恩格列净在2型糖尿病治疗中的研究进展

doi:10.20047/j.issn1673-7210.2023.16.07

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Abstract Type 2 diabetes mellitus is one of the most common chronic metabolic diseases worldwide. Traditional drug therapy of type 2 diabetes mellitus relies on the regulation of insulin and is associated with multiple side effects. Sodium-glucose co-transporter-2 is a new therapeutic target for type 2 diabetes mellitus identified in recent years. Empagliflozin, one of the SGLT-2 inhibitors, approved and shown excellent glucose-lowering effects and safety in the diabetes treatment, has been widely used in clinic therapy. Empagliflozin also has the functions of reducing oxidative stress, inhibiting inflammatory response, and regulating apoptosis. This article summarizes the therapeutic advances and mechanisms of Empagliflozin in type 2 diabetes mellitus, with a view to providing more ideas for clinical treatment of patients with type 2 diabetes mellitus and expanding the indications of Empagliflozin.

Key words： Empagliflozin Inflammatory response Oxidative stress Apoptosis Type 2 diabetes mellitus

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	HUO Qidong LI Deguan

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HUO Qidong LI Deguan. Research progress of Empagliflozin in the treatment of type 2 diabetes mellitus[J]. 中国医药导报, 2023, 20(16): 37-40,49.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.16.07 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I16/37

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