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2023 Vol. 20, No. 16 Published: 2023-06-05

	4	Study on the effect of amphotericin B on the biofilm of Candida and Lactobacillus
		SHANG Xiang1 BAI Huihui2 LIU Zhaohui1▲
		DOI: 10.20047/j.issn1673-7210.2023.16.01
		Objective To study the effect of amphotericin B on Candida and Lactobacillus biofilm. Methods From July 2022 to August 2022, four strains of Candida and four strains of Lactobacillus from the vagina of patients in Beijing Obstetrics and Gynecology Hospital, Capital Medical University were selected to determine their biofilm formation ability at different stages and observe their biofilm formation. The minimum inhibitory concentration (MIC) and minimum biofilm inhibitory concentration (MBIC) of amphotericin B on Candida and lactobacillus were determined respectively, and the effect of amphotericin B on the biofilms was observed under scanning electron microscope. Results The biofilm formation ability of Candida and Lactobacillus at 48 h was higher than that at 24 h (P＜0.05), and the biofilm formation ability of Lactobacillus No.7 at 48 h was higher than that at 72 h (P＜0.05). The MIC of amphotericin B against Candida albicans was 0.125 00 μg/ml. When the concentration of amphotericin B was 2 μg/ml, the biofilm forming ability of Candida No.1, No.3 and No.4 was lower than that of the positive control group (amphotericin B 0 μg/ml)(P＜0.05), and there was no difference between them and the subsequent concentrations (P＞0.05), the MBIC of amphotericin B against Candida albicans was 2 μg/ml. Amphotericin B had no inhibitory effect on Lactobacillus crispatus. The biofilm forming ability of Lactobacillus No.7 at concentration of 1, 8, and 16 μg/ml was higher than that of positive control group (P＜0.05), and the other Lactobacillus crispatus had no difference in biofilm forming ability at different concentrations (P＞0.05). Conclusion Candida albicans and Lactobacillus crispatus had the strongest biofilm forming ability at 48 h. Amphotericin B has strong antibacterial ability to Candida albicans, but it needs a larger dose to destroy the biofilms of Candida albicans which have formed. It has no inhibitory effect on Lactobacillus crispatus and biofilms destructive effect.
		2023 Vol. 20 (16): 4-10 [Abstract] ( 14 ) HTML (1 KB) PDF (3163 KB) ( 84 )

	11	Mechanism of iron death induced by hsa_circ_0006988 in glioma cells
		ZHAO Shuiqiang MENG Dawei CHEN Guoqiang LI Liangliang WANG Zhiwen HU Tiantian NIU Jianxing
		DOI: 10.20047/j.issn1673-7210.2023.16.02
		Objective To investigate the mechanism of hsa_circ_0006988 (circ_0006988) induced iron death in glioma cells. Methods The expression level of circ_0006988 in normal glioma cells HEB, A172, SHG44, and CHG-5 in gliomacells were detected. Glioma cells CHG-5 were then divided into Control group (blank control), si-NC group (transfected with siRNA control), si-circ group (transfected with circ_0006988 siRNA), si-Nrf2 group (transfected with Nrf2 siRNA), si-circ+Vector group (co-transfected circ_0006988 siRNA and negative control vector), si-circ+Nrf2 group (co-transfected circ_0006988 siRNA and Nrf2 overexpression vector). The expression of circ_0006988 in each group was detected by qRT-PCR. The content of Fe2+ was detected by colorimetry, the protein expressions of Nrf2, GPX4, Ferritin, TF, and TFR were detected by Western blot, ROS was detected by DCFHDA, and MDA was detected by thiobarbituric acid. Results The expression level of circ_0006988 in glioma cells A172, SHG44, and CHG-5 were higher than those in normal glioma cells (P＜0.05). The expression level of circ_0006988 in glioma cells A172 and SHG44 were lower than those of CHG-5 (P＜0.05). The contents of Fe2+, ROS, and MDA in glioma cells of si-circ group were higher than those of Control and si-NC group, and the protein expressions of Ferritin, TF, and TFR were higher than those of Control group and si-NC group (P＜0.05), while the protein expressions of Nrf2 and GPX4 were lower than those of Control group and si-NC group (P＜0.05). The protein expressions of Nrf2 and GPX4 in glioma cells in si-circ group were lower than those in si-NC group, the content of Fe2+, the protein expressions of Ferritin, TF and TFR, and the contents of ROS and MDA in glioma cells in si-NC group were higher than those in si-NC group (P＜0.05). The expression of Nrf2 and GPX4 proteins in glioma cells in si-circ+Nrf2 group were higher than that in si-circ+Vector group, the content of Fe2+, Ferritin, TF， and TFR proteins, the ROS and MDA contents in si-circ+Vector group were lower than those in si-circ+Vector group (P＜0.05). Conclusion Down-regulation of circ_0006988 can induce ferroptosis of glioma cells by inhibiting Nrf2/GPX4 signal.
		2023 Vol. 20 (16): 11-15 [Abstract] ( 12 ) HTML (1 KB) PDF (968 KB) ( 67 )

	16	Design, synthesize dicompound of Lapatinib and Aspirin and its in vitro activity
		YUAN Panpan1 GUO Kaili2 YAO Lin3 GUO Xiaofang4 LIU Jiping2 WANG Bin2 WANG Guoquan2 ZHU Xingmei1
		DOI: 10.20047/j.issn1673-7210.2023.16.03
		Objective To design, synthesize dicompound of Lapatinib and Aspirin, and investigate its activity in vitro. Methods Twin drug (CompdⅠ) was synthesized by using Lapatinib and Aspirin as raw materials. Human epidermal growth factor receptor 2 (HER2) positive breast cancer cells BT474 were divided into blank group, Aspirin group, Lapatinib group, and CompdⅠ group. CCK-8 method and plate cloning method were used to determine half inhibitory concentration (IC50) and cell clone formation rate; the binding of CompdⅠ to AMPK/mTOR pathway protein and cyclooxygenase 1 protein was investigated by molecular docking; the expression level of AMPK/mTOR pathway protein was revealed by Western blot. Results CompdⅠ was synthesized from Lapatinib and Aspirin by condensation reaction, and the yield was 78%, melting point was 101.7-102.7℃. The IC50 of CompdⅠ was significantly different from that of Lapatinib and Aspirin for 24, 48 h, and 72 h (P＜0.05 or P＜0.01). Compared with blank group, the clone formation rate in Aspirin group, Lapatinib group, and CompdⅠ group was lower, compared with Aspirin group and Lapatinib group, the clone formation rate in CompdⅠ group was lower, and the differences were statistically significant (P＜0.05 or P＜0.01). The binding energy absolute values of CompdⅠ with epidermal growth factor receptor (EGFR), HER2, AMPK, Akt1, and mTOR were all ≥5 kcal/mol, the binding energy of CompdⅠ with EFGR, Akt1, and mTOR was lower than that of Lapatinib, but it could not bind with cyclooxygenase 1. Compared with blank group, EGFR, HER2, p-Akt1-Ser124, p-Akt1-Ser169, Akt1, p-mTOR, and mTOR were down-regulated in CompdⅠ group and Lapatinib group, and p-Akt1-Ser169, p-mTOR were down-regulated in Aspirin group, p-AMPK and AMPK were up-regulated in CompdⅠ group, and AMPK was up-regulated in Lapatinib group, and the differences were statistically significant (P＜0.05 or P＜0.01). Compared with Lapatinib group, P-AMPK was up-regulated in CompdⅠ group, and the difference was highly statistically significant (P＜0.01). Conclusion CompdⅠ has stronger anti-HER2 proliferative activity, which acts mainly by activating AMPK, and inhibiting HER2/mTOR pathway.
		2023 Vol. 20 (16): 16-20 [Abstract] ( 21 ) HTML (1 KB) PDF (1209 KB) ( 78 )

	21	Effects of vitamin D intervention on balance regulation of peripheral blood T lymphocytes and intestinal flora in young rats with bronchial asthma
		CAI Zixiu1 ZHOU Guohua1 TIAN Jun2▲
		DOI: 10.20047/j.issn1673-7210.2023.16.04
		Objective To investigate the effects of vitamin D (VitD) intervention on the balance regulation of peripheral blood T lymphocytes and intestinal flora in young rats with bronchial asthma (hereinafter referred to as “asthma”). Methods Thirty SPF wild-type BALB/c female mice (4.09 - 6.13 g) aged seven days were selected as the study objects, and they were divided into asthma model group (15 rats) and VitD intervention group (15 rats) by random number table method, another ten rats were selected as healthy control group. On the first and seventh day of the experiment, asthma model group and VitD intervention group were injected intraperitoneally with 10% ovalbumin (OVA) sensitizing solution 200 μl, while healthy control group was injected with the same amount of normal saline. On the 18th day, VitD intervention group was given VitD drops (35 μg/kg, per week, one every two days) for two weeks, and healthy control group and asthma model group were given the same amount of phosphate buffer. On the 19th day, asthma model group and VitD intervention group were given atomized inhalation of 3%OVA solution 10 ml for 20 min, while healthy control group was given atomized inhalation of normal saline, once a day for six days. After the experiment, the hematoxylin-eosin staining results of lung tissue sections in three groups were observed. Serum Th1/Th2 and Th17/ regulatory T cell (Treg) ratios were measured and calculated by flow cytometry. The bacterial community in feces of the three groups was analyzed by 16S rDNA sequencing method. Results In the healthy control group, the structure of the bronchial wall and alveolar wall of the lung tissue were complete, there was no exudation in the alveolar cavity, the alveolar epithelium was orderly, and the alveolar wall thickness was normal. In asthmatic model group, the structure of alveolar wall was damaged, alveolar epithelial cells were destroyed, mucosal hyperemia and edema were observed, and perivascular inflammatory cells were infiltrated. The inflammatory reaction of lung tissue in VitD intervention group was less. The Shannon index curve of microbial species in the three groups was flat, and there was no statistical significance in Simpson index among the three groups (P＞0.05). PCoA diagram analysis showed that the distance between the asthma model group and the healthy control group was large, and the distance between the VitD intervention group and the asthma model group was close (P＜0.05). The three groups of intestinal flora involved 15 divisions and 23 genera. Th1/Th2 ratio and the abundance of Actinobacteriota, Helicobacter, and Colidextribacter in asthma model group were lower than those in healthy control group, Th17/Treg ratio and the abundance of Proteobacteria, Ligilactobacillus, and Bacteroides of asthma model group were higher than those of healthy control group (P＜0.05). Th1/Th2 ratio and the abundance of Actinobacteriota, Proteobacteria, Helicobacter, and Colidextribacter in VitD intervention group were higher than those in asthma model group, The Th17/Treg ratio and the abundance of Ligilactobacillus, Bacteroides in VitD intervention group were lower than those of the asthma model group (P＜0.05), which were consistent with the result of heatmap analysis based on genera level. Conclusion VitD intervention can regulate the balance of peripheral blood T lymphocytes and change the intestinal flora of young mice with asthma, which may be a new entry point for the pathogenesis of this disease.
		2023 Vol. 20 (16): 21-25,36 [Abstract] ( 18 ) HTML (1 KB) PDF (1753 KB) ( 22 )

	26	Protective effects of 5-Aza-2’-deoxycytidine on neurotoxicity of hippocampal neurons induced by benzo[a]pyrene
		WEI Zhichao1 FENG Jingyu2 NIE Jisheng1 WEI Jianhong2
		DOI: 10.20047/j.issn1673-7210.2023.16.05
		Objective To probe the protective effects of 5-Aza-2’-deoxycytidine (5-Aza-cdR) on the neurotoxicity of benzo[a] pyrene(B[a]P) to hippocampal neurons. Methods The hippocampal neurons were cultured until the 5th day. The cells were observed and identified. The experiment was divided into control group, B[a]P group(20 μmol/L, B[a]P), and B[a]P+5-Aza-cdR group (20 μmol/L B[a]P+10 μmol/L 5-Aza-cdR). Cell morphology was observed. Cell viability, DNA methyltransferase protein， and gene expression were detected. Total methylation level and apoptosis were measured. Results Compared with the control group, the B[a]P group decreased the viability of hippocampal neurons(P＜0.05). The apoptosis rate increased (P＜0.05). The expression level of DNMT3A, DNMT3B gene and DNMT1、DNMT3A protein increased (P＜0.05). The total methylation level increased (P＜0.05). Compared with the B[a]P group, the B[a]P+5-Aza-cdR group increased hippocampal neuronal viability (P＜0.05), and the apoptosis rate decreased (P＜0.01) and visibly decreased DNMTs gene and protein expression levels (P＜0.05). The methylation level was obviously decreased (P＜0.01). Conclusion 5-Aza-cdR has a protective effect on B[a] P-induced hippocampal neuron injury.
		2023 Vol. 20 (16): 26-30 [Abstract] ( 21 ) HTML (1 KB) PDF (953 KB) ( 21 )

	31	Effects of propofol on hypoxia/reoxygenation induced PC12 cell damage and its molecular mechanism
		XU Jie　WANG Hui　WEN Hong　ZHANG Jian
		DOI: 10.20047/j.issn1673-7210.2023.16.06
		Objective To investigate the effect of propofol on hypoxia/reoxygenation (H/R) induced PC12 cell damage and its molecular mechanism. Methods PC12 cells were cultured in vitro and divided into control group (21% O2/5% CO2/74% N2 culture under normal conditions) and H/R group (3% O2/5% CO2/92% N2 culture under hypoxia condition for 2 h, cultured for 12 h under normal conditions), H/R+ propofol group (50 μmol/L propofol pretreatment for 1 h and then treated with H/R), H/R+anti-miR-NC group (transfected with anti-miR-NC and then treated with H/R), H/R+anti-miR-1246 group (transfected with anti-miR-1246 and then treated with H/R), H/R+ propofol +miR-NC group (transfected miR-NC, and then treated with 50 μmol/L propofol and H/R), H/R+ propofol +miR-1246 (transfected with miR-1246 and then treated with 50 μmol/L propofol and H/R). MTT and flow cytometry were used to detect cell viability and apoptosis, respectively. Western blot analysis of apoptosis-related protein expression (B lymphoblastoma-2 [Bcl-2], B lymphoblastoma-2 associated with x protein [Bax]). The expression levels of pro-inflammatory cytokines and anti-inflammatory cytokines were detected by enzyme-linked immunosorbent assay. The expression level of miR-1246 was detected by quantitative reverse transcription polymerase chain reaction. Results The survival rate of cells was the highest when 50 μmol/L propofol was applied, so the concentration of propofol was 50 μmol/L in subsequent experiments. Compared with control group, the apoptosis rate, levels of Bax protein, tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-18 in H/R group were increased, while the levels of Bcl-2 protein and IL-10 were decreased (P＜0.05). Compared with H/R group, the apoptosis rate, levels of Bax protein, TNF-α, IL-1β, and IL-18 were decreased in H/R+ propofol group, while the levels of Bcl-2 protein and IL-10 were increased (P＜0.05). Compared with control group, the expression of miR-1246 in H/R group was increased (P＜0.05). Compared with H/R group, the expression of miR-1246 in H/R+ propofol group was decreased (P＜0.05). There were no significant differences in miR-1246 level, apoptosis rate, Bcl-2 protein, Bax protein, TNF-α, IL-1β, IL-18, and IL-10 between H/R group and H/R+anti-miR-NC group (P＞0.05). Compared with H/R+anti-miR-NC group, the levels of miR-1246, apoptosis rate, Bax protein, TNF-α, IL-1β, and IL-18 were decreased in H/R+anti-miR-1246 group, while the levels of Bcl-2 protein and IL-10 were increased (P＜0.05). Compared with H/R+ propofol +miR-NC group, the expression level of miR-1246, apoptosis rate, Bax protein, TNF-α, IL-1β, and IL-18 levels were increased in H/R+ propofol +miR-1246 group, while the levels of Bcl-2 protein and IL-10 were decreased (P＜0.05). Conclusion Propofol can relieve H/R induced PC12 cell damage by down-regulating miR-1246.
		2023 Vol. 20 (16): 31-36 [Abstract] ( 14 ) HTML (1 KB) PDF (1027 KB) ( 23 )

	37	Research progress of Empagliflozin in the treatment of type 2 diabetes mellitus
		HUO Qidong LI Deguan
		DOI: 10.20047/j.issn1673-7210.2023.16.07
		Type 2 diabetes mellitus is one of the most common chronic metabolic diseases worldwide. Traditional drug therapy of type 2 diabetes mellitus relies on the regulation of insulin and is associated with multiple side effects. Sodium-glucose co-transporter-2 is a new therapeutic target for type 2 diabetes mellitus identified in recent years. Empagliflozin, one of the SGLT-2 inhibitors, approved and shown excellent glucose-lowering effects and safety in the diabetes treatment, has been widely used in clinic therapy. Empagliflozin also has the functions of reducing oxidative stress, inhibiting inflammatory response, and regulating apoptosis. This article summarizes the therapeutic advances and mechanisms of Empagliflozin in type 2 diabetes mellitus, with a view to providing more ideas for clinical treatment of patients with type 2 diabetes mellitus and expanding the indications of Empagliflozin.
		2023 Vol. 20 (16): 37-40,49 [Abstract] ( 12 ) HTML (1 KB) PDF (619 KB) ( 112 )

	41	Research progress on the mechanism of 5-hydroxytryptamine in rotavirus diarrhea
		LI Feng SONG Lijun ZHOU Yujing FENG Yuxuan YUAN Yue QIAN Yupei YANG Siyan ZHAO Wenchang
		DOI: 10.20047/j.issn1673-7210.2023.16.08
		Rotavirus is a kind of enterovirus, the mechanism of which causes diarrhea is very complicated, and there is no specific drug to treat it. Recent studies have shown that 5-hydroxytryptamine plays a major role in rotavirus diarrhea. By modulating the expression of 5-hydroxytryptamine and the function of the enteric nervous system and intestinal epithelial barrier that it affects, the symptoms of rotavirus diarrhea can be effectively reduced. The relationship between 5-hydroxy tryptamine and rotavirus diarrhea has not been systematically organized. This review combines the latest relevant studies to provide a theoretical basis for the development of new anti-rotavirus drugs, with the aim of guiding clinical treatment more accurately.
		2023 Vol. 20 (16): 41-44 [Abstract] ( 21 ) HTML (1 KB) PDF (499 KB) ( 56 )

	45	Progress of experimental research on improving adolescents’ constitution by functional exercise of traditional Chinese medicine
		YANG Yuhe1　BAI Yu1　LENG Desheng1　LI Chenxue2　YU Qinming3
		DOI: 10.20047/j.issn1673-7210.2023.16.09
		Functional exercise of traditional Chinese medicine is closely related to adolescents’ constitution health. It has a positive impact on adolescents’ heart rate and respiration regulation, physical fitness improvement, exercise function, harmonizing qi and blood, and can significantly improve adolescents’ obesity, sub-health, myopia, exercise fatigue, and other states. Its effect mainly about the coordination of mind, qi, and force, pays attention to the integration of action, application, and medical science, and regulation of mental activity and nourishment of spirit. Adolescents’ scientific practice of functional exercise of traditional Chinese medicine can also play a role in keeping healthy without disease, preventing disease first, and preventing disease from changing. However, in recent years, relevant studies are mainly carried out from the perspectives of physiology, pathology, and emotion, and there are some problems such as small sample size, short intervention time, lack of quantification of effect, and mechanism of action. In the future, it is necessary to strengthen the mechanism elaboration and publicity of the influence of functional exercise of traditional Chinese medicine on adolescents’ constitution.
		2023 Vol. 20 (16): 45-49 [Abstract] ( 21 ) HTML (1 KB) PDF (765 KB) ( 63 )

	50	Research progress on prognostic predictive factors of anti-MDA5-DM combined with rapidly progressive interstitial lung disease
		WANG Nan LIU Hongju
		DOI: 10.20047/j.issn1673-7210.2023.16.10
		Anti-melanoma differentiation associated gene 5 antibody-positive dermatomyositis is a special subtype of dermatomyositis, which is very easy to be associated with rapidly progressive interstitial lung disease. In recent years, great progress has been made in the diagnosis and treatment of the disease through the joint efforts of doctors from respiratory department, rheumatology department, and severe medical department, but there are still high incidence rates and mortality rates in China. Comprehensive evaluation of predictive factors affecting patient prognosis is of great significance for timely adjustment of treatment plans and predicting outcomes. This article mainly summarizes the relevant domestic and foreign researches in recent years, and reviews research progress on the progress of predictive factors in anti-melanoma differentiation associated gene 5 antibody-positive dermatomyositis is combined with rapidly progressive interstitial lung disease.
		2023 Vol. 20 (16): 50-53,79 [Abstract] ( 21 ) HTML (1 KB) PDF (702 KB) ( 139 )

	54	Research progress on pharmacological action of acetyl shikonin
		JIANG Zhouying1* XIE Pengfa1* GUO Jiaxiu1 RONG Jiaying1 TANG Xingyu1 BAI Lin2 DENG Xin2
		DOI: 10.20047/j.issn1673-7210.2023.16.11
		Acetyl shikonin is a naphthoquinone compound with anti-bacterial, anti-inflammatory, anti-allergic, anti-viral, anti-tumor and other biological activities extracted from Chinese traditional herbal medicine Arnebiae Radix. Arnebiae Radix and its derivative acetyl shikonin have played an important role in anti-cancer and anti-viral studies. Only a few studies have reported the adverse effects of acetyl shikonin on liver and cardiomyocyte toxicity. Further studies on the toxicity and pharmacokinetics of acetyl shikonin are needed. In this paper, the physical and chemical properties, pharmacological action, mechanism and potential toxicity of acetyl shikonin are summarized and conclude, aiming to provide a reference for further study of acetyl shikonin.
		2023 Vol. 20 (16): 54-57 [Abstract] ( 16 ) HTML (1 KB) PDF (618 KB) ( 70 )

	58	Advances in molecular signaling pathways related to endometrial adhesions treated by stem cells related molecular signaling pathways
		MA Guohui1 HUANG Yanhong2▲
		DOI: 10.20047/j.issn1673-7210.2023.16.12
		Intrauterine adhesion (IUA) is an important cause of infertility due to endometrial injury and abnormal adhesion caused by infection, abortion and repeated intrauterine operations. At present, for the treatment of IUA, mild to moderate patients can still achieve a certain effect through traditional treatment, but for patients with severe or extensive endometrial injury, endometrial regeneration and functional recovery has become a clinical thorny problem. With the extensive research of stem cells, stem cells with low immunogenicity, proliferation and differentiation advantages are considered to be one of the most potential methods in the treatment of intrauterine adhesions. Previous studies have shown that the paracrine effect of stem cells can promote the formation of new blood vessels and improve intrauterine fibrosis by secreting growth factors and inhibiting inflammation in the lesion area. In this paper, we review the existing molecular mechanisms of stem cell therapy for intrauterine adhesions in order to provide guidance for future research.
		2023 Vol. 20 (16): 58-61 [Abstract] ( 24 ) HTML (1 KB) PDF (481 KB) ( 124 )

	62	Research progress on the relationship between dietary patterns, intestinal flora and obesity
		Ayimuguli Aini　JIN Jin
		DOI: 10.20047/j.issn1673-7210.2023.16.13
		Obesity is a complex, multifactorial, and largely preventable chronic metabolic disease, which has now become a serious health burden. Obesity is associated with an increased risk of multiple metabolic-related diseases and adverse prognosis. The occurrence and development of obesity are influenced by genetics, environment, diet, lifestyle and other factors, among which, dietary pattern and intestinal flora play a key role. Different dietary patterns bring different outcomes to the level of intestinal flora, which can further affect the occurrence and development trajectory of obesity. In this paper, dietary pattern and intestinal flora changes as the object of discussion, analysis of the two in improving the role of obesity.
		2023 Vol. 20 (16): 62-65 [Abstract] ( 23 ) HTML (1 KB) PDF (455 KB) ( 101 )

	66	Significance and practical strategy of aesthetic education in stomatology talent cultivation
		XIANG Lin1　LIU Jiayi2　JIA Yinan2　WU Bingfeng2
		DOI: 10.20047/j.issn1673-7210.2023.16.14
		Aesthetic education is an important part of higher education, which plays a significant role in cultivating students’ aesthetic and comprehensive quality. Due to the specialty of stomatology, students should have higher aesthetic quality to meet the aesthetic needs of patients. However, aesthetic education is still in a marginal position in the training system of stomatology students, and the professional knowledge related to oral aesthetics is not systematic enough. Therefore, the cultivation process should pay attention to the role of aesthetic education, so as to improve students’ aesthetic quality and practical application ability, and lay a solid foundation for clinical work in the future. Based on the current development status and existing problems of aesthetic education, this paper focuses on the demands of stomatology talent training for aesthetic education, emphasizes the important value of aesthetic education in the training of stomatology students, and puts forward a variety of innovative strategies to strengthen the aesthetic education of stomatology students and further promote the improvement of their humanistic quality.
		2023 Vol. 20 (16): 66-69,74 [Abstract] ( 23 ) HTML (1 KB) PDF (783 KB) ( 174 )

	70	Analysis of clinical skill assessment results of standardized training for resident doctors in Zhongnan Hospital of Wuhan University
		CHEN Jinyu1　YE Yanqing1　HE Li1　CHEN Zhiqiao2　WANG Shiyu1
		DOI: 10.20047/j.issn1673-7210.2023.16.15
		Objective To analyze the results and influencing factors of clinical skill assessment of the first year standardized training of residents in Zhongnan Hospital of Wuhan University. Methods The first-stage skill assessment results in April 2021 of 202 residents in grade 2021 were collected. Univariate analysis and logistic regression analysis were used to evaluate the main influencing factors of the passing rate of residents. Results The passing rate of residents was 68.32%. Univariate analysis results showed that the qualified rate of students in rotation departments and basic education background was statistically significant (P＜0.05). Multivariate logistic regression analysis showed that the passing rate of standardized training students in 985 colleges and universities was higher than that of students with basic education background of ordinary undergraduate colleges and universities (OR=2.604, 95%CI: 1.198-5.658, P＜0.05). The passing rate of standardized training students in non-clinical departments was lower than that in non-surgical departments (OR=0.194, 95%CI: 0.074-0.504, P＜0.05). The qualified rate of standardized training studentsin different rotation departments had statistical significance in the first, second, third, and fourth assessment items (P＜0.05). In the first assessment item, the qualified rate of standardized training students in non-surgical departments was higher than that in non-clinical departments (P＜0.017). In the second assessment item, the qualified rate of trainees in surgical and non-surgical departments was higher than that in non-clinical departments (P＜0.017). Conclusion The passing rate of residents may be related to their undergraduate education background and clinical departments. The hospital should take corresponding countermeasures according to the existing problems, strengthen the process management, and improve the quality of training.
		2023 Vol. 20 (16): 70-74 [Abstract] ( 17 ) HTML (1 KB) PDF (696 KB) ( 51 )

	75	Exploration on the practical approach of professional culture construction under the background of mass entrepreneurship and innovation in medical colleges and universities
		ZHANG Xintong　HAN Yanhua　CHE Zhiyuan
		DOI: 10.20047/j.issn1673-7210.2023.16.16
		The development of innovation and entrepreneurship education has become one of the main goals of the comprehensive reform of higher education in China. It is of great significance to promote the development of entrepreneurship and innovation education in medical colleges and universities to explore a suitable new road combining “entrepreneurship and innovation” education with the construction of medical professional culture. This paper focuses on the importance of constructing a professional culture system in medical colleges and universities under the background of entrepreneurship and innovation, and advocates taking professional culture as the carrier, cultivating innovative medical talents with lofty ideals and beliefs, medical ethics, and serving the people wholeheartedly through the path of clarifying talent training objectives, stimulating students’ awareness of innovation and entrepreneurship, perfecting teaching evaluation system, and building a comprehensive teaching staff.
		2023 Vol. 20 (16): 75-79 [Abstract] ( 20 ) HTML (1 KB) PDF (757 KB) ( 64 )

	80	Application of positive psychological group counseling in nursing teaching of mental disorders
		WANG Huadong1 LIU Chunhui2 WANG Hui1 LIAO Qiaoyi1 LUO Jie1 CAO Mei1
		DOI: 10.20047/j.issn1673-7210.2023.16.17
		Objective To explore the application effect of positive psychological group counseling in nursing teaching of mental disorders. Methods From September to December 2022, a total of 201 three-year junior nursing students from Sichuan Vocational College of Health and Rehabilitation, Grade 2021, were selected as the research objects and divided into 100 students in the experimental group and 101 students in the control group by random number table method. The control group was taught by conventional teaching, and the experimental group was taught by combining conventional teaching with extracurricular positive psychological group counseling. The results of classroom tests, theoretical exams, and comprehensive ability improvement of the two groups were compared. Results There was no significant difference in the scores of comprehensive ability of the control group before and after tutoring (P＞0.05). After tutoring, scores of communication interaction, active learning, thinking innovation, teamwork, humanistic care, and comprehensive nursing in experimental group were higher than those before tutoring, while higher than control group, and the differences were statistically significant (P＜0.05). The scores of in-class test, mid-term test, and final test of experimental group were higher than those of control group, and the differences were statistically significant (P＜0.05). Conclusion Positive psychological group counseling can significantly improve the comprehensive literacy of nursing students, improve academic performance, and enhance the teaching effect of nursing for mental disorders.
		2023 Vol. 20 (16): 80-83 [Abstract] ( 21 ) HTML (1 KB) PDF (662 KB) ( 191 )

	84	Discussion on teaching program of the standardized training in interventional ultrasound
		GONG Yafei LIANG Weixiang ZOU Huimin PAN Yu
		DOI: 10.20047/j.issn1673-7210.2023.16.18
		The standardized training of resident doctors in ultrasound medicine is becoming more and more systematic, and the skill of interventional ultrasound is one of the difficulties in teaching, but there are few teaching programs of systematic interventional ultrasound standardized training at home and abroad. This paper summarizes the teaching experience of interventional ultrasound in the Ultrasound Training Base of the Third Affiliated Hospital of Guangzhou Medical University (national level) in recent years, which mainly includes theoretical teaching, case discussion, basic operation skills teaching, and simulation practice. Through more reasonable teaching planning, students can participate in interventional ultrasound operation while watching it, and arouse their enthusiasm. Improve students’ knowledge of interventional ultrasound and clinical application ability. In this paper, the teaching plan and content of the standardized training of interventional ultrasound are discussed in combination with the means of standardized lesson preparation, online and offline mixed teaching, and the rotation characteristics of each subject and sub-specialty in the training, so as to provide reference for the improvement of clinical teaching methods of interventional ultrasound.
		2023 Vol. 20 (16): 84-86,102 [Abstract] ( 22 ) HTML (1 KB) PDF (653 KB) ( 23 )

	87	Meta-analysis of the effects of Hedan Tablets on blood-lipid levels and inflammatory factors in patients with dyslipidemia
		HUANG Chengxin1 SUN Yuanlong2 WANG Xiaolong2 LI Lin1 ZHAO Zhejun1 RUAN Xiaofen2
		DOI: 10.20047/j.issn1673-7210.2023.16.19
		Objective To systematically evaluate the effects of traditional Chinese patent medicines and simple preparations Hedan Tablets on blood-lipid levels and inflammatory factors in patients with dyslipidemia. Methods Clinical randomized controlled trials of Hedan Tablets in the treatment of dyslipidemia were retrieved from PubMed, CNKI, VIP, Wanfang Data, and China Biomedical Literature Service System from inception to March 2022. The meta-analysis of the results of the included literatures was performed by RevMan 5.3 analysis software and Stata 16.0 software. Results A total of 15 clinical randomized controlled trials were included, including 1 227 patients. The results of meta-analysis showed that the total clinical effective rate of the experimental group was higher than that of the control group (OR=0.28, 95%CI: 0.19 to 0.44, P＜0.000 01). Compared with experimental group, serum levels of total cholesterol (MD=0.65, 95%CI: 0.16 to 1.14, P=0.01), triglyceride (MD=0.84, 95%CI: 0.45 to 1.23, P＜0.000 01), low density lipoprotein cholesterol (MD=0.76, 95%CI: 0.08 to 1.44, P=0.03), C-reactive protein (SMD=2.60, 95%CI: 0.50 to 4.69, P=0.02) were higher in the control group, and serum level of high-density lipoprotein cholesterol (MD=-0.41, 95%CI: -0.70 to -0.12, P＜0.000 01) was lower in the control group. There was no significant difference in the total incidence of adverse reactions between the two groups (OR=1.11, 95%CI: 0.71 to 1.72, P=0.65). Meta-regression analysis showed that publication time, sample size, statin type, and medication duration did not affect the effects of Herdan Tablets on blood-lipid levels and inflammatory factors in patients with dyslipidemia. The results of sensitivity analysis showed that the meta-analysis was stable. The funnel plot was basically symmetrical and had no obvious publication bias. Conclusion Hedan Tablets is better than western medicine alone in improving blood-lipid and inflammatory response indexes in patients with dyslipidemia, and does not increase adverse reactions, the effect is worthy of affirmation.
		2023 Vol. 20 (16): 87-92 [Abstract] ( 15 ) HTML (1 KB) PDF (1215 KB) ( 24 )

	93	Expression of ω-3 PUFA in serum of patients with pulmonary nodules and establishment of a digital prediction model
		YAO Yi HU Qiuxia LI Ji WANG Yi YANG Yanhui LI Xiaoliang LUO Lei LEI Yu XIE Xiaoyang▲
		DOI: 10.20047/j.issn1673-7210.2023.16.20
		Objective To compare the ω-3 polyunsaturated fatty acid (ω-3 PUFA) expression in serum of patients with pulmonary nodules, and to explore the independent risk factors for benign and malignant pulmonary nodules and establish a malignant probability prediction model. Methods A total of 294 patients with pulmonary nodule with definite pathology admitted to the Department of Cardiothoracic Surgery of the First People’s Hospital of Neijiang City, Sichuan Province from January 2018 to December 2021 were selected, and the patients were randomly divided into modeling group (201 cases) and verification group (93 cases). The difference of serum expression of ω-3 PUFA in benign and malignant pulmonary nodules was compared in the modeling group. The influencing factors of malignant pulmonary nodules were analyzed by single factor and multiple factor, and the diagnosis and prediction model was established and verified. Results There were statistically significant differences in ω-3 PUFA, focal diameter, consolidation/tumorratio(CTR), short burr, vascular signs and pleural pull between benign and malignant pulmonary nodules in the modeling group (P＜0.05). Logistic regression showed that ω-3 PUFA, CTR, short burr, vascular sign, and pleural pull were independent influencing factors for benign and malignant pulmonary nodules (P＜0.05). The prediction model was established: P=ex/(1+ex).X=-5.020+ (0.042×ω-3 PUFA positive) + (1.613×CTR) + (1.185× short burr) + (1.081× pleural drag) + (0.936× vascular sign). The area under curve (AUC) of receiver operating characteristic (ROC) curve of this model was 0.837, and the sensitivity and specificity were 74.5% and 84.6%, respectively. The AUC of the ROC curve of verification group was 0.780. Conclusion Lung nodules with decreased serum ω-3 PUFA, CTR≥0.5, burr sign, vascular sign, and pleural pull need to be highly suspected of malignancy. The established diagnosis and prediction model has a good prediction of benign and malignant pulmonary nodules.
		2023 Vol. 20 (16): 93-97 [Abstract] ( 16 ) HTML (1 KB) PDF (788 KB) ( 37 )

	98	Relationship between serum phosphorylated neurofilament heavy subunit level and concurrent delirium in patients with septic shock
		LI Yunting LI Fen FENG Qitao
		DOI: 10.20047/j.issn1673-7210.2023.16.21
		Objective To investigate the relationship between serum phosphorylated neurofilament heavy subunit（pNF-H）level in patients with septic shock and the occurrence of delirium. Methods A total of 117 patients with septic shock admitted to the Second Affiliated Hospital of Hainan Medical University from January 2020 to March 2022 were selected. According to delirium diagnostic criteria, patients were divided into the 73 cases in non-delirium group and 44 cases in delirium group. Univariate analysis, binary logistic regression model analysis, and receiver operating characteristic(ROC) curve were used to explore the relationship between serum pNF-H level in patients with septic shock and the occurrence of delirium. Results The sequential organ failure assessment（SOFA) score，the proportion of mechanical ventilation，28-day mortality, and serum levels of pNF-H and interleukin-6(IL-6) in the delirium group were higher than those in the non-delirium group, while serum albumin levels were lower than those in the non-delirium group(P＜0.05). According to binary logistic regression model analysis, the elevated value of SOFA score, mechanical ventilation, and the elevated levels of serum pNF-H and IL-6 were independent risk factors for the occurrence of delirium in patients with septic shock(P＜0.05). According to ROC curve analysis, the area under the curve of pNF-H in predicting the occurrence of delirium in patients with septic shock were higher than those of IL-6 and SOFA score（P＜0.05）. Conclusion The elevated serum pNF-H level is an independent risk factor for the occurrence of delirium, which can be used as a predictor of delirium in patients with septic shock.
		2023 Vol. 20 (16): 98-102 [Abstract] ( 22 ) HTML (1 KB) PDF (731 KB) ( 29 )

	103	Application of three-dimensional reconstruction technology combined with modified swelling collapse method in thoracoscopic segmentectomy
		QIN Zhonghua SHAN Yibo HUANG Xiaofeng YU Guiping▲
		DOI: 10.20047/j.issn1673-7210.2023.16.22
		Objective To explore the clinical value of preoperative three-dimensional reconstruction technology combined with intraoperative modified swelling collapse in thoracoscopic segmentectomy. Methods The clinical data of 90 patients who underwent thoracoscopic segmentectomy in the Department of Thoracic Surgery of Jiangyin People’s Hospital from January 2019 to June 2021 were collected. Among them, 45 patients underwent preoperative three-dimensional bronchial vessel reconstruction and were assigned as the observation group, during which modified dilatation and collapse method was adopted. Another 45 patients who underwent direct segmental resection were used as control group, and conventional dilatation and collapse were performed during the operation. The clinical data and therapeutic effect were compared between the two groups. Results The operation time, postoperative extubation time, and postoperative hospital stay in the observation group were shorter than those in the control group, while intraoperative blood loss and total postoperative drainage were less than those in the control group, and the differences were statistically significant (P＜0.05). There was no significant differences in thoracotomy conversion rate and complication rate between the two groups (P＞0.05). All patients successfully completed the operation, one case in the control group was converted to thoracotomy, and patients of both groups were discharged. Conclusion Three-dimensional reconstruction technology combined with modified swelling collapse method can help the surgeon accurately identify the structure of the lung segment and carry out precise segmentectomy safely and effectively.
		2023 Vol. 20 (16): 103-106 [Abstract] ( 21 ) HTML (1 KB) PDF (718 KB) ( 47 )

	107	Effect of photon therapy apparatus combined with alginate powder on wound healing after hemorrhoidal surgery
		DING Weiwei1 LIU Qiao1 XU Hong2 XU Min2 SHANG Chao3 CHEN Xian4
		DOI: 10.20047/j.issn1673-7210.2023.16.23
		Objective To investigate the effect of photon therapy apparatus combined with alginate powder on wound healing after hemorrhoidal surgery. Methods Eighty patients with emorrhoids who underwent surgery in Jiangning Hospital Affiliated to Nanjing Medical University from February to September 2020 were selected as the study subjects, they were divided into control group and study group according to the random number table method, with 40 cases in each group. The patients in control group were treated with photon therapy apparatus, and the patients in study group were treated with photon therapy apparatus combined with alginate powder. The clinical efficacy between two groups were compared; the time of wound improvement, disappearance time of anal edema, disappearance time of bleeding, and disappearance time of exudation between two groups were compared; the inflammatory indexes (interleukin-8 [IL-8], tumor necrosis factor-α [TNF-α], and transforming growth factor-β1[TGF-β1]) were compared between two groups before and after treatment; visual analog scale (VAS) scores were compared between two groups at one day before treatment and one, two weeks, and four weeks after treatment. Results The clinical efficacy of study group was better than that of control group, and the difference was statistically significant (P＜0.05). The time of wound improvement, disappearance time of anal edema, disappearance time of bleeding, and disappearance time of exudation in study group were shorter than those in control group, and the differences were statistically significant (P＜0.05). After treatment, the levels of IL-8, TNF-α, and TGF-β1 in two groups were lower than those before treatment, and study group was lower than control group, and the differences were sta- tistically significant (P＜0.05). Pairwise comparison between the two groups at different time points showed statistically significant difference (P＜0.05); after one, two weeks, and four weeks of treatment, VAS scores of study group were lower than those of control group, and the differences were statistically significant (P＜0.05). Conclusion The application value of photon therapy apparatus combined with alginate powder in postoperative rehabilitation of hemorrhoids patients is high, which can improve the wound healing speed, reduce the level of inflammatory syndrome factors, relieve pain, and can be widely promoted and applied in clinical practice.
		2023 Vol. 20 (16): 107-110 [Abstract] ( 25 ) HTML (1 KB) PDF (972 KB) ( 121 )

	111	Safety and efficacy of Esketamine Hydrochloride combined with Propofol in painless colorectal sedation in obese patients
		YE Zong1 HE Yapeng1 XIANG Jun2 MOU Junying2 CUI Zhihong2 ZHANG Jie2 ZHU Xianlin2
		DOI: 10.20047/j.issn1673-7210.2023.16.24
		Objective To observe the safety and efficacy of Esketamine Hydrochloride combined with Propofol for obese patients undergoing painless colorectal endoscopy sedation. Methods A total of 88 obese patients who underwent painless colorectal endoscopy sedation in Outpatient Clinic of the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Hubei Province from March to October 2022 were included. They were divided into Esketamine group and control group using random number table and envelope allocation concealment method, with 44 cases in each group. Induction programme: Esketamine Hydrochloride (0.2 mg/kg)+Propofol (1-2 mg/kg) was injected intravenously in Esketamine group, and Sufentanil (0.1 μg/kg)+Propofol (1-2 mg/kg) was injected intravenously in control group; intraoperative anesthesia maintenance drugs: Propofol [3-4 mg/(kg·h)] was pumped intravenously. The drug was stopped five minutes before the end of the operation in both groups, and the patients were sent to the resuscitation room for observation after the examination. Effectiveness of sedation, anesthesia awakening time, time to discharge criteria, Propofol dosage, and visual analog scale (VAS) score at discharge between two groups were compared; heart rate (HR), mean arterial pressure (MAP), pulse oxygen saturation (SpO2), modified observer’s assessment of alert/sedation (MOAA/S) scores between two groups were compared after entering the room (T0), after completion of anesthesia induction (T1), enteroscopy into the anus (T2), enteroscopy to the ileocecal region (T3), end of colonoscopy withdrawal (T4), and five minutes after the end of examination (T5); intubation tolerance scores between two groups were compared at T2-T4; the incidence of complications between two groups were recorded. Results There were no significant differences in effectiveness of sedation, anesthesia awakening time, and VAS score at discharge between two groups (P＞0.05). The time to discharge criteria in Esketamine group was shorter than that in control group, the Propofol dosage was smaller than that in control group, and the differences were statistically significant (P＜0.05). At T0-T5, HR and MAP in two groups at different time points were compared, and the differences were statistically significant (P＜0.05). At T2, SpO2 was lower than that at T1, and the difference was statistically significant (P＜0.05); at T3, SpO2 in two groups were higher than those at T2, and the differences were statistically significant (P＜0.05); at T4, SpO2 in two groups were higher than those at T2-T3, and the differences were statistically significant (P＜0.05); At T5, SpO2 in Esketamine group was higher than that at T3, and the difference were statistically significant (P＜0.05). At T1-T4, HR of Esketamine group was higher than that of control group, and the difference was statistically significant (P＜0.05); at T1-T5, MAP of Esketamine group was higher than of control group, and the difference was statistically significant (P＜0.05); at T1-T3, SpO2 in Esketamine group was higher than that in control group, and the difference was statistically significant (P＜0.05). At T5, MOAA/S score in Esketamine group was lower than that at T0, and higher than that at T4, and the differences were statistically significant (P＜0.05). At T4, MOAA/S score in control group was higher than that at T1, and the difference was statistically significant (P＜0.05); at T5, MOAA/S score in control group was higher than that at T4, and the difference was statistically significant (P＜0.05). At T4, MOAA/S score of Esketamine group was higher than that of control group, and the difference was statistically significant (P＜0.05). No diplopia, hallucination, or postoperative agitation occurred in two groups. The incidence of respiratory depression and hypotension in Esketamine group was lower than that in control group, and the difference was statistically significant (P＜0.05); there was no significant difference in the incidence of bradycardia, tachycardia, dizziness, nausea, vomiting, and choking between two groups (P＞0.05). Conclusion Esketamine Hydrochloride combined with Propofol has high safety and efficacy for obese patients undergoing painless colorectal endoscopy sedation.
		2023 Vol. 20 (16): 111-116,121 [Abstract] ( 18 ) HTML (1 KB) PDF (857 KB) ( 33 )

	117	Effect of saphenous nerve block through inferior approach of medial femoris muscle in total knee arthroplasty in advanced age
		MEI Peiyi1 WU Jimin1 WU Yini1 YE Lvju2
		DOI: 10.20047/j.issn1673-7210.2023.16.25
		Objective To explore the effect of saphenous nerve block through inferior approach of medial femoris muscle in total knee arthroplasty in advanced age. Methods A total of 104 advanced age patients with total knee arthroplasty admitted to Lishui People’s Hospital, Zhejiang Province from January 2020 to January 2022 were selected, they were divided into study group (52 cases) and control group (52 cases) according to the random number table method. The control group received sciatic nerve block anesthesia through lower outer approach of large rotor, and study group was anesthetized by saphenous nerve block through inferior approach of medial femoris muscle. Surgical indexes and nerve block indexes were compared between two groups; visual analogue scale (VAS) scores of resting and active state were compared between two groups before surgery (T0), 6 h after surgery (T1), 12 h after surgery (T2), 24 h after surgery (T3) and 48 h after surgery (T4); the knee function scores of two groups were compared one and six months after surgery; the occurrence of adverse reactions was observed. Results There were no significant differences in operation time, anesthesia completion time, sensory block onset time, sensory block maintenance time, motor block onset time, motor block maintenance time, and motor block effect score between two groups (P＞0.05); the sensory block effect score in study group was higher than that in control group, and the difference was statistically significant (P＜0.05). At T1, there were no significant differences in resting and active VAS scores between two groups compared with T0 (P＞0.05); at T2-T4, the resting and active VAS scores of two groups were higher than those at T0, and the differences were statistically significant (P＜0.05). At T0-T1, there was no significant differences in resting and active VAS scores between two groups (P＞0.05); At T2-T4, the resting and active VAS scores of study group were lower than those of control group, and the differences were statistically significant (P＜0.05). Six months after surgery, the knee function scores of two groups were higher than those of one month after surgery, and the differences were statistically significant (P＜0.05); one and six months after surgery, there was no significant difference in knee function scores between two groups (P＞0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P＞0.05). Conclusion It is safe and reliable to apply saphenous nerve block through inferior approach of medial femoris muscle in total knee arthroplasty in advanced age, which can enhance analgesic effect and reduce postoperative pain.
		2023 Vol. 20 (16): 117-121 [Abstract] ( 18 ) HTML (1 KB) PDF (715 KB) ( 20 )

	122	Summary of Professor Zhao Haibin’s experience of treating double heart disease in the later stage based on classical prescriptions from Shaoyin’s “original meridian self-disease”
		LIU Yunlin1 ZHAO Haibin2 WANG Chao2 HOU Jiqiu2 LI Ruiyi1 YAN Shasha2
		DOI: 10.20047/j.issn1673-7210.2023.16.26
		Modern medicine regards cardiovascular disease combined with mental and psychological problems as double heart disease. Professor Zhao Haibin, the founder of the “double heart theory” of traditional Chinese medicine, finds that the late stage of double heart disease often leads to the same result and involves the two viscera of the heart and kidney, especially in the elderly, who are often accompanied by depression, deficiency of both heart and kidney yang qi in the later stage of heart disease. Therefore, this paper concludes that the pathogenesis of the late stage of double-heart disease belongs to the “stagnation” stage of “stasis and heat deficiency and stagnation”, that is, the damage of the heart and kidney Yang, the loss of the mind, the yang qi of upper jiao is insufficient, yin qi lower jiao is sufficient and the stagnation of the heart and qi.The treatment should be based on the prescription of the meridian, using syndrome differentiation of six channels theory and eight principles of Shaoyin meridian, the syndrome differentiation of zang-fu viscera and the two viscera of the heart and kidney, the combination of disease and syndrome, considering a syndrome by several diseases, diagnosis and treatment based on syndrome differentiation. The method should warm the heart and kidney, nourishing the heart and calming the mind, promoting blood and activating qi. Sini Decoction combined with self-designed “Shuangxin Decoction” addition and subtraction, the clinical effect proved remarkable.
		2023 Vol. 20 (16): 122-125 [Abstract] ( 23 ) HTML (1 KB) PDF (642 KB) ( 90 )

	126	Cui Yinglin’s experience in treating cerebral infarction from “deficiency, stasis, phlegm, and turbidity”
		ZHOU Panpan1 CUI Yinglin2
		DOI: 10.20047/j.issn1673-7210.2023.16.27
		Cerebral infarction is a common disease in neurology, with high incidence rate and high mortality, which seriously threatens human health. The etiology and pathogenesis of cerebral infarction are complex and varied, doctors of all dynasties have different opinions. Professor Cui, who has been engaged in the study of internal medicine for many years, believes that the core pathogenesis of cerebral infarction is “deficiency of yuan qi, static blood blocking collateral”, and deficiency, stasis, phlegm, and turbidity are the main pathological factors. Professor Cui proposes to take “benefiting qi for activating blood circulation, removing turbidity for removing obstruction in collaterals” as the basic treatment principles. Clinical treatment of cerebral infarction not only pays attention to the deficiency, stasis, phlegm, turbidity single disease evil nature changes, but also pay attention to their mutual combination of the change of pathogenesis. Therefore, when applying the basic principle of “benefiting qi for activating blood circulation, removing turbidity for removing obstruction in collateral”, the prescription Yiqi Tongmai Formula is formulated by add or subtract as required according to the course of disease, the changes of syndromes and years of clinical experience. The effect is remarkable when it is used in clinic.
		2023 Vol. 20 (16): 126-129 [Abstract] ( 12 ) HTML (1 KB) PDF (630 KB) ( 64 )

	130	Analysis on the idea of prevention and treatment of epidemic disease in Zhouhou Beiji Fang
		JI Yongkuan CHEN Guosen NI Ruifan LIANG Yanlin ZHANG Qian’ao LIU Guo
		DOI: 10.20047/j.issn1673-7210.2023.16.28
		The epidemic treatment ideas in the epidemic chapter of Zhouhou Beiji Fang are reflected in three aspects: understanding of epidemic diseases, epidemic prevention methods, and drug characteristics. The book believes that the epidemic is caused by “pestilential qi” and “gui du”. The book attaches importance to the prevention and control of epidemic diseases, and uses methods such as household medicine, pre-made pill scattering, nasal administration, powder, and burning and smoking to diagnose and treat epidemics as soon as possible to avoid the spread of epidemics. The nine prescriptions for curing epidemic diseases in the article are used by later doctors. The author refers to the herbal monographs as Great Dictionary of Chinese Medicine and Mingyi Bielu to analyze the characteristics and efficacy of the drug, and summarize the effects of those prescriptions as warming yang, sha gui, detoxifying, and removing dampness. According to modern pharmacological studies, the herbs of epidemic prescriptions can exert pharmacological effects such as cardiotonic action, anti-infection, anticonvulsant, antiviral, antibacteria, anti-anxiety, and depression. By summarizing the epidemic control ideas of Zhouhou Beiji Fang, those theory has value for the study of the historical evolution of the epidemic treatment theory and drug characteristics of Chinese medicine epidemic treatment.
		2023 Vol. 20 (16): 130-132,144 [Abstract] ( 8 ) HTML (1 KB) PDF (646 KB) ( 71 )

	133	Research on academic characteristics of cholera book in Japan Tenko Ketsubyoron
		CHEN Ting1 ZENG Yi2 SONG Baiyang2
		DOI: 10.20047/j.issn1673-7210.2023.16.29
		Tenko Ketsubyoron written by Japanese physician Isayama Shukuson. Isayama Shukuson (1825—1893) was born in Hita, Bungo Province of Japan. He named Rank, styled Pingfu, generally known as Dongzuo, Shukuson is its title, He was a doctor and educator during the end of the Shogunate to Meiji period. Tenko Ketsubyoron was written in 1862, and it was printing first time in 1893. It is a special book on epidemic treatment of traditional Chinese medicine. The text is composed of “name definition” “symptom” “contrast” “question”, and “treatment”. The symptoms, etiology and pathogenesis, principle and method of treatment, and prescriptions and contraindications for cholera and “Tianxing Juebing” were compared. Academic characteristics are mainly reflected in the following. Explain the name of “cholera” in detail, list the symptoms of “cholera”, “contrast” with Chinese medicine, “question” to explain the doubt. This book drew on many books, proved the present with the past. The book cited several authors, took advantage of everyone, and for the treatment of Tianxing Jue bing, this book adopted multiple methods or changed the classic prescription to treat the cholera, treatment based on syndrome differentiation in different periods, inherited China treatment experience. Through the study of this book, it can be seen that Chinese medicine has an important impact on the development of Japanese medicine.
		2023 Vol. 20 (16): 133-136 [Abstract] ( 15 ) HTML (1 KB) PDF (814 KB) ( 21 )

	137	Professor Hu Guoheng’s experience in the treatment of endogenous cough based on the theory of “liver is born on the left and lung is hidden on the right”
		CHEN Ya1　WANG Jinxi1　HU Guoheng1　YUAN Hua1　LIU Yingying1　XIE Jinru2　PIAO Meihong3　HE Piao2
		DOI: 10.20047/j.issn1673-7210.2023.16.30
		Endogenous cough is one of the most common diseases in internal medicine, its high incidence and recurrence rate is a clinical problem. Through many years of clinical diagnosis, Professor Hu Guoheng attributes the key pathogenesis to the reversed flow and disorder of liver and lung qi movement. Combined with the classic theory of “liver is born on the left and lung is hidden on the right”, he proposes the basic treatment of “harmonizing liver and spleen, opening stagnation, and dispersing excess”, which has remarkable effects. Endogenous cough is mostly caused by the dysfunction of zang-fu viscera, leading to the disorder of ascending and descending of yin and yang qi movement. The ascending and descending of liver and lung play a key role in the lifting axis, so it is mainly to “harmonizing liver and spleen, opening stagnation, and dispersing excess”, while not forgetting other zang-fu viscera. According to its deviation and impact on the running degree of qi, blood and body fluid, the overall grasp of ascending and descending of qi movement, which reflects the holistic traditional Chinese medicine thinking of syndrome differentiation.
		2023 Vol. 20 (16): 137-140 [Abstract] ( 25 ) HTML (1 KB) PDF (653 KB) ( 25 )

	141	Li Dongyuan’s discussion of the pathogenesis and treatment of polycystic ovary syndrome based on the theory of “rising of stomach qi”
		KONG Lingyuan　LI Xiuyang
		DOI: 10.20047/j.issn1673-7210.2023.16.31
		The theory of “rising of stomach qi” put forward by Li Dongyuan, a famous doctor of the Jin Dynasty, can be used to explain the pathological changes in polycystic ovary syndrome. Therefore, this paper tries to summarize the theory of “rising of stomach qi” and discuss the pathogenesis and treatment of polycystic ovary syndrome. Based on the analysis of the theory of “rising of stomach qi”, it can be seen that the basic pathogenesis of polycystic ovary syndrome is a malfunction of the rising of stomach qi, combined with liver qi stagnation, kidney essence qi deficiency, yin fire flaming upward and phlegm-dampness abundance inside. In the treatment of polycystic ovary syndrome, the primary treatment method is to rise the stomach qi, and according to the specific symptoms of the disease, methods such as regulating the rise of qi, tonifying the middle and benefiting the qi, removing heat with sweet-warm natured medicine, and benefiting the stomach to remove dampness are used. The theory of “rising of stomach qi” provides a new way of thinking for the clinical diagnosis and treatment of polycystic ovary syndrome and it is worth further exploration.
		2023 Vol. 20 (16): 141-144 [Abstract] ( 24 ) HTML (1 KB) PDF (653 KB) ( 35 )

	145	Application value of high resolution magnetic resonance imaging and positron emission tomography and computed tomography in the detection of peripheral metastatic small lymph nodes and preoperative T staging in rectal cancer
		QIN Xiaoxue ZHANG Wen GAO Hong HU Yuxia▲
		DOI: 10.20047/j.issn1673-7210.2023.16.32
		Objective To investigate the application value of high resolution magnetic resonance imaging (MRI) and positron emission tomography and computed tomography (PET/CT) in the detection of peripheral metastatic small lymph nodes and preoperative T staging in rectal cancer. Methods The clinical data of 109 patients with rectal cancer admitted to Qinhuai Medical District of the Chinese People’s Liberation Army Eastern Theater General Hospital from August 2019 to December 2021 were retrospectively analyzed. Taking the pathological results as the gold standard, the value of different methods (high resolution MRI and PET/CT examination) in screening peripheral metastatic small lymph nodes and preoperative T staging were analyzed. Results Pathological diagnosis showed that 352 peripheral metastatic small lymph nodes were found in 109 patients with rectal cancer, including 26 cases in T1-T2 staging, 68 cases in T3 stage, and 15 cases in T4 staging. High-resolution MRI was consistent with the gold standard in the diagnosis of peripheral metastatic small lymph nodes and preoperative T1-T2, T3 staging (Kappa=0.565, 0.705, 0.750, P＜0.05), there was no consistency in the diagnosis of preoperative T4 staging (P＞0.05). PET/CT was consistent with the gold standard in the diagnosis of peripheral metastatic small lymph nodes and preoperative T1-T2, T3 staging (Kappa=0.696, 0.590, 0.455, P＜0.05), there was no consistency in the diagnosis of preoperative T4 staging (P＞0.05). The combination of the two methods had strong consistency with the gold standard in the diagnosis of peripheral metastatic small lymph nodes and preoperative T1-T2, T3, T4 stage (Kappa=0.838, 0.808, 0.865, 0.709, P＜0.05). The sensitivity and specificity of high-resolution MRI combined with PET/CT in the screening of small peripheral metastatic lymph nodes and preoperative T staging were higher than 90%. Conclusion High-resolution MRI combined with PET/CT has a high detection rate of peripheral metastatic small lymph nodes around rectal cancer, and the combined examination has a high diagnostic value in preoperative T staging.
		2023 Vol. 20 (16): 145-148,153 [Abstract] ( 10 ) HTML (1 KB) PDF (645 KB) ( 22 )

	149	Parameters comparison of three-dimensional echocardiography left atrial automatic quantitative technique and Simpson’s biplane method in the determination of left atrial volume and function in patients with atrial fibrillation
		TANG Yueyue LI Shumin YANG Hanning LU Yongping
		DOI: 10.20047/j.issn1673-7210.2023.16.33
		Objective To compare the parameters of three-dimensional echocardiography left atrial automatic quantitative technique and Simpson’s biplane method in the determination of left atrial volume and function in patients with atrial fibrillation (AF). Methods A total of 54 AF patients admitted to Affiliated Hospital of Yunnan University from April to December 2020 were selected. Three-dimensional echocardiography left atrial automatic quantitative technique and Simpson’s biplane method were used to obtain left atrial maximum volume (LAVmax), left atrial minimum volume (LAVmin), left atrial pre-atrial contraction volume (LAVpreA), left atrial maximum volume index (LAVImax), left atrial total ejection fraction (LAEF), and the analysis time; at the same time, Left atrial active ejection fraction (LAAEF), left atrial passive ejection fraction (LAPEF), and left atrial expansion index (LAEI) were calculated; the consistency and repeatability of three-dimensional echocardiography left atrial automatic quantitative technique and Simpson’s biplane method were compared between intra-observer and inter-observer. Results There were no significant differences between LAVmax, LAVmin, LAVpreA, LAVImax, LAEF, LAAEF, LAPEF, and LAEI measured by three-dimensional echocardiography left atrial automatic quantitative technique and Simpson’s biplane method (P＞0.05). The analysis time of three-dimensional echocardiography left atrium automatic quantitative technique was shorter than that of Simpson’s biplane method (P＜0.05). The consistency and repeatability of the left atrial automatic quantitative technique of three-dimensional echocardiography left atrium automatic quantitative technique were better than those of Simpson’s biplane method in both intra-observer and inter-observer measurements. Conclusion Three-dimensional echocardiography left atrial automatic quantitative technique can accurately evaluate the changes of left atrial volume and function in patients with AF, with short time, better consistency and repeatability.
		2023 Vol. 20 (16): 149-153 [Abstract] ( 20 ) HTML (1 KB) PDF (748 KB) ( 31 )

	154	Application value of magnetic resonance T2WI image texture analysis in T2/3 staging of rectal cancer
		XIAO Jianyun YANG Zhiyong XIAO Zhifeng
		DOI: 10.20047/j.issn1673-7210.2023.16.34
		Objective To explore the application value of magnetic resonance T2 weighted image (T2WI) image texture analysis in T2/3 staging of rectal cancer. Methods The data of 92 patients with T2/3 staging of rectal cancer confirmed by pathological examination who were admitted to Rugao Hospital Affiliated to Nantong University from January 2019 to January 2022 were retrospectively analyzed. All patients received high-resolution plain rectal magnetic resonance imaging (MRI) before surgery, and axial T2WI images were selected for lesion texture analysis. MRI texture parameters were compared between T2 staging and T3 staging of rectal cancer patients; the relationship between MRI texture parameters and T2/3 staging of rectal cancer patients was analyzed; the diagnostic value of MRI texture parameters for T2/3 staging of rectal cancer patients was analyzed. Results The mean value, autocorrelation, entropy, and variance and sum of T3 staging patients were higher than those of T2 staging patients, while the contrast was lower than those of T2 staging patients, with statistical significance (P＜0.05). Mean value, autocorrelation, entropy, and variance and sum were all influencing factors for T2/3 staging of rectal cancer patients (P＜0.05). The combined detection of MRI texture parameters in the diagnosis of rectal cancer patients showed a higher area under the curve of T2/3 staging than each single detection. Conclusion Mean value, contrast, autocorrelation, entropy, and variance and sum of MRI texture parameters are influencing factors of T staging in patients with rectal cancer, magnetic resonance T2WI image texture analysis technology has a high diagnostic value for preoperative of T2/3 staging rectal cancer.
		2023 Vol. 20 (16): 154-157 [Abstract] ( 19 ) HTML (1 KB) PDF (612 KB) ( 28 )

	158	Application effect of rectal magnetic resonance imaging combined with endorectal ultrasound in diagnosis of complete response after neoadjuvant chemotherapy for rectal cancer
		ZHANG Chenxue1 SUN Yu1 YAN Ji1 LI Xiaoyu2 WU Xueliang3 LIU Bo4 CHEN Wenting5 WANG Likun2▲
		DOI: 10.20047/j.issn1673-7210.2023.16.35
		Objective To investigate the application effect of rectal magnetic resonance imaging (MRI) combined with endorectal ultrasound (ERUS) in diagnosis of complete response after neoadjuvant chemotherapy for rectal cancer. Methods A total of 66 patients with rectal cancer who received neoadjuvant chemotherapy and radical surgery in the First Affiliated Hospital of Hebei North University from January 2020 to December 2021 were selected. Rectal MRI and ERUS examinations were performed before and the seventh week after neoadjuvant chemotherapy to evaluate whether the patients had complete response. Pathological examination was used as the gold standard. The consistency of different tests in diagnosing complete response were compared with the gold standard. Results Pathological results showed that 22 of 66 patients with rectal cancer achieved complete response after neoadjuvant chemotherapy. There was no statistical significance between MRI and ERUS in the diagnosis of complete response after neoadjuvant chemotherapy and the gold standard (P＞0.05), while MRI combined with ERUS was consistent with the gold standard (Kappa=0.400, P＜0.05). The accuracy, specificity, and sensitivity of MRI combined with ERUS in the diagnosis of complete response after neoadjuvant chemotherapy in rectal cancer patients were 75.76%, 90.91%, and 45.45%. Conclusion After neoadjuvant chemotherapy for rectal cancer, the accuracy of simple MRI and ERUS in the diagnosis of complete response is not high, and the combined diagnosis has higher specificity and lower sensitivity than single diagnosis. For patients with non-complete response, radical surgery is simply performed. For patients with complete response, colonoscopy and digital examination are recommended, and subsequent treatment is implemented with caution.
		2023 Vol. 20 (16): 158-161 [Abstract] ( 13 ) HTML (1 KB) PDF (881 KB) ( 30 )

	162	Research on the effect of lean management of clinical pathway of surgical diseases base on DRG medical insurance payment
		MO Xiali1 HE Huimin2
		DOI: 10.20047/j.issn1673-7210.2023.16.36
		Objective To explore the effect of lean management (LM) on clinical pathway (CP) of surgical diseases under the background of medical insurance payment reform of diagnosis related groups(DRG). Methods Taking 13 surgical diseases under CP management in ethnic hospitals of Guangxi Zhuang Autonomous Region as the research object, 2020 (before LM application) as the control group, 2021 (after LM application) as the experimental group, the improvement of core indicators were compared, and the implementation effect of LM in surgical diseases CP was evaluated. Results The completion rate of the experimental group was 87.42% and that of the control group was 84.14%. The completion rates of laparoscopic appendectomy, ureteroscope pneumatic lithotripsy, breast benign tumor resection, coronary artery stenting, and carotid artery stenting in the experimental group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The mutation completion rate was 19.37% in the experimental group and 21.77% in the control group. Laparoscopic hysterectomy, laparoscopic appendectomy, endoscopic colorectal polypectomy, endoscopic thyroidectomy, coronary artery stenting, and carotid artery stenting in the experimental group were lower than those in the control group, with statistical significances (P＜0.05). The incidence of surgical complications was 2.60% in the experimental group and 3.33% in the control group. The complication rates of laparoscopic subtotal hysterectomy, laparoscopic appendectomy, endoscopic colorectal polypectomy, subtotal thyroidectomy and coronary stenting in the experimental group were lower than those in the control group, and the differences were statistically significant (P＜0.05). The average hospital stay and average preoperative hospital stay of most diseases were lower than those of control group, and the differences were statistically significant (P＜0.05). In the experimental group, average hospitalization cost, average drug cost and average consumables cost were decreased in different degrees, the differences were statistically significant (P＜ 0.05). Conclusion LM has a significant improvement effect on CP management of surgical diseases, can effectively improve the total number of surgical diseases, efficiency, benefit and quality indicators, and improve the level of hospital disease management.
		2023 Vol. 20 (16): 162-167 [Abstract] ( 19 ) HTML (1 KB) PDF (699 KB) ( 201 )

	168	Application effect of problem-oriented specialized nursing intervention in patients with acute lymphoblastic leukemia
		LI Jing ZHANG Yanming WANG Min WANG Li
		DOI: 10.20047/j.issn1673-7210.2023.16.37
		Objective To explore the application effect of problem-oriented specialized nursing intervention in patients with acute lymphoblastic leukemia. Methods A total of 160 patients with acute lymphoblastic leukemia from January 2018 to December 2021 were selected from the Huaian Second People’s Hospital, Jiangsu Province. According to the random number table method, the patients were divided into control group and research group, with 80 cases in each group. The control group was treated with routine nursing intervention, and the study group was treated with problem-oriented specialized nursing intervention on the basis of the control group. Both groups were treated for two months. Mental resilience, hope level, depression, anxiety, sleep quality, and quality of life were compared between the two groups. Results After two months of intervention, the scores of optimism, resilience, strength, intimacy, life attitude, positive action, and quality of life in two groups were higher than those before intervention, and the study group were higher than those in the control group (P＜0.05); depression self-rating scale, anxiety self-rating scale, Pittsburgh sleep quality indexes, quality of life symptom field scores were lower in two groups than those before intervention, and those of the study group were lower than those of the control group (P＜0.05). Conclusion Problem-oriented specialized nursing intervention can alleviate acute lymphoblastic leukemia patients with depression, anxiety, improve the psychological resilience of patients, improve the level of hope, improve patients’ sleep quality and quality of life, has a good intervention effect.
		2023 Vol. 20 (16): 168-172 [Abstract] ( 15 ) HTML (1 KB) PDF (609 KB) ( 64 )

	173	Effect of traditional Chinese medicine hot compress nursing on comfort and satisfaction of patients during colonoscopy
		CHEN Yixiu1 CAO Yanxia2 LUO Xiaoying1 YANG Jianqin1 ZHANG Manling1 BAI He1
		DOI: 10.20047/j.issn1673-7210.2023.16.38
		Objective To explore the influence of traditional Chinese medicine hot compress nursing on comfort level and satisfaction of patients during colonoscopy. Methods A total of 168 patients who underwent colonoscopy in Wangjing Hospital of China Academy of Chinese Medical Sciences from March to May 2022 were selected and divided into observation group and control group by random number table method, with 84 patients in each group. The control group received routine colonoscopy nursing, while the observation group was given traditional Chinese medicine hot compress nursingbefore colonoscopy operation on the basis of routine nursing. The total score of abdominal pain and abdominal distension in colonoscopy was used to evaluate the relieving effect of traditional Chinese medicine hot compress nursing on abdominal pain and abdominal distension during colonoscopy. Before and after colonoscopy, the state-trait anxiety inventory (STAI) in the state-trait anxiety questionnaire was used to evaluate the influence of traditional Chinese medicine hot compress nursing on the emotional state of patients, and the satisfaction score was used to investigate the acceptance of traditional Chinese medicine hot compress nursing, the satisfaction of colonoscopy experience, and the willingness to accept colonoscopy again. Results The total score of abdominal pain and abdominal distension in the observation group were lower than those in the control group during colonoscopy, and the differences were statistically significant (P＜0.05). After detection, S-AI scores of the two groups were lower than those before detection, and the differences were statistically significant (P＜0.05). After detection, there was no significant difference in S-AI score between the two groups (P＞0.05). There were no significant differences in the satisfaction of colonoscopy experience and the acceptance score of re-colonoscopy between the two groups (P＞0.05). There were no obvious abnormalities in heart rate, blood pressure, pulse and respiration in both groups before and after intervention. No other adverse reactions were observed in the two groups. Conclusion Traditional Chinese medicine hot compress nursing can relieve abdominal pain and abdominal distension during colonoscopy, improve the examination comfort and patient satisfaction to a certain extent, and the patient acceptance is high, worthy of clinical application.
		2023 Vol. 20 (16): 173-176 [Abstract] ( 22 ) HTML (1 KB) PDF (638 KB) ( 28 )

	177	Analysis on the risk factors of nosocomial infection in neonatal intensive care unit
		LI Yanqing HE Min TANG Ying
		DOI: 10.20047/j.issn1673-7210.2023.16.39
		Objective To explore the risk factors of nosocomial infection in neonatal intensive care unit. Methods A total of 200 neonates were selected from the Department of Neonatal Intensive Care Unit, Chenzhou First People’s Hospital, Hunan Province from January 2021 to June 2022, they were divided into infected group and non-infected group according to the presence or absence of infection, with 100 cases in each group. The incidence of nosocomial infection was analyzed by single factor and logistic multiple factor. Results There were statistically significant differences in the number of days in hospital, breastfeeding, mechanical ventilation, and risk perception of nursing staff between the two groups (P＜0.05); logistic regression analysis showed that mechanical ventilation ＞ 7 days, no breastfeeding, hospital stay ＞ 7 days were independent risk factors for neonatal nosocomial infection (P＜0.05). Conclusion Nosocomial infection of neonates in neonatal intensive care unit has many related effects. Through improving the management measures of nursing staff to ensure the early intake of newborn nutrition, the incidence of nosocomial infection of neonates can be reduced while enhancing the risk awareness and concept of nursing staff.
		2023 Vol. 20 (16): 177-180 [Abstract] ( 15 ) HTML (1 KB) PDF (587 KB) ( 109 )

	181	Effect of early neurodevelopmental therapy on intelligence and motor development of high-risk infants with brain injury
		LI Ling1 XING Mengting1 CHEN Chunli1 ZHANG Yaodan1 JIANG Suixue1 YANG Wenxu2▲
		DOI: 10.20047/j.issn1673-7210.2023.16.40
		Objective To investigate the effect of early neurodevelopmental therapy on intelligence and motor development of high-risk infants with brain injury. Methods A total of 100 children at high risk of brain injury from January 2018 to January 2022 in the Maternal and Child Health and Family Planning Service Center of Guang’an District, Sichuan Province were selected as the research objects. They were divided into observation group and control group by random number table method, with 50 cases in each group. The control group was treated with conventional nursing intervention, and the observation group was treated with neurodevelopmental therapy on the basis of control group. After intervention, developmental quotient (DQ) scale, gross motor function rating scale (GM-FM-88) and neonatal behavioral neurological assessment (NBNA) were respectively evaluated in the two groups. Results DQ score and total percentage of GM-FM-88 in both groups were significantly higher after 6 and 12 months than after 1 month of intervention, and DQ score and total percentage of GM-FM-88 after 12 months were significantly higher than those after 6 months (P＜0.05). Comparison between groups: DQ score and total percentage of GM-FM-88 in the observation group were higher than those in the control group at 3, 6, and 12 months after intervention (P＜0.05). Neurobehavioral scores in both groups were higher after intervention than before intervention, and those in the observation group were higher than those in the control group after treatment (P＜0.05). Conclusion Early neurodevelopmental therapy can significantly improve and promote the intellectual and motor development of children at high risk of brain injury.
		2023 Vol. 20 (16): 181-184,192 [Abstract] ( 21 ) HTML (1 KB) PDF (670 KB) ( 27 )

	185	Effect of family-member participatory intensive behavioral intervention on symptom control and parental mental health in children with asthma
		TAO Weiwei WU Yannan JIANG Xia▲
		DOI: 10.20047/j.issn1673-7210.2023.16.41
		Objective To explore the effect of family-member participatory intensive behavioral intervention on symptom control and parental mental health in children with asthma. Methods Seventy-eight children with asthma and their families treated in Nantong Maternal and Child Health Hospital of Jiangsu Province from April 2017 to March 2022 were selected as subjects. The children and their families were divided into control group and observation group by computer stratification, with 39 children and 39 family members in each group. The control group received routine intervention, and the observation group received intensive behavioral intervention based on family participation. After 12 weeks of intervention, parents’ mental health, asthma control and life quality of children in the two groups were observed and compared. Results The overall analysis showed that there were statistically significant differences between the two groups, time points and interactions in the evaluation of the childhood-asthma control test, pediatric asthma quality of life questionnaire, and parenting stress index short form (P＜0.05); there was statistical significance at each time point within the group (P＜0.05); and there was statistical significance at each time point between the two groups after intervention (P＜0.05). Conclusion Family participation intensive behavior intervention can effectively control the symptoms of asthma children and improve the quality of life, so as to improve the level of family members’ mental health.
		2023 Vol. 20 (16): 185-188 [Abstract] ( 21 ) HTML (1 KB) PDF (610 KB) ( 45 )

	189	Application effect of comprehensive nursing pathway based on mind mapping model in patients with preeclampsia of pregnancy
		JIANG Nannan XU Yetao SUN Dandan▲
		DOI: 10.20047/j.issn1673-7210.2023.16.42
		Objective To explore the application effect of comprehensive nursing pathway in preeclampsia of pregnancy based on mind mapping model. Methods A total of 88 patients with preeclampsia of pregnancy admitted to Jiangsu Provincial People’s Hospital from January to October 2020 were selected and divided into combined group and omnidirectional group according to random number table method, with 44 cases in both group. The omnidirectional group was treated with omni directional routing nursing, while the combined group was treated with routing nursing based on mind mapping model. The correlation of psychological stress, quality of life, and postpartum hemorrhage were observed in the two groups. Results After nursing, anxiety and depression scores of the two groups were lower than before nursing, and those of the combined group was lower than the omnidirectional group, with statistical significance (P＜0.05). After nursing, sleep quality and pregnancy stress scores in two groups were lower than before nursing, while those of combined group were lower than those of omnidirectional group, and the differences were statistically significant (P＜0.05). The proportion of total disease mastery in combination group was higher than that in omnidirectional group, and the difference was statistically significant (P＜0.05). The incidence of maternal outcomes (placental abruption and postpartum hemorrhage) in the combined group was lower than that in the omnidirectional group, while the birth weight and Apgar score were higher than those in the omnidirectional group, and the differences were statistically significant (P＜0.05). Conclusion Comprehensive nursing pathway based on mind mapping model can significantly reduce patients’ psychological stress, improve quality of life, and reduce postpartum hemorrhage.
		2023 Vol. 20 (16): 189-192 [Abstract] ( 19 ) HTML (1 KB) PDF (565 KB) ( 26 )

	193	Effect of nursing intervention based on Roy’s adaptation theory on intensive insulin pump therapy for type 2 diabetes mellitus
		LI Xiaomei NIU Dan
		DOI: 10.20047/j.issn1673-7210.2023.16.43
		Objective To explore the effect of nursing intervention based on Roy’s adaptation theory on blood glucose control, treatment compliance， and quality of life in patients with type 2 diabetes mellitus who received intensive insulin pump therapy. Methods A total of 300 patients with type 2 diabetes mellitus admitted to Nanjing First Hospital from January 2021 to February 2022 were selected and divided into observation group and control group according to random number table method, with 150 cases in each group. During intensive treatment with insulin pump, the control group was received routine nursing, while the observation group was combined with nursing intervention based on Roy’s adaptation theory on the basis of routine nursing, all intervention for four weeks. Treatment compliance, blood glucose control, and quality of life before and after intervention were compared between the two groups. Results After intervention, fasting plasma glucose, two-hours postprandial blood glucose in two groups were lower than those before intervention, and those of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). The treatment compliance of the observation group was better than that of the control group, and the difference was statistically significant (P＜0.05). After intervention, the satisfaction, impact, worry Ⅰ, worry Ⅱ scores, and diabetic quality of life scores of the two groups were lower than those before intervention, and those of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion Nursing intervention based on Roy’s adaptation theory can help type 2 diabetes mellitus patients adapt to insulin pump faster, strengthen blood sugar control effect, improve treatment compliance and quality of life.
		2023 Vol. 20 (16): 193-196 [Abstract] ( 23 ) HTML (1 KB) PDF (570 KB) ( 17 )

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