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2022 Vol. 19, No. 9 Published: 2022-03-25

	11	Protective effect and mechanism of basic fibroblast growth factor on human chondrocyte injury induced by tumor necrosis factor-α combined with cycloheximide#br#
		XIONG Chenghao1 YANG Bo1 TANG Daoqi1 XUE Qi2 FANG Haizhou1 WANG Jufang3
		Objective To investigate the protective effect and related mechanisms of basic fibroblast growth factor (bFGF) on human chondrocytes in an inflammatory environment in vitro. Methods Primary human chondrocyte injury model was established using 50 ng/ml tumor necrosis factor-α (TNF-α) combined with 1 μmol/L cycloheximide (CHX) and the effects of bFGF on the injury model were assessed. Low and high doses of bFGF groups were administered extra 1, 10 ng/ml bFGF based on model group, respectively. The effects of bFGF on the viability of model cells were detected by MTT assay after treatment for 48 hours, the effects of bFGF on apoptosis and mitochondrial membrane potential were investigated by flow cytometry after after 24 hours treatment, while the effects of bFGF on the expression of apoptosis-related proteins in model cells were detected by Western bolt after treatment for 24 hours. Results The cell viability of the model group (1 μmol/L CHX+50 ng/ml TNF-α) was significantly lower than that of the control group, and the difference was highly statistically significant (P ＜ 0.01); the cell viability of bFGF low-dose and high-dose groups were higher than that of the model group, and the differences were statistically significant (P ＜ 0.05). Flow cytometry results showed that the apoptosis rate of bFGF low-dose and high-dose groups was lower than that of the model group, and the difference was statistically significant (P ＜ 0.05). The results of JC-1 staining showed that the positive rate of FITC cells in the bFGF high-dose group was lower than that in the model group, and the difference was highly statistically significant (P ＜ 0.01). Western bolt showed that the expression level of Bcl-2 protein in the bFGF administration group was higher than that in the model group, while the expression level of Bax protein was lower than that in the model group, and the differences were statistically significant (P ＜ 0.05). Conlusion bFGF can protect chondrocytes from damage in inflammatory environment by inhibiting mitochondrial membrane damage and regulating the expression of apoptosis-related proteins Bax and Bcl-2, which has potential application prospects.
		2022 Vol. 19 (9): 11-15 [Abstract] ( 135 ) HTML (1 KB) PDF (1052 KB) ( 153 )

	16	Visual analysis of knowledge map of Banxia Xiexin Decoction based on VOSviewer and CiteSpace#br#
		YANG Yaqin1 ZHANG Duo1 LI Guoqiu2 LIU Chaonan3
		Objective To analyze the research situation of Banxia Xiexin Decoction in the past ten years through knowledge map. Methods Literature retrieval was conducted on CNKI, Wanfang, and VIP databases with the theme of “Banxia Xiexin Decoction”, the time was set from October 2010 to December 2020, VOSviewer and CiteSpace software were used to analyze the research status, hot spots, and trends of Banxia Xiexin Decoction. Results A total of 2553 literatures were included, and the annual number of literatures was generally on the rise; the core author groups were represented by Weiwei team, and so on; the research institutions were mainly universities of traditional Chinese medicine and hospitals of traditional Chinese medicine; high-frequency keywords were gastritis, Helicobacter pylori, and diabetes, etc; the hot spots and frontiers included network pharmacology, intestinal flora, and tumor, etc. Conclusion The knowledge map showes the research process of Banxia Xiexin Decoction, it involves clinical application and experience synecdoche, formula compatibility and dosage form, methodological exploration and experimental research, etc. In the future, treatment based on syndrome differentiation and mechanism discussion of multiple diseases may be a hot research direction.
		2022 Vol. 19 (9): 16-20,36 [Abstract] ( 175 ) HTML (1 KB) PDF (3621 KB) ( 109 )

	21	Effect of oncolytic virus loaded with MAGE-A10 / hβD-2 double gene on bladder cancer cell proliferation and tumor growth#br#
		ZHANG Jianjun1 CAI Longjun1 CAI Weiqi2
		Objective To explore the effect of oncolytic virus SG502-MAGE-A10-hβD-2 loaded with melanoma-associated antigen A10 (MAGE-A10) and human beta defensin 2 (hβD-2) genes on the proliferation and tumor growth of bladder cancer cell lines. Methods The oncolytic virus SG502-MAGE-A10-hβD-2 loaded with MAGE-A10 and hβD-2 genes was constructed. Virus titer was determined by 50% tissue culture infectious dose. CCK-8 method were used to determine the effects of oncolytic viruses SG502 and SG502-MAGE-A10-hβD-2 on the proliferation of T24 and MB49 cells. SG502 group was added with SG502 virus, SG502-MAGE-A10-hβD-2 group was added with SG502-MAGE-A10-hβD-2 virus, and the control group was added with PBS for 24, 48, 72, 96 h, respectively. The MB49 cell was used to construct a C57BL/6 mouse subcutaneously transplanted tumor model. After the tumor grew to 100-150 mm3, the eighteen mice were divided into control group, SG502 group and SG502-MAGE-A10-H βD-2 group according to the random number table method, with six mice in each group. The control group was given 50 μl normal saline for intratumoral multipoint injection. SG502 group was given 50 μl normal saline solution containing SG502 virus with 2×108 virus particles for intratumoral multipoint injection. SG502-MAGE-A10-hβD-2 group was given 50 μl normal saline solution containing SG502-MAGE-A10-hβD-2 virus particles of 2×108 in intratumoral multipoint injection, two times a week. The tumor volume, the expression of MAGE-A10 and hβD-2 proteins in tumor-forming tissues, the expression of Ki67 and the contents of TNF-α and IFN-γ in serum were detected five weeks after intratumoral injection. Results The oncolytic virus SG502-MAGE-A10-hβD-2 was successfully constructed, and the titer of the purified virus was 2.05×1010 PFU/ml. The inhibition rates of T24 and MB49 cells at each time point in SG502 group and SG502-MAGE-A10-hβD-2 group were statistically significant (P ＜ 0.05). There were statistically significant differences in T24 and MB49 cell inhibition rates between SG502 group and control group at 24, 48, 72, and 96 h (P ＜ 0.05). The inhibition rates of T24 and MB49 cells in SG502-MAGE-A10-hβD-2 group and SG502 group at 24, 48, 72, and 96 h were significantly different (P ＜ 0.05). The tumor volume of SG502 group and SG502-MAGE-A10-hβD-2 group at each time point was significantly different (P ＜ 0.05). There were statistically significant differences in tumor volume between SG502 group and control group at 14, 21, 28, 35, and 42 days (P ＜ 0.05). There were statistically significant differences in tumor volume between SG502-MAGE-A10-hβD-2 group and SG502 group at 14, 21, 28, 35, and 42 days (P ＜ 0.05). The tumor weight of SG502 group was lower than that of the control group, and that of SG502-MAGE-A10-hβD-2 group was lower than that of SG502 group, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). The levels of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in SG502 group were higher than those in control group, and the levels of TNF-α and IFN-γ in SG502-MAGE-A10-hβD-2 group were higher than those in SG502 group, the differences were highly statistically significant (P ＜ 0.01). After five weeks of intervention, MAGE-A10 and hβD-2 proteins were expressed in SG502-MAGE-A10-hβD-2 group, but not in the control group and SG502 group. The expressions of Ki67 in tumor tissues of SG502 group and SG502-MAGE-A10-hβD-2 group were lower than that of control group, and the differences were highly statistically significant (P ＜ 0.01). Conclusion SG502-MAGE-A10-hβD-2 can inhibit the proliferation of T24 and MB49 cells, inhibit the tumor growth of MB49 tumor-forming mice, and stimulate the secretion of TNF-α and IFN-γ in mice.
		2022 Vol. 19 (9): 21-26,45 [Abstract] ( 123 ) HTML (1 KB) PDF (1405 KB) ( 112 )

	27	Regulatory effect of Xifeng Dingchuan Prescription on VEGF, EGF and TGF-β2 in serum of asthmatic guinea pigs#br#
		GUO Sitong1 SHANG Lili2
		Objective To study the regulatory effect of Xifeng Dingchuan Prescription on vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) and transforming growth factor β2 (TGF-β2) in asthmatic guinea pigs and explore its mechanism of action. Methods Seventy-two general grade male guinea pigs were divided into normal control group, cold asthma model group, high dose group [22.72 g/(kg·d)], medium dose group [11.36 g/(kg·d)], low dose group [5.68 g/(kg·d)] of Xifeng Dingchuan Prescription, Dexamethasone group [0.5 mg/(kg·d)] according to random number table method, with 12 guinea pigs in each group. In addition to the normal control group, ovalbumin sensitization + cold stimulation was used to replicate the guinea pig model of cold asthma. The normal control group was given equal dose of normal saline. On the 29th day of the experiment, the high, medium and low dose groups of Xifeng Dingchuan Prescription were given orally, while normal control group and cold asthma model group were given normal saline. The general situation of guinea pigs in each group was observed. HE staining was used to detect the therapeutic effect of Xifeng Dingchuan prescription on guinea pig model of cold asthma. The contents of VEGF, EGF, and TGF-β2 in serum were
		2022 Vol. 19 (9): 27-30 [Abstract] ( 100 ) HTML (1 KB) PDF (1114 KB) ( 26 )

	31	Research on the action mechanism of Bushen Ankun Decotion in the treatment premature of ovarian insufficiency based on network pharmacology#br#
		XIE Xiaohui1 LIU Jinxing2
		Objective To study the action mechanism of Bushen Ankun Decotion in the treatment of premature ovarian insufficiency (POI ) based on network pharmacology. Methods With the help of traditional Chinese medicine system pharmacology database and analysis platform (TCMSP ), the effective components and related targets were obtained; the standard names of the targets were found according to the Uniprot database; based on Cytoscape software, the network diagram of traditional Chinese medicine component-target was obtained. According to Genecards and OMIM, target genes of disease were obtained. Protein-protein interaction network of core target proteins was obtained by using STRING database and Cytoscape software. DAVID database and Cluego software were used for GO enrichment analysis and KEGG enrichment analysis. PubChem database, Uniprot database, AutoDock Tools software and DS ViewerPro software were used for molecular docking of main components and key targets. Results According to the screening conditions, 150 active components and 1088 targets of Bushen Ankun Decotion were obtained. 2718 POI target genes were retrieved, and 166 common targets of Bushen Ankun Decoction and disease were obtained. The results of molecular docking showed that the main compounds and their corresponding target proteins had good binding activities. GO functional enrichment analysis showed that it was mainly involved in cell surface. KEGG pathway enrichment analysis, a total of 228 pathways were enriched. Conclusion The mechanism of Bushen Ankun Decoction in the treatment of POI reflects the characteristics of multi-component, multi-target and multi-channel of traditional Chinese medicine, and provides a theoretical basis for further study of related diseases and drugs.
		2022 Vol. 19 (9): 31-36 [Abstract] ( 89 ) HTML (1 KB) PDF (3476 KB) ( 115 )

	37	Study on the reliability of digital evaluation of gingival thickness in implant area of patients with dentition defect#br#
		ZHANG Ke CHEN Xubing▲ ZHANG Yuhui LIU Zhaogang
		Objective To explore the reliability of digital evaluation of gingival thickness of alveolar ridge crest in implant area of patients with dentition defect. Methods From January 2020 to June 2021, 47 patients with digital dental support guide implants were selected from the Department of Stomatology, Fuyang People’s Hospital, Anhui Province. All patients underwent cone beam CT photography and 3shape oral scanning. The gingival thickness of alveolar ridge crest was measured by digital technique before operation, and was measured again by modified gingival puncture method during operation. The difference and consistency of gingival thickness measured by the two methods were analyzed and compared, and the reliability of digital measurement results was tested by intraclass correlation coefficient (ICC). Results There was no significant difference in gingival thickness between the two methods (P ＞ 0.05). Bland-altman analysis showed that the consistency of the measurement results of the two methods was good, and no measurement outside the consistency interval appeared. The ICC and its 95%CI of measurement results by different surveyors using digital technology was 0.932（0.882-0.962）. Conclusion The results of measuring gingival thickness in implant area of patients with dentition defect by digital technique are consistent with the modified gingival puncture method, and the reliability is good.
		2022 Vol. 19 (9): 37-40 [Abstract] ( 43 ) HTML (1 KB) PDF (1276 KB) ( 63 )

	41	Research progress of Dexmedetomidine on organ protection by regulating autophagy#br#
		WU Bei1 LI Yuebing2 WANG Weina2
		Organ diseases such as traumatic brain injury, ischemic stroke, myocardial ischemia-reperfusion injury, acute lung injury, acute kidney injury, etc., there is still no good treatment method, which seriously affects the prognosis of patients, and effective treatment methods are urgently needed. Autophagy is very important in maintaining the homeostasis of the structure and function of brain, heart, lung, kidney, and other organs. The imbalance of autophagy will lead to the occurrence and development of a variety of organ diseases. A large number of studies have proved that Dexmedetomidine may play an organ protective role by regulating autophagy activity. This paper reviews the regulatory effect of Dexmedetomidine on autophagy in nervous system diseases, heart diseases, lung diseases, and other organ diseases, which opens up a new idea for the treatment of organ diseases.
		2022 Vol. 19 (9): 41-45 [Abstract] ( 86 ) HTML (1 KB) PDF (558 KB) ( 54 )

	46	Research progress on the clinical significance of nasal nitric oxide measurement for chronic sinusitis#br#
		CHEN Yijing YANG Jing CAO Zhiwei
		Chronic sinusitis is one of the most common inflammatory diseases of the nose, and it has a complicated pathogenesis, which is mostly related to the destruction of the nasal mucosa structure and ciliary dyskinesia. At present, many diagnostic methods, such as sinus imaging, sinus puncture, irrigation, are one-sided due to their complex and invasive operation, and high price. The nasal nitric oxide (nNO) measurement is a non-invasive, safe, simple, and reproducible auxiliary detection method. This method provides patients with direct detection of inflammation in the upper respiratory tract, and has important reference significance for the diagnosis of chronic sinusitis. At present, the research on differences in nNO levels in patients with different chronic sinusitis is still controversial. This article reviews the overview of nNO and its relationship with the severity of chronic sinusitis as well as its application in the diagnosis and treatment of chronic sinusitis in adults and children.
		2022 Vol. 19 (9): 46-49,54 [Abstract] ( 132 ) HTML (1 KB) PDF (561 KB) ( 130 )

	50	Comparison of three pressure injury assessment scales for predicting pressure injury in patients after cardiopulmonary bypass in ICU#br#
		LI Zhengang1 WANG Yating2 QI Jinfang3 DONG Zhenghui4
		Objective To compare the predictive effects of Braden, COMHON, Cubbin & Jackson scales on pressure injury in intensive care unit (ICU) patients after cardiopulmonary bypass, and to screen the best predictive tool for pressure injury risk in such patients. Methods The Braden scale, COMHON scale, and Cubbin & Jackson scale were used to assess the risk of pressure injury in 252 patients admitted to a tertiary hospital after cardiopulmonary bypass from September 2017 to February 2019. The predictive power of the three scales for pressure injury occurring within seven days was compared. Results Among 252 ICU patients after cardiopulmonary bypass, 150 patients developed pressure injury within seven days, and 102 patients did not develop pressure injury. There were significant differences in disease type, acute physiology and chronic health evaluationⅡ score and mechanical ventilation time between the two groups (P ＜ 0.05). Comparison of the predictive ability of the three scales: the Braden scale for predicting the occurrence of pressure injury in patients after cardiopulmonary bypass in the ICU with a critical value of 10 points, the area under the receiver operating characteristic curve (AUC), sensitivity, specificity, and positive likelihood ratio, the negative likelihood ratios were 0.512, 29.33%, 74.51%, 1.149, 0.948, and 0.523; the critical value of COMHON scale for predicting the occurrence of pressure injury in patients after cardiopulmonary bypass in ICU was 17 points, and its AUC, sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio were 0.523, 30.67%, 80.39%, 1.564, 0.862, respectively; the critical value of the Cubbin & Jackson scale for predicting the occurrence of pressure injury in patients after cardiopulmonary bypass in the ICU was 25 points, and its AUC, sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio were 0.687, 64.67%, 64.71%, 1.837, 0.546. There was a statistically significant difference in the scores of inotropic drugs between the two groups (P ＜ 0.05). Conclusion The Cubbin & Jackson scale in more suitable than the Braden scale and the COMHON scale to predict pressure injury in patients after cardiopulmonary bypass in the ICU.
		2022 Vol. 19 (9): 50-54 [Abstract] ( 90 ) HTML (1 KB) PDF (575 KB) ( 70 )

	55	Investigation on the current situation and influencing factors of outpatient pharmaceutical care clinic in our hospital#br#
		TONG Huan DAI Yaqin AN Wei XIA Fei ZHANG Bingwu ZHANG Mingwei
		Objective To explore the current situation and main influencing factors of outpatient pharmaceutical care (OPC) in the Third People’s Hospital of Hubei Province of Jianghan University(hereinafter referred to as “our hospital”). Methods Through consulting domestic and foreign literature and expert consultation, a questionnaire on knowledge, belief, and behavior of OPC was compiled, using both online and offline questionnaires. This questionnaire survey was conducted in the OPC of our hospital from August to November 2020, and multiple linear regression was used to explore its influencing factors. Results In this survey, a total of 450 questionnaires were distributed and returned, of which 438 were valid questionnaires, and the questionnaire effectiveness rate was 97.33%. There were statistically significant differences in the scores of daily medication experience (cognition) of respondents in different age and occupations (P ＜ 0.05); there were statistically significant differences in the scores of daily medication experience (cognition), clinical pharmacists’ personalized service (attitude), and OPC experience (behavior) among respondents with different educational backgrounds (P ＜ 0.05). Daily medication experience, personalized service from clinical pharmacists, and OPC experience were positively correlated with attitude toward OPC (r = 0.214, 0.240, 0.110, P ＜ 0.05 or P ＜ 0.01). Multiple linear regression analysis showed that after excluding gender, age, occupation, and educational background, the personalized service of clinical pharmacists could significantly and positively affect the acceptance of OPC, and the residuals of the linear regression model obeyed a normal distribution (P ＜ 0.05). Conclusion Educational level and personalized service of clinical pharmacists are the main factors affecting OPC.
		2022 Vol. 19 (9): 55-58 [Abstract] ( 130 ) HTML (1 KB) PDF (539 KB) ( 33 )

	59	Analysis of the current situation and influencing factors of psychological distress among tuberculosis patients in a hospital in Xinjiang#br#
		CHEN Han1 Gulisumuhan Abulaiti1 CHEN Weixing2 YANG Fengqin3 WANG Meixin1
		Objective To understand the current situation and influencing factors of psychological distress among tuberculosis patients in a hospital in Xinjiang. Methods From November 2020 to April 2021, a total of 280 tuberculosis patients in the respiratory department of a hospital in Xinjiang were conveniently selected, while the family function scale, Morisky medication adherence scale, and Kessler 10 scale were used to investigate and analyze the influencing factors of psychological distress. Results In this survey, a total of 280 questionnaires were distributed, 6 invalid questionnaires were excluded, and 274 questionnaires were recovered, with an effective recovery rate of 97.9%. There were statistically significant differences in the psychological distress scores of tuberculosis patients with different age, education level, place of residence, chronic diseases, and taking chronic disease drugs (P ＜ 0.05). The total score of psychological distress was (18.60±6.13) points, the incidence rate was 64.23%; the total score of family function was (7.66±2.41) points; the score of medication compliance was (6.09±1.32) points. Psychological distress was negatively correlated with family function and medication compliance (r = -0.520, -0.506, P ＜ 0.05), and family function was positively correlated with medication compliance (r = 0.133, P ＜ 0.01). Multiple linear regression analysis showed that hemoptysis, combined chronic diseases, time of taking anti-tuberculosis drugs, family support, and medication compliance were the main predictors of psychological distress in tuberculosis patients (P ＜ 0.05), which could explain 48.05% of the total variation of psychological distress in tuberculosis patients. Conclusion The incidence of psychological distress in tuberculosis patients is relatively high. Active measures should be taken related influencing factors, in order to improve the psychological status of patients and improve the quality of life.
		2022 Vol. 19 (9): 59-62 [Abstract] ( 128 ) HTML (1 KB) PDF (585 KB) ( 38 )

	63	Influencing factors of self-efficacy in patients with severe acute pancreatitis#br#
		HU Yingying WU Min
		Objective To analyze the influencing factors of self-efficacy in patients with severe acute pancreatitis (SAP). Methods A total of 100 SAP patients treated in the First Affiliated Hospital of Nanjing Medical University from April 2019 to April 2021 were selected, after the patients regained their self-consciousness for one week, self-efficacy, levels of post traumatic growth (posttraumatic growth inventory [PTGI]), self perceived burden (self perceived burden scale [SPBS]) and coping style (simplified coping style questionnaire [SCSQ]) of patients were evaluated. The family members of patients was asked and the relevant data of patients was recorded, the self-efficacy scores of patients with different data characteristics were compared, the influencing factors of self-efficacy of SAP patients were analyzed. Results In the 100 SAP patients included, the self-efficacy score was (2.24±0.22) points. The self-efficacy scores of active and active coping patients were higher than those of unemployed and passive coping patients, and the differences were statistically significant (P ＜ 0.05). The PTGI score of 100 SAP patients was (66.42±4.25) points, and the SPBS score was (36.52±3.85) points. Multiple linear regression analysis showed that unemployed (X1), SCSQ score (X2), decreased PTGI score (X3), and increased SPBS score (X4) were the influencing factors of decreased self-efficacy in SAP patients (P ＜ 0.05). The linear equation was obtained: Y=3.218+0.050X1-0.128X2-0.018X3+0.010X4. Conclusion Unemployment, lower SCSQ score, lower PTGI score, and higher SPBS score are the influencing factors of the lower self-efficacy of SAP patients.
		2022 Vol. 19 (9): 63-66 [Abstract] ( 126 ) HTML (1 KB) PDF (495 KB) ( 25 )

	67	Study on influencing factors of hyperuricemia in patients with type 2 diabetes mellitus#br#
		MU Lin1 LI Chao2 ZHAO Wenying1 DONG Huan1 WANG Yuan1 LI Xin1 ZHANG Baoyu1 YANG Longyan3
		Objective To explore the influencing factors of hyperuricemia in type 2 diabetes mellitus. Methods A total of 3427 patients with type 2 diabetes mellitus admitted to the Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University from October 2017 to February 2021 were retrospectively enrolled, and their data of demographic, clinical, and lifestyle were collected. They were divided into hyperuricemia group (399 cases) and control group (3028 cases) according to whether they were complicated with hyperuricemia. Univariate and multivariate analyses were conducted to evaluate the influencing factors of hyperuricemia in patients with type 2 diabetes mellitus. Results Systolic blood pressure, diastolic blood pressure, height, weight, body mass index, waist circumference, proportion of hypertension, proportion of hyperlipidemia, proportion of coronary heart disease, proportion of peripheral vascular disease, proportion of intake of adequate soy products, and proportion of annual income > 100 000 yuan in hyperuricemia group were all higher than those in control group, the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that hypertension, hyperlipidemia, annual income > 100 000 yuan, and adequate intake of soy products were independent risk factors for hyperuricemia in patients with type 2 diabetes mellitus (OR ＞ 1, P ＜ 0.05). Conclusion Hypertension, hyperlipidemia, annual income > 100 000 yuan, and adequate intake of soy products are the influencing factors of hyperuricemia in patients with type 2 diabetes mellitus.
		2022 Vol. 19 (9): 67-69,78 [Abstract] ( 175 ) HTML (1 KB) PDF (474 KB) ( 174 )

	70	Effects of probiotics on insulin resistance and intestinal flora structure in patients with gestational diabetes mellitus#br#
		LIN Xuanxia1 HUANG Hanwei1 WU Ren1 WU Jing2 GU Xiulan3 ZHAN Yongying1 SU Qiong4
		Objective To investigate the effects of probiotics on insulin resistance and intestinal flora structure in patients with gestational diabetes mellitus (GDM). Methods A total of 98 GDM patients admitted to Zhongshan Chenxinghai Hospital, Guangdong Province from January 2020 to January 2021 were selected and divided into two groups by random number table method, with 49 patients in each group. The control group was given insulin treatment, and the observation group was given probiotic treatment on the basis of the control group. After ten weeks of treatment, the therapeutic effects of the two groups were observed, and the differences of glycolipid metabolism, insulin resistance, intestinal flora structure, and pregnancy outcome were compared between the two groups. Results The total effective rate of observation group was higher than that control group, and the incidence of premature delivery and macrosomia was lower than that control group, the differences were statistically significant (P ＜ 0.05). After treatment, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), fasting blood glucose (FPG), 2 h postprandial blood glucose (2hPG), glycosylated hemoglobin (HbA1c), fasting insulin (FINS), and homeostasis model assessment- insulin resistance (HOMA-IR) index in two groups were all lower than those before freatment, high density lipoprotein cholesterol (HDL-C) was higher than that before treatment, the TC, TG, LDL-C, FPG, 2hPG, HbA1c, FINS, and HOMA-IR index in observation group were lower than those in control group, while HDL-C was higher than that in control group, the differences were statistically significant (P ＜ 0.05). After treatment, the abundances of Rumen coccus, Bacteroides faecalis, Bacteroides monoform, Spirospira, Bacteroides multiform, and Bacteroides nodicum in the observation group were all higher than those before treatment, the abundances of Bifidobacterium, Eubacterium hallii, Eubacterium limosum, and Clostridium perfringens were all lower than those before treatment, while the abundances of Rumen coccus, Bacteroides faecalis, Bacteroides monoform, Spirospira, Bacteroides multiform, and Bacteroides nodicum in the observation group were all higher than those in control group, while the abundance of Bifidobacterium, Eubacterium hallii, Eubacterium limosum, and Clostridium perfringens were all lower than those in control group, the differences were statistically significant (P ＜ 0.05). Conclusion The addition of probiotics on the basis of hypoglycemic treatment can correct the structural disorder of intestinal flora, inhibit insulin resistance, improve the disorder of glucose and lipid metabolism and pregnancy outcome of patients with GDM.
		2022 Vol. 19 (9): 70-74 [Abstract] ( 163 ) HTML (1 KB) PDF (646 KB) ( 67 )

	75	Relationship between complement-C1q / tumor necrosis factor-related protein 5 and gestational diabetes mellitus#br#
		XIN Yaping1 ZHU Yihan1 ZHANG Qi1 ZHANG Ke2 WANG Anying2
		Objective To study relationship between complement-C1q / tumor necrosis factor-related protein 5 (CTRP5) and gestational diabetes mellitus (GDM). Methods A total of 172 gravidas enrolled in the Second Affiliated Hospital of Zhengzhou University from June 2020 to June 2021 were divided into control group (80 gravidas) and GDM group (92 cases) according to whether they had GDM or not. Age, gestational age, pre-pregnancy body mass index (BMI), prenatal BMI, blood pressure, total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), fasting blood glucose (FBG), glucose load 2 h blood glucose, fasting insulin (FINS), glycated hemoglobin (HbA1c), homeostasis model assessment-insulin resistance (HOMA-IR) index, CTRP5, and adipose triglyceride lipase (ATGL) were compared between the two groups. The correlation between CTRP5 and all indicators was analyzed, and the relationship between CTRP5 and GDM was analyzed by logistic regression model. Results Pre-pregnancy BMI, prenatal BMI, TC, TG, FBG, glucose load 2 h blood glucose, HbA1c, FINS, and HOMA-IR indexes in GDM group were all higher than those in control group, while ATGL and CTRP5 were all lower than those in control group, the differences were statistically significant (P ＜ 0.05). CTRP5 was negatively correlated with pre-pregnancy BMI, prenatal BMI, TC, TG, FBG, HbA1c, glucose load 2 h blood glucose, FINS, HOMA-IR index (r ＜ 0, P ＜ 0.05), and positively correlated with ATGL (r ＞ 0, P ＜ 0.05). Logistic regression model analysis showed that CTRP5 was still an independent influencing factor for the occurrence of GDM after adjusting pre-pregnancy BMI, prenatal BMI, TC, TG, FBG, HbA1c, glucose load 2 h blood glucose, FINS, and HOMA-IR index (P ＜ 0.05). Conclusion CTRP5 is an influential factor of GDM, which may be related to insulin resistance and glycolipid metabolism.
		2022 Vol. 19 (9): 75-78 [Abstract] ( 115 ) HTML (1 KB) PDF (465 KB) ( 29 )

	79	Comparison of clinical efficacy and safety between endoscopic transareolar approach and open surgery in complex thyroid surgery#br#
		XU Fangzheng MA Boheng▲
		Objective To compare the clinical efficacy and safety between endoscopic transareolar approach and open surgery in complex thyroid surgery. Methods A total of 83 patients who underwent complex thyroid surgery in Rugao People’s Hospital, Jiangsu Province from January 2018 to May 2021 were selected, and they were divided into study group (endoscopic via areola approach, 43 cases) and control group (open surgery, 40 cases) according to different surgical methods. Surgery time, intraoperative blood loss, and hospital stay were compared between the two groups. The stress response related indexes of the two groups were compared 30 min before surgery, 6 h after surgery, and 12 h after surgery. Visual analogue scale (VAS) and Vancouver scar rating scale (VSS) scores were compared between the two groups. The perioperative complications of the two groups were recorded. Results The amount of intraoperative blood loss in the study group was lower than that in the control group, and the length of hospital stay was shorter than that in the control group, the differences were statistically significant (P ＜ 0.05). There were statistically significant differences in cortisol (Cor), angiotensin Ⅱ (AngⅡ), and adrenaline levels between the two groups at each time point (P ＜ 0.05). The levels of Cor, Ang Ⅱ, and adrenaline in the study group at 6 and 12 h after surgery were lower than those in the control group at the same time point, the differences were statistically significant (P ＜ 0.05). VAS and VSS scores of the study group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). The total incidence of perioperative complications in the study group was lower than that in the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Compared with open surgery, endoscopic surgery through areola approach for complex thyroid can guarantee the therapeutic effect and reduce intraoperative blood loss, shorten the length of hospital stay, relieve stress reaction, relieve postoperative pain, improve aesthetic value, and reduce postoperative complications.
		2022 Vol. 19 (9): 79-82 [Abstract] ( 205 ) HTML (1 KB) PDF (528 KB) ( 20 )

	83	Effect of reduced glutathione in the treatment of sepsis acute kidney injury#br#
		XI Xixiang MA Jinmiao XU Zhenyu
		Objective To investigate the effect of reduced glutathione in the treatment of patients with sepsis acute kidney injury. Methods From June 2018 to June 2020, 72 patients with sepsis acute kidney injury treated in the intensive care unit of the Department of Emergency in Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine were selected. They were divided into observation group and control group by random number table method, with 36 cases in each group. The control group was given routine treatment, and the observation group was treated with reduced glutathione injection on the basis of the control group. The changes of markers of kidney injury, malondialdehyde (MDA), and total antioxidant capacity (TAOC) in both groups were observed. Results After treatment, serum creatinine (Scr), Cystatin C (Cys-C), and serum neutrophil gelatinase-associated lipocalin (sNGAL) in the two groups were lower than those before treatment, Cys-C and sNGAL in the observation group were lower than those in the control group (P ＜ 0.05). After treatment, MDA in both groups was lower than that before treatment, and TAOC was higher than that before treatment, and MDA in observation group was lower than that in control group, and TAOC in observation group was higher than that in control group (P ＜ 0.05). Conclusion Reduced glutathione can improve the antioxidant capacity of the body, and promote the recovery of patients with sepsis acute kidney injury.
		2022 Vol. 19 (9): 83-86 [Abstract] ( 116 ) HTML (1 KB) PDF (518 KB) ( 39 )

	87	Effect of Shentong Zhuyu Paste in the auxiliary treatment of patients with blood stasis knee osteoarthritis #br#
		YI Tengda ZHANG Shumeng WANG Shasha LIU Lining YUAN Zhenyi
		Objective To study the effect of Shentong Zhuyu Paste in the auxiliary treatment of patients with blood stasis knee osteoarthritis (KOA). Methods A total of 50 patients with blood stasis knee osteoarthritis treated in the Department of Outpatient, the First Affiliated Hospital of Hunan University of Chinese Medicine from June 2020 to March 2021 were divided into control group and treatment group by random number table method, with 25 cases in each group. The treatment lasted for 14 days. The control group was treated with conventional therapy, and the treatment group was combined with plaster for external application on the basis of the control group. Clinical efficacy, coagulation function, KOA Chinese medicine score, visual analog scale (VAS) and Western Ontario and mcMaster Universities (WOMAC) index were compared between the two groups. Results The clinical efficacy of the treatment group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05). Before ard after treatment, there were no significant differences in prothrombin time, activated partial thromboplastin time, thrombin time and D-Dimer of within and between groups (P ＞ 0.05). Before treatment, there were no significant differences in KOA scores, VAS scores and WOMAC index between the two groups (P ＞ 0.05). After treatment, KOA Chinese medicine score, VAS score and WOMAC index in two groups were lower than before, and the treatment group was lower than the control group, the differences were statistically significant (P ＜ 0.05). Conclusion The clinical effect of Shentong Zhuyu Paste in the auxiliary treatment of blood stasis KOA is worthy of recognition. The treatment has obvious effects of relieving pain and improving joint movement function.
		2022 Vol. 19 (9): 87-90 [Abstract] ( 158 ) HTML (1 KB) PDF (574 KB) ( 43 )

	91	Effect of percutaneous kyphoplasty in the treatment of AO-A thoracolumbar fractures#br#
		WANG Yong ZHANG Zhengshi CHEN Ji CHENG Bin TANG Guoqing
		Objective To observe the clinical effect of percutaneous kyphoplasty（PKP） in the treatment of AO-A thoracolumbar fractures. Methods A total of 260 patients with AO-A thoracolumbar fractures who were admitted in Kunshan Hospital of Traditional Chinese Medicine from January 2018 to December 2020 were selected as the the research objects. They were divided into observation group and control group by random number table method, with 130 cases in each group. The control group was treated with Wiltse incision and reduction, the observation group was treated with PKP. The surgical trauma and hemorrhage, hospitalization time, and visual analog scale (VAS) were recorded, the complications of the two groups after operation were recorded. The height of the anterior border of the injured group, the change of the kyphosis Cobb angle, and the recovery of life function were compared between the two groups. Results The anterior height of the injured vertebrae in the two groups was higher than that before surgery, and the kyphosis Cobb Angle and Oswestry dysfunction index (ODI) score were lower than that before surgery, the differences were statistically significant (P ＜ 0.05). The ODI score of the observation group was lower than that of the control group after operation, and the difference was statistically significant (P ＜ 0.05). The VAS score of the observation group at three and seven days after surgery was lower than that before surgery, and at seven days after surgery was lower than that at three days after surgery, the differences were statistically significant (P ＜ 0.05), the VAS score of the control group at one day after surgery was higher than that before surgery, and at seven days after surgery was lower than that at three days after surgery and before surgery. VAS scores of the observation group at one, three and seven days after surgery were lower than those of the control group, the differences were statistically significant (P ＜ 0.05). The incidence of postoperative complications in the observation group was lower than that in the control group, the difference was statistically significant (P ＜ 0.05). Conclusion The PKP is effective in the treatment of Ao-a thoracolumbar fractures, which helps to reduce postoperative pain and promote early rehabilitation.
		2022 Vol. 19 (9): 91-94 [Abstract] ( 114 ) HTML (1 KB) PDF (567 KB) ( 46 )

	95	Effect of two anterior acetabular approaches with low notch reconstruction plate fixation for acetabular quadrangular fractures #br#
		YE Fang1 LAN Yinan2 HUANG Shuming1 YE Jifei1 XIE Panpan1 XING Hailin1 WANG Chong1
		Objective To investigate the effect of low profile reconstruction plate placement in the treatment of acetabular tetragonal fractures through the parabrectus approach or the ilioinguinal approach. Methods A total of 94 patients with acetabular tetragonal fracture from January 2016 to April 2021 in Lishui Central Hospital of Zhejiang Province were enrolled and they were divided into two groups by random number table method. The control group (47 cases) was treated with low profile reconstruction plate internal fixation via ilioinguinal approach, and the observation group (47 cases) was treated with low-notch reconstruction plate internal fixation via parabrectus approach. The operative time, intraoperative blood loss, incision length, fracture healing time, acetabular reduction effect, hip joint function, pain degree and complications were compared between the two groups. Results The operation time and incision length of the observation group were shorter than those of the control group (P ＜ 0.05), and the amount of intraoperative blood loss was less than that of the control group (P ＜ 0.05). In the observation group, the excellent and good rate was higher than that of the control group (P ＜ 0.05). Overall analysis showed that there were statistically significant differences in Harris score, modified Merle D’Aubigne-Postel score and VAS score between groups, time point comparison and interaction between the two groups (P ＜ 0.05). Intragroup comparison: Harris score and modified Merle D’Aubigne-Postel score at 6 and 12 weeks after surgery were higher than those before surgery, and 12 weeks after surgery were higher than those at 6 weeks after surgery. VAS score 6 and 12 weeks after surgery was lower than that before surgery, and 12 weeks after surgery was lower than that 6 weeks after surgery (P < 0.05). Comparison between groups: Harris score and modified Merle D’Aubigne-Postel score of observation group were higher than those of control group at 6 and 12 weeks after surgery (P ＜ 0.05), VAS score was lower than that of control group (P ＜ 0.05). The total incidence of complications in the observation group was lower than that in the control group (P ＜ 0.05). Conclusion The low profile reconstruction plate approach through the parastrectus abdominis has the advantages of less trauma, simple operation and high safety, and is more conducive to the reduction of the tetrahedral fracture block and the recovery of hip joint function, which is better than the ilioinguinal approach.
		2022 Vol. 19 (9): 95-98,106 [Abstract] ( 44 ) HTML (1 KB) PDF (911 KB) ( 41 )

	99	Clinical effect of anatomical repair of anterior talofibular ligament in the treatment of lateral malleolus avulsion fracture with lateral collateral ligament injury#br#
		MA Hujing LIU Yang ZHOU Junlin▲
		Objective To compare the clinical effects of surgical repair and simple plaster immobilization on patients with lateral collateral ligament injury and lateral malleolar avulsion fracture, in order to provide reference for the clinical treatment of patients with lateral collateral ligament injury and lateral malleolus avulsion fracture. Methods A total of 63 patients with lateral collateral ligament injury and lateral malleolus avulsion fracture treated in Beijing Chaoyang Hospital, Capital Medical University, from August 2017 to June 2021 were included in this study. According to the surgical method, the included patients were divided into two groups. Thirty-three cases in group A were treated with anatomic repair of the anterior talofibular ligament (fixation and resection according to the size of the fracture fragment), and 30 cases in group B were treated with plaster immobilization. After treatment, the two groups were followed up regularly to observe the pain, range of motion, walking gait and movement status of the affected ankle joint. The visual analog scale (VAS) pain score, American orthopedic foot and ankle society (AOFAS) score, Karlsson-Peterso ankle joint function score, and talus anterior displacement were compared and analyzed before and after operation. Results There were statistically significant differences of the VAS scores between the two groups, time and interaction (P ＜ 0.05). Among them, the 6 and 18 months after operation in the two groups were lower than those before operation, and the 18 months after operation was lower than that at 6 months after operation, and the differences were statistically significant (P ＜ 0.05); 6 months after operation the VAS score of group A was lower than that of group B, and the difference was statistically significant (P ＜ 0.05). The postoperative Karlsson score of the two groups were higher than that before operation, while the group A was higher than the group B, and the differences were statistically significant (P ＜ 0.05). There were statistically significant differences of AOFAS score between the two groups, time and interaction (P ＜ 0.05). The AOFAS scores of the two groups at 1, 3, and 18 months after the operation were higher than those before the operation, while the AOFAS scores of the group A at the 3 and 18 months after the operation were higher than those at the 1 month after the operation, and the AOFAS scores of the two groups at 18 months after the operation were higher than those at 3 months after the operation, and the differences were statistically significant (P ＜ 0.05); the AOFAS score of group A was higher than that of group B at 3 and 18 months after operation, and the differences were statistically significant (P ＜ 0.05). There were statistically significant differences in the distance of talus advancement difference between the two groups, time and interaction (P ＜ 0.05). Among the two groups, the distance of talus advancement difference at 12 and 18 months after operation were lower than that before operation, while the distance of talus advancement difference at 18 months after operation was higher than that at 12 months after operation, and the differences were statistically significant (P ＜ 0.05); at 12 and 18 months after operation, the distance of talus advancement difference in group A were higher than that in group B, and the differences were statistically significant (P ＜ 0.05). Conclusion Anatomical repair of the anterior talofibular ligament in the treatment of avulsion fractures of the lateral malleolus with lateral collateral ligament injury is more effective than conservative plaster immobilization, with faster recovery and better joint stability.
		2022 Vol. 19 (9): 99-102,119 [Abstract] ( 117 ) HTML (1 KB) PDF (808 KB) ( 25 )

	103	Analysis of the characteristics of seventy-six Children with Klebsiella pneumoniae bloodstream infection#br#
		ZHANG Chuanling1 ZHANG Yinghua2▲ LIU Wen1 ZHANG Yan1 HOU Dongni3
		Objective To investigate the characteristics of Klelbsiela pneumoniae bloodstream infection (KPBSI) of children in Xuzhou area, in order to provide basis for clinical drug therapy. Methods Clinical and laboratory infectivity indexes, and drug sensitivity tests of children with KPBSI from January 2015 to July 2021 in Xuzhou Children’s Hospital of Jiangsu Province were retrospectively analyzed. Results There were 19 cases of sepsis and 17 cases of pneumonia in 76 children with KPBSI, and 50 cases with fever, 15 cases with cough. The percentages of peripheral blood white blood cell (WBC), C-reactive protein, and procalcitonin increased, 63.2%, 95.1%, and 87.0% respectively. 16 strains (21.1%) of carbapenem-resistant Klebsiella pneumoniae (CRKP) were detected, and 60 strains (78.9%) of CRKP were detected. CRKP has a high drug resistance rate to all cephalosporin, amtronam and β-lactamase inhibitor compounds. Most of the children with CRKP were neonates, abnormal laboratory indicators and obvious clinical symptoms. Conclusion CRKP children have high drug resistance rate to commonly used drugs, and its clinical characteristics are obvious.
		2022 Vol. 19 (9): 103-106 [Abstract] ( 125 ) HTML (1 KB) PDF (545 KB) ( 28 )

	107	Application effect of self-formulated Yishen Huoxue Prescription for intra uterine adhesions patients with kidney deficiency and blood stasis type after trans cervical resection adhesions operation#br#
		MENG Yuanyuan1 LI Lanlan1 WU Haiyan1 WEI Bing2 LIU Hongxia1
		Objective To investigate the clinical efficacy of self-formulated Yishen Huoxue Prescription for patients with intra uterine adhesions (IUA) after trans cervical resection adhesions (TCRA) operation. Methods A total of 118 patients with refractory IUA admitted to Tongling Hospital of Traditional Chinese Medicine in Anhui Province from June 2019 to March 2021 were selected, and they were divided into control group and observation group according to random number table method, with 59 cases in each group. Both groups were treated with TCRA. The control group was treated with estradiol Valerate Tablets combined with Progesterone Capsules after operation. On the basis of the control group, the observation group was treated with Yishen Huoxue Prescription for three months. The clinical efficacy was evaluated after treatment. IUA score, traditional Chinese medicine syndrome score, uterine cavity volume, endometrial thickness, resistance index (RI), pulbeat index (PI) and serum transforming growth fanctor-β (TGF-β1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels were compared between the two groups before and after treatment. The incidence of adverse reactions during treatment was compared between the two groups. Results The clinical efficacy of observation group was better than control group, the difference was statistically significant (P ＜ 0.05). After treatment, IUA score, traditional Chinese medicine syndrome score, RI, PI, serum TGF-β1 and TIMP-1 levels in two groups were lower than before, and which of the observation group were lower than those of control group, while uterine cavity volume and endometrial thickness in two groups were higher than before, and observation group was higher than control group, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Self-formulated Yishen Huoxue prescription for patients with IUA after TCRA operation can improve the curative effect, relieve symptoms, increase endometrial thickness, and regulate the expression of fibrosis factors in vivo.
		2022 Vol. 19 (9): 107-111 [Abstract] ( 117 ) HTML (1 KB) PDF (678 KB) ( 34 )

	112	Diagnostic efficiency of combined detection of brain natriuretic peptide, glucose, neuron-specific enolase and S-100β protein in severe hand, foot and mouth disease#br#
		XU Lijuan HAO Gailing ZHANG Nan ZHENG Shaomin JIA Xiqun ZHANG Zhongfu
		Objective To explore the value of combined detection of brain natriuretic peptide (BNP), glucose (Glu), neuron-specific enolase (NSE), and S-100β protein (S-100β) in severe hand, foot and mouth disease. Methods A retrospective analysis was performed on the clinical data of 100 children hospitalized and diagnosed with hand, foot and mouth disease in the Department of Emergency, Hebei Children’s Hospital Affiliated to Hebei Medical University from May 2017 to May 2020, as well as 100 children who underwent physical examination during the same period. According to severity of the disease, the children with hand, foot and mouth disease were divided into mild group (41 cases) and severe group (59 cases), and the healthy children were taken as control group. The levels of BNP, Glu, NSE, and S-100β in three groups were compared, the influencing factors of severe hand, foot and mouth disease were analyzed by logistic regression, and the value of BNP, Glu, NSE, S-100β and the four indexes combined in the diagnosis of severe hand, foot and mouth disease were analyzed by ROC curve. Results The levels of BNP, Glu, NSE, and S-100β in severe group were higher than those in mild group and control group (P < 0.05); the levels of Glu and NSE in mild group were higher than those in control group (P < 0.05). BNP, Glu, NSE, and S-100β were the independent influencing factors of severe hand, foot and mouth disease (P < 0.05). The area under the curve of BNP, Glu, NSE, and S-100β and the four indicators combined to predict severe hand, foot and mouth disease were 0.815, 0.880, 0.639, 0.910, 0.914, and the sensitivity were 88.1%, 83.1%, 37.3%, 88.1%, 89.8%, the specificity were 61.0%, 87.8%, 95.1%, 90.2%, 90.2%. Conclusion The levels of BNP, Glu, NSE, and S-100β in children with severe hand, foot and mouth disease are significantly higher than those in mild children and healthy children. The combined examination of the four indicators is conducive to the early diagnosis of children with severe hand, foot and mouth disease.
		2022 Vol. 19 (9): 112-115 [Abstract] ( 86 ) HTML (1 KB) PDF (654 KB) ( 30 )

	116	Effect of low molecular weight heparin on uterine artery blood flow, immune index and hormone level of uterine artery in patients with unexplained recurrent abortion#br#
		JIANG Lulu PENG Yuan LIANG Zhe
		Objective To explore the effects of low molecular weight heparin (LMWH) on uterine artery blood flow and immune indexes in patients with unexplained recurrent abortion (RA). Methods A total of 120 patients with unknown RA in Huaian Maternal and Child Health Hospital of Jiangsu Province from May 2018 to December 2020 were selected as the research subjects. They were divided into two groups according to the ball method, with 60 cases in each group. The control group received oral treatment with glucocorticoids and multivitamins, the observation group was treated with LMWH on the basis of the control group and treated until 12 weeks of gestation. The systolic to diastolic blood flow ratio systolic / diastolic (S/D), pulsatile index (PI), resistance index (RI), immune indexes and fetal preservation were compared between the two groups at 7, 10 and 12 weeks of gestation. Results After 12 weeks of treatment, the overall analysis found that the differences between groups, time point comparisons, and interaction S/D, PI, and RI, and the differences were statistically significant (P ＜ 0.05). Intra-group comparison, the differences at each time point in the two groups, and the differences were statistically significant (P ＜ 0.05), in comparison between groups, S/D, PI and RI of the observation group were lower than those of the control group at 12 weeks of gestation, and the difference were statistically significant (P ＜ 0.05); interferon -γ (IFN-γ), interleukin (IL)-2 and IL-8 decreaseds in both groups, and observation group was lower than control group, and the differences were statistically significant (P ＜ 0.05); the success rate of fetus preservation in the observation group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion LMWH can reduce uterine artery blood flow resistance in patients with unknown RA, regulate immune function and improve the success rate of fetal preservation.
		2022 Vol. 19 (9): 116-119 [Abstract] ( 82 ) HTML (1 KB) PDF (575 KB) ( 31 )

	120	Clinical effects comparison of two different artificial lacrimal ducts in the treatment of obstruction of anterior lacrimal passage#br#
		AN Yan JIANG Yanhua
		Objective To compare the clinical effects of two different artificial lacrimal ducts in the treatment of obstruction of anterior lacrimal passage. Methods A total of 132 patients who received obstruction of anterior lacrimal passage combined with artificial lacrimal duct implantation in the Fourth People’s Hospital of Shenyang from January 2018 to April 2020 were collected. They were divided into RS artificial lacrimal duct group (67 cases) and ring artificial lacrimal duct group (65 cases) according to their wishes. The two groups were extubated nine months after operation, followed up for three months after extubation, and the time, effects, and complications of operation were compared between the two groups. Results The operation time of RS artificial lacrimal duct group was shorter than that of ring artificial lacrimal duct group, and the total incidence of complications was lower than that of ring artificial lacrimal duct group, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the success rate of operation between the two groups (P ＞ 0.05). Conclusion In the operative process of patients with obstruction of anterior lacrimal duct, the advantages of RS artificial lacrimal duct are more prominent, which can reduce the incidence of operative complications, shorten the operation time, and provide a more reliable implant material for obstruction of anterior lacrimal duct, which is worthy of promotion by clinicians.
		2022 Vol. 19 (9): 120-122,131 [Abstract] ( 178 ) HTML (1 KB) PDF (583 KB) ( 39 )

	123	Application effects of minimally invasive ultra-thin veneer technology in the aesthetic restoration of patients with anterior interdental space#br#
		XU Xiaohua CAO Xiaoma HUANG Qing
		Objective To study the clinical application effects of minimally invasive ultra-thin veneer technology in the aesthetic restoration of patients with anterior interdental space. Methods A total of 160 patients with anterior interdental space admitted to the Department of Stomatology of the Second People’s Hospital of Hefei from January 2017 to April 2019 were selected as the research subjects. They were divided into observation group and control group by random number table method, 80 cases in each group. The observation group was treated with minimally invasive ultra-thin veneer, while the control group was treated with conventional all-ceramic veneer. After the treatment, the self-made questionnaire was used to investigate the evaluation of the aesthetic degree of the prosthesis in both groups. Meanwhile, the two groups were followed up for 18 months. After the follow-up, the two groups were evaluated by the United States Public Health Service dental prosthodontic evaluation criteria, and the incidence of complications between the two groups was compared. Results Eighteen months after treatment, there were no statistical significances in the evaluation of dentition integrity, natural color of tooth surface, natural edge of tooth surface, and tooth body permeability between the two groups (P ＞ 0.05). The total satisfaction rate of the observation group was higher than that of the control group, the difference was statistically significant (P ＜ 0.05). Eighteen months after treatment, the total incidence of complications in the observation group was lower than that in the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Minimally invasive ultra-thin veneer has a relatively comprehensive aesthetic effect of tooth restoration, and patients have higher satisfaction with the restoration and fewer long-term complications. In clinical practice, patients’ dental conditions and actual needs can be combined to select a better dental restoration program.
		2022 Vol. 19 (9): 123-126 [Abstract] ( 46 ) HTML (1 KB) PDF (788 KB) ( 65 )

	127	Analysis on medication rule of Professor Liu Hongfang in treating diabetic nephropathy based on data mining#br#
		SU Jiaming WANG Lin LI Sicheng WU Xi JIANG Wei SONG Jiayin LIU Hongfang
		Objective To analyze the medication rule of Professor Liu Hongfang in the treatment of diabetic nephropathy based on data mining. Methods Prescriptions were collected from January 2015 to July 2021 for outpatient visits by Professor Liu Hongfang in Dongzhimen Hospital, Beijing University of Chinese Medicine. The selected prescriptions were analyzed by Chinese medicine inheritance auxiliary platform software, and draw a conclusion. Results A total of 189 prescriptions were collected, involving 186 kinds of herbs, of which, warm and mild were the main ones; sweet, bitter and pungent medicines accounted for a large proportion; the liver, kidney and spleen meridians appeared more frequently. The top five most frequently used herbs were Rehmanniae Radix Praeparata, Corni Fructus, Astragali Radix, Dioscoreae Rhizoma, and Atractylodis Macrocephalae Rhizoma. The most frequently used drug combinations were Rehmanniae Radix Praeparata-Corni Fructus, Rehmanniae Radix Praeparata-Astragali Radix, Corni Fructus-Astragali Radix. Four potential new prescriptions were developed. Conclusion Professor Liu Hongfang uses nourishing kidney essence and eliminating pathogens to unblock collaterals as the main treatment method for diabetic nephropathy, the prescription medicines are mainly tonification, reinforcement and elimination in combination, dispelling pathogenic factors without damaging healthy qi, with accurate medication.
		2022 Vol. 19 (9): 127-131 [Abstract] ( 204 ) HTML (1 KB) PDF (1464 KB) ( 39 )

	132	Professor Zhou Hua’s experience summary in treating heart failure based on the pathogenesis theory of “yang weakness and yin exuberance”#br#
		LIU Wenrui QU Huiyan WANG Tian TANG Qiaolin ZHOU Hua
		Heart failure is the end stage of various cardiovascular diseases. It has the clinical characteristics of high mortality, high hospitalization rate and high recurrence rate. Professor Zhou Hua considers that heart failure is the syndrome of root deficiency and tip excess, and its basic pathogenesis is yang weakness and yin exuberance. Yang weakness is the deficiency of body, which mainly means yang deficiency of heart and kidney. Yin exuberance is tip excess, which mainly means phlegm turbidity, fluid and blood stasis. As for the treatment, it is emphasized to treat heart from kidney, which can be divided into three stages: early stage, middle stage and late stage. In the early stage, yang deficiency of kidney is the major syndrome, warming and tonifying kidney yang is the treatment method, and Lujiao Prescription is selected. In the middle stage, kidney deficiency and blood stasis is the major syndrome, and Luhong Prescription is used to warm kidney and activate blood circulation. In the later stage, Luqi Prescription is selected for kidney deficiency, blood stasis, and fluid retention. Professor Zhou Hua has achieved marvelous clinical results in the treatment of heart failure according to the modified application of three prescriptions.
		2022 Vol. 19 (9): 132-135 [Abstract] ( 40 ) HTML (1 KB) PDF (609 KB) ( 72 )

	136	Clinical efficacy of moxibustion combined with electrical stimulation biofeedback in the treatment of pelvic organ prolapse#br#
		HU Qian1 ZHAO Di1 MA Xiaona2 XU Jia1
		Objective To evaluate the clinical efficacy of moxibustion combined with electrical stimulation biofeedback in the treatment of pelvic organ prolapse. Methods Sixty-one patients with pelvic organ prolapse (degree Ⅰ-Ⅱ) admitted to Gynecology Clinic of Beijing University of Chinese Medicine Third Affiliated Hospital from June 2020 to June 2021 were selected as the study subjects. They were divided into two groups according to the random number table method, with 30 cases in control group and 31 cases in observation group. The patients in control group were treated with electrical stimulation biofeedback therapy twice a week for three months. Observation group was treated with moxibustion on the basis of the treatment in control group once every other day for three months. The measured values of pelvic floor surface electromyography at each contraction stage, pelvic floor distress inventory-short form 20 (PFDI-20) score, pelvic floor impact questionnaire-7 (PFIQ-7) score and Chinese medicine syndrome score before and after treatment were compared between two groups. Results After treatment, the measured values of pelvic floor surface electromyography at rapid contraction stage, continuous contraction stage and durable contraction stage in observation group were higher than those before treatment, and the differences were statistically significant (P < 0.05). After treatment, the scores of PFDI-20 and PFIQ-7 in two groups were lower than those before treatment, and those in observation group were lower than those in control group, the differences were statistically significant (P < 0.05). After treatment, Chinese medicine syndrome score of two groups was lower than that before treatment, and that of observation group was lower than that of control group, the differences were statistically significant (P < 0.05). Conclusion Electrical stimulation biofeedback combined with moxibustion can significantly improve pelvic floor muscle strength and pelvic organ prolapse in patients with pelvic organ prolapse. At the same time, it can adjust the symptoms of qi deficiency, improve the clinical symptoms and quality of life of patients.
		2022 Vol. 19 (9): 136-139 [Abstract] ( 44 ) HTML (1 KB) PDF (563 KB) ( 38 )

	140	Summary of investigation and research of the origin of academic development and inheritance status of branches of famous schools in Longjiang medicine#br#
		LI Fuzhen SU Jinfeng JIANG Deyou
		This paper is based on years of research results, systematically combs the development sources of multivariate convergence of Longjiang medicine, extracts the diagnosis and treatment characteristics of Longjiang medicine, such as the correlation between phlegm and blood stasis, water and blood common treatment, and the promote simultaneously of warm, moist, and clear, and the paper outlines the inheritance status of branches of 12 famous schools in Longjiang medicine such as Gao’s internal medicine for the first time, excavates and explains the characteristics of schools, such as the method of applying big prescription to treat again, Hui nationality medicine characteristic external treatment, gynecology “liver and kidney theory”, medulla oblongata paralysis nape needle treatment, etc., it is concluded that the investigation and study of Longjiang medicine should be closely combined with the special natural and social factors of Longjiang region, it’s not inferred.
		2022 Vol. 19 (9): 140-143 [Abstract] ( 78 ) HTML (1 KB) PDF (717 KB) ( 95 )

	144	Experience of Professor Han Yanhua in the diagnosis and treatment of maternal-fetal blood group incompatibility#br#
		LIU Xiaofang1 HAN Yanhua1 SU Meng2 WANG Qingyi1
		The national traditional Chinese medicine master Professor Han Yanhua has enriched experience in maternal-fetal blood group incompatibility, and believes that maternal-fetal blood group incompatibility is mainly the syndrome of root deficiency and tip excess. Deficiency of spleen and kidney, thoroughfare vessel and conception vessel malnutrition, dereliction of duty in storage are root; steaming of humid, hot, and toxin are tip. For this disease, the remaining evils should be eliminated before pregnancy, the damage should be pre-treated, and the disease should be prevented first; treating disease and tranquilizing fetus to prevent miscarriage should be carried out in early pregnancy, invigorating kidney and spleen and tranquilizing fetus to prevent miscarriage, and clearing damp-heat at the same time; late pregnancy is mainly to clear damp-heat, accompanied by activating blood and resolving stasis. This article combines Professor Han Yanhua’s diagnosis and treatment of maternal-fetal blood group incompatibility cases, expounds Professor Han Yanhua’s academic thoughts and clinical ideas for differentiation and treatment of the disease, prescriptions and medications, in order to inspire clinical diagnosis and treatment.
		2022 Vol. 19 (9): 144-147,152 [Abstract] ( 200 ) HTML (1 KB) PDF (806 KB) ( 56 )

	148	Professor Huang Kaixing’s medication experience in treating stomachache#br#
		ZHANG Xinyue1 LI Jiang2 LIU Wei3 LIU Dingding2 XIE Youliang1 YAN Qin1
		Stomachache is mainly characterized by pain in the upper abdomen stomach duct near the precordia, it has seriously harmed people’s health and quality of life. Professor Huang is good at distinguishing Yin and Yang first and then discussing the treatment strategy in clinic, he believes that deficiency-cold in middle jiao and insufficiency of stomach yin are the basic pathogenesis of this disease. At the same time, he believes that disharmony of liver and stomach has an important position in stomachache. Professor Huang administeres different drugs according to different pathogenesis, and good at using couplet drugs. The treatment methods include warming spleen and stomach for dispelling cold, regulating qi-flowing for harmonizing stomach, nourishing yin for benefiting stomach, suppressing wood and soothing soil. This paper reviews the related literature on stomachache, introduces the understanding of stomachache by physicians in past dynasties, and uses traditional Chinese medicine dialectical thinking combined with Professor Huang’s clinical experience, expatiates Professor Huang’s thinking of diagnosing etiology and pathogenesis and distinguishing disease location, prevents and treats of stomachache caused by deficiency-cold in middle jiao and insufficiency of stomach yin.
		2022 Vol. 19 (9): 148-152 [Abstract] ( 43 ) HTML (1 KB) PDF (763 KB) ( 52 )

	153	Effect of ultrasonic visualization of jingjin bowstring acupotomy dissolution technique in treatment of knee osteoarthritis#br#
		LIU Jing1 ZHAO Hongjia2 LIN Qiaoxuan3 LU Liming3 GUO Zexing3 GONG Yurong2 ZENG Weiquan4 XIU Zhongbiao1
		Objective To observe the clinical effect of ultrasonic visualization of jingjin bowstring acupotomy dissolution technique in treatment of knee osteoarthritis (KOA). Methods Seventy-six patients diagnosed with KOA in Acupotomy Studio of Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine from February 2020 to February 2021 were selected and they were divided into ultrasonic acupotomy group and traditional acupotomy group according to random number table method, with 38 cases in each group. The ultrasonic acupotomy group was treated with ultrasonic visualization acupotomy, while the traditional acupotomy group was treated with non-direct acupotomy dissolution therapy. The treatment points were all “hèdǐngci”, “binneixia”, “binwaixia”, and “yinlingshang”, once a week for four consecutive times. Visual analogue scale (VAS), Western Ontario and McMaster University osteoarthritis index (WOMAC), and the pinnate angle, muscle thickness and elastic strain rate of rectus femoris which were detected by ultrasound were compared between the two groups before treatment and at three months follow-up, and the occurrence of adverse reactions between the two groups were observed. Results Before treatment, there were no significant differences in VAS, WOMAC score, and indicators of rectus femoris muscle ultrasound detection between the two groups (P ＞ 0.05). At three months follow-up, VAS and WOMAC score in both groups were decreased compared with before treatment, pinnate angle and muscle thickness of rectus femoris muscle were increased compared with before treatment, and elastic strain rate was decreased compared with before treatment, while the VAS and WOMAC score of the ultrasonic acupotomy group were lower than those of the traditional acupotomy group, the pinnate angle and muscle thickness of rectus femoris were higher than those of the traditional acupotomy group, and the elastic strain rate was lower than that of the traditional acupotomy group, with statistical significance (P ＜ 0.05). There were no obvious adverse reactions in both groups. Conclusion Ultrasonic visualization of jingjin bowstring acupotomy dissolution technique can adjust the structure and hardness of rectus femoris muscle, effectively improve joint pain and dysfunction in patients with KOA, and the efficacy is better than traditional acupotomy dissolution technique.
		2022 Vol. 19 (9): 153-156,172 [Abstract] ( 181 ) HTML (1 KB) PDF (779 KB) ( 58 )

	157	Clinical effect of ultrasound-guided acupotomy to dissolve ligamentum flavum in treatment of lumbar disc herniation#br#
		LIN Xiuhua LIU Cunbin GENG Kai LUO Shiyu LI Tao WU Liangliang YANG Yonghui
		Objective To observe the clinical effect of ultrasound-guided acupotomy to dissolve ligamentum flavum in treatment of lumbar disc herniation. Methods A total of 60 patients with lumbar disc herniation diagnosed and treated in Department of Acupotomy Rehabilitation, Anhui Hospital of Integrated Traditional Chinese and Western Medicine from March 2019 to December 2020 were selected and they were divided into control group and treatment group according to random number table method, with 30 patients in each group. The control group was treated with conventional ultrasound-guided acupotomy. The treatment group was additionally treated with the dissolution of ligamentum flavum of the affected side of the prominent segment on the basis of the control group, once every seven days for four consecutive times. Modified Japanese orthopaedic association scale (M-JOA) score, visual analogue scale (VAS) score and clinical efficacy were compared between the two groups before and after treatment. Results Before treatment, there was no significant difference in M-JOA and VAS scores between the two groups (P ＞ 0.05). After treatment, M-JOA and VAS scores in the two groups were significantly lower than those before treatment, and the treatment group was lower than the control group, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). The clinical efficacy of the treatment group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The treatment of lumbar disc herniation is effective in both groups, but the treatment of ultrasound-guided acupotomy to dissolve ligamentum flavum is more effective.
		2022 Vol. 19 (9): 157-160 [Abstract] ( 199 ) HTML (1 KB) PDF (800 KB) ( 40 )

	161	Clinical effect of acupotomy for treatment of subacromial impingement syndrome based on anatomic structure-selected#br#
		TIAN Xiangdong1 ZHOU Liqun2 ZHAO Jiping1 HUANG Ye3 DING Tiansong3
		Objective To observe the clinical effect of acupotomy for treatment of subacromial impingement syndrome based on anatomic structure-selected. Methods A total of 120 patients with subacromial impingement syndrome in the Department of Minimally Invasive Joint Arthrology Clinic of Beijing University of Chinese Medicine Third Affiliated Hospital from April 2020 to May 2021 were selected and they were divided into control group and experimental group according to random number table method, with 60 patients in each group. The control group was given conventional oral Diclofenac Sodium Sustained-release Tablets combined with plaster application, and the experimental group was given acupotomy treatment based on the control group. Shoulder pain and shoulder function were assessed using visual analogue scale (VAS) and Constant-Murley shoulder function score before and at 1, 2, and 4 weeks after treatment. Results Overall analysis: there were statistically significant differences in VAS scores between the two groups, time point comparison and interaction (P ＜ 0.05). Intra-group comparison: VAS scores of both groups at 1, 2 and 4 weeks after treatment were lower than those before treatment, VAS scores at 2 and 4 weeks after treatment were lower than those at 1 week after treatment, VAS score at 4 weeks after treatment was lower than that at 2 weeks after treatment, the differences were statistically significant (P ＜ 0.05). Comparison between groups: at 1, 2 and 4 weeks after treatment, VAS score of experimental group was lower than that of control group, the differences were statistically significant (P ＜ 0.05). Overall analysis: there were statistically significant differences in Constant-Murley scores between the two groups, time point comparison and interaction (P ＜ 0.05). Intra-group comparison: Constant-Murley scores of both groups at 1, 2 and 4 weeks after treatment were higher than those before treatment, Constant-Murley scores at 2 and 4 weeks after treatment were higher than those at 1 week after treatment, Constant-Murley score at 4 weeks after treatment was higher than that at 2 weeks after treatment, the differences were statistically significant (P ＜ 0.05). Conclusion Acupotomy treatment of subacromial impact syndrome based on specific anatomical structure-selected can effectively relieve shoulder pain and improve shoulder joint abduction, flexion and internal rotation, and the improvement effect is obvious immediately after treatment, the effect is significantly better than oral Diclofenac Sodium Sustained-release Tablets combined with local plaster application.
		2022 Vol. 19 (9): 161-164 [Abstract] ( 116 ) HTML (1 KB) PDF (570 KB) ( 46 )

	165	Clinical effect of acupotomy combined with stellate ganglion block on cervical vertigo#br#
		HU Guoqiang1 DU Xiaonan1 TIAN Jiaqi2
		Objective To observe the clinical effect of acupotomy combined with stellate ganglion block on cervical vertigo (CV) patients, and to provide ideas and methods for the treatment and research of CV. Methods A total of 60 CV patients admitted to Shijiazhuang Hospital of Traditional Chinese Medicine from January 2020 to January 2021 were selected and they were divided into control group and treatment group by random number table method, with 30 cases in each group. The control group was treated with stellate ganglion block once a week, twice in total. The treatment group was treated with acupotomy once a week on the basis of the control group, twice in total. The cervical vertigo symptoms and functional assessment scales (ESCV) and transcranial doppler (TCD) were performed in both groups before and after treatment, and the data of the two groups were compared before and after treatment. The clinical efficacy of the two groups was observed and compared. Results Before treatment, there were no significant differences in ESCV score, mean blood flow velocity, peak systolic blood flow velocity, and end diastolic blood flow velocity between the two groups (P ＞ 0.05). After treatment, ESCV score, mean blood flow velocity, peak systolic blood flow velocity, and end diastolic blood flow velocity in the two groups were higher than before treatment, and the treatment group was higher than the control group, the differences were statistically significant (P ＜ 0.05). The clinical efficacy of the treatment group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Acupotomy combined with stellate ganglion block is effective in the treatment of CV and has clinical significance. Its long-term efficacy needs further clinical verification.
		2022 Vol. 19 (9): 165-168,176 [Abstract] ( 110 ) HTML (1 KB) PDF (721 KB) ( 44 )

	169	Effect of husband and wife synchronous health education combined with psychological intervention on psychological status and pregnancy rate of patients after embryo transfer#br#
		XIE Zhenhui DIAO Yongping▲ LUO Fang
		Objective To explore the effect of husband and wife synchronous health education combined with psychological intervention on the psychological state and pregnancy rate of patients after embryo transfer. Methods A total of 60 patients admitted to the Department of Traditional Chinese Medicine, Liuzhou People’s Hospital, Guangxi Zhuang Autonomous Region from July 2019 to February 2021 after embryo transfer were selected as the research objects. They were divided into observation group and control group by random number table method, with 30 cases in each group. In the observation group, husband and wife synchronous health knowledge education combined with psychological intervention was used; the control group was treated with routine health knowledge education combined with psychological intervention, and the spouse did not participate in health knowledge education and psychological intervention. The awareness rate of health knowledge, psychological status and pregnancy outcome were compared between the two groups before and after intervention. Whether husband and wife synchronous health knowledge education combined with psychological intervention can improve the adverse psychological state and clinical pregnancy rate of patients after embryo transfer were evaluated. Results After intervention, the health knowledge awareness rate of two groups was higher than before intervention, and the observation group was higher than the control group, and the differences were statistically significant (P ＜ 0.05); the scores of self-rating anxiety scale, self-rating depression scale and symptom check-list in the two groups were lower than before intervention, and the observation group was lower than the control group, the differences were statistically significant (P ＜ 0.05); after the intervention, the number of clinical pregnancies in the observation group was more than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Simultaneous health education of husband and wife combined with psychological intervention can effectively improve the adverse psychological state of patients after embryo transfer and increase the clinical pregnancy rate of patients.
		2022 Vol. 19 (9): 169-172 [Abstract] ( 91 ) HTML (1 KB) PDF (575 KB) ( 37 )

	173	Application of directional health guidance based on patients’ feedback in extended nursing after radiofrequency ablation of paroxysmal supra-ventricular tachycardia#br#
		GAO Huimin WANG Xu WANG Lin▲
		Objective To investigate the application of directional health guidance based on patients’ feedback in extended nursing after radiofrequency catheter ablation (RFCA) of paroxysmal supra-ventricular tachycardia (PSVT). Methods A total of 90 PSVT patients treated with RFCA from May 2019 to April 2021 in Jiangsu Provincial People’s Hospital were selected, according to random number table, the patients were divided into routine group and observation group, with 45 cases in each group. The routine group received routine extended nursing intervention after discharge, while the observation group received routine extended nursing and directional health guidance based on patients’ feedback after discharge, and all of them were intervened for three months. The scores of health knowledge before and after intervention, the complete compliance rates of taking medicine and incidence rates of adverse events of anticoagulants were compared between the two groups. Results The scores of health knowledge in the two groups after the intervention were higher than those before the intervention, and the observation group after the intervention was higher than that in the routine group (P ＜ 0.05). The complete compliance rate of taking medicine in the observation group was higher than the routine group (P ＜ 0.05). The incidence rate of adverse events of anticoagulants in the observation group was lower than the routine group (P ＜ 0.05). Conclusion The application of directional health guidance based on patients’ feedback in extended nursing after RFCA of PSVT patients is helpful to improve the level of patients’ health knowledge, improve taking medicine compliance, and it can reduce the incidence rate of adverse event of anticoagulants.
		2022 Vol. 19 (9): 173-176 [Abstract] ( 146 ) HTML (1 KB) PDF (578 KB) ( 49 )

	177	Application of the health education model of knowledge, letter and behavior in the department of infectious diseases in improving the awareness rate of disease-related knowledge among parents of children with scarlet fever#br#
		ZHANG Yujing1 JIANG Lili2▲ GE Xiaohua1 LI Rui1 ZHANG Danni1
		Objective To explore the role of the health education model of knowledge, belief and practice in the department of infectious diseases in improving the awareness rate of disease-related knowledge among parents of children with scarlet fever. Methods A total of 100 parents of children with scarlet fever who were admitted to the Department of Infectious Diseases, Children’s Hospital of Capital Institute of Pediatrics from June 2020 to June 2021 were selected as the research objects. According to the random number table method, they were divided into the control group and the observation group, with 50 people in each group. The control group received routine health education guidance, and the observation group received knowledge, belief and action health education guidance from the department of infection, the awareness rate and coping style of the parents of the two groups were compared. Results After the intervention, the awareness rate of disease knowledge in the two groups was higher than before the intervention, and the observation group was higher than the control group (P ＜ 0.05); after the intervention, yield and avoidance subscale scores of the two groups were lower than before the intervention, and the face subscale scores was higher than before the intervention, and yield and avoidance subscale scores of the observation group were lower than those of the control group, and the face subscale score was higher than that of the control group (P ＜ 0.05). Conclusion The implementation of health education on knowledge, belief and practice for parents of children with scarlet fever in the department of infectious diseases can significantly increase their awareness of disease-related knowledge, improve their coping styles, and promote disease outcomes.
		2022 Vol. 19 (9): 177-180,193 [Abstract] ( 155 ) HTML (1 KB) PDF (725 KB) ( 51 )

	181	A case report of SOX regimen combined with terriprizumab in treatment of intermediate and advanced combined hepatocellular-cholangiocarcinoma#br#
		HE Yalin1 YANG Jiaxin1 CHENG Zhiqiang2
		Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare type of primary hepatocellular carcinoma, which has differentiation characteristics of hepatocellular carcinoma and cholangiocarcinoma, it is considered an aggressive tumor with poor prognosis and little improvement in survival. For unresectable cHCC-CCA, the evidence of standard treatment is limited, and there are few reports about it at home and abroad. This paper reports a case of stage ⅢB cHCC-CCA who was unable to undergo radical resection at the time of diagnosis, after 15 cycles of SOX chemotherapy plus terriprizumab, finally, the diagnosis and treatment process of complete pathological remission was achieved. In order to improve the clinical diagnosis and treatment level of cHCC-CCA, retrospective case analysis and literature review.
		2022 Vol. 19 (9): 181-184 [Abstract] ( 190 ) HTML (1 KB) PDF (1750 KB) ( 40 )

	185	Bibliometric analysis of demoralization syndrome based on Web of Science database#br#
		TAN Jianing SHEN Zhijia HAN Juan WANG Min SHAO Shihe LUO Caifeng
		Objective To promote the progress of domestic study by analyzing research status of demoralization syndrome abroad. Methods Using Web of Science as data source, the article relevant to demoralization syndrome from inception of the database up to February 2021 was searched. The CiteSpace software performed statistical analysis on the related literatures of amnesia syndrome. Results A total of 351 papers were included. The country with the highest number of papers was the United States, the institution with the highest number of papers was Monash University, and the authors with the highest number of papers were Kissane DW and Fava GA. The research area involved multiple disciplines like psychiatry and health care services. Keyword clustering containd critical illness, stress, community prevention, suicide intention, precise intervention, etc. According to timeline of co-citation clustering, the literatures were phenomenology, breast cancer patient, mediation model, postnatal demoralisation, short version, etc. Conclusion The overseas study can broaden research area of demoralization syndrome, provide new idea for risk prevention, clinical management and intervention.
		2022 Vol. 19 (9): 185-189 [Abstract] ( 171 ) HTML (1 KB) PDF (1794 KB) ( 173 )

	190	Analysis on the process, effect, and problem of standardized training for residents in China#br#
		LI Ni1 LIU Tiemei2
		Standardized training for residents is a systematic and standardized training, aiming to improve the clinical ability of medical graduates, and it has been routinely incorporated into the medical education system. Standardized training system for residents in China has been put forward and fully implemented, has experienced start-up, experiment, establishment, and implementation of four stages. Some achievements have been made since its full implementation, but there are still many problems. This paper reviews the course of the standardized training for residents in China, summarizes the achievements since its comprehensive implementation, analyzes the existing problems, and puts forward corresponding suggestions.
		2022 Vol. 19 (9): 190-193 [Abstract] ( 126 ) HTML (1 KB) PDF (1269 KB) ( 105 )

	194	Analysis on worldwide status of basic researches of artificial intelligence assisted biomarker research based on bibliometric #br#
		WANG Tingting CHEN Juan ZHANG Ting OUYANG Zhaolian
		Objective To analysis the worldwide status and basic of researches on artificial intelligence (AI)-assisted in biomarker research. Methods Literature on AI-assisted biomarker research was retrieved from Web of Science database, and the global research status was analyzed by bibliometrics. Results From 1970 to July 2020, a total of 10 281 papers on research have been published, with a compound growth rate of 21.36% in the past decade. The United States leads other countries in the number of papers (4331 papers), total cited times (114 774 times) and highly cited papers (80 papers), and 16 institutions were among the top 25 in the world with the most international cooperation. The number of papers published in the UK and Germany (1125 papers and 992 papers respectively) and the total citation frequency (28 588 and 26 601 respectively) were among the top in the world, with a lot of international cooperation. The number of Chinese papers (2250 papers) was second only to that of the United States, but the number of cited papers per paper (11.61 times) and highly cited papers per paper (35 papers) was low. Only three institutions were among the top in the world, and the international cooperation was not strong enough. Conclusion In the past decade, basic researces of AI-assisted biomarker has developed rapidly in this field. The quantity of scientific papers in China ranked second, however the influence is relatively weak.
		2022 Vol. 19 (9): 194-封三 [Abstract] ( 175 ) HTML (1 KB) PDF (1295 KB) ( 130 )

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