|
|
|
| Study on influencing factors of hyperuricemia in patients with type 2 diabetes mellitus#br# |
| MU Lin1 LI Chao2 ZHAO Wenying1 DONG Huan1 WANG Yuan1 LI Xin1 ZHANG Baoyu1 YANG Longyan3 |
1.Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China;
2.Department of Cardiology, the First Medical Center, Chinese PLA General Hospital, Beijing 100039, China;
3.Beijing Key Laboratory of Diabetes Research and Care, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China |
|
|
|
Abstract Objective To explore the influencing factors of hyperuricemia in type 2 diabetes mellitus. Methods A total of 3427 patients with type 2 diabetes mellitus admitted to the Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University from October 2017 to February 2021 were retrospectively enrolled, and their data of demographic, clinical, and lifestyle were collected. They were divided into hyperuricemia group (399 cases) and control group (3028 cases) according to whether they were complicated with hyperuricemia. Univariate and multivariate analyses were conducted to evaluate the influencing factors of hyperuricemia in patients with type 2 diabetes mellitus. Results Systolic blood pressure, diastolic blood pressure, height, weight, body mass index, waist circumference, proportion of hypertension, proportion of hyperlipidemia, proportion of coronary heart disease, proportion of peripheral vascular disease, proportion of intake of adequate soy products, and proportion of annual income > 100 000 yuan in hyperuricemia group were all higher than those in control group, the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that hypertension, hyperlipidemia, annual income > 100 000 yuan, and adequate intake of soy products were independent risk factors for hyperuricemia in patients with type 2 diabetes mellitus (OR ＞ 1, P ＜ 0.05). Conclusion Hypertension, hyperlipidemia, annual income > 100 000 yuan, and adequate intake of soy products are the influencing factors of hyperuricemia in patients with type 2 diabetes mellitus.
|
|
|
|
|
|
[1] Li L，Zhang Y，Zeng C. Update on the epidemiology，genetics，and therapeutic options of hyperuricemia [J]. Am J Transl Res，2020，12（7）：3167-3181.
[2] 中华医学会内分泌学分会.中国高尿酸血症与痛风诊疗指南（2019）[J].中华内分泌代谢杂志，2020，36（1）：1-13.
[3] Liu R，Han C，Wu D，et al. Prevalence of hyperuricemia and gout in mainland China from 2000 to 2014：A Systematic Review and Meta-analysis [J]. Biomed Res Int，2015（2015）：762820.
[4] 王荣，汤哲，孙菲，等.中国7城市老年人高尿酸血症患病率调查[J].中华流行病学杂志，2018，39（3）：286-288.
[5] 张凤，赵亮.房颤患者血清尿酸水平与心功能的相关性分析[J].中国医药科学，2020，10（13）：220-222，229.
[6] 陈蕾，伍成凯，康峻鸣，等.我国45岁及以上中老年人群高尿酸血症与常见慢性病的关联研究[J].中国全科医学，2021，24（4）：72-77.
[7] 曾朝东，邹蓉，陈丽清，等.高尿酸血症对急性冠脉综合征患者动脉硬化影响分析[J].中国医药科学，2020，10（15）：252-254.
[8] Bardin T，Richette P. Definition of hyperuricemia and gouty conditions [J]. Curr Opin Rheumatol，2014，26（2）：186-191.
[9] Paul BJ，Anoopkumar K，Krishnan V. Asymptomatic hyperuricemia：is it time to intervene？[J]. Clin Rheumatol，2017，36（12）：2637-2644.
[10] Bardin T，Richette P. Impact of comorbidities on gout and hyperuricaemia：an update on prevalence and treatment options [J]. BMC Med，2017，15（1）：123.
[11] 中华医学会，中华医学会杂志社，中华医学会全科医学分会，等.痛风及高尿酸血症基层诊疗指南（2019年）[J].中华全科医师杂志，2020，19（4）：293-303.
[12] Thottam GE，Krasnokutsky S，Pillinger MH. Gout and Metabolic Syndrome：a Tangled Web [J]. Curr Rheumatol Rep，2017，19（10）：60.
[13] Tung YC，Lee SS，Tsai WC，et al. Association between gout and incident type 2 diabetes mellitus：A Retrospective Cohort Study [J]. Am J Med，2016，129（11）：1219.e17-1219.e25.
[14] Juan J，Yang H. Prevalence，prevention，and lifestyle intervention of gestational diabetes mellitus in China [J]. Int J Environ Res Public Health，2020，17（24）：9517.
[15] 中华医学会糖尿病学分会.中国2型糖尿病防治指南（2020年版）[J].中华糖尿病杂志，2021，13（4）：315-409.
[16] Mayfield J. Diagnosis and classification of diabetes mellitus：new criteria [J]. Am Fam Physician，1998，58（6）：1355-1362.
[17] 肖元元，姜智峰，蒋伏松，等.不同糖代谢水平人群血尿酸水平与体脂分布的相关性分析[J].中国全科医学，2021，24（21）：2675-2679.
[18] Lai YJ，Chen YY，Ku PW，et al. Association between uric acid level and incidence of albuminuria in patients with type 2 diabetes mellitus：A 4.5-year cohort study [J]. Medicine，2021，100（41）：e27496.
[19] Liu N，Xu H，Sun Q，et al. The role of oxidative stress in hyperuricemia and Xanthine Oxidoreductase（XOR）Inhibitors [J]. Oxid Med Cell Longev，2021，2021（73）：1-15.
[20] Martínez-Sánchez FD，Vargas-Abonce VP，Guerrero-Castillo AP，et al. Serum uric acid concentration is associated with insulin resistance and impaired insulin secretion in adults at risk for type 2 diabetes [J]. Prim Care Diabetes，2021，15（2）：293-299.
[21] Yan D，Tu Y，Jiang F，et al. Uric Acid is independently associated with diabetic kidney disease：a cross-sectional study in a Chinese population [J]. PloS One，2015，10（6）：e0129797.
[22] Kim HS. Serum uric acid and metabolic syndrome：a Retrospective Cohort Study [J]. J Korean Med Sci，2019， 34（48）：e324.
[23] 戴德栋，陆少玲，叶燕平，等.2型糖尿病患者合并高尿酸血症的独立影响因素[J].智慧健康，2021，7（26）：69-71.
[24] Jeong J，Suh YJ. Association between serum uric acid and metabolic syndrome in Koreans [J]. J Korean Med Sci，2019，34（48）：e307.
[25] Lemieux I，Després JP. Metabolic Syndrome：Past，Present and Future [J]. Nutrients，2020，12（11）：3501.
[26] Li C，Hsieh MC，Chang SJ. Metabolic syndrome，diabetes，and hyperuricemia [J]. Curr Opin Rheumatol，2013，25（2）：210-216.
[27] Kanbay M，Jensen T，Solak Y，et al. Uric acid in metabolic syndrome：From an innocent bystander to a central player [J]. Eur J Intern Med，2016，29：3-8.
[28] Ali N，Miah R，Hasan M，et al. Association between serum uric acid and metabolic syndrome：a cross-sectional study in Bangladeshi adults [J]. Sci Rep，2020，10（1）：7841.
[29] 北京市统计局.2021北京统计年鉴[M].北京：中国统计出版社，2021.
[30] Pan Z，Huang M，Fang M，et al. Socioeconomic differences in hyperuricemia and gout：a systematic review and meta-analysis [J]. Endocrine，2020，69（2）：286-293.
[31] Zhou Y，Guo Y，Liu Y. Health，income and poverty：evidence from China’s rural household survey [J]. Int J Equity Health，2020，19（1）：36. |
|
|
|
