|
|
|
| Exploration of treatment rules of bronchiectasis in ancient books based on data mining |
| FAN Rongrong1 WANG Dawei2 ZHANG Zhongde3 WANG Yuanyuan3 JIN Lianshun3 LIU Yuntao3 |
1.Department of Intensive Care Unit, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510120, China;
2.Department of Emergency, Shunde Hospital, Guangzhou University of Chinese Medicine, Guangdong Province, Foshan 528000, China;
3.Department of Emergency, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510120, China |
|
|
|
Abstract Objective To analyze the treatment rules of bronchiectasis in ancient books of Chinese Medical Classics by data mining technology. Methods The ancient name of the bronchiectasis was determined through questionnaire and advice of the expert consultation, then the Chinese Medical Classics was retrieved electronically to find out the records that were relevant to bronchiectasis. The Access 2010 was used to make descriptive analysis on the frequency of use and functional classification of traditional Chinese medicine, the law of acupuncture point selection and channel tropism, and the selection law of therapeutic drugs in dietotherapy prescriptions. The Stata software was used to make cluster analysis on the top 60 traditional Chinese medicines. Results Among the articles related to bronchiectasis in ancient books of Chinese medicine, the most frequently used Chinese medicines were Glycyrrhizae Radix Et Rhizoma, Armeniacae Semen Amarum, Ginseng Radix Et Rhizoma, Poria, Cirrhosae Bulbus, Zingiberis Rhizoma Recens, Pinelliae Rhizoma, Schisandrae Chinensis Fructus, etc. Among the traditional Chinese medicines with frequency more than or equal to five times, the main functions were supplementing drugs, relieving cough, dissipating phlegm, and antiasthma drugs, relieving superficies drugs, clearing heat drugs, diuresis and diffusing dampness drugs, supplemented by astringent drugs, regulating qi drugs, warming interior drugs, promoting blood circulation for removing blood stasis drugs, hemostasis drugs, calming the liver to stop the wind drugs, among which supplementing drugs were mainly those with the effect of replenishing qi and nourishing yin, especially focusing on invigorating spleen and invigorating qi. A total of 17 cluster groups were obtained by cluster analysis. The most frequent acupuncture points were fèishù, lièquē, zúsānlǐ, dànzhōng, fēngmén, and gānshù. The most frequent acupuncture points were foot sun bladder channel, hand taiyin lung channel, foot yangming stomach channel, conception channel, foot shaoyin kidney channel, and foot jueyin liver channel. The main therapeutic drugs for patients with bronchiectasis were ginger, honey, chinese date, bitter apricot seed, sugar, wine, and other properties of warm or flat supplements. Conclusion This study summarizes the rules of medication, external treatment, and diet therapy in traditional Chinese medicines treatment of bronchiectasis through data mining technology, and provides reference for future clinical and scientific research.
|
|
|
|
|
|
[1] Ma Y，Liu D，Ji Y，et al. Clinical features related to hospital expenses for non-cystic fibrosis bronchiectasis in China [J]. J Int Med Res，2020，48（6）：300060520931616.
[2] Guan WJ，Han XR，de la Rosa Carrillo D，et al. The significant global economic burden of bronchiectasis：a pending matter [J]. Eur Respir J，2019，53（2）：1802392.
[3] 周玉民，王辰，姚婉贞，等.我国7省市城区40岁及以上居民支气管扩张症的患病情况及危险因素调查[J].中华内科杂志，2013，52（5）：379-382.
[4] 徐金富，林洁璐，瞿介明.中国支气管扩张症诊治现状及面临的挑战[J].中华结核和呼吸杂志，2017，40（1）：8-10.
[5] 陈荣昌，关伟杰，钟南山.支气管扩张症：需要更多的关注和研究[J].中华结核和呼吸杂志，2017，40（1）：5-7.
[6] 刘学东，赵伟业，张淑立，等.成人支气管扩张症的研究进展[J].中华结核和呼吸杂志，2020，43（10）：902-905.
[7] 任红伟，曹国芸，李梦云，等.清肺化痰解毒汤联合西医治疗支气管扩张伴感染（痰热壅肺证）患者的临床疗效[J].实用心脑肺血管病志，2022，30（5）：84-88.
[8] 钱宇杰，蒋胜利，李波，等.加味桔梗汤加减治疗稳定期支气管扩张患者的效果及对支气管肺泡灌洗液炎症细胞和炎症因子的影响[J].广西医学，2022，44（4）：385-388， 393.
[9] 杨丽莉，王兆邦，陈芳，等.参芪扶正注射液对支气管扩张症伴铜绿假单胞菌感染患者Th17/Treg免疫失衡的影响[J].广东药科大学学报，2021，37（6）：115-119.
[10] 谢文，黄青松.中医药治疗支气管扩张症的药理机制研究进展[J].中医药导报，2021，27（8）：123-127.
[11] 余汉霞，蔡德栋.自拟益脾清肺汤对支气管扩张的治疗作用及对炎性因子含量的影响[J].中医药学报，2017， 45（3）：123-125.
[12] 邓飞.清金化痰汤加味联合支气管肺泡灌洗治疗支气管扩张合并感染疗效及对血清炎症因子的影响[J].现代中西医结合杂志，2017，26（11）：1190-1192.
[13] 宋雪萍.补脾清肺汤治疗支气管扩张症（脾虚肺热症）的临床观察[D].北京：北京中医药大学，2015.
[14] 陈蕾.支气管扩张症急性加重期中医证候调查及清金苇茎地黄汤对BE大鼠NF-κB信号通路的影响[D].合肥：安徽中医药大学，2020.
[15] 裘沛然，邓铁涛，王永炎.中华医典[M].5版.长沙：湖南电子音像出版社，2014.
[16] 南京中医药大学.中药大辞典[M].南京：上海科学技术出版社，2006.
[17] 中华中医药学会肺系病分会，中华中医药学会内科分会，中国民族医药学会肺病分会.支气管扩张症中医证候诊断标准（2019版）[J].中医杂志，2020，61（15）：1377- 1380.
[18] 邱磊，杨铭，张少言，等.基于现代文献和数据挖掘探讨支气管扩张症的中医组方用药规律[J].结核与肺部疾病杂志，2020，1（3）：233-239.
[19] 张智玲，薛汉荣.薛汉荣运用麻杏参苓白术散加味治疗支气管扩张经验[J].中医药通报，2015，14（5）：25-27.
[20] 李欣.吴银根治疗支气管扩张症的经验[J].中国中医药信息杂志，2003，10（7）：68-69.
[21] 李雪，马君.陶凯教授辨治支气管扩张的经验[J].吉林中医药，2019，39（2）：151-154.
[22] 卫慧.史锁芳运用健脾清肺法治疗支气管扩症经验[J].江西中医药，2006，37（287）：10-11.
[23] 陈剑锋.培土生金法对支气管扩张症稳定期肺脾气虚型患者的临床疗效观察[D].广州：广州中医药大学，2015. |
|
|
|
