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| Research progress on the expression of miR-21 and miR-29 and renal fibrosis |
| DU Wenhua1 SHI Liang2 CHENG Xiaohong2 ZAHNG Xiaofeng2 |
1.Department of Integrated Chinese and Western Medicine, the First Chinical Medical College of Shaanxi University of Traditional Chinese Medicine, Shaanxi Province, Xianyang 712046, China;
2.the Second Department of Nephrology, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Shaanxi Province, Xi’an 710000, China |
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Abstract Renal fibrosis is the main pathological change of kidney disease progression to the later stage, and inflammatory stimulation is the main factor of renal fibrosis progression. Its irreversibility and outcome difference have become one of the difficult problems in modern medicine. The microRNA (miRNA) is a short-chain endogenous non-coding small molecule RNA present in stable form in plasma, serum and body fluids, post-transcriptionally regulated encoding protein genes, involved in the regulation of various biological processes. Studies have shown that some of the miR contained in miRNA play an important role in the fibrosis process and are key regulatory factors in the fibrosis/inflammation process. In kidney disease, miR-21 and miR-29 regulate target genes and related signaling pathways, acting on inflammation/promoting fibrosis process. This paper will focus on the signaling pathway of the pathogenesis of renal fibrosis infiltrated by inflammatory cells, and explore the mechanism and potential therapeutic effects of miR-21 and miR-29 in renal fibrosis from the molecular level.
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