|
|
|
| Current status of research on treatment of knee osteoarthritis with platelet-rich plasma based on Wnt/β-catenin signaling pathway |
| DENG Lei1 WANG Shaohua2 HOU Yingzhou2 YANG Guangya1 LI Kewei2 SUN Bo2 |
1.The First Clinical Medical College, Henan University of Chinese Medicine, Henan Province, Zhengzhou 450003, China;
2.Department of Joint Surgery, Zhengzhou Orthopedic Hospital, Henan Province, Zhengzhou 450003, China |
|
|
|
|
Abstract Knee osteoarthritis (KOA) is a chronic degenerative bone disease characterized by the wear of articular cartilage. In the early stage, the main manifestations are knee pain, swelling, and limited joint movement, which can eventually lead to locking of the knee, deformity, and disability. Wnt/β-catenin signaling pathway plays an important role in the pathogenesis and development of KOA, which influences the metabolic balance of articular cartilage and subchondral bone by regulating cell proliferation and differentiation. Platelet-rich plasma (PRP), as a new treatment for KOA, can slow down the pathologic progression of KOA by delaying cartilage degeneration, promoting cartilage regeneration, and inhibiting intra-articular inflammation, which may be related to its involvement in the regulation of Wnt/β-catenin signaling pathway. This article mainly introduces the pathological relationship between Wnt/β-catenin signaling pathway and KOA, the application of PRP in the treatment of KOA, and the research status of PRP based on Wnt/β-catenin pathway in the treatment of KOA, aiming to provide more theoretical basis for the clinical treatment of KOA with PRP.
|
|
|
|
|
|
[1] Cui A，Li H，Wang D，et al. Global，regional prevalence，incidence and risk factors of knee osteoarthritis in population-based studies [J]. E Clinical Medicine，2020，29-30：100587.
[2] Alharbi KS，Afzal O，Altamimi A，et al. Potential role of nutraceuticals via targeting a Wnt/β-catenin and NF-κB pat- hway in treatment of osteoarthritis [J]. J Food Biochem，2022， 46（12）：e14427.
[3] Everts P，Onishi K，Jayaram P，et al. Platelet-Rich Plasma：New Performance Understandings and Therapeutic Considerations in 2020 [J]. Int J Mol Sci，2020，21（20）：7794.
[4] Dong B，Liu X，Li J，et al. Berberine Encapsulated in Exosomes Derived from Platelet-Rich Plasma Promotes Chondrogenic Differentiation of the Bone Marrow Mesenchymal Stem Cells via the Wnt/beta-Catenin Pathway [J]. Biol Pharm Bull，2022，45（10）：1444-1451.
[5] Ma Q，Yu J，Zhang X，et al. Wnt/β-catenin signaling pathway-a versatile player in apoptosis and autophagy[J]. Bio- chimie，2023，211：57-67.
[6] Liu J，Xiao Q，Xiao J，et al. Wnt/β-catenin signalling：function，biological mechanisms，and therapeutic opportunities [J]. Signal Transduct Target Ther，2022，7（1）：3.
[7] Szponder T，Latalski M，Danielewicz A，et al. Osteoarthritis：Pathogenesis，Animal Models，and New Regenerative Therapies [J]. J Clin Med，2022，12（1）：5.
[8] 罗媚，杜信眉，周学东.基质金属蛋白酶与骨关节炎发生发展关系的研究进展[J].四川大学学报（医学版），2023， 54（1）：77-82.
[9] Cheng J，Li M，Bai R. The Wnt signaling cascade in the pathogenesis of osteoarthritis and related promising treatment strategies [J]. Front Physiol，2022，13：954454.
[10] Li J，Han G，Ma M，et al. Xanthan Gum Ameliorates Osteoarthritis and Mitigates Cartilage Degradation via Regulation of the Wnt3a/β-Catenin Signaling Pathway [J]. Med Sci Monit，2019，25：7488-7498.
[11] Yao N，Chen GC，Lu YY，et al. Bushen Qiangjin capsule inhibits the Wnt/α-catenin pathway to ameliorate papain- induced knee osteoarthritis in rat [J]. J Tradit Chin Med，2021，41（6）：935-942.
[12] Hua B，Qiu J，Ye X，et al. Intra-articular injection of a novel Wnt pathway inhibitor，SM04690，upregulates Wnt16 expression and reduces disease progression in temporoman- dibular joint osteoarthritis [J]. Bone，2022，158：116372.
[13] Kramer I，Halleux C，Keller H，et al. Osteocyte Wnt/β- catenin signaling is required for normal bone homeostasis [J]. Mol Cell Biol，2010，30（12）：3071-3085.
[14] 吴铭，张岩.调控骨髓间充质干细胞成骨分化的Wnt/ β-catenin信号通路及相关因素[J].中国组织工程研究，2021，25（1）：116-122.
[15] 吴疆，吴龙，马龙，等.SOST和β-catenin在不同分期膝骨关节炎患者软骨及软骨下骨表达的研究[J].中国骨质疏松杂志，2016，22（6）：689-694.
[16] Li J，Xue J，Jing Y，et al. SOST Deficiency Aggravates Osteoarthritis in Mice by Promoting Sclerosis of Subchondral Bone [J]. Biomed Res Int，2019，2019：7623562.
[17] Ding QH，Ye CY，Chen EM，et al. Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo [J]. Int Immunopharmacol，2018，61：222-230.
[18] Hu L，Luo D，Zhang H，et al. Polydatin inhibits IL-1beta- mediated chondrocyte inflammation and ameliorates cartilage degradation：Involvement of the NF-κB and Wnt/ β-catenin pathways [J]. Tissue Cell，2022，78：101865.
[19] Xia H，Cao D，Yang F，et al. Jiawei Yanghe decoction ameliorates cartilage degradation in vitro and vivo via Wnt/ β-catenin signaling pathway [J]. Biomed Pharmacother，2020，122：109708.
[20] Rodriguez-Merchan EC. The Current Role of Disease-modifying Osteoarthritis Drugs [J]. Arch Bone Jt Surg，2023，11（1）：11-22.
[21] Lietman C，Wu B，Lechner S，et al. Inhibition of Wnt/β- catenin signaling ameliorates osteoarthritis in a murine model of experimental osteoarthritis [J]. JCI Insight，2018，3（3）：e96308.
[22] 卫愉轩，张昭远，范峥莹，等.中国富血小板血浆临床制备方法的研究进展[J].中华关节外科杂志（电子版），2020，14（2）：196-200.
[23] 黄象艳，张强，钟萍，等.自体单采富血小板血浆关节腔注射治疗膝骨关节炎的专家共识[J].中国输血杂志，2022，35（12）：1187-1194.
[24] Wang Z，Wang Z，Zhang B，et al. Effect of Activated Platelet- Rich Plasma on Chondrogenic Differentiation of Rabbit Bone Marrow-Derived Mesenchymal Stem Cells [J]. Stem Cells Int，2021，2021：9947187.
[25] Zhao H，Zhu W，Mao W，et al. Platelet-rich plasma inhibits Adriamycin-induced inflammation via blocking the NF-κB pathway in articular chondrocytes [J]. Mol Med，2021，27（1）：66.
[26] Jiang W，Xiang X，Song M，et al. An all-silk-derived bilayer hydrogel for osteochondral tissue engineering [J]. Mater Today Bio，2022，17：100485.
[27] Elik H，Do■u B，Y?覦lmaz F，et al. The efficiency of platelet- rich plasma treatment in patients with knee osteoarthritis [J]. J Back Musculoskelet Rehabil，2020，33（1）：127-138.
[28] Lin W，Xie L，Zhou L，et al. Effects of platelet-rich plasma on subchondral bone marrow edema and biomarkers in synovial fluid of knee osteoarthritis [J]. Knee，2023，42：161- 169.
[29] Zhong G，Liang R，Yao J，et al. Artemisinin Ameliorates Osteoarthritis by Inhibiting the Wnt/β-Catenin Signaling Pathway [J]. Cell Physiol Biochem，2018，51（6）：2575-2590.
[30] 赵泉，吴剑.富血小板血浆对硝普钠诱导的软骨细胞Wnt/ β-catenin信号通路的影响[J].中医正骨，2018，30（4）：4-7，12.
[31] Wu J，Huang JF，Qin XX，et al. Platelet-rich plasma inhibits Wnt/β-catenin signaling in rabbit cartilage cells activated by IL-1β [J]. Int Immunopharmacol，2018，55：282-289.
[32] Sun X，Mi L，Du G，et al. Platelet-rich plasma treatment alleviates osteoarthritis-related pain，inflammation，and apo- ptosis by upregulating the expression levels of microRNA-375 and microRNA-337 [J]. Immunopharmacol Immunotoxicol，2022，44（1）：87-98.
[33] Liu X，Wang L，Ma C，et al. Exosomes derived from platelet- rich plasma present a novel potential in alleviating knee osteoarthritis by promoting proliferation and inhibiting apoptosis of chondrocyte via Wnt/β-catenin signaling pathway [J]. J Orthop Surg Res，2019，14（1）：470.
[34] 刘杰，史超，刘杨，等.淫羊藿苷联合富血小板血浆对骨性关节炎的软骨保护作用和分子机制研究[J].中国医院用药评价与分析，2022，22（8）：944-949，954. |
|
|
|
