ω-3 PUFA在肺结节患者血清中的表达及数字预测模型的建立

doi:10.20047/j.issn1673-7210.2023.16.20

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Abstract Objective To compare the ω-3 polyunsaturated fatty acid (ω-3 PUFA) expression in serum of patients with pulmonary nodules, and to explore the independent risk factors for benign and malignant pulmonary nodules and establish a malignant probability prediction model. Methods A total of 294 patients with pulmonary nodule with definite pathology admitted to the Department of Cardiothoracic Surgery of the First People’s Hospital of Neijiang City, Sichuan Province from January 2018 to December 2021 were selected, and the patients were randomly divided into modeling group (201 cases) and verification group (93 cases). The difference of serum expression of ω-3 PUFA in benign and malignant pulmonary nodules was compared in the modeling group. The influencing factors of malignant pulmonary nodules were analyzed by single factor and multiple factor, and the diagnosis and prediction model was established and verified. Results There were statistically significant differences in ω-3 PUFA, focal diameter, consolidation/tumorratio(CTR), short burr, vascular signs and pleural pull between benign and malignant pulmonary nodules in the modeling group (P＜0.05). Logistic regression showed that ω-3 PUFA, CTR, short burr, vascular sign, and pleural pull were independent influencing factors for benign and malignant pulmonary nodules (P＜0.05). The prediction model was established: P=ex/(1+ex).X=-5.020+ (0.042×ω-3 PUFA positive) + (1.613×CTR) + (1.185× short burr) + (1.081× pleural drag) + (0.936× vascular sign). The area under curve (AUC) of receiver operating characteristic (ROC) curve of this model was 0.837, and the sensitivity and specificity were 74.5% and 84.6%, respectively. The AUC of the ROC curve of verification group was 0.780. Conclusion Lung nodules with decreased serum ω-3 PUFA, CTR≥0.5, burr sign, vascular sign, and pleural pull need to be highly suspected of malignancy. The established diagnosis and prediction model has a good prediction of benign and malignant pulmonary nodules.

Key words： ω-3 polyunsaturated fatty acid Pulmonary nodules Lung cancer Benign and malignant diagnosis Prediction model

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	YAO Yi HU Qiuxia LI Ji WANG Yi YANG Yanhui LI Xiaoliang LUO Lei LEI Yu XIE Xiaoyang▲

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YAO Yi HU Qiuxia LI Ji WANG Yi YANG Yanhui LI Xiaoliang LUO Lei LEI Yu XIE Xiaoyang▲. Expression of ω-3 PUFA in serum of patients with pulmonary nodules and establishment of a digital prediction model[J]. 中国医药导报, 2023, 20(16): 93-97.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.16.20 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I16/93

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