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2023 Vol. 20, No. 34 Published: 2023-12-05

	4	Visual analysis of traditional Chinese medicine application in pancreatic cancer treatment based on CiteSpace
		ZHANG Dingdan TIAN Shaodan LYU Liyuan LUO Mei MIAO Lu
		DOI: 10.20047/j.issn1673-7210.2023.34.01
		Objective To explore the visual analysis of traditional Chinese medicine application in pancreatic cancer treatment based on CiteSpace. Methods Literatures related to the treatment of pancreatic cancer by traditional Chinese medicine collected in CNKI and Web of Science databases from January 2000 to December 2021 were searched by computer, and the author, institution, keyword co-occurrence, clustering, and emergence of this study were mapped and analyzed by using CiteSpace software. Results A total of 614 papers were included in the study, and the overall number of papers was on the rise, with 23 core authors, the largest number of papers was published by Fudan University. The keyword clustering graph showed that the current hot spots were mainly concentrated in traditional Chinese medicine syndrome differentiation and treatment, traditional Chinese medicine clinical research and mechanism of action, cell research, and other aspects. Conclusion The research heat of traditional Chinese medicine treatment of pancreatic cancer is increasing, and the research focus is gradually shifting to traditional Chinese medicine clinical observation and mechanism research. It is suggested to strengthen the connection between basic research and clinical practice, focus on transformation research, and fully explore the therapeutic value of traditional Chinese medicine.
		2023 Vol. 20 (34): 4-10,15 [Abstract] ( 23 ) HTML (1 KB) PDF (2953 KB) ( 206 )

	11	Factorial analysis of premeal and postmeal equivalence of mirtazapine bioequivalence test
		LI Wen LU Shousi ZHANG Tingting LIU Ping SONG Jie DUAN Yunxia QIAO Hong
		DOI: 10.20047/j.issn1673-7210.2023.34.02
		Objective To evaluate the bioequivalence and safety of two Mirtazapine Tablets in healthy Chinese subjects. Methods Plasma concentrations of Mirtazapine Tablets were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The pharmacokinetic parameters were calculated and bioequivalence was evaluated under the two conditions. Results Non-atrioventricular model was used to calculate the pharmacokinetic parameters. The geometric mean ratios of Cmax, AUC0-t, and AUC0-∞ in plasma of mirtazapine test preparation/reference preparation in fasting group were 127.85%, 113.03%, and 113.18%, respectively. The 90% confidence intervals (90%CI) were 108.42%-150.75%, 105.96%- 120.57%, 106.03%-120.81%, respectively, and the Cmax 90%CI did not completely fall within 80.00%-125.00% and was not equivalent. The geometric mean ratios of the main pharmacokinetic parameters of plasma Cmax, AUC0-t, and AUC0-∞ of the test preparation/reference preparation of mirtazapine in postprandial group were 95.48%, 99.71%, and 99.74%, respectively. The 90%CI was 83.01%-109.84%, 92.65%-107.31%, 92.36%-107.70%, respectively. 90%CI completely fell within 80.00%-125.00%. Conclusion The tested preparation Mirtazapine Tablets have the characteristics of postprandial bioequivalence and fasting non-equivalence, so it is necessary to optimize the factors of drug preparation, pharmacokinetics and strengthening subject management to achieve the equivalence with the reference preparation.
		2023 Vol. 20 (34): 11-15 [Abstract] ( 26 ) HTML (1 KB) PDF (806 KB) ( 166 )

	16	Study on the mechanism of inhibiting iron death of AGS cells in Jiawei Qifang Weitong Granules
		ZHANG Qinglang1 MO Xueni2 WANG Ting2 TANG Meiwen1
		DOI: 10.20047/j.issn1673-7210.2023.34.03
		Objective To investigate the mechanism of Jiawei Qifang Weitong Granules on inhibiting iron death of in gastric cancer cells. Methods Wistar rats were selected to prepare drug-containing serum. Gastric cancer AGS cells were divided into AGS group, blank serum group, and drug-containing serum group. The drug-containing serum was prepared by the conversion method of 19.4 g/(kg·d) intragastric administration of supplemented Qifang Weitong Granules fors seven days. Blank serum was prepared by routine feeding of rats in blank serum group. After two days of intervention, the cell activity and morphology of each group were detected, the contents of malondialdehyde (MDA) and glutathione (GSH) were detected by colorimetry, and the mRNA contents and protein expression levels of SLC7A11, P53 and GPX4 were detected by RT-qPCR and Western blot. Results The cell proliferation rate of drug-containing serum group was lower than that of blank serum group (P＜0.05). The mRNA contents of SLC7A11 and GPX4 in drug-containing serum group were lower than those in blank serum group, and the mRNA contents of P53 were higher than those in blank serum group (P＜0.01). The expression levels of SLC7A11 and GPX4 in drug-containing serum group were lower than those in blank serum group, and the expression level of P53 was higher than that in blank serum group (P＜0.01). The MDA content in drug-containing serum group was lower than that in blank serum group, and the GSH content was higher than that in blank serum group (P＜0.01). Conclusion Jiawei Qifang Weitong Granules can inhibit the proliferation of gastric cancer cells, and its effect may be related to the inhibition of ferroptosis signal.
		2023 Vol. 20 (34): 16-20 [Abstract] ( 20 ) HTML (1 KB) PDF (1181 KB) ( 208 )

	21	Explore the action mechanism of Bizhengning Decoction in the treatment of wind-cold-dampness bi type rheumatoid arthritis based on metabonomics
		HE Dongchu1* LI Jiangfeng2*
		DOI: 10.20047/j.issn1673-7210.2023.34.04
		Objective To explore the action mechanism of Bizhengning Decoction against wind-cold-dampness bi type rheumatoid arthritis based on the method of serum metabolomics. Methods A total of 24 SPF Wistar female rats, 160-180 g at seven weeks were divided into normal group, model group, and Bizhengning Decoction group according to the random number table method, with eight rats in each group. Wind-cold-dampness bi type rheumatoid arthritis rat model was prepared in model group and Bizhengning Decoction group, after seven days of modeling, there was limited movement, obvious swelling of the right foot, swelling of the left joint, and deformation of the relevant joint, indicating successful modeling. Bizhengning Decoction group was given 17.86 g/（kg·d） intervention for 28 days, and normal group and model group were given the same amount of normal saline for 28 days. The changes of hair color, diet, walking activity, and other general conditions were observed; differential metabolites and metabolic pathways were analyzed and screened. Results Compared with normal group, rats in the model group had weak mental state, less glossy hair, less dietary water intake, and obvious lameness on the right foot when walking; compared with model group, the mental state, hair luster, eating water, and walking lameness of right foot were improved in Bizhengning Decoction group. Compared with the normal group, the synovial tissue was hyperplasia, the joint cavity was blurred and narrow, and the inflammatory cell infiltration was obvious, the joint bone was destroyed, the joint surface was rough and uneven, and pannus was formed in the rate of the model group; compared with model group, the synovial tissue proliferation decreased, the joint cavity became clear and enlarged gradually, the inflammatory cell infiltration decreased significantly, the joint bone destruction and the joint surface roughness improved significantly, and the number of pannus decreased significantly in Bizhengning Decoction group. There were 45 different metabolites in normal group and model group, and 51 different metabolites in model group and Bizhengning Decoction group; the main pathways involved steroid hormone biosynthesis, arginine and proline metabolism, etc. Conclusion Bizhengning Decoction may affects the metabolism of arginine and proline, porphyrin and chlorophyll, and glycine, serine and threonine, etc.
		2023 Vol. 20 (34): 21-25,35 [Abstract] ( 15 ) HTML (1 KB) PDF (1243 KB) ( 229 )

	26	Effect of long non-coding RNA HOX transcript antisense inter genic RNA targeting miR-206 on migration and invasion of colorectal cancer cells
		XUE Qiang1 WU Xueliang2 SUN Guangyuan3 YANG Dongdong3 LI Kun4
		DOI: 10.20047/j.issn1673-7210.2023.34.05
		Objective To investigate the effect of long noncoding RNA (lncRNA) HOX transcript antisense inter genic RNA (HOTAIR) targeting miR-206 on invasion and migration of colorectal cancer cells. Methods HT-29 cells of human colorectal cancer were cultured regularly, and the synthetic HOTAIR siRNA and siRNA control were transfected into HT-29 cells as si-HOTAIR group and si-con group, and the non-transfected HT-29 cells were set as blank group. Real time-quantitative polymerase chain reaction was used to determine the transfection effect, and Transwell and scratch healing tests were used to detect the invasion and migration of HT-29 cells. Bioinformatics software analyzed the binding sites of HOTAIR and miR-206 region, and constructed mutant (HOTAIR 3’UTR mut) and wild type (HOTAIR 3’UTR wt) luciferase reporter vectors. HOTAIR 3’UTR wt and HOTAIR 3’UTR mut were transfected into HT-29 cells with miR-206 mimic or miR-NC vector. HOTAIR 3’UTR wt/miR-NC group, HOTAIR 3’UTR wt/miR-206 group, HOTAIR 3’UTR mut/miR-NC group and HOTAIR 3’UTR mut/miR-206 group were cultured for 48 h to detect luciferase activity. HOTAIR siRNA and miR-206 inhibitor were co-transfected into HT-29 cells, si-HOTAIR+anti-NC group and si-HOTAIR+anti-miR-206 group were set up, and the cell invasion and migration levels were analyzed by Transwell and scratch healing assay. Results There was no significant difference in the expression level of HOTAIR mRNA in HT-29 cells between blank group and si-con group (P＞0.05). Compared with si-con group, the expression level of HOTAIR mRNA in HT-29 cells in si-HOTAIR group was decreased (P＜0.01). There was no significant difference in HT-29 cell invasion number and cell scratch healing rate between blank group and si-con group (P＞0.05). Compared with the si-con group, the invasion number of HT-29 cells in the si-HOTAIR group was decreased, and the cell scratch healing rate was decreased (P＜0.01). Compared with HOTAIR 3’UTR wt/miR-NC group, the luciferase activity of HOTAIR wt in the HOTAIR 3’UTR wt/ miR-206 group decreased (P＜0.01). There was no significant difference in fluorescein activity between HOTAIR 3’UTR mut/miR-NC group and HOTAIR 3’UTR mut/miR-206 group (P＞0.05). Compared with si-HOTAIR+anti-NC group, the expression level of miR-206 in si-HOTAIR+anti-miR-206 group was decreased (P＜0.01). Compared with si-HOTAIR+anti-NC group, the invasion and mobility of HT-29 cells in si-HOTAIR+anti-miR-206 group were increased (P＜0.01). Conclusion HOTAIR promotes the invasion and migration of HT-29 cells by negatively regulating miR-206.
		2023 Vol. 20 (34): 26-30 [Abstract] ( 18 ) HTML (1 KB) PDF (1174 KB) ( 219 )

	31	Expression of acidic ribosomal phosphoprotein P2 in hepatocellular carcinoma and its influence on prognosis
		YANG Qingqing HUANG Yang CHEN Jin XIAO Xueyi WU Xudong▲
		DOI: 10.20047/j.issn1673-7210.2023.34.06
		Objective To investigate the expression of acidic ribosomal phosphoprotein P2 (RPLP2) in hepatocellular carcinoma (HCC) and its influence on prognosis. Methods The expression of RPLP2 in HCC tissues and its relationship with overall survival (OS) and disease-free survival (DFS) were analyzed by TCGA database. Cancer tissues and adjacent tissues of 60 HCC patients treated in Yancheng NO.1 People’s Hospital, Jiangsu Province from June 2018 to June 2022 were selected and the expression level of RPLP2 were detected by Western blot. According to the immunohistochemical staining score of RPLP2 in the cancer tissues, the patients were divided into high expression group (51 cases) and low expression group (nine cases). Survival curve and Cox regression model were used to analyze the expression of RPLP2 and its influence on the prognosis of HCC. Results According to the results of database analysis, the expression of RPLP2 in HCC cancer tissues was significantly up-regulated, and the OS and DFS in patients with high RPLP2 expression were shorter than those with low RPLP2 expression, the differences were statistically significant (P＜0.05). The expression levels of RPLP2 protein in cancer tissues of 60 HCC patients were higher than those in adjacent tissues, and the differences were statistically significant (P＜0.05). OS and DFS in high expression group were shorter than those in low expression group, and the differences were statistically significant (P＜0.05). Cox regression model analysis showed that TNM stage, Barcelona clinical liver cancer stage, Edmondson grade, alpha-fetoprotein, and RPLP2 expression levels were influencing factors for OS and DFS in HCC patients (P＜0.05). Conclusion RPLP2 is highly expressed in HCC tissues and is closely related to the clinical prognosis of patients.
		2023 Vol. 20 (34): 31-35 [Abstract] ( 21 ) HTML (1 KB) PDF (1251 KB) ( 83 )

	36	Research progress on the mechanism of damage of diabetic kidney disease glomerular filtration barrier caused by lipotoxicity
		SONG Kaiyong1 XIONG Weijian1 TIAN Lu1 XIONG Mengyuan2 TAO Wenqiang1 WANG Miao1
		DOI: 10.20047/j.issn1673-7210.2023.34.07
		More than 10% of the population is affected by abnormal kidney function, and most kidney diseases are characterized by a breakdown of the glomerular filtration barrier. Glomerular filtration barrier is a unique multilayered structure composed of glomerular endothelial cells, basement membrane, and podocytes. When lipid metabolism is disturbed, it will induce P2X7R-NLRP3 inflammatory body axis, sterol-regulatory element binding protein, vascular endothelial growth factor-B, junction adhesion molecule-like protein, sterol-O-acyl transferase 1, ATP-binding cassette transporter A1, and other proteases and factors to produce inflammatory response and oxidative stress. This paper focuses on the effects of lipid toxicity caused by ectopic lipid deposition on glomerular filtration barrier, which will provide a new idea for the treatment of diabetic kidney disease.
		2023 Vol. 20 (34): 36-39 [Abstract] ( 15 ) HTML (1 KB) PDF (701 KB) ( 230 )

	40	Research progress on the construction methods and main uses of index system in the research field of traditional Chinese medicine
		FU Jing
		DOI: 10.20047/j.issn1673-7210.2023.34.08
		With the vigorous development of Chinese medicine, all kinds of information are extremely abundant, the evaluation and choice faced by Chinese medicine workers is becoming more and more complex. As a tool or means to assist decision-making, there are increasing studies on the construction and application of indicator system. In this paper, the methods of interview, grounded theory, Delphi method, and chromatographic analysis are sorted out in the field of traditional Chinese medicine; the index system is mainly used for suitable technology screening, clinical efficacy evaluation, service ability evaluation, talent training quality evaluation, and so on; on this basis, it points out the limitations of the construction and application of the current index system, and gives suggestions for further research and application in the future.
		2023 Vol. 20 (34): 40-43 [Abstract] ( 25 ) HTML (1 KB) PDF (692 KB) ( 89 )

	44	Research progress on the relationship between anti-neutrophil cytoplasmic antibody-associated vasculitis and infection
		GAO Chang MA Liang GOU Shenju▲
		DOI: 10.20047/j.issn1673-7210.2023.34.09
		Under the current treatment strategy of glucocorticoid combined with immunosuppressants, infection has become one of the main complications and early causes of death in the treatment of anti-neutrophil cytoplasmic antibody associated vasculitis (AAV). At the same time, infection can also induce and aggravate AAV through various mechanisms, increasing the incidence and recurrence rate of AAV. In clinical practice, the clinical manifestations of active AAV and infection are similar, and it is easy to be misdiagnosed. It is necessary to distinguish infection and AAV from multiple levels and use multiple detection methods to achieve early diagnosis and treatment. With the continuous improvement of current detection methods and in-depth understanding of pathogens, it will be beneficial to further understand the close relationship between infection and AAV, and provide help for clinical differential diagnosis and treatment of the two.
		2023 Vol. 20 (34): 44-47,52 [Abstract] ( 20 ) HTML (1 KB) PDF (708 KB) ( 77 )

	48	Research progress of Chinese medicine treatment of vascular dementia based on PI3k/Akt pathway
		ZHOU Kaijun1 YANG Zhihong2 ZHOU Yue1 KANG Yu1
		DOI: 10.20047/j.issn1673-7210.2023.34.10
		Taking the phosphatidylinositol 3-kinase (PI3K)/Akt kinase (Akt) signaling pathway as the entry point, this paper summarizes the research progress of Chinese medicine in treating vascular dementia (VD) through PI3K/Akt signaling pathway, in order to provide reference for the mechanism research and clinical application of Chinese medicine in treating VD. Chinese medicine compound, Chinese medicine active ingredient, and acupuncture treatment mainly play the role of inhibiting inflammatory response, anti-oxidative stress, anti-apoptosis, regulating autophagy, protecting brain neurology, and improving synaptic plasticity through regulating PI3K/Akt signaling pathway to intervene the occurrence and development of VD.
		2023 Vol. 20 (34): 48-52 [Abstract] ( 24 ) HTML (1 KB) PDF (711 KB) ( 164 )

	53	Current status of research on treatment of knee osteoarthritis with platelet-rich plasma based on Wnt/β-catenin signaling pathway
		DENG Lei1 WANG Shaohua2 HOU Yingzhou2 YANG Guangya1 LI Kewei2 SUN Bo2
		DOI: 10.20047/j.issn1673-7210.2023.34.11
		Knee osteoarthritis (KOA) is a chronic degenerative bone disease characterized by the wear of articular cartilage. In the early stage, the main manifestations are knee pain, swelling, and limited joint movement, which can eventually lead to locking of the knee, deformity, and disability. Wnt/β-catenin signaling pathway plays an important role in the pathogenesis and development of KOA, which influences the metabolic balance of articular cartilage and subchondral bone by regulating cell proliferation and differentiation. Platelet-rich plasma (PRP), as a new treatment for KOA, can slow down the pathologic progression of KOA by delaying cartilage degeneration, promoting cartilage regeneration, and inhibiting intra-articular inflammation, which may be related to its involvement in the regulation of Wnt/β-catenin signaling pathway. This article mainly introduces the pathological relationship between Wnt/β-catenin signaling pathway and KOA, the application of PRP in the treatment of KOA, and the research status of PRP based on Wnt/β-catenin pathway in the treatment of KOA, aiming to provide more theoretical basis for the clinical treatment of KOA with PRP.
		2023 Vol. 20 (34): 53-56 [Abstract] ( 16 ) HTML (1 KB) PDF (701 KB) ( 28 )

	57	Research progress on artificial intelligence-assisted clinical ultrasound -tongue image multiomics combined diagnosis of non-puerperal mastitis
		LI Menghan1* SONG Renfeng2* JIANG Jiuzhi3 LIU Mengyou4 XU Bin5 PIAO Mingji6 CUI Jianchun7
		DOI: 10.20047/j.issn1673-7210.2023.34.12
		With the increasing pressure of life, the prevalence of non-puerperal mastitis in women is increasing. How to effectively diagnose and treat this disease situation is urgent. At present, clinical experience has confirmed that traditional Chinese medicine is the most effective way to treat non-puerperal mastitis. However, Chinese medicine and western medicine are two relatively independent diagnosis and treatment systems, and the theory of traditional Chinese medicine is mostly ancient traditional philosophical thought, which is different from the modernization of western medicine, resulting in the inability to popularize the diagnosis and treatment of traditional Chinese medicine in western medicine hospitals. Therefore, if traditional Chinese medicine factors are applied to the diagnosis and treatment of western medicine systems for multi-omics combination, it is expected to solve this problem. As one of the objective indicators in traditional Chinese medicine theory, traditional Chinese medicine tongue elephant is relatively intuitive and clear, and is expected to become one of the factors in the diagnosis of non-puerperal mastitis by combining Chinese medicine and western medicine. This article mainly discusses the research progress of clinical symptomatology, ultrasound imaging, and Chinese medicine tongue imaging in non-puerperal mastitis, and combines the development process of artificial intelligence disease diagnosis to form a precision system of integrated traditional Chinese and western medicine for multiomics joint diagnosis of this disease, which is expected to promote the homogeneous promotion of this technology in western medicine hospitals and grassroots hospitals.
		2023 Vol. 20 (34): 57-60,73 [Abstract] ( 26 ) HTML (1 KB) PDF (1136 KB) ( 213 )

	61	Research progress on the relationship between hemorrhagic stroke and pyroptosis
		GUO Peixin1 ZOU Wei2
		DOI: 10.20047/j.issn1673-7210.2023.34.13
		Hemorrhagic stroke is a serious disease with a high mortality and disability rate, including intracerebral hemorrhage and subarachnoid hemorrhage, which poses a serious threat to the life and quality of life of patients. Pyroptosis is a kind of proinflammatory cell death. In recent years, studies have found that pyroptosis plays an important role in the physiological and pathological process of stroke, and is a potential therapeutic target to reduce inflammatory response and restore neurological function after stroke. However, there are relatively few discussions on the role and mechanism of pyroptosis in cell death and inflammatory response after hemorrhagic stroke. This article discusses the molecular mechanism of pyroptosis and its difference from other cell death modes, summarizes the experimental studies on the molecules related to pyroptosis and hemorrhagic stroke in the published literature in recent years, and explores the role of pyroptosis in the neuronal death and inflammatory response of hemorrhagic stroke.
		2023 Vol. 20 (34): 61-64 [Abstract] ( 16 ) HTML (1 KB) PDF (696 KB) ( 78 )

	65	Research status and prospect of circRNA in Cisplatin resistance in bladder cancer
		WANG Qun SUN Yuxin LUAN Ting WANG Haifeng
		DOI: 10.20047/j.issn1673-7210.2023.34.14
		Bladder cancer is one of the most common tumors in the human urogenital system. Currently, the first-line treatment for advanced and metastatic bladder cancer is Cisplatin-based chemotherapy. However, the overall clinical efficacy of Cisplatin is unsatisfactory due to the emergence of drug resistance. With the recent intensive research on circular RNA (circRNA), which regulates downstream mRNA through the regulation of miRNA, it has been found to be involved in the progression of bladder cancer and chemotherapy resistance. Therefore, circRNA may be a potentially promising target for the treatment of bladder cancer. This paper mainly reviewed the mechanism of different circRNA and cisplatin resistance in bladder cancer. These studies will deepen the understanding of the role of the circRNA in the progression of bladder cancer and provide a new entry point for further explore bladder cancer and its Cisplatin resistance mechanisms.
		2023 Vol. 20 (34): 65-68 [Abstract] ( 12 ) HTML (1 KB) PDF (693 KB) ( 54 )

	69	Teaching design and practice of input-enabling progressive activities in traditional Chinese medicine English listening and speaking class
		YAN Li1 LI Xiaoying2 WANG Shanshan1
		DOI: 10.20047/j.issn1673-7210.2023.34.15
		Listening and speaking teaching is a difficulty in traditional Chinese medicine English teaching. Students always suffer from their oral activities fear, output difficulties, and sparse statements, which is closely related to the fact that the listening text fails to serve the students’ oral output. Based on the production-oriented approach, this paper makes a teaching design of input-enabling progressive activities from the perspective of full analysis of listening texts in the traditional Chinese medicine English listening and speaking class, and carries out a practice research from three dimensions of What, How, and Why. It is proved that the teaching design is helpful for teachers to make full use of the teaching materials, for students to improve their listening and speaking capacity of traditional Chinese medicine English, and finally to improve the teaching effect of the course.
		2023 Vol. 20 (34): 69-73 [Abstract] ( 23 ) HTML (1 KB) PDF (690 KB) ( 82 )

	74	Application of integrated teaching platform based on motivational control strategy in nursing practice teaching
		ZHANG Huan1 XU Min1 CHEN Jing1 SUN Lingyun1 WANG Xueyang1 XU Zheng2 LIU Yang3
		DOI: 10.20047/j.issn1673-7210.2023.34.16
		Objective To explore the application effect of integrated teaching platform based on motivation control strategy in nursing practice teaching. Methods A total of 56 undergraduate nursing students who practiced breast surgery in the Affiliated Cancer Hospital of Harbin Medical University from July 2021 to April 2022 were selected as the study objects, 29 nursing students who practiced from July to November 2021 were selected as the control group, and 27 nursing students who practiced from December 2021 to April 2022 were selected as the test group. The control group adopted the traditional clinical practice teaching mode, and the experimental group received the integrated teaching platform based on motivation regulation strategy. After the teaching, the differences of assessment scores, autonomous learning ability and clinical thinking ability were compared between the two groups. Results After teaching, test group score was higher than control group, the difference was statistically significant (P＜0.05). After teaching, the self-management ability, information ability, learning cooperation ability and total score of the two groups were higher than before intervention, and the experimental group was higher than the control group, the difference was statistically significant (P＜0.05). After teaching, the total score of clinical thinking ability and the scores of systematic thinking and evidence-based thinking in experimental group were higher than those in control group (P＜0.05). Conclusion Applying the integrated teaching platform based on motivation regulation strategy to nursing clinical practice teaching can improve students’ autonomous learning ability and clinical thinking ability, and it is worth applying and promoting.
		2023 Vol. 20 (34): 74-77,82 [Abstract] ( 23 ) HTML (1 KB) PDF (646 KB) ( 265 )

	78	Teaching reform of basic medicine morphology based on practical ability training
		WEI Yuanyuan1 GAO Fanfan1 Dilinaer·Bolati1 BAI Shengbin2 WANG Song1 XU Qi1
		DOI: 10.20047/j.issn1673-7210.2023.34.17
		This paper aims to improve the practical innovation ability of students majoring in basic medicine, and explores the training path of high-quality basic medical talents through the reconstruction of morphological teaching content, methods and means. First of all, through selecting interdisciplinary teaching content, students’ overall medical view is constructed, and the key knowledge points are taken as clues, the course contents of anatomy, embryo formation, and physiology are integrated, and the integration of ideological and political courses and majors is emphasized, so as to form a relatively complete basic medical knowledge system. On this basis, diversified teaching methods such as case-based learning and problem based learning, internet + individualized teaching and second classroom are applied to continuously expand the depth and breadth of knowledge, and use mind mapping to integrate teaching at all levels to cultivate students’ divergent thinking and innovative thinking. Finally, take the innovation and entrepreneurship competition as the starting point, improve the innovative experimental teaching mode and enhance the practical innovation ability, and lay a foundation for the subsequent training of top-notch talents.
		2023 Vol. 20 (34): 78-82 [Abstract] ( 22 ) HTML (1 KB) PDF (1066 KB) ( 201 )

	83	Application effect of ADDIE model teaching combined with CBL teaching method in the training of physicians in hematology department
		DING Xiaoxiao1 DING Xinhua2 GUO Yanrong1
		DOI: 10.20047/j.issn1673-7210.2023.34.18
		Objective To analyze the application effect of ADDIE model teaching combined with case-based learning(CBL) teaching method in the standardized training of resident doctors rotating (referred to as “training”) in hematology department. Methods Fifty-one training physicians in Department of Hematology, Taizhou Central Hospital (Taizhou University Affiliated Hospital), Zhejiang Province from February 2020 to October 2022 were selected as the study objects, and according to the method of random number table, they were divided into 25 subjects in the control group (CBL method) and 26 subjects in the study group (ADDIE model method combined with CBL method). The results, satisfaction survey, mini-clinical evaluation exercise (Mini-CEX), subjective objective assessment plan (SOAP) score, and direct observation of procedural skills (DOPS) score of the two groups were compared. Results The scores of theoretical exams, medical record writing and clinical thinking decision making in the study group were higher than those in the control group (P＜0.05); the total satisfaction in the study group was higher than that in the control group (P＜0.05); Mini-CEX scores of medical consultation, physical examination, communication skills, and humanistic care treatment plan in the study group were higher than those in the control group(P＜0.05); the scores of SOAP and DOPS in the study group were higher than those in the control group (P＜0.05). Conclusion The ADDIE model teaching method combined with CBL teaching method is helpful to strengthen the clinical practice ability and improve the satisfaction of teaching mode in the training of hematology physicians.
		2023 Vol. 20 (34): 83-86 [Abstract] ( 13 ) HTML (1 KB) PDF (638 KB) ( 106 )

	87	Study on the correlation and influencing factors of manual function in elderly people
		HOU Xue1 WEN Xiaoni2
		DOI: 10.20047/j.issn1673-7210.2023.34.19
		Objective To explore the correlation and influencing factors of elderly people’s hand function. Methods A total of 100 elderly residents of Yijun County, Tongchuan City, Shaanxi Province meeting the inclusion criteria from June to Sep- tember 2022 were selected by simple random sampling method. The participants were tested for grip strength, hand flexibility (box and block test [BBT test]), coordination ability, functional extension, timed stand up, and walk, static balance, 30 s sitting and standing, 6 min walking distance, shoulder joint flexibility, lumbar motion and other functional tasks. After excluding invalid data, the test data of 88 elderly people were finally included in this study. Then the correlation and influencing factors were analyzed and studied. Results The BBT values of the left hand and the right hand were (38±8) number/min and (39±8) number/min respectively. The grip strength of the dominant hand was (166.8±75.0) N. The correlation results showed that BBT left hand test was positively correlated with BBT right hand test, grip strength, Schober test, 30 s sitting and standing test, functional extension test, right back scratching test, left back scratching test, static balance and coordination function, and was negatively correlated with age and timing standing and walking test (P＜0.05). BBT right hand test was positively correlated with grip strength, Schober test, 30 s sitting and standing test, functional extension test, right back scratching test, left back scratching test, static balance and coordination function, but was negatively correlated with age and timing standing and walking test (P＜0.05). Grip strength was positively correlated with 6 min walking test, Schober test, 30 s sitting and standing test, functional stretching test, static balance and coordination function, and was negatively correlated with timed standing and walking test (P＜0.05). 6min walking test, timed standing up and walking test, and functional stretching test were all influencing factors of grip strength, among which the test value of timed standing up and walking test has the greatest influence on grip strength (B=-14.916, P=0.030). The regression equation was as follows: grip strength =73.31+0.26×6 min walking test -14.91× timed stand up and walk test +3.61× functional stretching test. Factors affecting hand flexibility included 30 s sitting and standing test, functional extension test, and Schober test, among which Schober test value (B=1.140, P=0.029) had the greatest influence on hand flexibility. Regression equation: hand flexibility =2.58+0.70×30 s sitting and standing +0.25× functional stretching test +1.14×Schober test. Conclusion The manual flexibility and grip strength of the elderly are correlated with functional tasks that reflect postural control, such as standing up and walking, sitting and standing for 30 s, functional extension, static balance, coordination and lumbar motion, among which functional extension test is a common factor affecting grip strength and hand flexibility. It is speculated that hand function assessment may be one of the important methods to indirectly reflect functional extension test.
		2023 Vol. 20 (34): 87-91 [Abstract] ( 17 ) HTML (1 KB) PDF (785 KB) ( 118 )

	92	Influence of childhood parenting style on personality development of adolescents with depression
		HUANG Kaiyi LYU Xueyu CHANG Jingjing ZHANG Liang LI Li WANG Weidong
		DOI: 10.20047/j.issn1673-7210.2023.34.20
		Objective To explore the influence of childhood rearing style on personality development of depression patients. Methods From January 2020 to December 2021, a total of 324 patients with depression (depression group) were selected from the outpatient clinic of Guanganmen Hospital of the Chinese Academy of Chinese Medical Sciences, and 328 normal subjects (control group) who matched the age, gender, years of education, and whether they were only children in the national urban population norm database of Wang Weidong’s retrospective personality developmental inventory (WMPI) were selected. The WMPI scale was used to compare the differences in childhood parenting style and adolescent personality development between the two groups. and the effect of childhood parenting styles on personality development in adolescence in the depression group. Results The scores of punishment, harshness, excessive interference, indulgence, contradictory education and neglect protection in depression group were higher than those in control group, and the difference was statistically significant (P＜0.05). Conclusion The parenting style of depressed patients has a significant impact on their personality development during adolescence. Especially in terms of doting, neglect of protection, excessive interference, etc.
		2023 Vol. 20 (34): 92-95,100 [Abstract] ( 22 ) HTML (1 KB) PDF (781 KB) ( 172 )

	96	Effect of Cuyu Xunxi Decoction on postoperative complications and wound healing of complex anal fistula with syndrome of dampness-heat diffusing downward
		YANG Qiqi LUO Chunsheng QU Yin WANG Qingyuan YANG Wei ZHENG De▲
		DOI: 10.20047/j.issn1673-7210.2023.34.21
		Objective To summarize and observe effect of Cuyu Xunxi Decoction on postoperative complications and wound healing of complex anal fistula with syndrome of dampness-heat diffusing downward. Methods A total of 120 complex anal fistula patients with syndrome of dampness-heat diffusing downward which hospitalized and operated in Shushuang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from July 2021 to October 2022 were selected as the study objects, and were divided into treatment group and control group according to random number table method, with 60 cases in each group. After anal fistulectomy, the treatment group was given Cuyu Xunxi Decoction and the control group was given Permanganometric Solution. Both groups were treated for 14 days. Postoperative complication score, wound healing area, and gastrointestinal quality of life score of the two groups were observed at different time points before and after intervention, and the levels of platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) in wound secretions before and after intervention were compared. Results The pain and exudation scores of the treatment group on the 7th and 14th day after operation were lower than those of the operation day and the control group at the same time; the edema score was higher than that of the operation day, and lower than that of the control group at the same time; the bleeding score on the 14th day after operation was lower than that on the 7th day after operation, and the bleeding score on the 7th day after operation was lower than that in the control group at the same time (P＜0.05). The pain and exudation scores of the control group on the 14th day after operation were lower than those on the operation day and the 7th day after operation; the edema scores on the 7th and 14th day after operation were higher than those on the day of operation; the bleeding score on the 7th day after operation was higher than that on the day of operation, and the bleeding score on the 14th day after operation was lower than that on the 7th day after operation (P＜0.05). On the 14th and 28th day after operation, the wound area of the two groups was smaller than that on the operation day, and the gastrointestinal quality of life index was higher than that on the operation day; on the 28th day after operation, the wound area of the two groups was smaller than that on the 14th day after operation, and that of the treatment group was smaller than that of the control group at the same time, the gastrointestinal quality of life index of the two groups was higher than that on the 14th day after operation, and that of the treatment group was higher than that of the control group at the same time (P＜0.05). After fumigation and washing 14 days, the levels of PDFG and VEGF in wound secretion of the two groups were higher than those before fumigation and washing, and those in the treatment group were higher than those in the control group (P＜0.05). Conclusion Cuyu Xunxi Decoction can effectively reduce postoperative complications in patients with complicated anal fistula, promote growth factor secretion, accelerate wound healing, and have significant clinical effects.
		2023 Vol. 20 (34): 96-100 [Abstract] ( 22 ) HTML (1 KB) PDF (777 KB) ( 32 )

	101	Comparative study on uric acid lowering effects of different regimens on pyrazinamide induced hyperuricemia
		SU Lingling1 ZHENG Meiqin2 XU Rui2 LIU Qiuyue3 GUO Zhenyong2 LIU Shuo2
		DOI: 10.20047/j.issn1673-7210.2023.34.22
		Objective To compare the effect of different intervention schemes on lowering uric acid in pyrazinamide induced hyperuricemia. Methods The adverse reaction reports of pyrazinamide induced hyperuricemia in Beijing Chest Hospital Affiliated to Capital Medical University from January 2012 to December 2022 were searched. The basic information and blood uric acid level of the patients were collected, and the patients were divided into benbromarone treatment group (74 cases), lifestyle intervention group (31 cases), pyrazinamide disuse group (25 cases) and allopurinol treatment group (4 cases) according to the way of lowering uric acid. Using the change rate of blood uric acid level as index, the effect of lowering uric acid in each group was compared by one-way ANOVA. Results A total of 134 patients were included, including 91 males (67.9%). The median age was 30 (22, 51) years; body weight (58.8±11.8) kg; height (169.1±7.4) cm; 107 cases (79.9%) were treated with first-line anti-tuberculosis therapy. Days of application of pyrazinamide 7 (6, 9) days; there were 22 patients (16.4%) with history of drug allergy. There were significant differences in blood uric acid at 3 to 5 weeks after the intervention and the change rate of uric acid after the intervention (P＜0.05). Among them, the change rate of blood uric acid in benbromarone treatment group, lifestyle intervention group and allopurinol treatment group at 3 to 5 weeks after intervention was higher than that of pyrazinamide disuse group, and the change rate of uric acid in lifestyle intervention group was higher than that of benbromarone treatment group, with statistical significances (P＜0.05). Conclusion Among the four programs to reduce blood uric acid, the withdrawal of pyrazinamide is the most effective, and the use of benzbromarone can also reduce uric acid, but the effect of lifestyle intervention is not as good as the above two programs.
		2023 Vol. 20 (34): 101-104 [Abstract] ( 17 ) HTML (1 KB) PDF (716 KB) ( 63 )

	105	Analysis of clinicopathological features of orbital meningioma in 27 cases
		WANG Jia CAI Fengmei▲ ZHAO Ying ZHANG Ge QIAN Wei LI Yuanpeng ZHI Lingran WANG Huifang
		DOI: 10.20047/j.issn1673-7210.2023.34.23
		Objective To investigate the clinicopathologic features of orbital meningioma. Methods A total of 27 patients with orbital meningioma admitted to Xi’an People’s Hospital from October 2015 to June 2021 were collected, the clinicopathological features of the patients were analyzed retrospectively, and relevant literatures were reviewed. Results The median age of 27 patients with orbital meningioma was 50 years old, with 11 cases occurring in the right orbit and 16 cases in the left orbit. Most clinical symptoms were mainly eye pain, bloating, unclear vision, and protruding eyeballs or eye masses. There were 17 cases of meningeal epithelial cell type, one case of fibrous type, five cases of transitional type, three cases of atypical, and one case of clear cell type. A total of 27 patients were followed up for 1-68 months after surgery, with an average of 18.5 months. Among them, four cases recurred and the rest recovered well. Immunohistochemical results showed that somatostatin receptor-2, progesterone receptor, vimentin, and epithelial membrane antigen were positive in all patients, extremely low molecular weight keratin CAM5.2 and glial fibrillary acidic protein were negative in all patients. There were 25 cases of D2-40 positive, two cases of S-100 focal positive. Ki-67 appreciation index was about 1%-2% in 24 cases and 3%-8% in three cases. Conclusion The histological morphology of primary orbital meningioma is mainly meningeal epithelial cell type. The markers of tumor-related antibodies somatostatin receptor-2, progesterone receptor, Vimentin, epithelial membrane antigen, and D2-40 are helpful for diagnosis.
		2023 Vol. 20 (34): 105-110 [Abstract] ( 17 ) HTML (1 KB) PDF (3190 KB) ( 100 )

	111	Clinical effect of She medicine Shiliangcha Prescription combined with continuous positive airway pressure per nasal in the treatment of obstructive sleep apnea hypopnea syndrome and obesity with pattern of phlegm-damp congestion and excessiveness
		WEI Yibo CHEN Linjing CHENG Ling JI Xingzu
		DOI: 10.20047/j.issn1673-7210.2023.34.24
		Objective To observe the efficacy of She medicine Shiliangcha Prescription combined with continuous positive airway pressure (CPAP) per nasal in the treatment of obstructive sleep apnea hypopnea syndrome (OSAHS) and obesity patients with pattern of phlegm-damp congestion and excessiveness. Methods A total of 100 OSAHS and obesity patients with pattern of phlegm-damp congestion and excessiveness admitted to Lishui Traditional Chinese Medicine Hospital of Zhejiang Province from January 2021 to January 2023 were selected, and they were divided into observation group and control group according to the random number table method, with 50 cases in each group. The control group was treated with CPAP per nasal, and the observation group was treated with CPAP per nasal combined with She medicine Shiliangcha Prescription,both groups were treated for 12 weeks. The clinical efficacy, and traditional Chinese medicine syndrome scores, poly- somnography parameters (apnea hypopnea index [AHI], mean arterial oxygen saturation [MSaO2], ratio of SaO2＜90% time/total sleep time), serum indexes (C-reactive protein [CRP], interleukin-8 [IL-8]), and body mass index (BMI) before and after treatment were compared between the two groups. Results There was no significant difference in the efficacy between the two groups (P＞0.05). After treatment, the traditional Chinese medicine syndrome scores, AHI, the ratio of SaO2＜90% time/total sleep time, body mass index, and serum CRP, IL-8 in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05). The MSaO2 of the two groups was higher than that before treatment, and that of the observation group was higher than that of the control group, and the differences were statistically significant (P＜0.05). Conclusion She medicine Shiliangcha Prescription combined with CPAP per nasal in the treatment of OSAHS and obesity patients with pattern of phlegm-damp congestion and excessiveness can effectively improve the signs and clinical symptoms.
		2023 Vol. 20 (34): 111-114,148 [Abstract] ( 27 ) HTML (1 KB) PDF (1313 KB) ( 96 )

	115	Analysis of prognostic influencing factors in patients with acute pancreatitis and abnormal liver function
		ZHANG Chen XU Jing REN Jing WANG Rong▲
		DOI: 10.20047/j.issn1673-7210.2023.34.25
		Objective To explore the prognostic influencing factors of patients with acute pancreatitis and abnormal liver function. Methods A retrospective study was conducted to select 236 patients with acute pancreatitis with abnormal liver function from January 2017 to May 2021 in Jiangsu Provincial People’s Hospital. The differences of hypertension, diabetes, and clinical data of patients with different prognosis during hospitalization were analyzed. Results The age, acute physiological function, and chronic health status score Ⅱ (APACHEⅡ), bedside index of acute pancreatitis severity (BISAP) score, modified CT severity index (MCTSI) score and lactate dehydrogenase (LDH) of the poor prognosis group were higher than those of the good prognosis group, with statistical significances (P＜0.05). The proportion of hypertension and diabetes mellitus in the poor prognosis group was higher than that in the good prognosis group, the difference was statistically significant (P＜0.05). Logistic regression analysis showed that age, diabetes mellitus, APACHEⅡ score, BISAP scores, MCTSI score, and LDH were the prognostic factors of patients (OR＞1，P ＜ 0.05). Logit (P) =-12.321+0.519× age +0.722× diabetes +1.054×APACHEⅡ score +1.544×BISAP score+1.201×MCTSI score +0.822×LDH equation predicted the prognosis of patients with the area under ROC curve was 0.891 (P＜0.05), the sensitivity and specificity were 80.00% and 82.00%, respectively. Conclusion The prognosis of patients with acute pancreatitis with abnormal liver function is affected by many factors, such as age, diabetes mellitus, APACHEⅡ score, etc., which should be paid attention to in clinical treatment.
		2023 Vol. 20 (34): 115-119 [Abstract] ( 24 ) HTML (1 KB) PDF (754 KB) ( 262 )

	120	Application effect of two-stage citric acid anticoagulant therapy in hem-odialysis patients with active bleeding or high risk of bleeding
		WU Chunxiang LIU Chunxiao ZHANG Cuiyong LUO Shuwen WEI Xinyue LUO Chunming
		DOI: 10.20047/j.issn1673-7210.2023.34.26
		Objective To investigate the application effect of two-stage citric acid anticoagulant therapy in hemodialysis patients with active bleeding or high risk of bleeding. Methods A total of 100 hemodialysis patients with active bleeding or high risk of bleeding admitted to Liuzhou Worker’s Hospital, Guangxi Zhuang Autonomous Region from May 2021 to March 2022 were selected as the study objects, and they were divided into study group and control group according to random number table method, with 50 cases in each group. The control group was treated with one-stage citric acid anticoagulant therapy, while the study group was treated with two-stage citric acid anticoagulant therapy. The dialysis time, anticoagulant efficiency of dialyzer, anticoagulant efficiency of intravenous pot of the two groups were compared, and the hemodialysis blood gas index, peripheral blood serum electrolyte level, and urea clearance at the end of dialysis were compared between the two groups. The occurrence of adverse events in both groups was recorded. Results The dialysis time of the study group was longer than that of the control group, and the anticoagulant effect of intravenous pot was higher than that of the control group, the differences were statistically significant (P＜0.05). After dialysis, the blood pH value and HCO3- of the two groups were higher than those before treatment, and the differences were statistically significant (P＜0.05). The online Kt/V value of the study group was higher than that of the control group, and the difference was statistically significant (P＜0.05). During dialysis, there was no significant difference in the total incidence of adverse events between the two groups (P＞0.05). Conclusion For hemodialysis patients with active bleeding or high risk of bleeding, two-stage citric acid anticoagulant therapy is superior to one-stage citric acid anticoagulant therapy in terms of dialysis time, anticoagulant efficiency of intravenous pot, and urea clearance in hemodialysis.
		2023 Vol. 20 (34): 120-123 [Abstract] ( 18 ) HTML (1 KB) PDF (768 KB) ( 29 )

	124	Clinical efficacy and safety of Duloxetine Hydrochloride and Amitriptyline in patients with herpes zoster neuralgia
		LI Xiaoqian LI Jing MA Chao HUANG Ying
		DOI: 10.20047/j.issn1673-7210.2023.34.27
		Objective To compare the clinical efficacy and safety of Duloxetine Hydrochloride and Amitriptyline in patients with herpes zoster neuralgia. Methods A total of 120 patients with herpes zoster neuralgia admitted to the Department of Pain Medicine, Nanjing Drum Tower Hospital Affiliated Nanjing University Medical College from January to August 2022 were selected, they were divided into Amitriptyline group (60 cases, Amitriptyline combined with Pregabalin orally) and Duloxetine group (60 cases, Duloxetine Hydrochloride combined with Pregabalin orally) by random number table method. Visual analogue scale (VAS) scores were compared between two groups before treatment and at 7, 14 d, and 28 d after treatment; Hamilton depression scale 17 (HAMD-17) scores was compared between two groups before treatment and at 14 d and 28 d after treatment; Pittsburgh sleep quality index (PSQI) scores were compared between two groups before treatment and at 28 d after treatment; the dosage of Pregabalin at 28 d after treatment was compared between two groups; the occurrence of adverse reactions at 28 d after treatment was recorded in both groups. Results Two cases in Amitriptyline group and one case in Duloxetine group could not be effectively eliminated due to adjustment of dosage. The overall analysis showed that there were statistically significant differences in the time, inter-group, and interaction of VAS scores between two groups (P＜0.05). Further pairwise comparison, intra-group comparison: VAS scores of two groups at 7, 14 d, and 28 d after treatment were lower than those before treatment, and the differences were statistically significant (P＜0.05). Comparison between groups: VAS scores at 7, 14 d, and 28 d after treatment of Duloxetine group were lower than those of Amitriptyline group, and the differences were statistically significant (P＜0.05). Overall analysis showed that there was no significant difference in HAMD-17 score between two groups (P＞0.05). There were significant differences in HAMD-17 score time and interaction between two groups (P＜0.05). Further pairwise comparison, intra-group comparison: HAMD-17 scores at 14 d and 28 d after treatment of two groups were lower than those before treatment, and the differences were statistically significant (P＜0.05). Comparison between groups: there was no significant difference in HAMD-17 scores at 14 d and 28 d after treatment between two groups (P＞0.05). Before treatment, there was no significant difference in PSQI score between two groups (P＞0.05). At 28 d after treatment, PSQI scores in two groups were lower than those before treatment, and Duloxetine group was lower than Amitriptyline group, and the differences were statistically significant (P＜0.05). There was no significant difference in dosage of Pregabalin between two groups (P＞0.05). The incidence of dry mouth in Duloxetine group was lower than that in Amitriptyline group, and the difference was statistically significant(P＜0.05); there were no significant differences in the incidence of nausea, dizziness, lethargy, and palpitation between two groups (P＞0.05). Conclusion Duloxetine Hydrochloride combined with Pregabalin in the treatment of herpes zoster neuralgia has more accurate effect and higher safety, can effectively relieve pain and improve life quality, and is worthy of clinical application.
		2023 Vol. 20 (34): 124-128 [Abstract] ( 16 ) HTML (1 KB) PDF (510 KB) ( 102 )

	129	Effects of continuous anterior serratus plane block on oxygenation function and the levels of polymorphonuclear leukocytes, adiponectin， and matrix metalloproteinase-9 in patients undergoing thoracoscopic radical resection of lung cancer
		FU Jie LI Na QI Yu LIANG Jing▲
		DOI: 10.20047/j.issn1673-7210.2023.34.28
		Objective To investigate the effects of continuous anterior serratus plane block on oxygenation function and the levels of polymorphonuclear leukocytes (PMN), adiponectin (ADP), and matrix metalloproteinase-9 (MMP-9) in patients undergoing thoracoscopic radical resection of lung cancer. Methods A total of 93 patients who underwent thoracoscopic radical resection of lung cancer in Xuzhou Central Hospital, Jiangsu Province from August 2021 to August 2022 were divided into control group and study group according to the random number table method; there were 46 cases in control group and 47 cases in study group. The dosage of narcotic drugs was compared between two groups; the oxygenation index (P/F) of two groups were compared before anesthesia induction (T0), immediately after surgery (T1), 2 h after extubation (T2), 6 h after extubation (T3), and 24 h after extubation (T4); visual analogue scale (VAS) scores were compared between two groups at T2-T4; the levels of PMN, ADP, and MMP-9 were compared between two groups at T0, 15 min after skin resection (T5), and 7 d after surgery (T6). Results There were no significant differences in dosage of Sufentanil, Remifentanil, and Propofol between two groups (P＞0.05). The overall analysis showed that there were statistically significant differences between groups, time, and interaction of P/F between two groups (P＜0.05). Further pairwise comparison and intra-group comparison: pairwise comparison of P/F between T0-T4 in control group showed statistically significant difference (P＜0.05). The pairwise comparison of P/F in T0-T3 in study group were statistically significant (P＜0.05); P/F at T4 was higher than that at T2-T4, and the differences were statistically significant (P＜0.05). Comparison between groups: there were statistical significance in P/F at T1-T4 between two groups(P＜0.05). The overall analysis showed that there were statistically significant differences between groups, time, and interaction of resting and active VAS between two groups (P＜0.05). Further pairwise comparison and intra-group comparison: the pairwise comparison of resting and active VAS scores at T2-T4 between two groups showed statistically significant differences (P＜0.05); comparison between groups: the resting and active VAS scores at T2-T4 of study group were lower than those of control group, and the differences were statistically significant (P＜0.05). Overall analysis showed that there were statistically significant differences between groups, time, and interaction of the levels of PMN, ADP, and MMP-9 between two groups (P＜0.05). Further pairwise comparison and intra-group comparison: pairwise comparison of PMN and ADP at different time points in control group had statistical significance (P＜0.05); the levels of MMP-9 at T5-T6 were higher than those at T1, and the differences were statistically significant (P＜0.05). Pairwise comparison of the levels of PMN, ADP and MMP-9 at different time points in study group showed statistically significant differences (P＜0.05). Comparison between groups: at T5-T6, the levels of PMN and MMP-9 in study group were lower than those in control group, and the level of ADP was higher than that in control group, and the differences were statistically significant (P＜0.05). Conclusion The application of continuous anterior serranus plane block in thoracoscopic radical resection of lung cancer has significant analgesic effect and is helpful to the recovery of oxygenation function.
		2023 Vol. 20 (34): 129-133 [Abstract] ( 22 ) HTML (1 KB) PDF (510 KB) ( 75 )

	134	Comparison of analgesic effect of ultrasound-guided pectoralis nerves block and erector spinal plane block in modified radical resection for breast cancer
		ZHU Yunqing1 WEI Guohua2 YU Min2 ZHOU Xiaokai2
		DOI: 10.20047/j.issn1673-7210.2023.34.29
		Objective To compare the analgesic effect of ultrasound-guided pectoralis nerves block (PECS) and erector spinae plane block (ESPB) in modified radical mastectomy for breast cancer. Methods A total of 80 female patients diagnosed with stage Ⅰ-Ⅱ primary breast cancer by menstrual puncture biopsy and selected for modified radical mastectomy in First Affiliated Hospital with Nanjing Medical University from January to October 2022 were selected. They were divided into PECS group (group A) and ESPB group (group B) by random number table method, with 40 cases in each group. After anesthesia induction, group A was given PECS under ultrasound-guidance, including 0.25% Ropivacaine injected into 10 ml by type Ⅰ PECS intraplane technique and 0.25% Ropivacaine injected into 15 ml by type Ⅱ PECS intraplane technique; in group B, 0.25% Ropivacaine 25 ml was injected into the transverse surface of T4 using ultrasound-guided ESPB. The numerical rating scale (NRS) scores at 15 min, 30 min, 60 min, 120 min, 12 h, and 24 h after surgery were compared between two groups; intraoperative amount of Fentanyl, postoperative dose of Tramadol, and number of cases requiring remedial analgesia after surgery were compared between two groups; the occurrence of adverse reactions in the two groups was observed. Results There were statistically significant differences in the inter-group, time, and interaction effects of NRS scores between two groups (P＜0.05). In group A, the NRS scores at 60 min and 120 min after surgery were higher than those at 15 min and 30 min after surgery; NRS score at 120 min after surgery was higher than that at 60 min after surgery; NRS score at 24 h after surgery was lower than that at 60 min, 120 min, and 12 h after surgery, and the differences were statistically significant (P＜ 0.05). In group B, The NRS scores at 60 min, 120 min, 12 h, and 24 h after surgery were higher than those at 15 min and 30 min after surgery; NRS score at 12 h after surgery was higher than that at 60 min after surgery; NRS score at 24 h after surgery was lower than that at 120 min and 12 h after surgery, and the differences were statistically significant (P＜0.05). The NRS scores at 60 min, 120 min, 12 h, and 24 h after surgery in group A were lower than those in group B, and the differences were statistically significant (P＜0.05); there were no significant differences in NRS scores at 15 and 30 min after surgery between two groups (P＞0.05). There was no significant difference in intraoperative amount of Fentanyl between two groups (P＞0.05); the postoperative dose of Tramadol, number of cases requiring remedial analgesia after surgery in group A were lower than those in group B, and the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P＞0.05). Conclusion Ultrasound-guided PECS in modified radical mastectomy for breast cancer can provide better postoperative analgesia and reduce the postoperative dose of analgesic drugs.
		2023 Vol. 20 (34): 134-138 [Abstract] ( 27 ) HTML (1 KB) PDF (725 KB) ( 36 )

	139	Analysis on the syndromes distribution characteristics of upper airway cough syndrome based on clinical retrospective study
		LUO Jingshu1 MA Jianling2 SHI Liqing2 WANG Liyun2 JI Kun2 DONG Shangjuan2 FAN Yuhan1 LIU Zhilin1
		DOI: 10.20047/j.issn1673-7210.2023.34.30
		Objective To investigate the distribution of traditional Chinese medicine syndromes of upper airway cough syndrome. Methods A total of 117 patients with upper airway cough syndrome admitted to the Department of Respiratory Heat Disease, Dongfang Hospital of Beijing University of Chinese Medicine from January 2009 to August 2023 were selected as the study objects. Their gender, age, medical history, and syndromes were statistically analyzed, and the high-frequency symptoms and commonly used Chinese medicines were systematically clustered. Results A total of 159 times were diagnosed in 117 patients, among which the syndrome of wind pathogen invading lung was the most, followed by the syndrome of dampness-heat stagnated in lung-defense phase and syndrome of phlegm-damp amassing in lung. The traditional Chinese medicine syndrome type of patients with upper airway cough syndrome was related to age (P＜0.05), but was not related to sex or common rhinitis disease type (P＞0.05). Traditional Chinese medicine syndromes were characterized by lung symptoms, wind, phlegm, dampness, and heat. Systematic clustering could be divided into three association combinations, including the syndrome of wind pathogen invading lung, the syndrome of dampness-heat stagnated in lung-defense phase, and syndrome of phlegm-damp amassing in lung. By systematic clustering, the commonly used Chinese medicine can be divided into three groups: the drugs of activating qi-flowing and dissipating phlegm for resuscitation, clearing heat and eliminating dampness, and dispelling wind and arresting cough. Conclusion The main syndromes of upper airway cough syndrome are wind evil and lung stagnation, followed by dampness-heat stagnation and phlegm-dampness accumulation of lung. The manifestations of wind, phlegm, dampness, and heat are common. Therefore, targeted treatment can be carried out in clinic.
		2023 Vol. 20 (34): 139-143 [Abstract] ( 16 ) HTML (1 KB) PDF (1091 KB) ( 98 )

	144	Professor Qin Xiude’s clinical experience in treating migraine based on syndrome differentiation
		HUANG Mengni1 CHEN Xueyan1 ZHANG Xiaofan1 GAO Xinyu1 LIU Yu2 QIN Xiude3
		DOI: 10.20047/j.issn1673-7210.2023.34.31
		Migraine is a common chronic disease in the department of neurology, the incidence of which is increasing year by year. Professor Qin Xiude has achieved good results in the clinical diagnosis and treatment of migraine with the theory of traditional Chinese medicine. According to the clinical characteristics of migraine, combined with his own clinical experience, Professor Qin Xiude believes that migraine is closely related to pathological constitution, its core disease is in the liver, can extend to the spleen and kidney, the pathogenesis is yin deficiency and yang depression, phlegm and blood stasis hiding collaterals, the main treatment is to nourish yin, relieve depression, treat both phlegm and blood stasis. During the attack period of migraine, Professor Qin focuses on the treatment of liver differentiation, dividing which into four syndromes in terms of emphasis: liver-qi stagnation, stagnant heat in the liver meridian, wind-yang upward disturbance, and liver blood deficiency, and selects the specific prescription in terms of specific syndrome, while not forgetting other organs, with the addition and subtraction according to the symptoms; in the stable stage, attention should be paid to regulating the pathological constitution mildly. This paper explores and summarizes the clinical academic experience of Professor Qin Xiude in the diagnosis and treatment of migraine in order to better serve the clinic. Case one is supported for proof.
		2023 Vol. 20 (34): 144-148 [Abstract] ( 19 ) HTML (1 KB) PDF (853 KB) ( 190 )

	149	Visual analysis of traditional Chinese medicine in the treatment of urinary tract infection based on CiteSpace
		WANG Haoyuan TANG Ge ZHU Changhao GUO Yanhua LI Wenting
		DOI: 10.20047/j.issn1673-7210.2023.34.32
		Objective To visually analyze the literature in the treatment of urinary tract infection by traditional Chinese medicine in the past 20 years. Methods The relevant literatures on traditional Chinese medicine treatment of urinary tract infection from 2003 to 2023 were retrieved from CNKI, VIP, and Wanfang Data, and CiteSpace software was used to analyze the annual number of publications, authors, institutions, and keywords. Results A total of 1 562 literature were included, and the number of published papers showed a downward trend in recent years. Among different authors, Professor Sun Wei published the most papers, and Tianjin University of Traditional Chinese Medicine published the most papers. The keyword atlas showed that the heat of integrated Chinese and western medicine treatment and chronic pyelonephritis were high. The keywords with strong recent emergence were data mining, Relinqing Granules, recurrent urinary tract infection. Conclusion In the past 20 years, the treatment of urinary tract infection by traditional Chinese medicine has attracted wide attention. Chronic pyelonephritis and the treatment of integrated Chinese and western medicine are the main research hotspots. The future research trend may be the in-depth study on the treatment of recurrent urinary tract infection and the mechanism of action and clinical efficacy evaluation of Relinqing Granules.
		2023 Vol. 20 (34): 149-153 [Abstract] ( 42 ) HTML (1 KB) PDF (2207 KB) ( 171 )

	154	Professor Li Junxiang’s experience in treating chronic recurrent ulcerative colitis with New Wumei Pills
		DENG Yuqing LI Junxiang MAO Tangyou WANG Muyuan CHEN Xiaowei
		DOI: 10.20047/j.issn1673-7210.2023.34.33
		Chronic recurrent ulcerative colitis is a commonly encountered subtype of ulcerative colitis within clinical practice, known for its persistent and refractory characteristics. Professor Li Junxiang from Dongfang Hospital, Beijing University of Chinese Medicine emphasizes that the underlying cause of chronic recurrent ulcerative colitis resides in the insufficiency of both the spleen and kidney, giving rise to symptoms of dampness and heat obstruction, as well as qi-stagnation and blood stasis. Primary therapeutic strategies encompass the elimination of dampness and heat, facilitation of blood circulation to alleviate blood stasis, and fortification of kidney and spleen functions. Drawing upon extensive clinical experience and a comprehensive assimilation of medical knowledge across various historical periods, Professor Li Junxiang has refined the traditional Wumei Pills Prescription from the Treatise on Cold Pathogenic Diseases by incorporating personalized adjustments. This innovative approach, known as the New Wumei Pills Prescription, has demonstrated remarkable efficacy in clinical practice, yielding favorable treatment outcomes. This paper mainly encapsulates the theoretical underpinnings and facilitates a clinical discourse concerning the treatment of chronic recurrent ulcerative colitis with the New Wumei Pills Prescription. Furthermore, a validated case is appended to furnish empirical substantiation.
		2023 Vol. 20 (34): 154-156,166 [Abstract] ( 20 ) HTML (1 KB) PDF (848 KB) ( 123 )

	157	Effect of Huangdi Neizhen Method combined with Sini Yulian Zheshi Decoction on gastric gastroesophageal reflux disease with syndrome of gallbladder heat invading stomach
		LI Huili LI Yong MU Qian
		DOI: 10.20047/j.issn1673-7210.2023.34.34
		Objective To observe the effect of Huangdi Neizhen Method combined with Sini Yulian Zheshi Decoction in the treatment of gastric gastroesophageal reflux disease with syndrome of gallbladder heat invading stomach. Methods A total of 80 patients with gastric gastroesophageal reflux disease with syndrome of gallbladder heat invading stomach admitted to Dezhou Traditional Chinese Medicine Hospital, Shandong Province from August 2021 to February 2023 were selected and divided into control group and treatment group according to random number method, with 40 cases in each group. The control group was given Rabeprazole orally, and the treatment group was given Huangdi Neizhen Method acupuncture and Sini Yulian Zheshi Decoction orally on the basis of the control group. The course of treatment in both groups was eight weeks. The traditional Chinese medicine efficacy, and the changes of traditional Chinese medicine syndrome score, gastrin, motilin, interleukin (IL)-6, IL-17 levels in serum before and after treatment were observed. The patients were follow-up for three months after treatment, and the recurrence rate was observed, and the status of esophageal mucosal inflammation was evaluated under endoscopy. Results The traditional Chinese medicine efficacy of the treatment group was better than that of the control group, the difference was statistically significant (P＜0.05). After treatment, the scores of traditional Chinese medicine symptoms in both groups were lower than those before treatment, and those of treatment group were lower than those of control group, the differences were statistically significant (P＜0.05). After treatment, serum gastrin and motilin in two groups were higher than those before treatment, IL-6 and IL-7 were lower than those before treatment, and serum gastrin and motilin in treatment group were higher than those of control group, and IL-6 and IL-7 were lower than those of control group, the differences were statistically significant (P＜0.05). In the control group and the treatment group, five and four patients did not complete the follow-up, and six and eight patients did not receive endoscopy, respectively. The recurrence rate of the treatment group was lower than that of the control group, and the difference was statistically significant (P＜0.05). At three months after treatment, the scores of esophageal mucosa inflammation in both groups were lower than those before treatment, and those of treatment group were lower than those of control group, the differences were statistically significant (P＜0.05). Conclusion Huangdi Neizhen Method combined with Sini Yulian Zheshi Decoction oral administration can improve the symptoms of gastroesophageal reflux disease, increase gastrointestinal motility, reduce inflammation, reduce recurrence, and other effects.
		2023 Vol. 20 (34): 157-161 [Abstract] ( 21 ) HTML (1 KB) PDF (856 KB) ( 88 )

	162	Master of traditional Chinese medicine Wang Lie’s experience in the treatment of chronic eczema in children based on syndrome differentiation on five zang viscera and three-stage treatment
		YU Peihang1 WANG Lie2 SUN Liping2
		DOI: 10.20047/j.issn1673-7210.2023.34.35
		Professor Wang Lie, the master of traditional Chinese medicine, treats children with chronic eczema, according to the characteristics of pathogenesis, the disease is divided into attack stage, remission stage, and stable stage. Professor Wang believes that in the attack period, excluding the pathogenic wind, damp, and heat of exogenous disease, there are still five zang viscera consumed injury, mainly the liver, spleen, and lung. Therefore, we should further clear heat and dissipate dampness, desensitizing and dispelling wind, and Jiajian Tuomin Powder should be given. In the remission stage, the heart and liver are mainly consumed, the treatment is to nourishing blood for tranquillization, supplemented by regulating and tonifying the spleen and kidney, Jiajian Anshen Decoction is commonly used. In the stable stage, the main symptoms are insufficient nephros and lung yin depletion injury. The treatment was to nourishing the lung and kidney, supplementing qi and tonifying blood, and Jiajian Buxue Powder should be given. In the treatment, special attention should be paid to the protection after recovery, and the sequential treatment has a lasting effect.
		2023 Vol. 20 (34): 162-166 [Abstract] ( 20 ) HTML (1 KB) PDF (808 KB) ( 103 )

	167	Professor Lu Jianxin’s experience in the treatment of female bladder detrusor underactivity with a integration of traditional Chinese and western medicine
		ZHOU Jiale1 WANG Ziqiang1 LAI Jingling2 AN Yifang1 ZHU He1 SHI Peiqi1 LU Jianxin1
		DOI: 10.20047/j.issn1673-7210.2023.34.36
		Bladder detrusor underactivity refers to a series of lower urinary tract symptoms caused by the delayed or incomplete emptying of the bladder during the normal urination period due to the reduced contractility or duration of the bladder detrusor. The serious complications include upper urinary tract damage and renal failure, which threaten the life and health of patients. At present, the treatment methods at home and abroad are limited, and there is still a lack of targeted treatment programs. Through many years of clinical observation and practical experience, Professor Lu Jianxin believes that the key pathogenesis of this disease lies in “qi mechanism disorder”, and puts forward the treatment idea of “regulating qi and restoring”. At the same time, Professor Lu Jianxin also found that such patients are often accompanied by “relative obstruction” problems, which makes the disease further aggravated. Therefore, Professor Lu Jianxin through the integration of traditional Chinese and western medicine treatment, on the basis of the operation to remove the “relative obstruction”, combined with the traditional Chinese medicine thought of “conditioning qi mechanism” throughout the whole, syndrome differentiation and subtraction. This also reflects Professor Lu Jianxin’s medical philosophy of “accepting the strengths of each institution, integrating Chinese and western medicine, and striving for effectiveness”.
		2023 Vol. 20 (34): 167-171 [Abstract] ( 17 ) HTML (1 KB) PDF (1167 KB) ( 427 )

	172	Professor Wang Youpeng’s experience in treating tinnitus of children in cold areas
		SHI Mengdi1 WANG Chao1 LIU Lujia2 WANG Youpeng2
		DOI: 10.20047/j.issn1673-7210.2023.34.37
		Tinnitus is a common disease and complication in clinic, which is more common in adults. In recent years, with the change of lifestyle and the increase of learning pressure, more and more children have been diagnosed with tinnitus, especially for children who do not correctly express the condition, which often leads to delay of the condition and brings difficulties to clinical diagnosis and treatment. Therefore, tinnitus should be paid attention to in pediatrics. This paper summarizes the clinical experience of Professor Wang Youpeng, a famous traditional Chinese medicine doctor, in the treatment of tinnitus, and concludes that characteristics of children in cold areas are prone to external evil, dampness and heat in the spleen and stomach, and fire of the heart and liver. The etiology and pathogenesis are divided into four aspects: wind-cold external attack, phlegm turbidness and dampness, liver-qi stagnation, and kidney unit loss. In the treatment, attention should be paid to both manifestation and root cause, strengthening vital qi to eliminate pathogenic factor, so as to stop tinnitus and clear the ear. At the same time, regulate children’s psychological problems in order to treat the mind and body together. Attached to the document is a detailed explanation of the case.
		2023 Vol. 20 (34): 172-175 [Abstract] ( 20 ) HTML (1 KB) PDF (797 KB) ( 95 )

	176	Ultrasound diagnostic value of pernicious placenta previa with placenta accreta
		WANG Guan1 TANG Qiuqin2 WU Ya1 ZHANG Rui2 WANG Lvlan2▲
		DOI: 10.20047/j.issn1673-7210.2023.34.38
		Objective To investigate the clinical value of ultrasonography in the diagnosis of pernicious placenta previa (PPP) with placenta accreta. Methods A total of 86 cases with PPP patients admitted to Nanjing Women and Children’s Healthcare Hospital from January 2020 to June 2022 were selected. According to the postpartum pathology results, they were divided into implantation group (42 cases) and control group (44 cases). The ultrasonographic characteristics, ultrasound score, and pregnancy outcome were compared between two groups; receiver operating characteristic curve was drawn to evaluate the diagnostic value of ultrasound score in PPP pregnant women with placenta accreta. Results The proportion of the thinning of myometrium≤2.0 cm, thickening of placenta＞5.0 cm, absence of postplacental space, disordered arrangement of arcuate artery of myometrium, disordered arrangement of vessels at the junction of serous layer and bladder, distension of lower uterine segment, cervical enlargement, and rich blood flow in the placenta covering of cervical canal in the implantation group were higher than those in control group (P＜0.05). Prenatal ultrasound scores in implantation group were higher than those in control group (P＜0.05). The cut-off value of ultrasound score for the diagnosing placenta of placenta accreta in pregnant women was 7.6 points, and the area under the curve was 0.877 (95%CI: 0.832-0.927, P＜0.001), the sensitivity was 85.78%, the specificity was 78.40%, and the Joaden index was 0.64. Delivery bleeding in implantation group was higher than that in control group, the incidence of hysterectomy, neonatal jaundice, neonatal asphyxia, and neonatal death were higher than those in control group (P＜0.05). Conclusion Ultrasonographic characteristics and ultrasound scores have high clinical value in prenatal diagnosis of placenta accreta in PPP pregnant women. Placenta accreta in PPP pregnant women will significantly increase the incidence of adverse pregnancy outcomes.
		2023 Vol. 20 (34): 176-179 [Abstract] ( 15 ) HTML (1 KB) PDF (512 KB) ( 29 )

	180	Differentiate diagnostic value of strain elastography technology for breast BI-RADS 4A type nodules
		XING Boyuan DONG Meng FU Chenghui LI Xingzi ZHANG Bingyi
		DOI: 10.20047/j.issn1673-7210.2023.34.39
		Objective To investigate the differential diagnostic value of strain elastography technology for breast imaging reporting and data system (BI-RADS) 4A type nodules, in order to reduce unnecessary surgery or puncture biopsy. Methods The clinical and elastography data of 237 patients with BI-RADS 4A type nodules diagnosed and treated in Yichang Central People’s Hospital, Hubei Province from May 2021 to May 2023 were retrospectively analyzed. With the pathological results as the gold standard, the clinical and ultrasound imaging characteristics of benign and malignant BI-RADS 4A type nodules were compared; the receiver operating characteristic curve was drawn to obtain the optimal threshold value of elastic strain rate ratio method for the diagnosis of benign and malignant breast gland nodules, and the BI-RADS classification of nodules was adjusted according to the elastography technology; the diagnostic efficacy and consistency results between elastic scoring method and strain rate ratio method for BI-RADS 4A type nodules was compared. Results Among 237 BI-RADS 4A type nodules, 214 were benign and 23 were malignant. There were statistically significant differences in age, elasticity score, and strain rate ratio between benign and malignant nodules (P＜0.05); there were no significant differences in the maximum diameter, shape, orientation, edge, internal echo, posterior echo, and microcalcification between benign and malignant nodules (P＞0.05). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of the elastic score method were 60.87%, 97.20%, 93.67%, 70.00%, and 95.85%, respectively; Kappa value was 0.617, consistent with high. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of the elastic ratio method were 73.91%, 81.31%, 80.59%, 29.82%, and 96.67%, respectively; Kappa value was 0.333, showing poor consistency. Conclusion Strain elastography technology has certain value in differential diagnostic benign and malignant BI-RADS 4A nodules, and can reduce unnecessary puncture biopsy.
		2023 Vol. 20 (34): 180-184 [Abstract] ( 23 ) HTML (1 KB) PDF (594 KB) ( 160 )

	185	Application of group resource management model in young patients with hemiplegia after first stroke
		ZHENG Ya WANG Huayan▲ WANG Dandan
		DOI: 10.20047/j.issn1673-7210.2023.34.40
		Objective To explore the application of group resource management model in young patients with hemiplegia after first stroke. Methods A total of 100 young patients with hemiplegia formed by first stroke collected from the Huaian First People’s Hospital, Jiangsu Province from January 2019 to June 2022 were selected as the study objects. According to random number table method, they were divided into control group and observation group, with 50 cases in each group. The control group was treated with routine nursing mode, and the observation group was treated with group resource management nursing. Motor function score, acceptance of disability scale, and quality of life score of hemiplegia after stroke were compared between the two groups before and after care. Results After intervention, the scores of motor function scale, disability acceptance and quality of life scale in both groups were higher than that before intervention, and those of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05). Conclusion For young patients with hemiplegia caused by first-episode stroke, group resource management nursing can effectively improve the motor function of patients, increase the disability acceptance of the disease, and improve the quality of life score, and the prognosis is ideal, which is worthy of reference and adoption by various departments.
		2023 Vol. 20 (34): 185-188,封三 [Abstract] ( 22 ) HTML (1 KB) PDF (656 KB) ( 67 )

	189	Construction and application of personalized nutrition management system for patients undergoing head and neck cancer surgery based on network platform
		CHEN Feilin GUI Yihua
		DOI: 10.20047/j.issn1673-7210.2023.34.41
		Objective To construct a personalized nutrition management system for patients undergoing head and neck cancer surgery based on the network platform, and to discuss its application effect. Methods A research group on personalized nutrition management system based on internet platform for patients undergoing head and neck cancer surgery were established, and a personalized nutrition management system based on internet platform for patients undergoing head and neck cancer surgery was built. A total of 91 patients undergoing head and neck cancer surgery in Li Huili Hospital of Ningbo Medical Center, Zhejiang Province from May 2020 to August 2022 were prospectively included as the study objects. They were divided into control group (45 cases) and observation group (46 cases) by random number table method. The control group was treated with routine nursing intervention, and the observation group was treated with individualized nutrition management system based on the network platform. Swallowing function (assessed by the Chinese version of dysphagia index scale [DHI]), anthropometric indicators, nutritional indicators (albumin [ALB], prealbumin [PA]), and sleep quality (assessed by the Pittsburgh sleep quality index scale [PSQI]) of the two groups before and after intervention were compared. Results After intervention, the total DHI score of the two groups was lower than that before intervention, and those of the observation group were lower than those of the control group (P＜0.05). Weight and body fat percentage in the two groups were higher than that before intervention, and observation group was higher than those of control group (P＜0.05). Serum ALB and PA in the two groups were higher than that before intervention, and those of observation group were higher than those of control group (P＜0.05). The PSQI scores of both groups were lower than that before intervention, and the observation group was lower than those of the control group (P＜0.05). Conclusion The constructed personalized nutrition management system for patients undergoing head and neck cancer surgery based on the network platform can effectively improve the swallowing function and nutritional status of patients undergoing head and neck cancer surgery, and has a positive impact on the sleep quality of patients.
		2023 Vol. 20 (34): 189-192 [Abstract] ( 25 ) HTML (1 KB) PDF (519 KB) ( 39 )

	193	Effect of nutritional intervention guided by NRS2002 nutritional risk screening on patients with compensatory cirrhosis
		BAO Xiaochun ZHANG Lihua HUA Ping SHI Cenjuan WANG Zhongcheng▲
		DOI: 10.20047/j.issn1673-7210.2023.34.42
		Objective To explore the effect of nutritional intervention guided by NRS2002 nutritional risk screening on patients with compensatory cirrhosis. Methods Ninety-eight patients with cirrhosis treated by the Department of Integrated Chinese and Western Medicine, Nantong Third Hospital Affiliated to Nantong University Nantong Third People’s Hospital from January 2021 to December 2021 were selected as the study objects, and they were divided into control group and observation group by random number table method, with 49 cases in each group. The control group received routine nutrition care, and the observation group received nutrition intervention guided by NRS2002 nutrition risk screening on this basis. The level of serum nutrition index, liver function index, and complication rate of the two groups were observed and compared before intervention and eight weeks after intervention. Results After intervention, the levels of serum albumin, transferrin, and prealbumin in two groups were higher than that before intervention, and those of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05); after intervention, the levels of total bilirubin and alanine transaminase in two groups were lower than that before intervention, and those of the observation group were lower than those of the control group, and the level of prothrombin activity was higher than that before intervention, and the observation group was higher than that of the control group, the differences were statistically significant (P＜0.05); the total complication rate of observation group was lower than that of control group, the differences were statistically significant (P＜0.05). Conclusion Nutrition assessment and management can improve the nutritional level, protect liver function and reduce the risk of complications.
		2023 Vol. 20 (34): 193-封三 [Abstract] ( 17 ) HTML (1 KB) PDF (658 KB) ( 106 )

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