|
|
|
| Efficiency of combination therapy with Jiannao Zhichou Granules and Tiapride in children with tourette syndrome |
| YANG Shenghai1 WANG Liwen1 WANG Jun1 XU Cuijuan1 WAN Fuqin1 GUO Jian2 |
1.Department of Neurology, Children′s Hospital, Capital Institute of Pediatrics, Beijing 100020, China;
2. Department of Rehabilitation, Beijing Shou′er Liqiao Children′s Hospital, Beijing 101314, China |
|
|
|
Abstract Objective To observe the clinical efficacy of combination therapy with Jiannao Zhichou Granules and Tiapride in children with Tourette syndrome (TS). Methods Children with TS diagnosed in outpatient of Children′s Hospital affiliated to Children′s Hospital, Capital Institute of Pediatrics were collected from March to November in 2015, which were randomly divided into treatment group and control group, with 30 cases in each group. The control group was treated with monotherapy of Tiapride, and the treatment group was treated with combination therapy with Jiannao Zhichou Granules and Tiapride. They were treated for 12 weeks. The daily dosage of Tiapride in the two groups were recorded, the Yale global tic severity scale (YGTSS) before and after treatment and the treatment efficiency in the two groups were compared. Results The daily dosage of Tiapride in the treatment group was lower than that in the control group (P < 0.05). The YGTSS scores at 4, 8 and 12 weeks after treatment in both groups were lower than that before treatment in the same group (P < 0.05), besides after treatment, the YGTSS scores in the treatment group at 4, 8 and 12 weeks after treatment were lower than those in the control group at the same time (P < 0.05). There was no statistically significant difference between the two groups in treatment efficiency (P > 0.05). Conclusion Combination therapy with Jiannao Zhichou Granules and Tiapride cannot significantly improve the treatment efficiency, while it can reduce the daily dosage of Tiapride and the YGTSS score clearly, compared with monotherapy of Tiapride.
|
|
|
|
|
|
[1] Hallett M. Tourette Syndrome：Update [J]. Brain Dev，2015， 37（7）：651-655.
[2] Muth CC. Tics and Tourette Syndrome [J]. JAMA，2017， 317（15）：1592.
[3] Dale RC. Tics and Tourette：a clinical，pathophysiological and etiological review [J]. Curr Opin Pediatr，2017，29（6）：665-673.
[4] 郑萍.抽动秽语综合征相关基因研究进展[J].国际儿科学杂志，2012（2）：155-158.
[5] Lee MH. A single case of Tourette′s syndrome treated with traditional Chinese medicine [J]. J Acupunct Meridian Stud， 2017，10（1）：55-61.
[6] 屈春媛.维尔康口服液结合硫必利治疗儿童抽动-秽语综合征74例疗效观察[J].辽宁医学院学报，2016，37（1）：26-28.
[7] 李少春.自拟静宁汤治疗儿童抽动-秽语综合征临床观察[J].中国中医急症，2010，19（8）：1299.
[8] American Psychiatric Association. Diagnostic and statistical manual of mental disorders [M]. 4th edition, text revision. Washington DC：American Psychiatric Association，2000.
[9] 江育仁，张奇文.实用中医儿科学[M].上海:上海科学技术出版社，1996.
[10] Leckman JF，Riddle MA，Hardin MT，et al. The Yale global tic severity scale：initial testing of a clinician rated scale of tic severity [J]. J Am Acad Child Adolesc Psychiatry，1989，28：566-573.
[11] Robertson MM，Eapen V，Singer HS，et al. Gilles de la Tourette syndrome [J]. Nat Rev Dis Primers，2017，2（3）：16 097.
[12] Robertson MM. A personal 35 year perspective on Gilles de la Tourette syndrome：prevalence，phenomenology，comorbidities，and coexistent psychopathologies [J]. Lancet Psychiatry，2015，2（1）：68-87.
[13] Pauls DL，Fernandez TV，Mathews CA，et al. The inheritance of tourette disorder：a review [J]. J Obsessive Compuls Relat Disord，2014，3（4）：380-385.
[14] Martino D，Zis P，Buttiglione M. The role of immune mechanisms in Tourette syndrome [J]. Brain Res，2015，18（1617）：126-143.
[15] Hoekstra PJ，Dietrich A，Edwards MJ，et al. Environmental factors in Tourette syndrome [J]. Neurosci Biobehav Rev，2013，37（6）：1040-1049.
[16] Mogwitz S，Buse J，Ehrlich S，et al. Clinical pharmacology of dopamine-modulating agents in Tourette′s syndrome [J]. Int Rev Neurobiol，2013，112：281-349.
[17] 张同园.中医药治疗抽动秽语综合征近况[J].北京中医，2007，26（5）：314-315.
[18] 黄宇虹，刘晋平，马融.辨证分型治疗抽动障碍的临床观察[J].天津中医药，2003，20（2）：76-77.
[19] 刘大为，张骠.滋肾平肝、熄风化痰法治疗小儿多发性抽动症18例报道[J].甘肃中医，2005，18（6）：14-15.
[20] 刘弼臣.小儿抽动-秽语综合征治疗经验[J].中国中医药现代远程教育，2004，2（7）：19-21. |
|
|
|
