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Analysis on medication rule of Professor Liu Hongfang in treating diabetic nephropathy based on data mining#br# |
SU Jiaming WANG Lin LI Sicheng WU Xi JIANG Wei SONG Jiayin LIU Hongfang |
Department of Nephrology and Endocrinology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China |
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Abstract Objective To analyze the medication rule of Professor Liu Hongfang in the treatment of diabetic nephropathy based on data mining. Methods Prescriptions were collected from January 2015 to July 2021 for outpatient visits by Professor Liu Hongfang in Dongzhimen Hospital, Beijing University of Chinese Medicine. The selected prescriptions were analyzed by Chinese medicine inheritance auxiliary platform software, and draw a conclusion. Results A total of 189 prescriptions were collected, involving 186 kinds of herbs, of which, warm and mild were the main ones; sweet, bitter and pungent medicines accounted for a large proportion; the liver, kidney and spleen meridians appeared more frequently. The top five most frequently used herbs were Rehmanniae Radix Praeparata, Corni Fructus, Astragali Radix, Dioscoreae Rhizoma, and Atractylodis Macrocephalae Rhizoma. The most frequently used drug combinations were Rehmanniae Radix Praeparata-Corni Fructus, Rehmanniae Radix Praeparata-Astragali Radix, Corni Fructus-Astragali Radix. Four potential new prescriptions were developed. Conclusion Professor Liu Hongfang uses nourishing kidney essence and eliminating pathogens to unblock collaterals as the main treatment method for diabetic nephropathy, the prescription medicines are mainly tonification, reinforcement and elimination in combination, dispelling pathogenic factors without damaging healthy qi, with accurate medication.
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