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| Research status and prospect of circRNA in Cisplatin resistance in bladder cancer |
| WANG Qun SUN Yuxin LUAN Ting WANG Haifeng |
| Department of Urology, the Second Affiliated Hospital of Kunming Medical University, Yunnan Province, Kunming 650101, China |
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Abstract Bladder cancer is one of the most common tumors in the human urogenital system. Currently, the first-line treatment for advanced and metastatic bladder cancer is Cisplatin-based chemotherapy. However, the overall clinical efficacy of Cisplatin is unsatisfactory due to the emergence of drug resistance. With the recent intensive research on circular RNA (circRNA), which regulates downstream mRNA through the regulation of miRNA, it has been found to be involved in the progression of bladder cancer and chemotherapy resistance. Therefore, circRNA may be a potentially promising target for the treatment of bladder cancer. This paper mainly reviewed the mechanism of different circRNA and cisplatin resistance in bladder cancer. These studies will deepen the understanding of the role of the circRNA in the progression of bladder cancer and provide a new entry point for further explore bladder cancer and its Cisplatin resistance mechanisms.
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