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| Meta-analysis of the effects of Hedan Tablets on blood-lipid levels and inflammatory factors in patients with dyslipidemia |
| HUANG Chengxin1 SUN Yuanlong2 WANG Xiaolong2 LI Lin1 ZHAO Zhejun1 RUAN Xiaofen2 |
1.Institute of Cardiovascular Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
2.Sub-center of National Center for Clinical Medical Research on Cardiovascular Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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Abstract Objective To systematically evaluate the effects of traditional Chinese patent medicines and simple preparations Hedan Tablets on blood-lipid levels and inflammatory factors in patients with dyslipidemia. Methods Clinical randomized controlled trials of Hedan Tablets in the treatment of dyslipidemia were retrieved from PubMed, CNKI, VIP, Wanfang Data, and China Biomedical Literature Service System from inception to March 2022. The meta-analysis of the results of the included literatures was performed by RevMan 5.3 analysis software and Stata 16.0 software. Results A total of 15 clinical randomized controlled trials were included, including 1 227 patients. The results of meta-analysis showed that the total clinical effective rate of the experimental group was higher than that of the control group (OR=0.28, 95%CI: 0.19 to 0.44, P＜0.000 01). Compared with experimental group, serum levels of total cholesterol (MD=0.65, 95%CI: 0.16 to 1.14, P=0.01), triglyceride (MD=0.84, 95%CI: 0.45 to 1.23, P＜0.000 01), low density lipoprotein cholesterol (MD=0.76, 95%CI: 0.08 to 1.44, P=0.03), C-reactive protein (SMD=2.60, 95%CI: 0.50 to 4.69, P=0.02) were higher in the control group, and serum level of high-density lipoprotein cholesterol (MD=-0.41, 95%CI: -0.70 to -0.12, P＜0.000 01) was lower in the control group. There was no significant difference in the total incidence of adverse reactions between the two groups (OR=1.11, 95%CI: 0.71 to 1.72, P=0.65). Meta-regression analysis showed that publication time, sample size, statin type, and medication duration did not affect the effects of Herdan Tablets on blood-lipid levels and inflammatory factors in patients with dyslipidemia. The results of sensitivity analysis showed that the meta-analysis was stable. The funnel plot was basically symmetrical and had no obvious publication bias. Conclusion Hedan Tablets is better than western medicine alone in improving blood-lipid and inflammatory response indexes in patients with dyslipidemia, and does not increase adverse reactions, the effect is worthy of affirmation.
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