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| Clinical effect of She medicine Shiliangcha Prescription combined with continuous positive airway pressure per nasal in the treatment of obstructive sleep apnea hypopnea syndrome and obesity with pattern of phlegm-damp congestion and excessiveness |
| WEI Yibo CHEN Linjing CHENG Ling JI Xingzu |
| Department of Respiratory and Critical Care Medicine, Lishui Traditional Chinese Medicine Hospital, Zhejiang Province, Lishui 323000, China |
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Abstract Objective To observe the efficacy of She medicine Shiliangcha Prescription combined with continuous positive airway pressure (CPAP) per nasal in the treatment of obstructive sleep apnea hypopnea syndrome (OSAHS) and obesity patients with pattern of phlegm-damp congestion and excessiveness. Methods A total of 100 OSAHS and obesity patients with pattern of phlegm-damp congestion and excessiveness admitted to Lishui Traditional Chinese Medicine Hospital of Zhejiang Province from January 2021 to January 2023 were selected, and they were divided into observation group and control group according to the random number table method, with 50 cases in each group. The control group was treated with CPAP per nasal, and the observation group was treated with CPAP per nasal combined with She medicine Shiliangcha Prescription,both groups were treated for 12 weeks. The clinical efficacy, and traditional Chinese medicine syndrome scores, poly- somnography parameters (apnea hypopnea index [AHI], mean arterial oxygen saturation [MSaO2], ratio of SaO2＜90% time/total sleep time), serum indexes (C-reactive protein [CRP], interleukin-8 [IL-8]), and body mass index (BMI) before and after treatment were compared between the two groups. Results There was no significant difference in the efficacy between the two groups (P＞0.05). After treatment, the traditional Chinese medicine syndrome scores, AHI, the ratio of SaO2＜90% time/total sleep time, body mass index, and serum CRP, IL-8 in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05). The MSaO2 of the two groups was higher than that before treatment, and that of the observation group was higher than that of the control group, and the differences were statistically significant (P＜0.05). Conclusion She medicine Shiliangcha Prescription combined with CPAP per nasal in the treatment of OSAHS and obesity patients with pattern of phlegm-damp congestion and excessiveness can effectively improve the signs and clinical symptoms.
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