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| Analysis of drug rules of Taiping Shenghui Fang for lumbago based on data mining |
| HAN Tao ZHU Liguo WEI Xu YU Jie WANG Shangquan ZHAN Jiawen YIN Xunlu |
| Department of Orthopaedic, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China |
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Abstract Objective To explore the drug rules of the prescription for the treatment of lumbago in Taiping Shenghui Fang and the academic thought of this book. Methods The prescriptions for the treatment of lumbago in Taiping Shenghui Fang were collected, and the lumbago prescription database was established. Drug frequency, four nature of drugs, five flavours, and channel tropism, drug efficacy, drug core combination, association rules, and K-means clustering new prescriptions were analyzed in the prescription database through the traditional Chinese medicine inheritance computing platform. Results A total of 77 prescriptions for the treatment of lumbago were collected, involving 108 traditional Chinese medicine flavors, 22 traditional Chinese medicine with frequency ≥five times, and the top five traditional Chinese medicine were Cinnamomi Cortex, Aconiti Lateralis Radix Praeparata, Achyranthis Bidentatae Radix, Eucommiae Cortex and Aucklandiae Radix. The properties of traditional Chinese medicine were mainly warm. The flavors of drugs were mainly sweet, pungent and bitter; drugs mainly return to kidney, liver, and spleen channels; the main efficacy of the drug was supplementing deficiency, warming interior, and promoting blood circulation and removing blood stasis. The top three drug combinations were Cinnamomi Cortex, Achyranthis Bidentatae Radix; Cinnamomi Cortex, Aconiti Lateralis Radix Praeparata; Cinnamomi Cortex, Eucommiae Cortex. Nine drug association rules; four new squares were obtained by K-means clustering. Conclusion The prescription of Taiping Shenghui Fang for the treatment of lumbago mainly focuses on “warming the spleen and tonifying the liver and kidney”, which provides an important reference for clinical diagnosis and treatment of lumbago.
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