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| Research progress on the mechanism of 5-hydroxytryptamine in rotavirus diarrhea |
| LI Feng SONG Lijun ZHOU Yujing FENG Yuxuan YUAN Yue QIAN Yupei YANG Siyan ZHAO Wenchang#br# |
College of Pharmacy, Guangdong Medical University, Guangdong Province, Dongguan 523109, China
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Abstract Rotavirus is a kind of enterovirus, the mechanism of which causes diarrhea is very complicated, and there is no specific drug to treat it. Recent studies have shown that 5-hydroxytryptamine plays a major role in rotavirus diarrhea. By modulating the expression of 5-hydroxytryptamine and the function of the enteric nervous system and intestinal epithelial barrier that it affects, the symptoms of rotavirus diarrhea can be effectively reduced. The relationship between 5-hydroxy tryptamine and rotavirus diarrhea has not been systematically organized. This review combines the latest relevant studies to provide a theoretical basis for the development of new anti-rotavirus drugs, with the aim of guiding clinical treatment more accurately.
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