vitamin E and testosterone attenuates the atrazine-induced toxic effects on sperm quality and testes in rats [J]. Cell J,2017,19(2):292-305.
[21] Adami LNG,Belardin LB,Lima BT,et al. Effect of in vitro vitamin E(alpha-tocopherol)supplementation in human spermatozoon submitted to oxidative stress [J]. Andrologia,2018.Doi:10.1111/and.12959.
[22] Balasuriya A,Serhal P,Doshi A,et al. Processes involved in assisted reproduction technologies significantly increase sperm DNA fragmentation and phosphatidylserine translocation [J]. Andrologia,2014,46(2):86-97.
[23] Mostek A,Dietrich MA,S?覥owinska M,et al. Cryopreservation of bull semen is associated with carbonylation of sperm proteins [J]. Theriogenology,2017,92:95-102.
[24] Soleimanzadeh A,Saberivand A. Effect of curcumin on rat sperm morphology after the freeze-thawing process [J]. Vet Res Forum,2013,4(3):185-189.
[25] Fontoura P,Mello MD,Gallo-Sa P,et al. Leptin improves sperm cryopreservation via antioxidant defense [J]. J Reprod Infertil,2017,18(1):172-178.
[26] Tasdemir U,Buyukleblebici S,Tuncer PB,et al. Effects of various cryoprotectants on bull sperm quality,DNA integrity and oxidative stress parameters [J]. Cryobiology,2013,66(1):38-42.
[27] 毕明帅,李俊君,陈帝昂,等.抗氧化类中药对睾丸生精功能的影响研究进展[J].中国男科学杂志,2015,29(8):59-61. |
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