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2022 Vol. 19, No. 36 Published: 2022-12-25

	4	Role of FAM83H and its natural antisense transcript FAM83H-AS1 in the occurrence and development of lung adenocarcinoma and ovarian cancer
		LIU Mengzhen1 SUN Rongrong2 LIU Yanhua2 ZHANG Youwei2
		DOI: 10.20047/j.issn1673-7210.2022.36.01
		Objective To investigate the biological roles of FAM83H and its natural antisense transcript FAM83H-AS1 in the occurrence and development of tumor, and the regulatory relationship between them. Methods The expression and prognosis of FAM83H and FAM83H-AS1 in various tumor tissues were analyzed by GEPIA online tool. Logarithmic growth stage A549 and SKOV3 cell lines were selected for transfection and divided into blank control group (control group), no-load control group (siNC group) and experimental group (siFAM83H group, SIFAM83H-AS1 group). The cell proliferation, apoptosis, and migration after FAM83H and Fam83H-AS1 knockdown were compared in each group. Results The expressions of FAM83H and FAM83H-AS1 mRNA were up-regulated in various tumor tissues, including lung adenocarcinoma and ovarian serous cystadenocarcinoma. In lung adenocarcinoma, the survival curves of FAM83H mRNA high expression group and FAM83H low expression group were compared, and the difference was statistically significant (P＜0.05). In A549 and SKOV3 cells, the expressions of FAM83H mRNA and protein in siFAM83H group were lower than those in siNC group (P＜0.05); the expression of FAM83H-AS1 mRNA in siFAM83H-AS1 group was lower than that in siNC group (P＜0.05); cell proliferation in siFAM83H group was lower than that in siNC group after transfection for 24, 48 and 72 h (P＜0.05); the cell proliferation ability of siFAM83H-AS1 group was lower than that of siNC group after transfection for 24, 48 and 72 h (P＜0.05); the apoptosis number of siFAM83H group and siFAM83H-AS1 group was higher than that of siNC group (P＜0.05); the number of cell migration in siFAM83H group and siFAM83H-AS1 group was lower than that in siNC group (P＜0.05). After FAM83H knockdown, there was no significant difference in sIFAM83H-AS1 mRNA between siFAM83H group and siNC group (P＞0.05); after FAM83H-AS1 knockdown, there was no statistical significance in FAM83H mRNA and protein between siFAM83H-AS1 group and siNC group (P＞0.05). Conclusion FAM83H and FAM833H-AS1 play the role of oncogenes in the occurrence and development of lung adenocarcinoma and ovarian cancer, but no mutual regulatory relationship has been found between them, and the specific mechanism remains to be further studied.
		2022 Vol. 19 (36): 4-10,16 [Abstract] ( 30 ) HTML (1 KB) PDF (3923 KB) ( 36 )

	11	Bibliometric analysis of tranexamic acid in total knee arthroplasty based on CiteSpace
		WAN Xianjie1 XU Ke1 WANG Huan2 YANG Mingyi1 MA Yujie1 HOU Weikun1 XU Peng1
		DOI: 10.20047/j.issn1673-7210.2022.36.02
		Objective To measure and visualized analysis the literature on tranexamic acid used in total knee arthroplasty based on CiteSpace software. Methods Literature on the application of tranexamic acid in total knee arthroplasty in the Web of Science core collection database was searched from January 2000 to December 2020. Excel 2016 was used to make a descriptive analysis of the included literature, and CiteSpace 5.8.R3 software carried out co-citation analysis of the country/region, institution and author, journal and literature co-citation analysis, and carried out co-occurrence analysis, cluster and breakout analysis of keywords. Results A total of 994 relevant publications were obtained, and the overall trend of tranexamic acid in total knee arthroplasty research was increasing from 2000 to 2020. The highest number of publications were mainly from China and the United States, with Sichuan University being the highest publisher and Fuxing Pei was the most published individual. The most cited journal in this field was J Bone Joint Surg Am, a meta-analysis published by Yang in 2012 was the highest quoted literature. Its keyword clustering can be divided into three categories by induction, which reflect the research hotspots of blood loss, use path and postoperative rehabilitation from the aspects of intraoperative, postoperative, and drug itself respectively. Conclusion The study of tranexamic acid in total knee arthroplasty is generally on the rise, and the research on perioperative blood loss, the route of tranexamic acid use and postoperative rehabilitation are the hotspots in this field and also the future research trends.
		2022 Vol. 19 (36): 11-16 [Abstract] ( 9 ) HTML (1 KB) PDF (1813 KB) ( 35 )

	17	Analysis of drug rules of Taiping Shenghui Fang for lumbago based on data mining
		HAN Tao ZHU Liguo WEI Xu YU Jie WANG Shangquan ZHAN Jiawen YIN Xunlu
		DOI: 10.20047/j.issn1673-7210.2022.36.03
		Objective To explore the drug rules of the prescription for the treatment of lumbago in Taiping Shenghui Fang and the academic thought of this book. Methods The prescriptions for the treatment of lumbago in Taiping Shenghui Fang were collected, and the lumbago prescription database was established. Drug frequency, four nature of drugs, five flavours, and channel tropism, drug efficacy, drug core combination, association rules, and K-means clustering new prescriptions were analyzed in the prescription database through the traditional Chinese medicine inheritance computing platform. Results A total of 77 prescriptions for the treatment of lumbago were collected, involving 108 traditional Chinese medicine flavors, 22 traditional Chinese medicine with frequency ≥five times, and the top five traditional Chinese medicine were Cinnamomi Cortex, Aconiti Lateralis Radix Praeparata, Achyranthis Bidentatae Radix, Eucommiae Cortex and Aucklandiae Radix. The properties of traditional Chinese medicine were mainly warm. The flavors of drugs were mainly sweet, pungent and bitter; drugs mainly return to kidney, liver, and spleen channels; the main efficacy of the drug was supplementing deficiency, warming interior, and promoting blood circulation and removing blood stasis. The top three drug combinations were Cinnamomi Cortex, Achyranthis Bidentatae Radix; Cinnamomi Cortex, Aconiti Lateralis Radix Praeparata; Cinnamomi Cortex, Eucommiae Cortex. Nine drug association rules; four new squares were obtained by K-means clustering. Conclusion The prescription of Taiping Shenghui Fang for the treatment of lumbago mainly focuses on “warming the spleen and tonifying the liver and kidney”, which provides an important reference for clinical diagnosis and treatment of lumbago.
		2022 Vol. 19 (36): 17-20,35 [Abstract] ( 18 ) HTML (1 KB) PDF (1244 KB) ( 26 )

	21	Summary of experience in treating non-proliferative diabetic retinopathy with traditional Chinese medicine based on data mining and network pharmacology
		WU Xiaocui1 YANG Zhihua2 XIE Yiqiang3 LI Rui4 CHENG Yawei5
		DOI: 10.20047/j.issn1673-7210.2022.36.04
		Objective To summarize the experience of traditional Chinese medicine in treating non-proliferative diabetic retinopathy (NPDR) based on data mining and network pharmacology. Methods Literatures of treating NPDR with traditional Chinese medicine from CNKI and Wanfang Data were searched and collated, and the limited time was from inception to December 2020. Traditional Chinese medicine inheritance computing platform V 3.0 was used to build a prescription database, and the frequency, flavor, meridian transformation, and efficacy of related prescriptions were counted. Association rules of related drug pairs were analyzed, and medication rules and core compatibility of traditional Chinese medicine treatment of NPDR were summarized. For the core drug pairs, the traditional Chinese medicine systems pharmacology database and analysis platform, traditional Chinese medicine integrative database, Uniprot, and GeneCards were used to construct the “ingredient-target” network, and the protein-protein interaction network was constructed with STRING database and Cytoscape software, and molecular docking was carried out. GO classification enrichment analysis and KEGG pathway enrichment analysis were performed by R language. Results According to the analysis of 107 prescriptions of NPDR treated by traditional Chinese medicine, ten drugs were commonly used, among which Radix Astragali seu Hedysari, Radix Rehmanniae Recens, and Radix Notoginseng were the most frequently used. The four nature of drugs were mainly cold, flat, and warm, the five flavours were mainly bitter and sweet, the channel tropism were mainly liver, lung, and kidney channel. There were seven drug pairs with high frequency of use, among which Radix Astragali seu Hedysari-Radix Rehmanniae Recens, Radix Astragali seu Hedysari-Radix Notoginseng, and Radix Astragali seu Hedysari- Radix Notoginseng ranked the top three. Network pharmacological analysis of the Radix Astragali seu Hedysari-Radix Rehmanniae Recens drug pair showed that the main components included quercetin, kaempferol, formononetin, isorhamnetin, etc., and the main targets included TP53, SERPINE1, VEGFA, TNF, etc. KEGG and GO enrichment pathways showed that the active components of traditional Chinese medicine were related to cell proliferation, cell response to chemical stress, and cell response to lipopolysaccharide. The free energy calculation of core target protein and core active ingredient showed that the core active ingredient in Radix Astragali seu Hedysari-Radix Rehmanniae Recens drug pair (quercetin, kaempferol) had a good binding effect with the key core target in NPDR. Conclusion Radix Astragali seu Hedysari-Radix Rehmanniae Recens is a high-frequency drug for NPDR treatment in traditional Chinese medicine. Its components may play a regulatory role on multiple pathways by acting on multiple targets, which can provide guidance for clinical and basic research.
		2022 Vol. 19 (36): 21-28 [Abstract] ( 17 ) HTML (1 KB) PDF (3264 KB) ( 58 )

	29	CiteSpace-based visualization of the current status of the application of Sinomenine in Chinese medicine research
		ZHANG Zixuan1 AN Yi1 ZHANG Xinwen1 ZHAO Xin1 ZHANG Xieyu1 ZHAO Jiahe2 CAO Wei3
		DOI: 10.20047/j.issn1673-7210.2022.36.05
		Objective To analyze the current status and future development trend of Chinese medicine related research on Sinomenine in the past 20 years at home and abroad by scientific knowledge mapping methods. Methods The research literatures related to Sinomenine from January 2001 to April 2022 included in China Knowledge Network and Web of Science databases were searched, and the authors, countries, institutions, and keywords were visualized analyzed by CiteSpace software. Results A total of 973 Chinese literatures and 264 English literatures were obtained. The number of publications on Sinomenine research had shown a fluctuating upward trend in the last 20 years. Zhou Liling and Liu Liang were the authors with the highest number of publications in English and Chinese, respectively. The publishing institutions were concentrated in China, mainly in Guangzhou University of Chinese Medicine, but there was a lack of cooperation between teams and institutions. Keywords analysis showed that Sinomenine, proliferation, apoptosis, rat, and cyanophylline were the hotspots of cyanophylline research in Chinese, cell expression, apoptosis, activation, metabolism, inhibition, rheumatoid arthritis, mouse, and proliferation were the hotspots of research in English, and domestic and foreign research trends focused on apoptosis and cell proliferation. Conclusion At present, the field of Cyanophylline is in the rising stage of development, and the research hotspots and trends are apoptosis and cell proliferation, but there is little cooperation among team institutions, and the communication and cooperation should be increased, which is conducive to promoting the long-term development of cyanophylline.
		2022 Vol. 19 (36): 29-35 [Abstract] ( 16 ) HTML (1 KB) PDF (2428 KB) ( 75 )

	36	Clinical outcomes of patients with lumbar disc herniation with lateral recess stenosis treated by percutaneous transforaminal endoscopic lumbar discectomy
		YANG Gang TIAN Yafeng YU Jian ZHU Yanfeng HAN Kun DONG Junge
		DOI: 10.20047/j.issn1673-7210.2022.36.06
		Objective To evaluate the outcome and safety of percutaneous endoscopic lumbar discectomy (PELD) for lumbar disc herniation with lateral recess stenosis. Method A total of 85 patients with lumbar disc herniation admitted to the First Department of Osteology, Hebei Hospital of Traditional Chinese Medicine from August 2014 to August 2019 were selected as the study subjects. All patients received PELD, and 70 patients were followed up for two years. Postoperative MRI or CT examination was performed. Clinical outcomes were evaluated using the visual analog scale (VAS) score, Oswestry disability index (ODI), and modified MacNab criteria at three, six month, one, and two year after surgery. Results 70 patients were followed up for two years, including three patients with the L3-4 lumbar segment, 57 patients with the L4-5 lumbar segment, 10 patients with the L5-S1 lumbar segment, 31 males and 39 females. The age range was 44 to 75 years old, with a mean of (54.2±7.7) years old. All patients underwent PELD for nucleus pulposus removal and lateral recess enlargement decompression. Three patients with transient postoperative sensory disturbance were L5-S1 segment patients, and postoperative MRI/CT examination showed sufficient decompression. None of the patients developed postoperative infection, dysfunction, nerve root injury, or iatrogenic segmental instability. The VAS scores and ODI values of the 70 patients were lower than those before surgery at all follow-up time points, and the differences were statistically significant (P＜0.05). MacNab score two years after surgery, 24 cases were excellent, 39 cases were good, 6 cases were fair, and 1 case was poor. The rate of excellent and good was 90.0%. Conclusion PELD is a less invasive, effective and safe surgery for lumbar disc herniation with lateral recess stenosis.
		2022 Vol. 19 (36): 36-40 [Abstract] ( 21 ) HTML (1 KB) PDF (1591 KB) ( 22 )

	41	Research progress on the expression of miR-21 and miR-29 and renal fibrosis
		DU Wenhua1 SHI Liang2 CHENG Xiaohong2 ZAHNG Xiaofeng2
		DOI: 10.20047/j.issn1673-7210.2022.36.07
		Renal fibrosis is the main pathological change of kidney disease progression to the later stage, and inflammatory stimulation is the main factor of renal fibrosis progression. Its irreversibility and outcome difference have become one of the difficult problems in modern medicine. The microRNA (miRNA) is a short-chain endogenous non-coding small molecule RNA present in stable form in plasma, serum and body fluids, post-transcriptionally regulated encoding protein genes, involved in the regulation of various biological processes. Studies have shown that some of the miR contained in miRNA play an important role in the fibrosis process and are key regulatory factors in the fibrosis/inflammation process. In kidney disease, miR-21 and miR-29 regulate target genes and related signaling pathways, acting on inflammation/promoting fibrosis process. This paper will focus on the signaling pathway of the pathogenesis of renal fibrosis infiltrated by inflammatory cells, and explore the mechanism and potential therapeutic effects of miR-21 and miR-29 in renal fibrosis from the molecular level.
		2022 Vol. 19 (36): 41-44 [Abstract] ( 21 ) HTML (1 KB) PDF (453 KB) ( 30 )

	45	Research progress of non-pharmacological therapy for essential hypertension
		BAI Xiaoxu1 WANG Haifang2 YANG Xunchao3
		DOI: 10.20047/j.issn1673-7210.2022.36.08
		Essential hypertension is a common chronic non-communicable disease and is the most important risk factor for cardiovascular and cerebrovascular diseases. Currently, the main treatments for essential hypertension are pharmacological and non-pharmacological therapies. Clinically, although the patient’s blood pressure can be lowered by medication, the symptoms cannot be fully controlled and its toxic side effects are more frequent and add to the patient’s burden. Compared with drug therapy, the efficacy of lifestyle interventions and traditional Chinese medicine appropriate techniques such as acupuncture, moxibustion, massage, auricular pressure, acupuncture point application, scrapping therapy, ear tip bloodletting, herbal tea substitution, and traditional traditional Chinese medicine exercises such as taijiquan, baduanjin, and yijinjing are gradually being recognized both at home and abroad. This article reviews the progress in the application of non-pharmacological therapies for essential hypertension, with a view to providing a reference basis for the clinical application of non-pharmacological therapies for the treatment of hypertensive disorders.
		2022 Vol. 19 (36): 45-48 [Abstract] ( 21 ) HTML (1 KB) PDF (578 KB) ( 124 )

	49	Changes of clinical test indexes after treatment with common psychotropic drugs
		GUO Qi LING Sihai HE Jing LI Wenbiao LIU Chengeng▲ WANG Gang▲
		DOI: 10.20047/j.issn1673-7210.2022.36.09
		In the treatment of psychotropic illness, the use of psychotropic drugs is particularly important. The International Convention on Psychotropic Substances fully affirms the medical and scientific value of psychotropic substances. While psychotropic drugs are effective, their toxic effects involve many aspects of the nervous system, and affect the heart, liver, kidney, and other important organs as well as blood and endocrine system functions, it can cause changes in relevant test indicators, including blood routine, coagulation function, liver and kidney function, blood glucose, blood lipid, blood electrolyte, myocardial injury markers, prolactin, and thyroid hormone, etc. The changes of blood test indexes can comprehensively reflect the pathophysiological changes experienced by the body, so as to evaluate the severity of the disease, judge the prognosis, guide treatment, and treatment monitoring.
		2022 Vol. 19 (36): 49-53 [Abstract] ( 17 ) HTML (1 KB) PDF (644 KB) ( 39 )

	54	Effects of intestinal flora on the occurrence and development of type 2 diabetes mellitus and diabetic foot
		WANG Jialin1 WANG Yuqing1 HUANG Xiaoting1 ZHOU Mingmei2 ZHAO Cheng3▲
		DOI: 10.20047/j.issn1673-7210.2022.36.10
		Type 2 diabetes mellitus and its complications are a common health problem endangering health today, and its incidence is increasing year by year. Cardiovascular, renal, and peripheral nerve complications related to type 2 diabetes mellitus accelerate the risk of disability or death in patients. Some studies have shown that intestinal flora disorders can increase the incidence of type 2 diabetes mellitus and diabetic foot by affecting blood lipids, blood pressure, and glucolipid metabolism, and thus affect the development and prognosis of these diseases. Intestinal flora research is a new entry point for the prevention and treatment of a series diseases including type 2 diabetes and diabetic foot. In this paper, the recent studies on the effects of intestinal flora on the occurrence and development of type 2 diabetes mellitus and type 2 diabetic foot.
		2022 Vol. 19 (36): 54-57,65 [Abstract] ( 18 ) HTML (1 KB) PDF (566 KB) ( 36 )

	58	Research progress of signal pathways in the treatment of chronic atrophic gastritis by traditional Chinese medicine
		JIANG Yuping1 LIU Weifeng2 WU Shanshan3 WEN Zhixi4
		DOI: 10.20047/j.issn1673-7210.2022.36.11
		[Abstract] Chronic atrophic gastritis (CAG) is one of the common chronic diseases of the digestive system. It is complex and has a long course, and can be further developed to gastric cancer, which is a key link in the development process of gastric cancer. A variety of related inflammatory factors are involved in this link, and blocking this link is of great value to prevent the occurrence of gastric cancer. At present, modern medicine has no effective method to intervene in this link, so seeking effective intervention measures for CAG is the goal of many scholars. Studies have confirmed that traditional Chinese medicine has unique advantages in the treatment of CAG disease, and can exert potential effects through multi-directional, multi-level and multi-target. The purpose of this paper is to summarize the current situation and treatment prospect of traditional Chinese medicine in this field, and to provide basis for the future treatment of CAG, so as to better improve clinical efficacy.
		2022 Vol. 19 (36): 58-61,69 [Abstract] ( 17 ) HTML (1 KB) PDF (733 KB) ( 66 )

	62	Research progress on the protective effect of Dapagliflozin on kidney and cardiovascular
		WANG Wenjing ZHENG Wenfei LI Shengnan LIU Qian
		DOI: 10.20047/j.issn1673-7210.2022.36.12
		Dapagliflozin, sodium-glucose cotransporter 2 inhibitor, a new type of hypoglycemic agent. Dapagliflozin effectively inhibits the renal tubule SGLT2 receptor, reduces the renal tubule glucose reabsorption, and promotes the glucose excretion from urine, and reduces blood glucose levels in a non-insulin-dependent manner. In addition to lowering blood glucose, Dapagliflozin also has osmotic diuretic, weight loss, antihypertensive, lipid lowering, urate lowering, and other effects, and plays a protective effect of heart and kidney through anti-fibrosis, anti-inflammatory, antioxidant stress, improving mitochondrial function, regulating autophagy, and restoring tube-ball balance and so on. This article summarizes the protective effect and possible mechanisms of Dapagliflozin on kidney and cardiovascular, in order to provide reference for the clinical application of the drug.
		2022 Vol. 19 (36): 62-65 [Abstract] ( 19 ) HTML (1 KB) PDF (486 KB) ( 95 )

	66	Research progress of acupuncture and moxibustion in the treatment of postoperative urinary retention in anorectal diseases
		SUN Yubin1 ZHANG Xiangan2 AN Yongkang2 NIU Li1 CHEN Shujun2 PAN Hui2 SHI Menghua1
		DOI: 10.20047/j.issn1673-7210.2022.36.13
		Urinary retention is one of the common complications after anorectal surgery, which is easy to induce urinary system infection and affect postoperative healing and recovery of urination function. In the recovery process after anorectal surgery, different acupuncture and moxibustion treatments have the advantages of relieving perianal pain, reducing residual urine volume, coordinating detrusor muscle, and urethral sphincter, and alleviating urinary tract infection, etc. Diversified acupuncture and moxibustion treatments provide a more effective plan for the treatment of urinary retention. In this paper, the relevant clinical studies on acupuncture and moxibustion in the treatment of this disease in recent five years are summarized, and the commonly used methods include ordinary acupuncture therapy, electroacupuncture, ear acupuncture, characteristic moxibustion therapy, etc. At the same time, the similarities and differences of different acupuncture and moxibustion methods and the mechanism of action are compared, and relevant opinions are put forward in order to provide reference for clinical research.
		2022 Vol. 19 (36): 66-69 [Abstract] ( 19 ) HTML (1 KB) PDF (617 KB) ( 59 )

	70	Investigation and analysis of community residents’ cognition and demand for genetic testing technology services in Nanning
		QIN Rong GUAN Yanqiu HUANG Fen
		DOI: 10.20047/j.issn1673-7210.2022.36.14
		Objective To understand the cognitive status, demand willingness, and influencing factors of community residents on genetic testing technology services in Nanning, so as to provide reference for improving population health management strategies and developing large health industry. Methods A field questionnaire survey was conducted among 3 378 community residents in 16 communities of Nanning from March to December 2019 by convenience sampling method. Results 39.72% of community residents had not heard of genetic testing technology services. There were statistically significant differences in the cognition of gene testing technology service among community residents with different gender, age, marital status, education level, monthly income, and suffered from chronic diseases (P＜0.05). Logistic regression analysis showed that the community residents with college/bachelor degree below had lower cognition on the service of gene testing technology (OR＜1, P＜0.05). 2 468 residents (73.06%) indicated that they were willing to receive genetic testing services, the most concerned gene testing for disease susceptibility was malignant tumors, and the most desired follow-up service was preventive measures for susceptible diseases. The main reasons for residents’ reluctance to accept genetic testing services were high cost (542 residents, 59.56%) and fear of privacy disclosure (342 residents, 37.58%). Conclusion Community residents have a low awareness of genetic testing technology services, but the potential demand is larger. It is suggested to strengthen the knowledge popularization of genetic testing technology services, give full play to the professional role of medical personnel, provide personalized health management guidance for community residents, and promote the development of large health industry.
		2022 Vol. 19 (36): 70-73 [Abstract] ( 19 ) HTML (1 KB) PDF (556 KB) ( 39 )

	74	Correlation analysis of nurses’ demand for further training with professional identity and sense of professional benefit in a tertiary care hospital in Tianjin
		GENG Pengfei1 WANG Zhangyi2 ZHANG Yajun3 WANG Weining4
		DOI: 10.20047/j.issn1673-7210.2022.36.15
		Objective To understand the current situation of nurses’ demand for further training in tertiary care hospitals in Tianjin, to explore the correlation between them and nurses’ professional identity and sense of professional benefit, and to provide reference and direction for constructing training and education programs to improve nurses’ continuing education needs in tertiary care hospitals in Tianjin. Methods From November to December 2021, a total of 341 nurses from seven tertiary level A hospitals in Tianjin were selected as the study population by convenience sampling method, and questionnaires were administered using the general information questionnaire, the demands assessmant scale of refresher nurses (DASRN), the occupational identity scale (OIS), and the sense of professional benefit scale (SPBS). Results The total score of nurses’ demand for further training in tertiary care hospitals in Tianjin was (82.12±12.83) points, the total score of professional identity was (120.55±21.07) points, and the total score of sense of professional benefit was (138.67±19.82) points, all three of which were in the middle to upper level. The differences were statistically significant when comparing the total DASRN scores by education level, technical title, length of service, and position(P＜0.05). The total DASRN score and dimensions of nurses were positively correlated with the total OIS score and dimensions and the total SPBS score and dimensions (r＞0, P＜0.05). Conclusion It is suggested that hospital administrators should pay attention to nurses’ further education and training, improve the system of nurses’ further education and training, and enhance their professional identity and professional benefits in multiple ways, so as to satisfy their further education needs to the greatest extent.
		2022 Vol. 19 (36): 74-77,91 [Abstract] ( 14 ) HTML (1 KB) PDF (654 KB) ( 103 )

	78	Mediating effect of mental resilience on alarm fatigue and occupational stress in ICU nurses
		TANG Wenqi1 MA Jun2▲ FENG Xiao1 ZHANG Zuoyan1 ZHOU Wenjie1
		DOI: 10.20047/j.issn1673-7210.2022.36.16
		Objective To explore the influence of occupational stress on alarm fatigue of intensive care unit (ICU) nurses, and to analyze the mediating role of mental resilience in occupational stress and alarm fatigue of ICU nurses. Methods Using the cluster sampling method, from October to November 2020, a total of 752 ICU nurses in six general hospitals in Shanghai (Shanghai Sixth People’s Hospital, Shanghai Huashan Hospital, Shanghai Ruijin Hospital, Shanghai Cancer Hospital, Shanghai Eighth People’s Hospital, Shanghai Jinshan Central Hospital) were respectively treated with job stressors scale, ICU nurse alarm fatigue scale and mental resilience scale table Chinese version (CD-RISC) for investigation and analysis. Results The occupational stress scores of ICU nurses with different hospital grades, age, gender, education background, years of working in ICU, marital status, children, monthly income, shift number in the last three months, and blood type were statistically significant (P＜0.05). The occupational stress scores of different work/life events in the past three months were compared, and the differences were statistically significant (P＜0.05). Correlation analysis showed that the scores of each dimension of occupational stress of ICU nurses were negatively correlated with the scores of each dimension of mental resilience (r＜0, P＜0.05), and positively correlated with the scores of alarm fatigue (r＞0, P＜0.05). Linear regression results showed that ICU nursing staff working years, children, shift, dimission thoughts, alarm fatigue, and mental resilience were the factors influencing occupational stress (P＜0.05). The relationship between occupational stress, alarm fatigue, and mental resilience of ICU nurses were linear, and the mediating effect was verified. The mediating effect value of mental resilience was 0.134, accounting for 64.73% of the overall effect. Conclusion Occupational stress of ICU nurses has mediating effect on alarm fatigue through mental resilience.
		2022 Vol. 19 (36): 78-81 [Abstract] ( 16 ) HTML (1 KB) PDF (538 KB) ( 58 )

	82	Analysis of the current situation of professional benefits of intravenous therapy nurses and its influencing factors
		ZHU Shengnan WANG Juan▲
		DOI: 10.20047/j.issn1673-7210.2022.36.17
		Objective To investigate the current state of perceived professional benefits of intravenous therapy nurses and to analyze its influencing factors. Methods From August to September 2021, a total of 231 nurses from Nanjing First Hospital, Nanjing Medical University, were selected for the study, and the nurses’ perception of occupational benefit was assessed using the nurses’ perception of occupational benefit questionnaire, and the nurses’ baseline information was investigated to analyze the relevant factors that may affect the perception of occupational benefit of nurses in intravenous therapy. Results The results of the nurses’ sense of professional benefit questionnaire showed that 231 nurses had a sense of professional benefit score of (118.74±12.03) points. The differences were statistically significant when comparing the scores of nurses’ sense of professional benefit across monthly income, employment method, involvement in research, and hours worked per week (P＜0.05). The equation was obtained by multiple linear regression analysis: Y=138.714-7.075×monthly income 3 000 to 5 000 yuan-17.697×monthly income＞5 000 yuan-4.602×formal establishment-2.991×participation in scientific research-1.501×weekly working hours 40 to 44 h+9.271×weekly working hours＞44 h. The results showed that monthly income of 3 000 to 5 000 yuan, monthly income＞5 000 yuan, formal establishment, and participation in research were protective factors for the perceived occupational benefit score of intravenous therapy specialist nurses (P＜0.05), while weekly working hours＞44 h were risk factors for the perceived occupational benefit score of intravenous therapy specialist nurses (P＜0.05). Conclusion Monthly income of 3 000 to 5 000 yuan, monthly income＞5 000 yuan, formal establishment, and participation in research are protective factors for the perceived occupational benefit score of intravenous therapy specialist nurses, and weekly working hours＞44 h are risk factors for the perceived occupational benefit score of intravenous therapy specialist nurses.
		2022 Vol. 19 (36): 82-85 [Abstract] ( 19 ) HTML (1 KB) PDF (500 KB) ( 21 )

	86	Visual analysis of manual reduction and small splint fixation for distal radius fractures
		CHEN Tianxin ZHANG Zhilong YANG Shengping ZHU Yuqi
		DOI: 10.20047/j.issn1673-7210.2022.36.18
		Objective To visually analyze the status of research on manual reduction and small splint fixation for treatment of distal radius fractures, and to predict research hotspots and trends. Methods From January 1, 2000 to February 1, 2022, literature published on the treatment of distal radius fractures with manual reduction and small splint fixation was retrieved from CNKI, Wanfang and VIP databases. The number of annual publications, authors, institutions, and key words were analyzed visually using VOSviewer and CiteSpace software. Results A total of 2 465 articles were included, and 190 articles were published annually on average from 2012 to 2020. About 222 major authors were identified, who constituted 11 research teams. A total of 511 institutions released reports, among which Foshan Hospital of Traditional Chinese Medicine published the most. About 528 keywords, 18 clusters and 26 emergent keywords were acquired. The research focus was the pain-relieving and swelling-improving effect of Wenyang Jiangu Decoction and Taohong Siwu Decoction on patients with distal radius fractures. Conclusion During the last two decades, the clinical research on manual reduction and small splint fixation for treatment of distal radius fractures has developed rapidly in China. Senile and osteoporotic fractures are the highlights of future research, but there are still some problems and challenges that need to be addressed.
		2022 Vol. 19 (36): 86-91 [Abstract] ( 17 ) HTML (1 KB) PDF (2237 KB) ( 35 )

	92	Clinical effect of adjuvant therapy of topical application with Huoxue Zhitong Ointment in the treatment of simple rib fracture
		SONG Meng DAI Dongyang XIA Wanqing
		DOI: 10.20047/j.issn1673-7210.2022.36.19
		Objective To explore the clinical effect of adjuvant therapy of topical application with Huoxue Zhitong Ointment in the treatment of simple rib fracture. Methods A total of 112 patients with simple rib fracture admitted to Taizhou Hospital of Integrated Traditional Chinese and Western Medicine in Jiangsu Province from September 2017 to December 2021 were selected as the research objects. They were divided into study group and control group by random number table method, with 56 cases in both groups. The control group was given basic treatment and elastic rib external fixation, and the study group was combined with adjuvant therapy of topical application with Huoxue Zhitong Ointment on the basis of the control group. The efficacy of both groups was evaluated after one month of treatment. Traditional Chinese medicine syndrome scores, serum inflammatory factor levels, pain degree, and sleep quality of the two groups were compared before and after treatment for one month, and the complications and adverse drug reactions during treatment was observed. Results The clinical efficacy of the study group was better than that of the control group, and the bone healing time was shorter than that of the control group (P＜0.05). After one month of treatment, the main syndrome score, secondary syndrome score, neutrophil elastase, interleukin-10, visual analog scale score, and Pittsburgh sleep quality index of both groups were lower than those before treatment, and those of the study group were lower than the control group (P＜0.05). There was no significant difference in the total incidence of complications between the two groups (P＞0.05). There was no obvious adverse drug reaction in the two groups during treatment. Conclusion Adjuvant therapy of topical application with Huoxue Zhitong Ointment combined with conservative treatment for simple rib fracture is more helpful to reduce the inflammatory reaction and promote the recovery of patients, the clinical effect is superior.
		2022 Vol. 19 (36): 92-95 [Abstract] ( 18 ) HTML (1 KB) PDF (632 KB) ( 32 )

	96	Visual analysis of traditional Chinese and western medicine treatment of infantile spasms based on VOSviewer and CiteSpace
		AN Zimeng FU Qianfang CHEN Zhaoyuan WANG Heyu ZHANG Xilian▲
		DOI: 10.20047/j.issn1673-7210.2022.36.20
		Objective To analyze the current situation and development trend of Chinese and western medicine in the treatment of infantile spasms (IS) in the past 50 years. Methods Relevant literature from January 1975 to June 2022 in CNKI, Wanfang, VIP, and CBM were searched. VOSviewer and CiteSpace were used to draw the author’s cooperation density map, keyword co-occurrence, cluster analysis map, etc., and conduct visual analysis of the author and keyword information. Results A total of 1 767 papers were included, and the number of papers published in this field showed a gradual upward trend. The author with the highest amount of western medicine publications was Zou Liping; Chinese medicine was Liu Jinmin. Western medicine with the largest number of papers was adrenocorticotropic hormone, and the traditional Chinese medicine was Chaibei Zhixian Decoction. Eight cluster labels were formed through visualization software, and the cluster with the highest number of nodes was cerebral palsy. The research was carried out according to the etiology, treatment methods, and Chinese and western medicine, etc. The development trend was analyzed according to the treatment concepts and methods. Conclusion Integrative traditional Chinese and western medicine has a good prospect in treating IS, and precise treatment and the ketogenic diet may become hot spots in the future.
		2022 Vol. 19 (36): 96-100 [Abstract] ( 21 ) HTML (1 KB) PDF (2610 KB) ( 131 )

	101	Clinical observation on the treatment of milk and food stagnation constipation by Chinese medicine umbilical application in children
		FENG Yanhua HUANG Ju LIU Jinlan SUN Wuquan ZHANG Hao
		DOI: 10.20047/j.issn1673-7210.2022.36.21
		Objective To observe the clinical effect of Chinese medicine umbilical application on milk and food stagnation constipation children. Methods From December 2018 to March 2021, 120 children with milk and food stagnation constipation admitted to Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine were selected. They were divided into treatment group (60 cases) and control group (60 cases) by random number table method. The treatment group was treated with Chinese medicine umbilical application combined with massage, and control group was treated with massage alone. The clinical efficacy of two groups was compared; the traditional Chinese medicine syndrome scores of two groups were compared before and after treatment; the two groups were followed up one week, two weeks and one month after treatment, and the recurrence and adverse reactions were recorded in both groups. Results After treatment, the total traditional Chinese medicine syndrome scores of two groups were lower than those before treatment, and treatment group was lower than control group (P＜0.05). The traditional Chinese medicine scores of principal syndrome and concurrent syndrome in two groups were lower than those before treatment, and treatment group was lower than control group (P＜0.05). The clinical effect of treatment group was better than that of control group (P＜0.05). There was no significant difference in recurrence rate between two groups (P＞0.05). There were no obvious adverse reactions in two groups during treatment and follow-up. Conclusion Chinese medicine umbilical application combined with massage has a significant effect on the treatment of children with milk and food stagnation constipation, it is worthy of clinical promotion.
		2022 Vol. 19 (36): 101-104 [Abstract] ( 13 ) HTML (1 KB) PDF (610 KB) ( 18 )

	105	Effect of goals-activity-motor enrichment intervention on motor function and ability of daily living of children with global developmental delay
		JIA Yufeng LI Yang▲ ZHANG Shuang GAO Shuzhi GAO Jingyun LI Shuang
		DOI: 10.20047/j.issn1673-7210.2022.36.22
		Objective To investigate the effect of goals-activity-motor enrichment (GAME) intervention on motor function and activity of daily living of children with global developmental delay. Methods A total of 82 children with global developmental delay admitted to the Department of Children Rehabilitation, Tangshan Maternal and Child Health Hospital of Hebei Province from January to April 2021 were selected. They were divided into GAME group (41 cases, the routine rehabilitation therapy combined with GAME intervention) and control group（41 cases, the routine rehabilitation therapy）by random number table method. The treatment lasted for 16 weeks. Gross motor development quotient (GMQ), fine motor development quotient (FMQ), total motor development quotient (TMQ) and children’s activity of daily living scale (ADL) scores were compared between the two groups before and after treatment. Results During the study, one case dropped out of each group, 40 cases were included in control group and 40 cases were included in GAME group. After treatment, the scores of GMQ, FMQ, TMQ, and ADL of two groups were higher than those before treatment, and those of GAME group were higher than those of control group, and the differences were statistically significant (P＜0.05). Conclusion GAME intervention can promote the motor ability of children with global developmental delay and improve their activity of daily living, which is worthy of clinical application.
		2022 Vol. 19 (36): 105-108 [Abstract] ( 22 ) HTML (1 KB) PDF (541 KB) ( 87 )

	109	Clinical effect of GnRHa combined with LNG-IUS regimen in the treatment of adenomyosis
		YU Lingyun1 HUANG Xiaoqin2 SHEN Hengchun1▲
		DOI: 10.20047/j.issn1673-7210.2022.36.23
		Objective To investigate the clinical effect of gonadotropin-releasing hormone agonist (GnRHa) combined with levonorgestrel intrauterine release system (LNG-IUS) in the treatment of adenomyosis. Methods A total of 90 patients with adenomyosis admitted to Neijiang First People’s Hospital of Sichuan Province from May 2018 to January 2021 were selected. They were divided into two groups by random number table method, with 45 cases in each group. The experimental group was given GnRHa and LNG-IUS combined treatment, and the control group was given single GnRHa treatment. Visual analogue scale (VAS), menstrual volume score, uterine volume, endometrial thickness, and carbohydrate antigen-125 (CA125) level were compared between two groups before treatment, six months after treatment, and one year after treatment, and the occurrence of adverse reactions was observed. Results Six months and one year after treatment, VAS score, uterine volume, endometrial thickness, menstrual volume score, and CA125 between two groups were less than those before treatment, and the differences were statistically significant (P＜0.05). One year after treatment, VAS score of the experimental group was lower than that six months after treatment; VAS score, endometrial thickness, and CA125 of control group were lower than those six months after treatment, and the differences were statistically significant (P＜0.05). Six months after treatment, VAS score, uterine volume, endometrial thickness, menstrual volume score, and CA125 of experimental group were lower than those of control group, and the differences were statistically significant (P＜0.05). One year after treatment, VAS score, uterine volume, menstrual volume score, and CA125 of experimental group were lower than those of control group, and the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P＞0.05). Conclusion The combination of GnRHa and LNG-IUS in the treatment of adenomyosis has a better curative effect and a superior application prospect.
		2022 Vol. 19 (36): 109-112 [Abstract] ( 17 ) HTML (1 KB) PDF (553 KB) ( 112 )

	113	Effect of fenestration combined with orthodontic traction on root growth in child patients with maxillary central incisor embedded in dental cysts of replacement stage
		XIAO Gaotian LIU Siyuan CHEN Linyu YU Meichan▲
		DOI: 10.20047/j.issn1673-7210.2022.36.24
		Objective To analyze the effect of fenestration combined with orthodontic traction on the root growth child patients with maxillary central incisor embedded in dental cysts of replacement stage. Methods Retrospective analysis was performed on the data of 48 child patients with maxillary central incisor embedded in dental cysts of replacement stage admitted to Department of Stomatology, Ningde Municipal Hospital of Ningde Normal University from November 2016 to November 2021. According to the surgical methods, they were divided into control group (44 affected teeth, standard square wire bow technique correction) and observation group (46 affected teeth, fenestration combined with orthodontic traction). The root length and root canal wall thickness of two groups were compared before and after treatment; the level and thickness of labial-palatal alveolar bone were compared between two groups after treatment. Results After treatment, the root length and root canal wall thickness of two groups were greater than those before treatment, and observation group was greater than control group, and the differences were statistically significant (P＜0.05). There was no significant difference in the level and thickness of palatal alveolar bone between two groups (P＞0.05); the level and thickness of labial alveolar bone in observation group were less than those in control group, and the differences were statistically significant (P＜0.05). Conclusion Fenestration combined with orthodontic traction can promote the normal development of root and canal wall in patients with maxillary central incisor embedded in dental cysts of replacement stage.
		2022 Vol. 19 (36): 113-116 [Abstract] ( 23 ) HTML (1 KB) PDF (896 KB) ( 62 )

	117	Exploration of treatment rules of bronchiectasis in ancient books based on data mining
		FAN Rongrong1 WANG Dawei2 ZHANG Zhongde3 WANG Yuanyuan3 JIN Lianshun3 LIU Yuntao3
		DOI: 10.20047/j.issn1673-7210.2022.36.25
		Objective To analyze the treatment rules of bronchiectasis in ancient books of Chinese Medical Classics by data mining technology. Methods The ancient name of the bronchiectasis was determined through questionnaire and advice of the expert consultation, then the Chinese Medical Classics was retrieved electronically to find out the records that were relevant to bronchiectasis. The Access 2010 was used to make descriptive analysis on the frequency of use and functional classification of traditional Chinese medicine, the law of acupuncture point selection and channel tropism, and the selection law of therapeutic drugs in dietotherapy prescriptions. The Stata software was used to make cluster analysis on the top 60 traditional Chinese medicines. Results Among the articles related to bronchiectasis in ancient books of Chinese medicine, the most frequently used Chinese medicines were Glycyrrhizae Radix Et Rhizoma, Armeniacae Semen Amarum, Ginseng Radix Et Rhizoma, Poria, Cirrhosae Bulbus, Zingiberis Rhizoma Recens, Pinelliae Rhizoma, Schisandrae Chinensis Fructus, etc. Among the traditional Chinese medicines with frequency more than or equal to five times, the main functions were supplementing drugs, relieving cough, dissipating phlegm, and antiasthma drugs, relieving superficies drugs, clearing heat drugs, diuresis and diffusing dampness drugs, supplemented by astringent drugs, regulating qi drugs, warming interior drugs, promoting blood circulation for removing blood stasis drugs, hemostasis drugs, calming the liver to stop the wind drugs, among which supplementing drugs were mainly those with the effect of replenishing qi and nourishing yin, especially focusing on invigorating spleen and invigorating qi. A total of 17 cluster groups were obtained by cluster analysis. The most frequent acupuncture points were fèishù, lièquē, zúsānlǐ, dànzhōng, fēngmén, and gānshù. The most frequent acupuncture points were foot sun bladder channel, hand taiyin lung channel, foot yangming stomach channel, conception channel, foot shaoyin kidney channel, and foot jueyin liver channel. The main therapeutic drugs for patients with bronchiectasis were ginger, honey, chinese date, bitter apricot seed, sugar, wine, and other properties of warm or flat supplements. Conclusion This study summarizes the rules of medication, external treatment, and diet therapy in traditional Chinese medicines treatment of bronchiectasis through data mining technology, and provides reference for future clinical and scientific research.
		2022 Vol. 19 (36): 117-121 [Abstract] ( 18 ) HTML (1 KB) PDF (1087 KB) ( 80 )

	122	Professor Sun Weizheng’s experience in treating chronic aplastic anemia in children
		WU Yuantian1 SUN Weizheng2 YUSUN-Wanqi3 WANG Jinhuan2
		DOI: 10.20047/j.issn1673-7210.2022.36.26
		Aplastic anemia is a kind of hematological disease characterized by pancytopenia and decline of hematopoietic function of bone marrow, and its clinical manifestations are anemia, hemorrhage, repeated infection and so on. This paper introduces Professor Sun Weizheng’s clinical experience in the treatment of chronic aplastic anemia in children. Professor Sun believes that marrow depletion due to kidney deficiency is the core pathogenesis of the disease. Children’s delicate viscera, easy to transmit after feeling evil，and the physiological and pathological characteristics of being easy to injure yin make the performance of the disease in children more complex than that in adult patients. in addition, “blood stasis” and “heat” also have an important impact on the development and evolution of the disease. According to the etiology and pathogenesis of this disease, Professor Sun carefully examines yin and yang, distinguishes specimens, takes tonifying the kidney as the core, pays attention to taking care of children’s spleen and stomach, integrates the treatment of blood stasis and prevention of blood stasis in the whole process of treatment, and pays attention to the influence of daily life and emotions on the disease, and had excellent clinical effect.
		2022 Vol. 19 (36): 122-125,130 [Abstract] ( 23 ) HTML (1 KB) PDF (814 KB) ( 38 )

	126	Influence of different electro-acupuncture timing on the analgesic effect of primary dysmenorrhea with a cold and damp stagnation pattern
		LI Chunhua1 HU Nijuan1 XU Dazhao2 MA Liangxiao3 WU Xiaohong1 LIU Ping1 ZHU Jiang3 DUO Haoying4
		DOI: 10.20047/j.issn1673-7210.2022.36.27
		Objective To explore the influence of different electro-acupuncture timing on the analgesic effect of primary dysmenorrhea (PD) with a cold and dampness stagnation pattern. Methods A total of 72 PD patients with cold and dampness syndrome enrolled in the outpatients of Electric Power Teaching Hospital of Capital Medical University from December 2018 to December 2020 were selected as the research objects. They were divided into premenstrual group and menstrual group by random number table method, with 36 cases in each group. Both groups were treated with electroacupuncture for 30 minutes at the sānyīnjiāo, dìjī, and xuánzhōng for three consecutive menstrual cycles and followed up for two menstrual cycles. The visual analogue scale (VAS) and the retrospective symptom scale-COX2 (RSS-COX2) were used to evaluate clinical symptoms. Results The overall analysis showed that there was no significant difference in the VAS scores of inter-group comparison and interaction (P＞0.05). Time point comparison of VAS scores, the difference was statistically significant (P＜0.05). The VAS score in the first to fifth cycle was decreased compared with that before treatment, the VAS score in the second to fifth cycle was decreased compared with that in the first cycle, the VAS score in the third to fifth cycle was decreased compared with that in the second cycle, the VAS score in the fourth to fifth cycle was decreased compared with that in the third cycle, and the VAS score in the fifth cycle was decreased compared with that in the fourth cycle, the difference was statistically significant (P＜0.05). Overall analysis: there were statistically significant differences between groups, time point comparison and RSS-COX2 scores of interaction (P＜0.05). Intra-group comparison: The RSS-COX2 score in the first to fifth cycle was lower than before treatment, the RSS-COX2 score in the second to fifth cycle was lower than that in the first cycle, the RSS-COX2 score in the third to fifth cycle was lower than that in the second cycle, the RSS-COX2 score in the fourth cycle was lower than that in the third cycle, and the RSS-COX2 score in the fifth cycle was lower than that in the fourth cycle, the differences were statistically significant (P＜0.05). Comparison between groups: from the second to fifth cycle, the RSS-COX2 score of the menstruating group was higher than that of the menstruating group(P＜0.05). Conclusion Both premenstrual and menstrual electroacupuncture can significantly relieve pain and accompanying symptoms for PD with a cold and dampness stagnation pattern, and pre-menstrual treatment is better than menstrual treatment in improving the accompanying symptoms.
		2022 Vol. 19 (36): 126-130 [Abstract] ( 22 ) HTML (1 KB) PDF (1424 KB) ( 45 )

	131	Discussion on traditional Chinese medicine diagnosis and treatment of “stroke” based on the thinking of supporting yang and the ontology structure of yin and yang
		XIE Rongxin1 WANG Jinping2 MO Xueni3
		DOI: 10.20047/j.issn1673-7210.2022.36.28
		Human life activities are completed by the interaction between yin and yang. In the position relationship between yin and yang, yang is relatively internal, and yin is relatively external. On the basis of this position, the upward outward movement of yang and the downward inward movement of yin realize the interaction between yin and yang. Therefore, it is believed that the core of traditional Chinese medicine diagnosis is to find the abnormal position of yin and yang or the abnormal sympathetic state under the internal yang and external yin structure of patients through pulse syndrome. The core of traditional Chinese medicine treatment is to restore the yin and yang of human body to the original position or normal sympathetic state, and the physical characteristics of stroke patients are summarized as “deficiency of yuan and yang” and “deficiency of yang” combined with clinical practice. The principle direction of warming and activating yang and the treatment method of “triple energizer secondary” are proposed.
		2022 Vol. 19 (36): 131-134,152 [Abstract] ( 17 ) HTML (1 KB) PDF (732 KB) ( 22 )

	135	Study on drug laws of Beiji Qianjin Yao Fang and Qianjin Yi Fang in the treatment of renal edema based on data mining
		LI Xiyao1 GAO Hongjie2 SUN Luying1 BAO Wujisiguleng1 ZHANG Mingzhu1 WEI Shuguang1
		DOI: 10.20047/j.issn1673-7210.2022.36.29
		Objective To use the data mining technology to explore and summarize the drug laws of the treatment of renal edema in Beiji Qianjin Yao Fang and Qianjin Yi Fang (hereinafter referred to as Qianjin Fang). Methods The prescriptions for treating renal edema in Qianjin Fang were selected to establish a standard medical record database, and the cloud platform of ancient and modern medical records was used to make statistics on drug frequency, drug properties, drug flavor, channel tropism, drug association rules, and cluster analysis. Results A total of 67 formulas for the treatment of renal edema from Qian Jin Fang were included in this study, involving 67 prescriptions, among which 44 were Beiji Qianjin Yao Fang and 23 were Qianjin Yi Fang. A total of 144 traditional Chinese medicine were involved, and the top three drugs with high frequency were Atractylodis Macrocephalae Rhizoma, Poria, and Cinnamomi Ramulus. The drug properties were more warm, the drug flavors were more sweet, pungent, and bitter, more return to the lung, spleen, kidney channel. The drug efficacy was more inducing diuresis for removing edema, invigorating spleen, diuresis and diffusing dampness, dispelling pathogenic wind and relieving pain, eliminating dampness and diuresis, and so on. In the association rules of the two drug patterns, the confidence of Stephaniae Tetrandrae Radix→Atractylodis Macrocephalae Rhizoma was the highest. Drugs used more than 20 times could be grouped into four groups by cluster analysis. Conclusion Through data mining, the differentiation and treatment ideas of renal edema in Qianjin Fang are shown, that is, the idea of taking deficiency and excess as the key line, sanjiao as the differentiation method and elimination as the method is formed, which provided reference for the clinical practice of traditional Chinese medicine treatment of renal edema.
		2022 Vol. 19 (36): 135-139 [Abstract] ( 14 ) HTML (1 KB) PDF (1267 KB) ( 26 )

	140	Experience of professor Fan Maorong in treating cough related to idiopathic pulmonary interstitial fibrosis from the perspective of “ben xu luo bi”
		LIANG Yanxia1 DAI Zhaoxin2 ZHAO Yuan1 WANG Bing1 MU Qingxiang3 FAN Maorong1
		DOI: 10.20047/j.issn1673-7210.2022.36.30
		Chronic irritant dry cough is one of the most common symptoms of idiopathic interstitial pulmonary fibrosis (IPF). About 80% of IPF patients have chronic irritant dry cough, with daytime symptoms being the most common, and in severe cases it can lead to serious complications such as syncope and fractures, which can aggravate respiratory distress and hypoxia. However, the traditional cough medicine has poor curative effect, and the patients cough can not be cured, whith has a serious impact on patients’ quality of life and psychological well-being. Through clinical observation and practice, Professor Fan Maorong discusses the pathogenesis of cough associated with IPF from the perspective of “original deficiency and paralysis of the lung”, and treats it by emphasising the innate nature, the interplay of gold and water, nourishing the latter and mediating the middle jiao.
		2022 Vol. 19 (36): 140-143 [Abstract] ( 16 ) HTML (1 KB) PDF (640 KB) ( 33 )

	144	Discussion on moxibustion for pediatric diseases in Quanying Fanglun
		CHEN Shaohua MA Qin ZHAO Kezhuo DING Kan ZHANG Lijun
		DOI: 10.20047/j.issn1673-7210.2022.36.31
		Quanying Fanglun is written by Zheng Duanyou, a Southern Song Dynasty physician, as a monograph on paediatrics, the book is based on a collection of his clinical experience and the doctrines of various schools. Although it is not a monograph on moxibustion, it has a special volume on moxibustion for children. This paper analyzes the points for attention of children moxibustion method, moxibustion points for common diseases, and moxibustion epilepsy in the book. It is found that Quanying Fanglun advocates the same body inches method in the selection of acupoints, and believes that the selection of acupoints should be efficient and accurate. Precautions mainly involved in climate, patient status, time, location, moxibustion amount, and other aspects of avoidance. Among the 29 common diseases applicable to moxibustion method, most of them are liver and gallbladder diseases and heart diseases in internal medicine. The main points selected are conception channel, governor channel, and extra points. The book holds that the key to moxibustion epilepsy lies in deficiency and excess, and summarizes four syndroms of convulsive epilepsy. The moxibustion for children recorded in Quanying Fanglun still has a certain enlightening effect on pediatrics and clinical acupuncture and moxibustion, which has the value of in-depth exploration.
		2022 Vol. 19 (36): 144-147 [Abstract] ( 20 ) HTML (1 KB) PDF (606 KB) ( 22 )

	148	Professor Shao Yingxin’s experience in treating thyroid nodules is differentiated from qi deficiency
		ZHENG Xiuyue1 SHAO Yingxin2
		DOI: 10.20047/j.issn1673-7210.2022.36.32
		The prevalence of thyroid nodules in Chinese adults is as high as 20%, western medicine mainly adopts surgical treatment and follow-up observation. Thyroid nodules are called gall tumor in traditional Chinese medicine. It is generally treated from the liver and spleen. It is considered that the liver is out of order due to emotional trauma, or the spleen is out of health and transportation due to improper diet, which leads to qi stagnation, phlegm coagulation and blood stasis, and obstructs the neck. The gall is treated by regulating qi and activating blood, resolving phlegm and eliminating gall. Professor Shao Yingxin believes that the main cause of this disease is congenital deficiency, namely fetal transmission, or ( and ) improper intake of iodine in the diet, and emotional but not the main cause. Due to congenital deficiency or acquired disorders caused by qi deficiency, qi deficiency can not promote the movement of qi, blood and body fluid is not smooth, resulting in the combination of qi, phlegm and blood stasis, the neck and the disease. The basic pathogenesis is qi deficiency, accumulation of phlegm and blood stasis, and the key pathogenesis is qi deficiency. Qi deficiency leads to qi stagnation, phlegm coagulation, blood stasis, and accumulation of phlegm and blood stasis, forming gall tumors. The basic syndrome type is deficiency of vital qi, phlegm and blood stasis syndrome. The treatment is tonifying qi and removing blood stasis, eliminating phlegm and dispersing stagnation. Clinically, it is proved that the treatment of gall tumors based on qi deficiency is satisfactory, which provides a new idea for the treatment of thyroid nodules and is worthy of reference and application.
		2022 Vol. 19 (36): 148-152 [Abstract] ( 13 ) HTML (1 KB) PDF (774 KB) ( 42 )

	153	Influence of akupotomye release based on the theory of tendon and ligament in the treatment of joint function in patients with femoral head necrosis
		WANG Junyu SONG Mengge HE Haijun LI Yan LIU Daobing
		DOI: 10.20047/j.issn1673-7210.2022.36.33
		Objective To study the influence of akupotomye release based on the theory of tendon and ligament in the treatment of joint function in patients with femoral head necrosis. Methods A total of 76 patients with early-middle stage femoral head necrosis received hip preservation therapy in the Third Department of Bone and Joint, Wangjing Hospital, China Academy of Chinese Medical Sciences from August 2017 to July 2020 were collected and divided into treatment group and control group by random number table method, with 38 cases in each group. The treatment group was treated with acupotomology to release the focal points of peripheral hip tendon and ligament, and massage through the theory of tendon and ligament, while the control group was treated with massage through the tendon and ligament. Both groups were treated for two weeks and underwent hip rehabilitation training for six months after treatment. The clinical efficacy was followed up three and six months after treatment, and the efficacy was evaluated by visual analog scale (VAS) score, range of hip motion, and Harris hip function score. Results The VAS scores at three and six months after treatment were lower than those before treatment, and six months after treatment was lower than three months after treatment, the differences were statistically significant (P＜0.05). VAS scores of the treatment group were lower than those of the control group at three and six months after treatment, and the differences were statistically significant (P＜0.05). The range of hip motion at three and six months after treatment were higher than those before treatment, and six months after treatment was higher than three months after treatment, the differences were statistically significant (P＜0.05). The range of hip motion three and six months after treatment in the treatment group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The Harris hip function scores of the treatment group were better than those of the control group at three and six months after treatment, and the differences were statistically significant (P＜0.05). Conclusion Both treatments achieved significant clinical effects. The akupotomye release was superior to the massage in reducing pain and restoring hip function, which is worthy of clinical promotin.
		2022 Vol. 19 (36): 153-156,169 [Abstract] ( 20 ) HTML (1 KB) PDF (744 KB) ( 24 )

	157	Nursing effect of risk management on early interventional therapy for acute cerebral infarction
		WANG Zenglong1 YU Yan2 CAO Yuezhou1 GU Mei1 HANG Yu1 WANG Xuemei1▲ SHI Haibin1
		DOI: 10.20047/j.issn1673-7210.2022.36.34
		Objective To explore the nursing effect of risk management on early interventional therapy for acute cerebral infarction. Methods A total of 163 patients with acute cerebral infarction who received early interventional therapy in Jiangsu Provincial People’s Hospital from January to August 2021 were selected as subjects. The patients were divided into observation group (82 cases) and control group (81 cases) by random number table method. The control group was given routine nursing management, and the observation group was given risk management based on the control group. The National Institute of Health stroke score scale (NIHSS), exercise of self-careagency scale and Barthel index were compared between the two groups. Results After intervention, NIHSS scores of both groups were lower than before intervention, and observation group was lower than control group, and the differences were statistically significant (P＜0.05); exercise of self-careagency scale scores in both groups were higher than before intervention, and observation group was higher than control group, and the differences were statistically significant (P＜0.05); Barthel index scores of the two groups were higher than before intervention, and the observation group was higher than the control group, and the differences were statistically significant (P＜0.05). Conclusion Risk management can improve the neurological function, exercise of self-careagency scale and daily living ability of patients with acute cerebral infarction after early interventional therapy, which has important application significance.
		2022 Vol. 19 (36): 157-160 [Abstract] ( 21 ) HTML (1 KB) PDF (546 KB) ( 51 )

	161	Effect of the application effect of breastfeeding closed-loop management in NICU patient children
		SHAO Xuehua1 CAI Zhiqin2 WANG Lizhen1 FENG Jing3▲
		DOI: 10.20047/j.issn1673-7210.2022.36.35
		Objective To probe the effect of closed loop management of breastfeeding in neonatal intensive care unit (NICU) patient children. Methods A total of 377 premature infants admitted to NICU of Taizhou Hospital in Zhejiang Province from January 2020 to January 2021 were selected, according to the random number table method, they were divided into the conventional group (190 cases) and the closed-loop management system group (187 cases), two groups were given routine intervention and breastfeeding closed-loop management system. Breastfeeding self-efficacy, skills, knowledge, and time ability were compared between the two groups, the development of preterm infants was assessed, and the breastfeeding rate in different periods was analyzed. Results After intervention, the head circumference of preterm infants in the two groups was greater than that before intervention, and the height and weight of preterm infants in the closed-loop management system group were higher, while the height and weight of preterm infants in the conventional group were higher than those in the conventional group(P＜0.05); the scores of inner activity, skills and total scores, feeding skills, feeding knowledge, and practical ability in both groups were higher than those before intervention, and the closed-loop management system group was higher than the conventional group (P＜0.05). The scores of inner activity, skills and total scores, feeding skills, feeding knowledge, and practical ability of the two groups were higher than those before intervention, and the closed-loop management system group was higher than the conventional group (P＜0.05); the first breastfeeding age, exclusive breastfeeding time, and intravenous nutrition time in the closed-loop management system group were shorter than those in the conventional group, and the feeding intolerance was lower than that in the conventional group (P＜0.05). The breastfeeding rate during hospitalization and one month after discharge in the closed-loop management system group were higher than those in the conventional group (P＜0.05). Conclusion Closed-loop breastfeeding management system is established for premature infants in NICU to reduce their intolerance to breastfeeding and promote their development. Significantly improve the self-efficacy of maternal breastfeeding, improve the rate of breastfeeding, effectively help maternal breastfeeding to establish a positive attitude, high clinical application value.
		2022 Vol. 19 (36): 161-164,189 [Abstract] ( 17 ) HTML (1 KB) PDF (663 KB) ( 39 )

	165	Application of internal arteriovenous fistula management scheme based on evidence-based concept in hemodialysis patients
		WEI Weiguang CHEN Jiayi
		DOI: 10.20047/j.issn1673-7210.2022.36.36
		Objective To explore the application of internal arteriovenous fistula management scheme based on evidence- based concept in maintenance hemodialysis (MHD) patients. Methods A total of 126 MHD patients admitted to the Nanning Second People’s Hospital from January 2020 to December 2021 were selected, and they were divided into control group and observation group according to random number table method, with 63 cases in each group. The control group received routine nursing management, and the observation group received the management scheme of internal arteriovenous fistula based on evidence-based concept. Self-care ability, maturity of arteriovenous fistula, incidence of complications, and quality of life of patients were compared between the two groups. Results After intervention, the scores of all dimensions and total scores of self-care ability in the observation group were higher than those before intervention and higher than those in the control group, and the scores of signs and symptoms management in the control group were higher than those before intervention, and the differences were statistically significant (P＜0.05). The loss rate and complication rate of arteriovenous fistula in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05). The score of life quality of the observation group was higher than that before intervention, and the observation group was higher than the control group, and the differences were statistically significant (P＜0.05). Conclusion The management scheme of intervention arteriovenous fistula based on the evidence-based concept can effectively improve the self-care ability of MHD patients, reduce the incidence of arteriovenous fistula complications, improve the function of arteriovenous fistula, and improve the quality of life of patients.
		2022 Vol. 19 (36): 165-168 [Abstract] ( 17 ) HTML (1 KB) PDF (683 KB) ( 38 )

	170	Establishment of the nursing mode of non-vomiting ward in chemotherapy and its application effect in advanced chemotherapy in medical oncology
		WANG Qian1 Rezi Wanguli·Rexiti2 HE Juan1
		DOI: DOI：10.20047/j.issn1673-7210.2022.36.37
		Objective To investigate the establishment of the nursing mode of non-vomiting ward in chemotherapy and its application effect in advanced chemotherapy in medical oncology. Methods A total of 1 377 patients with advanced chemotherapy in the Department of Oncology who were admitted to the First Affiliated Hospital of Xinjiang Medical University (hereinafter referred to as “our hospital”) from January to June 2021 before the establishment of the no-vomiting ward nursing mode were selected as the control group. In addition, 1 312 patients with advanced chemotherapy in the Department of Oncology who were admitted to our hospital from July to December 2021 after the establishment of the no-vomiting ward in chemotherapy were selected as the study group. The frequency and degree of nausea and vomiting were compared between the two groups. The quality of life and patient satisfaction were compared between the two groups. Results There were significant differences in the frequency and degree of nausea between the two groups (P＜0.05). There were significant differences in the frequency and degree of vomiting between the two groups (P＜0.05). The quality of life score of the study group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The patient satisfaction score in the study group was higher than that in the control group (P＜0.05). Conclusion The establishment of a non-vomiting ward in chemotherapy for chemotherapy can reduce the frequency of nausea and vomiting in patients with advanced chemotherapy in medical oncology, and can improve the quality of life and satisfaction of patients, which can be further promoted.
		2022 Vol. 19 (36): 170-173 [Abstract] ( 12 ) HTML (1 KB) PDF (560 KB) ( 49 )

	174	Influence of quantitative assessment-guided flow nursing model on pregnancy outcomes in patients with gestational hypertension
		ZHENG Qi WU Xiaoqing WANG Bo JIANG Chunyi▲
		DOI: 10.20047/j.issn1673-7210.2022.36.38
		Objective To investigate the influence of quantitative assessment-guided flow nursing model on pregnancy outcomes in patients with gestational hypertension. Methods A total of 91 patients with pregnancy-induced hypertension admitted to Huaian First People’s Hospital, Jiangsu Province from January 2019 to December 2021 were selected by simple random sampling method as subjects. The patients were divided into two groups by random number table method. The control group (46 cases) received routine nursing, and the observation group (45 cases) received quantitative evaluation guided flow nursing mode based on routine nursing. At the time of enrollment (T0), three weeks after intervention (T1), before delivery (T2), the blood pressure levels and pregnancy outcomes of the two groups were observed. Results Systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels were different between the two groups at different time and groups, and there was an interaction between time and group, with statistical significances (P＜0.05). Further pairwise comparison, intra-group comparison: SBP and DBP levels in T1 and T2 were lower than those in T0, and SBP and DBP levels in T2 were lower than those in T1 (P＜0.05); comparison between groups: SBP level at T1 and T2 in observation group was lower than that in control group, DBP level at T2 was lower than that in control group (P＜0.05). The incidence of preterm birth in observation group was lower than that in control group (P＜0.05). Conclusion Quantitative assessment-guided flow nursing model can help control blood pressure levels and improve pregnancy outcomes in patients with gestational hypertension.
		2022 Vol. 19 (36): 174-177 [Abstract] ( 14 ) HTML (1 KB) PDF (1651 KB) ( 16 )

	178	Influence of quality control circle on the accuracy of assessment of living ability of inpatients in cardiology department
		ZHAO Xueli XU Dongni
		DOI: 10.20047/j.issn1673-7210.2022.36.39
		Objective To explore the influence of quality control circle on the accuracy of assessment of living ability of inpatients in cardiology department. Methods A total of 600 patients hospitalized in the Department of Cardiology, Beijing Shijitan Hospital Affiliated to Capital Medical University from December 2017 to December 2021 were selected as subjects. A total of 320 patients without quality control circle (December 2017 to October 2019) were used as the control group, a total of 280 patients after the implementation of quality control circle (November 2019 to December 2021) were included as the observation group. The accuracy rate of patients’ activities of daily living was assessed, and the practical results of carrying out quality control circle nursing activities in improving the accuracy rate of patients’ life ability assessment were analyzed. Results The accuracy activities of daily living ability score in observation group was higher than that in control group, and the difference was statistically significant (P＜0.05); the accuracy of activities of daily living ability score of in observation group was higher than that in control group, and the difference was statistically significant (P＜0.05). Conclusion Carrying out quality control circle nursing activities in the assessment of patients’ living ability can improve the accuracy of assessment, and the application value of nursing methods is worthy of affirmation.
		2022 Vol. 19 (36): 178-181 [Abstract] ( 23 ) HTML (1 KB) PDF (820 KB) ( 41 )

	182	Application effect of intensive respiratory function training intervention in postoperative nursing of chronic obstructive emphysema
		LIU Na1 LI Xiaoqiong2 CHENG Hao3 DUAN Wenjie4▲
		DOI: 10.20047/j.issn1673-7210.2022.36.40
		Objective To study the application effect of intensive respiratory function training intervention in postoperative nursing of chronic obstructive emphysema. Methods A total of 100 patients with chronic obstructive emphysema after lung volume reduction in the Third Clinical Medical College of China Three Gorges University from January 2017 to December 2021 were divided into conventional group (50 cases) and intervention group (50 cases) by random number table method. The conventional group was given traditional routine nursing, and the intervention group was given intensive respiratory function training intervention at the same time. Both groups were given intervention for three months. Pulmonary function, respiratory function, motor function, and quality of life of the two groups before and after intervention were observed and compared. Results After intervention, the forced expiratory volume in one second (FEV1), forced vital capacity (FVC), FEV1/FVC, and six minutes walking test (6MWT) distance in both groups were higher than those before intervention, Borg scale scores and St. George’s respiratory questionnaire (effects of disease, clinical symptoms, mobility) scores were lower than those before intervention, while the FEV1, FVC, FEV1/FVC, and 6MWT distance in the intervention group were higher than those in the conventional group, the scores of Brog scale and St. George’s respiratory questionnaire were lower than those of the conventional group, and the differences were statistically significant (P＜0.05). Conclusion Intensive respiratory function training can improve the pulmonary function and respiratory function of patients with emphysema after surgery, enhance their exercise endurance, and significantly improve their quality of life.
		2022 Vol. 19 (36): 182-185 [Abstract] ( 22 ) HTML (1 KB) PDF (558 KB) ( 22 )

	186	Effect of early rehabilitation intervention on postoperative complications and recovery time in the nursing of patients with dissection of aorta operation
		MENG Zhen
		DOI: 10.20047/j.issn1673-7210.2022.36.41
		Objective To explore the effect of early rehabilitation intervention in the nursing of patients with dissection of aorta operation. Methods A total of 85 patients with dissection of aorta received surgical treatment in Provincial Hospital Affiliated to Shandong First Medical University from February 2020 to February 2021 were selected and divided into routine group and intervention group by random number table method. The routine group (42 cases) received routine postoperative nursing, intervention group (43 cases) received early rehabilitation intervention on the basis of the control group. The degree of postoperative pain, negative emotion, occurrence of common postoperative complications, and recovery process of the two groups were observed after one week of intervention. Results After intervention, the scores of pain, Hamilton anxiety scale, and Hamilton depression scale in two groups were lower than those before intervention, and the intervention group was lower than the conventional group, the differences were statistically significant (P＜0.05). The total incidence of postoperative complications in the intervention group was lower than that in the conventional group, the difference was statistically significant (P＜0.05). The time of postoperative ventilator offline, first time out of bed, intensive care unit stay, drainage tube extraction, urinary tube extraction, and hospital stay in the intervention group were all shorter than those in the conventional group, and the differences were statistically significant (P＜0.05). Conclusion Early rehabilitation intervention in postoperative nursing of patients with aortic dissection can significantly reduce the degree of postoperative pain, improve the psychological state of patients, reduce complications and accelerate the speed of postoperative rehabilitation.
		2022 Vol. 19 (36): 186-189 [Abstract] ( 13 ) HTML (1 KB) PDF (582 KB) ( 41 )

	190	Application of narrative medicine in acupuncture anel moxibustion treatment of allergic diseases
		XING Yu1 ZHANG Chongyang1 LIANG Junjie1 PAN Ting1 ZHANG Jiajia1 WANG Xinru2 BAI Peng1
		DOI: 10.20047/j.issn1673-7210.2022.36.42
		The efficacy of acupuncture anel moxibustion on allergic diseases is gradually being recognized, and these diseases often have both physical and psychological symptoms, so it is worthwhile to seek more effective acupuncture treatment. Narrative medicine is a medical model that pays more attention to humanistic care, and the idea of “spirit-regulation” embodied in the process of clinical diagnosis and treatment of acupuncture anel moxibustion is related to the core of narrative medicine, namely “empathy” and “reflection”. The application of narrative medicine to acupuncture anel moxibustion treatment of allergic diseases can improve patient compliance through “empathy”, optimize the treatment plan through “reflection”, and build a doctor-patient community by cultivating the narrative ability of the practitioner, so as to better solve the patient’s pain. In this way, the application of narrative medicine with clinical characteristics of acupuncture anel moxibustion is promoted, the clinical efficacy is comprehensively improved, the clinical path of narrative medicine is further enriched, and the traditional Chinese medicine culture would be better inherited and developed.
		2022 Vol. 19 (36): 190-193，封三 [Abstract] ( 18 ) HTML (1 KB) PDF (754 KB) ( 35 )

	194	Analysis and intervention of non-rational use of cephalosporins situation in inpatients in the Second Hospital of Jinhua in Zhejiang Province
		SHENG Wei1 CHEN Jinhao1 ZHOU Hong1 ZHOU Chen1 DU Hong1 LING Yingchun2
		DOI: 10.20047/j.issn1673-7210.2022.36.43
		Objective To investigate and intervene the non-rational use of cephalosporins situation in medical orders of inpatients in the Second Hospital of Jinhua, Zhejiang Province (hereinafter referred to as “our hospital”). Methods A total of 1 550 medical orders of cephalosporins issued to inpatients in the internal medicine ward of our hospital from January to December 2020 were selected for investigation, 750 medical orders from January to June 2020 were evaluated according to relevant standards, and 800 medical orders were intervened from July to December 2020. Relevant indicators in the doctor’s orders and the use of cephalosporins before and after intervention were counted, and the situation of non-rational use of drug before and after intervention was compared. Results Before and after intervention, the average number of drug varieties prescribed by doctors, the percentage of antibiotics prescribed by doctors, the proportion of cephalosporins used, the average amount of medical orders, and the proportion of cephalosporins prescribed by doctors were all in a stable and normal range. Most cephalosporins were Cefoperazone Sodium Sulbactam Sodium (41.94%), Ceftazidime (22.58%), Cefuroxime Sodium Powder Needle (9.67%), and Cefuroxime Ester Tablets (9.67%). After intervention, the incidence of unsuitable indications, unsuitable drug selection, unsuitable drug dosage form or route of administration, and unsuitable drug combination were all lower than those before intervention (P＜0.05). The reasons for irrational drug use were mainly the lack of pharmacological knowledge of physicians and patients’ failure to follow the doctor’s advice. Conclusion Medical orders for cephalosporins in our hospital basically meet the standards, and non-rational use of drug is less. In the future, we should continue to strengthen the supervision of medical orders, conduct regular drug use investigation, and supervise rational drug use, so as to reduce the incidence of irrational drug use and provide guarantee for the safety of drug use for the majority of patients.
		2022 Vol. 19 (36): 194-封三 [Abstract] ( 18 ) HTML (1 KB) PDF (527 KB) ( 20 )

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