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| Research progress on the relationship between hemorrhagic stroke and pyroptosis |
| GUO Peixin1 ZOU Wei2 |
1.The First Clinical Medical College, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150036, China;
2.the Third Department of Acupuncture and Moxibustion, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150036, China |
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Abstract Hemorrhagic stroke is a serious disease with a high mortality and disability rate, including intracerebral hemorrhage and subarachnoid hemorrhage, which poses a serious threat to the life and quality of life of patients. Pyroptosis is a kind of proinflammatory cell death. In recent years, studies have found that pyroptosis plays an important role in the physiological and pathological process of stroke, and is a potential therapeutic target to reduce inflammatory response and restore neurological function after stroke. However, there are relatively few discussions on the role and mechanism of pyroptosis in cell death and inflammatory response after hemorrhagic stroke. This article discusses the molecular mechanism of pyroptosis and its difference from other cell death modes, summarizes the experimental studies on the molecules related to pyroptosis and hemorrhagic stroke in the published literature in recent years, and explores the role of pyroptosis in the neuronal death and inflammatory response of hemorrhagic stroke.
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